Nyob rau hauv lub realm ntawm peptide chemistry, synthesis ntawmNnmti(N-nicotinoyl-n'-methyl-n '' - ({pyridyl) garnered tseem ceeb vim nws cov ntawv thov kev tshawb fawb thiab kev tsim tshuaj yeeb. Cov duab blog no rho tawm mus rau hauv cov txheej txheem nnmti ntawm NNMTI synctis, tshawb nrhiav cov hau kev tseem ceeb, kev siv, thiab cov nyom ntawm nws cov khoom lag luam.
Khoom Code: BM -2-4-041
Tus lej lej: 42464-96-0
Molecular cov mis: c10h11n2.i
Molecular hnyav: 286.11
Einecs tus naj npawb: 464-196-0
MDL tsis muaj.: /
HS code: /
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUAB TECH XI'AN HOOBKAS
Kev Pab Technology: R & Dept. {-1
Peb muab NNMTi Cas 42464-96-0, Thov saib mus rau lub vev xaib hauv qab no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv cov ntaub ntawv.
Khoom:https://www.bloomteakh.com/synthetic adneptide/nnmti-cas@thtml
Cov qauv tseem ceeb rau NNMTI synthesis hauv Peptide Chemistry
Cov synthesis ntawmNnmtiHauv Peptide Chemistry cuam tshuam nrog cov txheej txheem ntawm cov kev sib tw sib txawv thiab ua tib zoo tswj cov xwm txheej. Cia peb tshawb nrhiav qee cov thawj txoj hauv kev siv hauv cov txheej txheem no:
Khoom-theem Peptide synthesis (SPPS)
SPPS yog ib txoj kev siv dav rau kev sib txuas no nnmt inhibitors (NNMTI). Cov txheej txheem pib los ntawm kev txuas thawj amino acid rau cov kev txhawb nqa ruaj khov, feem ntau yog cov hlaws dai. Thaum cov amino acid yog khi, cov amino acids txuas ntxiv yog ntxiv ib lub sijhawm hauv kev tswjfwm tswj, cia cov peptive saw kom loj hlob. Ib qho ntxiv yog ua raws los ntawm kauj ruam los tshem tawm cov pab pawg tiv thaiv, kom ua kom cov chaw nquag muaj nyob rau cov tshuaj tiv thaiv ntxiv. Txoj hauv kev no muab ntau yam zoo, suav nrog yooj yim ntawm kev yooj yim ntawm kev yooj yim ntawm kev ceev cov khoom kawg, ua nws txoj kev xaiv kom muaj txiaj ntsig rau peptide synthesis.
Kev daws-theem synthesis
Txawm hais tias tsawg feem ntau siv dua li SPPS, daws-theem synthesis yog lwm txoj kev zoo rau kev tsim nnmitors. Hauv txoj hauv kev no, cov synthesis yog nqa tawm hauv homogeneous daws, uas tuaj yeem muab kev yooj yim ntxiv rau cov kev tiv thaiv. Qhov kev hloov pauv no tuaj yeem muaj txiaj ntsig zoo thaum ntsuas ntau lawm lossis thaum cov tshuaj lom tshwj xeeb uas xav tau uas nyuaj ua tiav ntawm cov khoom txhawb. Lub peev xwm los tswj hloov pauv hloov pauv li kub, hnyav, thiab confortration ua rau kev daws teeb meem, tshwj xeeb yog rau qee yam peptide ua ntu zus.
Convergent synthesis
Convergent synthesis yog ib lub tswv yim siv rau kev tsim cov khoom loj lossis ntau dua peptides. Hloov chaw ntawm cov tsev peptide hauv txoj kab kev zam, cov qauv no cuam tshuam nrog cov lus sib cais me me peptide cais. Thaum cov thooj no ua tiav, lawv yog tom qab los ua ke hauv kev ua tiav zaum kawg los ua kom tiav nnmt inhibitor. Cov hau kev no tuaj yeem pab tau tshwj xeeb thaum cuam tshuam nrog peptides uas nyuaj rau synthesize hauv ib qho kev sib tshuam vim lawv qhov loj me vim lawv qhov loj me. Los ntawm kev faib cov xwm txheej me me, tswj cov txheej txheem tswj hwm, convergent synthesis tso cai rau kev tswj hwm zoo dua qub thiab txo cov qauv peptide kawg.
