Methylisothiazolinone(MIT Txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/methylisothiazolinone-products-cas-2682-20-4.html) yog ib tug tshiab fungicide imported los ntawm cov teb chaws Europe nyob rau hauv kuv lub teb chaws. Isothiazolinone organic tshuaj muaj peev xwm inhibit qhov kev loj hlob thiab kev loj hlob ntawm ntau yam kab mob (xws li kab mob, fungi, poov xab, thiab lwm yam), thiab yog ib chav kawm ntawm broad-spectrum fungicides uas tau siv dav. Piv nrog rau lwm hom fungicides, isothiazolinone fungicides muaj qhov zoo ntawm cov txiaj ntsig pom tseeb thiab kev ua haujlwm nrawm hauv kev tswj kev loj hlob thiab cov metabolism ntawm cov kab mob thiab tiv thaiv kev tsim ntawm biofilm. Qhov siab tshaj plaws tso cai ntawm methylisothiazolinone hauv tshuaj pleev ib ce yog 0.01 feem pua ; nws tsuas yog siv tau los ua ib qho khoom noj. Tsis tas li ntawd, kuv lub teb chaws "Kev Nyab Xeeb Technical Specifications for Cosmetics" (2015 tsab) qhia tias methylisothiazolinone tuaj yeem siv los ua cov tshuaj tua kab mob hauv cov tshuaj pleev ib ce, thiab nws qhov siab tshaj plaws tso cai yog 0.01 feem pua.
Methylisothiazolinone (MIT) tuaj yeem tau txais los ntawm ntau txoj hauv kev kuaj kev sib txuas. Cov hauv qab no yog cov lus piav qhia ntxaws ntxaws ntawm ntau txoj hauv kev kuaj sim ua ke rau methylisothiazolinone:
Txoj Kev 1: Isothiocyanate method:
C3H8O plus C2H3NWS → C4H5NOS
Kev sim cov kauj ruam:
1. Noj cov tshuaj isopropanol uas tsim nyog los ua cov kuab tshuaj thiab muab tso rau hauv lub nkoj kom huv.
2. Kub lub isopropanol kom reflux. Lub phaj kub los yog lub tshuab cua sov tuaj yeem siv los ua kom sov cov isopropanol hauv cov hlab ntsha.
3. Maj mam ntxiv methyl isothiocyanate rau isopropanol. Methyl isothiocyanate tuaj yeem maj mam ntxiv dropwise siv lub burette lossis ib qho ntxiv funnel, xyuam xim rau kev tswj tus nqi ntawm qhov sib ntxiv.
4. Nyob rau tib lub sijhawm, dilute hydrochloric acid ntxiv dropwise rau cov tshuaj tiv thaiv hlab ntsha los kho cov pH ntawm cov tshuaj tiv thaiv sib tov. Qhov sib ntxiv ntawm dilute hydrochloric acid pab kom tsis txhob muaj cov tshuaj alkaline tsim.
5. Thaum lub sij hawm dropwise ntxiv, cov tshuaj tiv thaiv sib tov yog txuas ntxiv stirred nrog ib tug do bar kom paub meej tias cov tshuaj tiv thaiv yog tov zoo.
6. Nws feem ntau siv sijhawm ntev los ua kom tiav cov tshuaj tiv thaiv ntawm methylisothiazolinone, feem ntau yog li ntawm 12-24 teev. Lub sijhawm tshuaj tiv thaiv tuaj yeem hloov kho raws li qhov xwm txheej tshwj xeeb.
7. Tom qab cov tshuaj tiv thaiv tiav lawm, tshem tawm cov tshuaj tiv thaiv los ntawm cov cuab yeej cua sov thiab cia nws txias rau chav sov. Cov txheej txheem txias tuaj yeem ua kom nrawm dua los ntawm kev tso cov tshuaj tiv thaiv cov hlab ntsha hauv cov dej txias da dej.
8. Tom qab txias, saib cov tshuaj tiv thaiv sib tov rau nag lossis daus, uas yog tsim ntawm methylisothiazolinone. Lub precipitate feem ntau yog dawb los yog lub teeb daj.
