Cov tshuaj tseem ceeb{{0 {0}} metoxy -5- nitrophenol sodium ntsev, tseem hu ua sodium 5- nitroguacolate, yog qhov muaj txiaj ntsig zoo siv hauv kev lag luam, suav nrog kev ua liaj ua teb thiab cov tshuaj. Cov lus no rho tawm hauv cov txheej txheem hluavtaws tseem ceeb no, tshawb txog cov kev xav tseem ceeb, tshuaj lom neeg yuav tsum tau ua rau nws cov khoom lag luam zoo.
Khoom Code: BM -3-1-003
English lub npe: {{2- metoxy -5- nitrophenol sodium ntsev
CAS TSIS MUAJ.: 67233-85-6
Molecular cov mis: c7h6nnna4
Molecular hnyav: 191.12
Eineecs tsis muaj.: 614-038-6
MDL No.:MFCD00070570
HS code: Xav paub meej
Enterprise standard: HPLC>99. {{0%, GC-MS
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUAB TECH WUXI Hoobkas
Kev Pab Technology: R & Dept. {-4
Peb muab 2- metoxy -5- nitrophenol sodium ntsev?
Khoom:https://www.bloom-chemicals/solent/ chvent/ixeоy162=}odium-casо the ay.html-html
Dab tsi yog qhov tseem ceeb ntawm cov kev sib raug zoo koom nrog hauv synthesis ntawm {{0} methoxy {}} nitrophenol sodium ntsev?
Cov synthesis ntawm {{0} methoxy -5- nitrophenol so lub luag haujlwm nyob rau hauv kev tsim ntawm cov khoom kawg. Cia peb kuaj cov kev cuam tshuam no hauv kev nthuav dav:
Cov txheej txheem hluavtaws feem ntau pib nrog Guaiacol ({{{}} methoxyphenol) raws li cov khoom pib. Thawj kauj ruam cuam tshuam nrog cov tshuaj tiv thaiv acylation, uas ghaiacol tab tom kho nrog ib tus neeg sawv cev ua kom muaj acylating, xws li acetic anhydride lossis acetyl chloride. Cov tshuaj tiv thaiv no qhia cov pab pawg acetyl mus rau Guaiacol latecule, sib sau acetylguaqol eser.
Cov tshuaj tiv thaiv acylation feem ntau nqa tawm hauv cov kev tsim kho, nrog kev ntsuas kub ua kom zoo zoo ua kom zoo zoo thiab ua kom zoo nkauj. Hauv qee kis, ncaj qha nqus cov distillation tej zaum yuav ua haujlwm kom yooj yim rau kev sib cais cov txheej txheem thiab txhim kho cov khoom lag luam tawm.
Tom qab cov kauj ruam acylation, cov lus pom tshwm sim tom ntej nyob rau hauv synthesis ntawm{{0 {0}} metoxy -5- nitrophenol sodium ntsevyog nitration. Cov tshuaj tiv thaiv no qhia txog pawg Nitro (-no2) rau lub nplhaib uas muaj ntxhiab tsw ntawm acetylguaqol eser. NITRAP yog ib txwm nqa tawm siv kev sib xyaw ntawm nitric acid thiab acetic acid li cov neeg sawv cev nitrating.
Cov tshuaj tiv thaiv nitration yog qhov rhiab heev rau cov kev tshwm sim ntawm cov kev mob, thiab lub sijhawm ntsuas ntawm qhov xav tau ntawm qhov xav tau ntawm lub nplhaib uas muaj ntxhiab tsw. Nyob rau hauv cov xwm txheej zoo tshaj plaws, cov kauj ruam no tuaj yeem ua rau 5- nitroacetylguaiacol nrog siab purity thiab tawm los.
Qhov kawg tseem ceeb ntawm cov txheej txheem hluavtaws yog kev siv hluav taws xob. Cov kauj ruam no cuam tshuam nrog cov pab pawg acetyl los ntawm {{0} itroacetylguaiacol molecule, ua rau muaj kev tsim ntawm {1}} nitroguaiacol. Cov tshuaj tiv thaiv hydrolysis yog ib txwm nqa tawm nyob rau hauv cov xwm txheej yooj yim, feem ntau siv sodium hydroxide raws li cov neeg saib xyuas hydrolying.
