Yuav Ua Li Cas Milbemycin Oxime Powder Fits Rau Kev Tiv Thaiv Kab Mob plawv

Kab mob Heartworm ua rau muaj kev hem thawj rau dev thiab miv thoob plaws ntiaj teb. Kis los ntawm yoov tshaj cum tom, tus kab mob Dirofilaria immitis tuaj yeem ua ntsiag to tsim nws tus kheej hauv cov tsiaj lub plawv ua ntej pom cov tsos mob tshwm sim. Los ntawm lub sij hawm kho mob cov cim qhia, qhov kev puas tsuaj twb tseem ceeb heev. Kev tiv thaiv, tsis kho, tseem yog lub tswv yim zoo tshaj plaws thiab milbemycin oxime hmoovzaum ntawm qhov chaw ntawm lub tswv yim ntawd rau cov kws kho tsiaj thiab cov tswv lub luag haujlwm zoo ib yam.

Cov kab lus no rhuav tshem yuav ua li cas milbemycin oxime hmoov ua haujlwm tiv thaiv kab mob plawv, dab tsi ua rau nws cov tshuaj siv tshuaj kom meej, thiab vim li cas kev tswj hwm txhua hli tau dhau los ua cov txheej txheem hauv kev noj qab haus huv ntawm cov tsiaj.

Milbemycin Oxime hmoov

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
Rau dev: 2.3mg / 5.75mg / 11.5mg / 23.0mg
Rau miv: 5.75mg / 11.5mg / 23.0mg
(3) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-1-112
Milbemycin Oxime CAS 129496-10-2
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.

Yuav Ua Li Cas Milbemycin Oxime Powder Act ntawm Kev Txhim Kho Heartworm Larvae?

Qhov rai ntawm Vulnerability hauv Larval Development

Thaum yoov tshaj cum muab Dirofilaria immitis larvae rau ntawm tus tswv tsev ntawm daim tawv nqaij, cov larvae, uas yog hu ua L3-stage infective larvae, txav mus los ntawm tus tswv tsev cov ntaub so ntswg subcutaneous thiab hloov mus rau L4 larvae. Tom qab ntawd lawv loj hlob ntau dua. Lub sijhawm no, uas feem ntau kav li ntawm 30 thiab 60 hnub tom qab kis kab mob, cov tshuaj siv tau zoo tshaj plaws los tiv thaiv tus kab mob. Cov larvae tseem tsis tau ua rau lub plawv lossis cov hlab ntsha loj txaus, uas ua rau lawv yooj yim dua los tua nrog cov tshuaj tiv thaiv kab mob.

Milbemycin oxime hmoov zoo heev ntawm kev tua cov -theem larvae thaum ntxov.

Veterinary pharmacology cov ntaub ntawv hais txog cov kev tshawb fawb uas qhia tias muab cov tshuaj ib hlis ib zaug ntawm cov tshuaj pom zoo ntawm 0.5 txog 0.99 mg / kg tau tshem ntawm L3 thiab L4 theem cov kab mob plawv uas tau loj hlob dhau lub hli dhau los. Qhov "retroactive" qhov rais ntawm kev ua tau zoo yog ib qho laj thawj vim li cas 30-hnub noj sijhawm ua rau muaj kev nkag siab zoo thiab tsis yog tsim los xwb.

Larval Paralysis thiab Mechanism of Elimination

Thaum noj los ntawm qhov ncauj thiab kis los ntawm cov rog thiab cov leeg, milbemycin oxime hits qib siab txaus kom tsis txhob ua kom cov nqaij ntshiv ua haujlwm zoo.

Cov tshuaj tsuas yog khi rau glutamate-gated chloride channels, uas yog cov qauv uas muaj nyob rau hauv cov hlab ntsha thiab cov leeg hlwb ntawm invertebrates tab sis tsis nyob rau hauv cov tsiaj nyeg.Cov ntaub ntawv qhib cov channel nyob rau hauv ib txoj kev uas tsis tuaj yeem thim rov qab, sau cov kab mob hauv lub hlwb nrog cov tshuaj chloride ions.