9. Cov tshuaj tiv thaiv sib tov tau lim kom cais cov methylisothiazolinone ua cov khoom. Kev lim dej tuaj yeem ua tau siv cov ntawv lim los yog lub tshuab nqus tsev lim.
10. Cov khoom tau txais yuav tsum tau qhuav kom tshem tawm cov residual hnyav thiab noo noo. Nws tuaj yeem maj mam muab tso rau hauv lub rhaub lossis ziab hauv qhov muaj desiccant.
11. Thaum kawg, ntsuas qhov tseeb thiab sau cov txiaj ntsig ntawm methylisothiazolinone siv lub ntsuas ntsuas.
Txoj Kev 2: Pyrrolidone method:
C6H10O plus C2H3NWS → C4H5NOS
Kev sim cov kauj ruam:
1. Siv ib qho nyiaj tsim nyog ntawm cyclohexanone ua cov kuab tshuaj thiab muab tso rau hauv cov hlab ntsha huv.
2. Thaum tshav kub kub cyclohexanone rau reflux. Lub phaj kub los yog lub tshuab cua sov tuaj yeem siv los ua kom sov lub cyclohexanone hauv cov hlab ntsha.
3. Maj mam ntxiv methyl isothiocyanate dropwise rau cyclohexanone. Ib qho burette lossis ntxiv funnel tuaj yeem siv los tswj tus nqi ntawm qhov sib ntxiv.
4. Nyob rau tib lub sijhawm, ntxiv cov tshuaj sodium hydroxide uas tsim nyog los ua kom tsis muaj cov tshuaj alkaline generated. Neutralization pab tswj kom zoo acid-base tshuav nyiaj li cas.
5. Thaum lub sij hawm dropwise ntxiv, cov tshuaj tiv thaiv sib tov yog txuas ntxiv stirred nrog ib tug do bar kom paub meej tias cov tshuaj tiv thaiv yog tov zoo.
6. Lub sijhawm tshuaj tiv thaiv tuaj yeem txiav txim siab raws li qhov xwm txheej tshwj xeeb, feem ntau nyob ib puag ncig 12-24 teev. Rau cov khoom purity siab dua, lub sij hawm tshuaj tiv thaiv tuaj yeem txuas ntxiv.
7. Tom qab cov tshuaj tiv thaiv tiav lawm, tshem tawm cov tshuaj tiv thaiv los ntawm cov cuab yeej cua sov thiab cia nws txias rau chav sov. Cov txheej txheem txias tuaj yeem ua kom nrawm dua los ntawm kev tso cov tshuaj tiv thaiv cov hlab ntsha hauv cov dej txias da dej.
8. Tom qab txias, saib cov tshuaj tiv thaiv sib tov rau nag lossis daus, uas yog tsim ntawm methylisothiazolinone. Lub precipitate feem ntau yog dawb los yog lub teeb daj.
9. Cov tshuaj tiv thaiv sib tov tau lim kom cais cov methylisothiazolinone ua cov khoom. Kev lim dej tuaj yeem ua tau siv cov ntawv lim los yog lub tshuab nqus tsev lim.
10. Cov khoom tau txais yuav tsum tau qhuav kom tshem tawm cov residual hnyav thiab noo noo. Nws tuaj yeem maj mam muab tso rau hauv lub rhaub lossis ziab hauv qhov muaj desiccant.
11. Thaum kawg, ntsuas qhov tseeb thiab sau cov txiaj ntsig ntawm methylisothiazolinone siv lub ntsuas ntsuas.
Txoj Kev 3: Cov tshuaj tiv thaiv ncaj qha ntawm isothiocyanate thiab ketones:
Txoj kev tawm tsam ncaj qha ntawm isothiocyanate ntawm Methylisothiazolinone (MIT) thiab ketones yog ib txoj kev siv hluavtaws feem ntau.
Ketones plus C2H3NWS → C4H5NOS
Kev sim cov kauj ruam:
1. Siv ib qho tsim nyog ntawm ketone compound raws li cov tshuaj tiv thaiv substrate, thiab ncuav nws mus rau hauv cov tshuaj tiv thaiv kab mob huv.