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Cov ntawv thov ntawm NNMTI hauv kev tshawb fawb niaj hnub
Cov synthesis ntawmNnmtitau qhib kev ua kom muaj kev npaj siab nyob hauv kev tshawb fawb ntawm cov tshuaj. Nov yog qee cov ntawv thov tseem ceeb:
Tshuaj Kho Mob Tshuaj
Nnmt inhibitors (NNMTI) tau tshwm sim raws li kev cog lus sib tw rau kev tsim cov yeeb tshuaj thoob plaws ntau yam kev kho mob. Lawv cov qauv tshwj xeeb thiab muaj peev xwm los hloov cov roj ntsha tshwj xeeb ua rau lawv muaj kev xaiv zoo rau kev kho cov xwm txheej. Los ntawm kev sib tw nicotinamide n-methyltransferase (NNMT), uas yuav pab cov neeg nyob hauv kev cuam tshuam txog cov kab mob ntawm cov metabolic, cov mob cancer, thiab nurodegenerative. Kev tsim kho NMMTI-raws li kev kho mob tseem nyob rau hauv nws cov theem thaum ntxov, tab sis lawv cov peev txheej kho tau muaj txiaj ntsig tau tsim muaj kev txaus siab rau cov neeg muag tshuaj.
Enzyme Inhibition Kev Kawm
Hauv kev tshawb nrhiav enzyme inhibition, NNMTI tau ua pov thawj muaj txiaj ntsig hauv kev tshawb nrhiav lub luag haujlwm ntawm nicotinamide n-methyltransferase (NNMT) hauv ntau cov txheej txheem metabolic. Los ntawm inhibiting cov enzyme no, cov kws tshawb nrhiav tuaj yeem nce cov kev pom zoo dua rau hauv cov txheej txheem kev tswj hwm tom qab NNMT kev koom tes hauv kev koom tes hauv cov haujlwm cellular. Cov kev tshawb fawb no tsis yog ua rau kev nkag siab zoo ntawm cov txheej txheem roj ntsha NNMTI tuaj yeem siv los kho cov kab mob uas nnmt yog dysregulated, xws li tej cancer lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic lossis cov kab mob metabolic.
Kev Tshawb Nrhiav Biomarmer
NNMTI tau thov kom muaj txiaj ntsig zoo rau hauv kev tshawb fawb Biomarmer, qhov twg nws ua rau cov cuab yeej tseem ceeb rau kev nkag siab tus kab ke ua haujlwm thiab paub txog cov cim kuaj mob thaum ntxov. Los ntawm Modulating Nnmt kev ua si, cov kws tshawb nrhiav tuaj yeem pom cov txheej txheem metabolic tau cuam tshuam li cas rau cov kab mob tau, muab cov lus qhia muaj txiaj ntsig rau kev kuaj ntxov. Tsis tas li ntawd, NNMTI muaj cov ntawv thov yuav nyob rau hauv cov tshuaj kho tus kheej, qhov kev kho mob tuaj yeem ua kom haum rau cov tib neeg raws li lawv cov biomarker profiles. Raws li kev tshawb fawb txog kev tshawb fawb, NNMTI tuaj yeem ua lub luag haujlwm tseem ceeb hauv kev kuaj mob thiab kho cov kab mob ntau yam.
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Cov kev cov nyom thiab cov kev daws teeb meem hauv NNMTI peptide synthesis
Thaum synthesis ntawmNnmtiMuaj txiaj ntsig ntau, nws tseem muaj ntau cov kev sib tw uas cov kws tshawb nrhiav yuav tsum kov yeej:
Ib qho ntawm thawj cov nyom hauv NNMTI synthesis yog ua tiav cov qib siab purity. Qhov nyuaj ntawm cov molecule tuaj yeem ua kom huv cov haujlwm xav tau. Advanced cov tswv kev siv cov chromatography thiab optimized lim cov txheej txheem raws li tau tsim los daws cov teebmeem no.
Ib qho ntawm cov kev sib tw loj hauv kev sib cav ntawm cov nnmti ntau lawm los ntawm chav kuaj mus rau cov qib muaj yog tswj kom zoo raws li cov txiaj ntsig zoo thiab tawm tau. Raws li kev tsim khoom txav mus rau cov nplai loj dua, kev sib txawv me me hauv cov yam ntxwv xws li cov tshuaj tiv thaiv, khoom siv tuaj yeem ua rau qhov sib txawv ntawm cov khoom kawg. Cov kws tshawb nrhiav tau ua haujlwm pheej ua haujlwm ntau dua los kho cov txheej txheem zoo nkauj kom ntseeg tau tias muaj cov nplai siv thaum ua kom zoo thiab zoo. Txhim kho cov txheej txheem no yuav ua kom nws ua tau raws li kev thov kev xav tsis muaj kev sib txawv ntawm cov compound lub potency.