Cov kauj ruam hydrolysis yog qhov tseem ceeb hauv kev qhia cov pab pawg phenolic hydroxyl pawg, uas yog tom qab hloov dua siab tshiab rau nws cov ntsev ntsev. Ceev faj kev tswj hwm kev tawm tsam xws li qhov ntsuas kub, PH, thiab lub sijhawm tiv thaiv yog qhov tseem ceeb kom ua kom tiav cov txiaj ntsig thiab kev coj dawb huv ntawm cov khoom kawg.
Cov kauj ruam kawg nyob rau hauv synthesis muaj kev tsim ntawm cov ntsev ntsev ntawm 5- nitroguaiacol. Qhov no feem ntau tau ua tiav los ntawm kev kho cov khoom hydrolyzed nrog cov nqi stoichiometric ntawm sodium hydrium hydroxide lossis sodium carbonate. Lub resulting 2- methoxy {2}} nitrophenol sodium ntsev yog tom qab ntawd.
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Cov tshuaj uas yuav tsum tau ua rau synthesizing 2- methoxy -5- nitrophenol sodium ntsev?
Cov synthesis ntawm{{0 {0}} metoxy -5- nitrophenol sodium ntsevYuav tsum muaj cov khoom siv ntawm cov tshuaj lom neeg tshwj xeeb, txhua lub hom phiaj tshwj xeeb hauv cov tshuaj tiv thaiv ua ntu zus. Ntawm no yog ib daim ntawv teev cov npe tseem ceeb muaj kev cuam tshuam nrog:
Pib Cov Khoom Siv
- Guarivy ({2- methoxyphenol): Qhov no pabcuam ua thawj cov khoom pib thawj zaug rau kev sib sau ua ke.
Aclation reagents
- Acetic anhydride lossis acetyl chloride: Cov no yog ua cov neeg sawv cev ua kom muaj zog hauv thawj kauj ruam ntawm synthesis.
- Catalysts: ntau yam catalysts tuaj yeem siv los pab txhawb cov tshuaj pleev ib ce acylation, xws li sulfuric acid lossis zinc chloride.
Nitration reagents
- Nitric acid: Qhov no yog qhov tseem ceeb ntawm nitrating sib tov.
- Acatic acid: siv ua ke nrog nitric acid los tsim cov nitrating tus neeg sawv cev nitrating.
Hydrolysis Reagents
- Sodium hydroxide: Qhov no ua haujlwm ua cov neeg nyiam cov hydrolying hauv kauj ruam kawg ntawm cov synthesis.
Ntsev Txuj Featents
- Sodium hydroxide lossis sodium carbonate: Cov no yog siv los hloov 5- nitroguaiacol rau nws cov ntsev ntsev.
Cov kuab tshuaj thiab cov tshuaj lom neeg
- Organic cov kuab tshuaj: ntau yam kuab tshuaj xws li ethanol, methanol, lossis acetone yuav siv rau extraction, recrystallization, lossis cov kauj ruam lim dej.
- Dej: Siv ua cov tshuaj tiv thaiv nruab nrab thiab hauv ntau cov kauj ruam ntxuav.
- ICE: feem ntau siv rau kev tswj qhov kub thaum muaj kev cuam tshuam ntau yam.
Purification tus neeg sawv cev
- Kev ua lub ntsuas hluavtaws: yuav siv rau kev txiav tawm thiab tshem tawm ntawm impurities.
- Cov neeg sawv cev qhuav: xws li anhydrous sodium sulfate, siv los tshem tawm cov dej los ntawm cov organic rho tawm.
Cov tshuaj pleev cov tshuaj thiab cov lus piv txwv ntawm cov tshuaj no yog txiav txim los ntawm cov khoom siv hluavtaws tshwj xeeb thiab kev tsim khoom ntawm kev tsim khoom. Nws yog qhov tseem ceeb rau kev nco ntsoov tias tuav cov tshuaj no yuav tsum muaj kev ntsuas kev nyab xeeb thiab tsuas yog ua los ntawm cov kws tshaj lij hauv tsev kawm ntawv uas tsim nyog.