2. Ntxiv methyl isothiocyanate rau cov hlab ntsha cov tshuaj tiv thaiv. Methyl isothiocyanate tuaj yeem maj mam ntxiv dropwise siv lub burette lossis ib qho ntxiv funnel, xyuam xim rau kev tswj tus nqi ntawm qhov sib ntxiv.
3. Rau cov tshuaj tiv thaiv substrate nrog cov solubility tsis zoo, nws tuaj yeem ua ntej yaj hauv cov kuab tshuaj tsim nyog los tsim cov tshuaj, thiab tom qab ntawd cov tshuaj ntxiv rau cov tshuaj tiv thaiv cov hlab ntsha.
4. Thaum lub sij hawm dropwise ntxiv, cov tshuaj tiv thaiv sib tov yog txuas ntxiv stirred nrog ib tug do bar kom paub meej tias cov tshuaj tiv thaiv yog tov zoo.
5. Raws li kev xav tau tshwj xeeb, cov tshuaj tiv thaiv sib xyaw tuaj yeem ua kom sov hauv cov khoom siv cua sov. Kev ua haujlwm cua sov tuaj yeem ua tau siv cov khoom siv xws li cov phaj kub, cov cua sov, lossis cov da dej kub kub.
6. Lub sij hawm yuav tsum tau ua kom tiav cov tshuaj tiv thaiv nws txawv nyob ntawm seb cov xwm txheej tshwj xeeb, feem ntau yog los ntawm ob peb teev mus rau ob peb hnub. Nws tuaj yeem hloov kho raws li qhov xwm txheej ntawm cov tshuaj tiv thaiv substrate thiab cov txheej txheem tshuaj tiv thaiv.
7. Tom qab cov tshuaj tiv thaiv tiav lawm, tshem tawm cov tshuaj tiv thaiv los ntawm cov cuab yeej cua sov thiab cia nws txias rau chav sov. Cov txheej txheem txias tuaj yeem ua kom nrawm dua los ntawm kev tso cov tshuaj tiv thaiv cov hlab ntsha hauv cov dej txias da dej.
8. Tom qab txias, saib cov tshuaj tiv thaiv sib tov rau nag lossis daus, uas yog tsim ntawm methylisothiazolinone. Lub precipitate feem ntau yog dawb los yog lub teeb daj.
9. Cov tshuaj tiv thaiv sib tov tau lim kom cais cov methylisothiazolinone ua cov khoom. Kev lim dej tuaj yeem ua tau siv cov ntawv lim los yog lub tshuab nqus tsev lim.
10. Cov khoom tau txais yuav tsum tau qhuav kom tshem tawm cov residual hnyav thiab noo noo. Nws tuaj yeem maj mam muab tso rau hauv lub tshuab cua sov los yog ziab hauv lub xub ntiag ntawm lub desiccant.
11. Thaum kawg, ntsuas qhov tseeb thiab sau cov txiaj ntsig ntawm methylisothiazolinone siv lub ntsuas ntsuas.
Nws yuav tsum raug sau tseg tias qhov kev siv tau thiab cov kauj ruam tshwj xeeb ntawm cov txheej txheem kev sim ua kom sib txawv tuaj yeem sib txawv raws li kev tshawb fawb lub hom phiaj, substrate thiab cov tshuaj tiv thaiv. Yog li ntawd, thaum ua kev kuaj sim, nws yog ib qho tsim nyog yuav tsum tau ua tib zoo xaiv ib txoj hauv kev uas tsim nyog, thiab ua kom zoo dua thiab txheeb xyuas cov kev mob tshwm sim thiab cov txheej txheem purification kom ntseeg tau tias muaj txiaj ntsig zoo thiab purity ntawm cov khoom. Tsis tas li ntawd, rau qhov laj thawj kev nyab xeeb, txhua qhov kev sim yuav tsum tau ua raws li cov cai tswj kev nyab xeeb thiab cov lus qhia ua haujlwm hauv chav kuaj.