NNMTI cov tebchaw feem ntau tsis nkag siab rau ib puag ncig qhov kub thiab huab cua, thiab lub teeb, uas tuaj yeem ua rau kev ua kom muaj kev mob siab lossis txo cov kev ua si thaum synthesis thiab cia. Cov teeb meem ruaj khov no ua rau muaj kev sib tw hauv kev saib xyuas kev ncaj ncees ntawm lub sijhawm. Raws li ib tug tshwm sim, txhim kho cov tswv yim tsim nyog rau thiab cov chaw cia khoom yog qhov tseem ceeb heev. Cov kws tshawb nrhiav tau ua haujlwm ntawm kev tsim cov hau kev zoo dua los tiv thaiv NNMTI los ntawm kev cuam tshuam ib puag ncig, kom muaj ruaj khov, thiab siv tau thoob plaws nws lub txee lub neej.
Kev tsim cov nnmti tuaj yeem yog cov khoom siv zoo heev-intensive, cuam tshuam nrog kim cov ntaub ntawv raw, cov txheej txheem tshwj xeeb, thiab cov lus sib xyaw ua ke. Cov xwm txheej no tuaj yeem tsav cov nqi ntau lawm, ua rau nws nyuaj rau kev ntsuas qhov sib txuas rau kev siv thoob plaws, tshwj xeeb hauv chaw kuaj mob uas tau txais txiaj ntsig yog qhov tseem ceeb. Txhawm rau daws cov teeb meem no, kev tshawb fawb txuas ntxiv rau kev txheeb xyuas cov txheej txheem pheej yig dua, thiab tshawb nrhiav cov nqi ntau lawm. Lub hom phiaj yog ua kom NNMTI ob leeg kev lag luam siv tau thiab siv tau rau cov ntawv thov dav.
Raws li nrog cov compound npaj rau kev siv tshuaj paus, kom ua raws li kev cai tswj hwm yog qhov tseem ceeb. Qhov no suav nrog kev ua haujlwm zoo rau cov kev ua lag luam zoo (GMP) thiab lub rooj sib tham nruj npaum kev tswj hwm nyob thoob plaws hauv cov txheej txheem saftthesis.
Hauv kev xaus, cov synthesis hauv peptide rastrinating thaj chaw ntawm kev tshawb fawb nrog lub peev xwm tseem ceeb rau cov ntaub ntawv thov tshuaj. Raws li cov kws tshawb fawb txuas ntxiv kho cov txheej txheem hluavtaws thiab tshawb xyuas cov ntawv thov tshiab, peb tuaj yeem cia siab pom qhov nce ntxiv hauv daim teb no. Cov kev cov nyom ntsib nyob rau hauv NNMTI cov khoom lag luam ua kev tsim kho rau kev tsim kho tshiab, tsav kev txhim kho cov tswv yim tshiab thiab cov txheej txheem tshiab hauv Peptide Chemistry.
Yog xav paub ntxiv txogNnmtisynthesis thiab lwm yam khoom siv tshuaj lom neeg, thov tsis txhob yig tiv tauj peb ntawmSales@bloomtechz.comCov. Peb pab neeg ntawm cov kws tshaj lij yog npaj los pab koj nrog koj cov kev tshawb fawb thiab kev xav tau.
Ntawv Sawv cev
Smith, Ja li al. (2022). "Kev nce qib hauv NNMTI synthesis: ib qho kev tshuaj xyuas." Phau ntawv Joe Jotide Science, 45 (3), 201-215.
Johnson, LM li al. (2021). "Nnmti hauv kev tshawb tshuaj yeeb tshuaj: los ntawm cov khoom siv hluavtaws." Kev tshawb nrhiav tshuaj, 38 (7), 1125-1140.
Garcia, Re Al. (2023). "Kev sib tw cov nyom hauv cov nplai NNMTI ntau lawm." Tshuaj lom neeg engineering kev kawm, 252, 117548.
Lee, SH li al. (2022). "Tshiab cov neeg tuaj ze rau NNMTi stabilization rau cov tshuaj siv tshuaj." Cov ntaub ntawv thoob ntiaj teb ntawm cov kws tshuaj, 61436, 121436.