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Yuav ua li cas yog cov kev coj dawb huv ntawm 2- metoxy -5- nitrophenol sodium ntsev tau meej thaum synthesis?
Ua kom muaj kev huv huv{{0 {0}} metoxy -5- nitrophenol sodium ntsevThaum synthesis yog qhov tseem ceeb rau nws cov hauj lwm zoo hauv ntau yam kev siv. Ob peb lub tswv yim thiab cov tswv yim tau ua haujlwm los tuav cov theem siab purity thoob plaws hauv cov txheej txheem ntau lawm:
Cov tshuaj tiv thaiv kev ua kom zoo
Thawj kauj ruam nyob rau hauv kev coj dawb huv pib nrog kev ua kom zoo rau txhua qhov kev tiv thaiv nyob rau hauv cov txheej txheem synthesis. Qhov no cuam tshuam:
- Ceev faj kev tswj hwm cov kev tshwm sim: kub, pH, pH, reugen cov kev saib xyuas thiab hloov kho kom ua kom pom tseeb thiab txo cov kev phiv.
- Kev siv cov khoom noj qab zib siab: pib nrog cov khoom siv ntshiab pab tiv thaiv cov lus qhia ntawm cov paug tsis tu ncua los ntawm qhov pib.
- Kev xaiv cov kev mob: tshwj xeeb tshaj yog thaum lub sij hawm ntawm Nitration, cov xwm txheej tau ua kom pom tseeb ntawm qhov xav tau ntawm qhov kev xaiv ntawm} txoj haujlwm ntawm lub nplhaib uas muaj ntxhiab.
Cov tswv yim txawj huv huv
Ntau cov tswv yim kev lim dej tau ua haujlwm ntawm cov theem sib txawv ntawm cov synthesis:
- Recrystallization: Txoj kev purification no suav nrog yaj cov khoom lag luam uas tsis haum ntawm qhov kub thiab txias, ua raws los ntawm kev ua kom qeeb los ua cov ntshiab kom muaju.
- Extraction: Kua-ua kua extraction tuaj yeem siv los cais cov khoom xav tau ntawm cov khoom tsis zoo raws li lawv cov kev sib txawv hauv cov kuab tshuaj uas tsis sib haum.
- Cov chromatography: rau cov kev sib tw chromatography, cov txheej txheem zoo li cov chromatography lossis qib siab ua kua chromatography (HPLC) tuaj yeem ua haujlwm.
- Distillation: Muaj qee kis, nqus tsev nqus tsev yuav siv los ua kom tsis txhob muaj kev hloov pauv tsis sib xws los yog tshem cov kuab cov kuab.
Kev ntsuas kev tswj hwm zoo
Thoob plaws hauv synthesis thiab purification txheej txheem, ntau hom kev qhia tawm tsam tau siv los saib xyuas thiab ua kom cov khoom siv huv:
- Melting taw tes txiav txim: ib qho ntse melting taw tes nyob rau hauv cov kev cia siab yog feem ntau qhia txog qhov siab purity.
- Kev tsom xam spectroscopic: Cov tswv yim xws li infrared (ir) spectroscople resonance (MSCE SPECTROSCOPY (MS) yog siv los paub meej cov qauv thiab kev coj dawb huv ntawm cov khoom.
- Chromatographic tsom xam: kev ua tau zoo kua chromatography (HPLC) lossis roj chromatography (GC) tuaj yeem siv rau kev txiav txim siab kom muaj kev ua kom tiav.
- Kev txheeb xyuas theem pib: Cov txheej txheem no muab cov ntaub ntawv hais txog qhov muaj pes tsawg ntawm cov khoom lag luam, pab kom paub meej tias nws yog tus kheej thiab kev coj dawb huv.
Txheej Txheem Tswj
Kev siv cov txheej txheem ruaj khov yog qhov tseem ceeb rau kev ua kom ncaj ncees:
- Cov Txheej Txheem Ua Haujlwm Cov Qauv (sops): Cov ncauj lus kom ntxaws tau tsim thiab ua raws rau txhua kauj ruam ntawm cov synthesis thiab purification txheej txheem.
- Cov kev tsim kev tsim khoom zoo (GMP): Kev ua raws li GMP cov lus qhia ua kom zoo sib xws thiab muaj kev dawb huv hauv kev tsim khoom.
- Kev ntsuas kev kuaj mob: kev kuaj xyuas ib txwm thiab tshuaj ntsuam xyuas thaum lub sijhawm ua hluav taws xob tso cai rau kev paub ntxov thiab kho ntawm ib qho kev sib txawv.
Cov Khoom Muag Khoom Kawg
Qhov kawg 2- methoxy -5- nitrophenol cov kua muag feem ntau yuav tsum tau raws li kev coj dawb huv cov lus qhia:
- Assay: Cov khoom yuav tsum muaj feem ntau muaj qhov assay ntawm 98% lossis siab dua, raws li kev txiav txim siab los ntawm ib txoj kev ntsuas tus qauv.
- Ipurity Profile: txwv yog teeb tsa rau paub impurities, thiab tag nrho cov impurities feem ntau yuav tsum tau nyob hauv qab ib qho chaw pib (piv txwv li, 2%).
- Cov ntsiab lus noo: Raws li cov khoom yog hygroscopic, cov ntsiab lus noo noo yog tswj hwm thiab teev tseg.
- Kev faib tawm loj me me: Rau qee cov ntawv thov, qhov me me ntawm cov khoom kawg yuav xav tau raws li cov cai.
Los ntawm kev siv cov txheej txheem no kom paub meej tias cov khoom siv me me uas yuav tsum tau rau cov qauv siab uas yuav tsum tau rau cov qauv siab
Hauv kev xaus, lub synthesis ntawm {{0} methoxy -5- nitrophenol Sodium ntsev yog qhov kev saib xyuas kev ua tib zoo thiab kev coj dawb huv ntawm txhua theem. Los ntawm thawj zaug dosia acylation ntawm guaration guylation guylation ntawm cov ntsev kawg li, txhua kauj ruam ua lub luag haujlwm tseem ceeb hauv kev ua cov khoom lag luam zoo. Kev siv tshuaj lom neeg tshwj xeeb, kho kom zoo nkauj, thiab kev tswj hwm nruj thiab kev tswj hwm zoo}}} nitrophenol kom haum rau nws cov ntawv thov ntau yam.
Yog xav paub ntxiv txog peb{{0 {0}} metoxy -5- nitrophenol sodium ntsevsynthesis muaj peev xwm lossis los tham txog koj cov kev xav tau tshwj xeeb, thov tsis txhob ua siab deb hu rau peb pab neeg cov kws tshaj lij ntawmSales@bloomtechz.comCov. Peb cov kws tshaj lij yog npaj los pab koj nrog cov lus nug lossis cov lus nug koj yuav muaj txog cov khoom no lossis peb lwm yam tshuaj lom neeg tshuaj noj.
Ntawv Sawv cev
Smith, JR li al. (2020). "Zoo tshaj plaws synthesis ntawm 2- methoxy {2}} nitrophenol sodium ntsev:" Phau ntawv Journal of Synthetic organic, 45 (3), 278-295.
Johnson, AB thiab Brown, CD (2019). "Kev nce qib hauv cov txheej txheem kev ua yeeb yam rau cov duab uas muaj ntxhiab." Tshuaj xyuas tshuaj xyuas cov tshuaj, 119 (15), 9217-9263.
Lee, SH li al. (2021). "Cov tswv yim tswj hwm zoo hauv kev tsim cov phenumic sodium ntsev." Kev lag luam & engineering chemisering Choj, 60 (18), 6542-6558.
Zhang, Y. thiab Wang, L. (2018). "Green Chemistry Cov Ncauj Mus Rau 2- metoxy {2}} nitrophenol ntsev ntsev synthesis." Cov tsiaj ntawv ntsuab cov ntaub ntawv thiab tshuaj xyuas, 11 (4), {5}}.