Qhov no ua rau cov leeg nqaij daim nyias nyias ua kom them sai heev. Cov larvae nres tsiv thiab pub mis, thiab cov kab mob hauv lub cev kaw. Cov tshuaj tiv thaiv kab mob no ua haujlwm tau zoo txawm tias thaum koob tshuaj tsawg, uas pab piav qhia vim li cas nws thiaj li muaj kev nyab xeeb rau dev, miv, thiab lwm yam tsiaj. Cov larvae tuag yam tsis muaj kev sib ntaus sib tua tiag tiag, tshwj xeeb tshaj yog thaum lawv tseem hluas thiab tseem tab tom loj hlob.

Milbemycin Oxime Powder thiab Glutamate-Gated Chloride Channel Ua kom muaj zog

Dab tsi ua rau Lub Hom Phiaj Channel no muaj txiaj ntsig zoo

Glutamate-gated chloride channels, los yog GluCls, yog ib hom ligand-gated ion channel uas tsuas pom muaj nyob hauv kab thiab lwm yam tsiaj. Lawv tsis pom nyob rau hauv vertebrate neurology, uas yog lub ntsiab yog vim li cas vim li cas macrocyclic lactone tshuaj nyiam.milbemycin oxime hmoovmuaj kev nyab xeeb rau cov tsiaj. Cov kev tshawb fawb hauv phau ntawv xov xwm kab mob parasitology tau ua pov thawj tias cov kab no tswj cov nematodes lub cev muaj zog thiab kev siv lub pharyngeal, ob txheej txheem uas tsim nyog rau cov kab mob kom ciaj sia.

Milbemycin oxime khi rau GluCl receptor heev thiab kaw cov channel hauv qhov qhib. Qhov no tsis yog luv luv - cov tshuaj tiv thaiv.

Qhov tsis tu ncua ntawm cov tshuaj chloride ions ua rau nws tsis yooj yim rau cov cab cab kom txav mus rau hauv txoj hauv kev. Qhov no txhais tau hais tias cov kab mob plawv tsis tuaj yeem txav mus los, tshem lawv cov tawv nqaij, lossis loj hlob, txhua yam uas tsim nyog rau tus kab mob kis mus.

Vim li cas Qhov Mechanism no tseem ceeb rau cov dev rhiab heev

Collies, Australian Shepherds, thiab lwm yam herding breeds nrog MDR1 (ABCB1) gene mutation rhuav tshem qee cov tshuaj tiv thaiv kab mob qeeb dua vim tias lawv cov P-glycoproteins tsis ua hauj lwm zoo ntawm cov ntshav - hlwb barrier. Piv txwv li, ivermectin tuaj yeem tsim nyob rau hauv cov tsiaj no mus rau qib uas yog neurotoxic. Milbemycin oxime hmoov, ntawm qhov tod tes, muaj qhov sib luag qis dua rau kev hla cov ntshav- hlwb teeb meem hauv cov tsiaj. Nws kuj tseem muaj qhov pheej hmoo tsawg dua ntawm kev mob neurotoxicity hauv cov dev uas yog MDR1- cuam tshuam, uas ua rau nws pom zoo xaiv rau cov pab pawg no.

Cov ntaub ntawv tshuaj lom neeg muaj peev xwm rov qab tau qhov kev thov no: muab 3 mg / kg ib hnub rau cov dev tsis tu ncua tsis ua rau muaj kev cuam tshuam lub hlwb tsis zoo. Lub cushion kev nyab xeeb no ua rau cov kws kho tsiaj muaj kev ywj pheej ntau thaum lawv ua raws li ntev -cov kev tiv thaiv kev coj ua nrog cov tsiaj rhiab.

Vim li cas Milbemycin Oxime Powder siv rau kev tiv thaiv kab mob plawv txhua hli

Aligning Pharmacokinetics Nrog Parasite's Life Cycle

Lub sijhawm 30-hnub noj tshuaj rau milbemycin oxime hmoov tsis yog kev txiav txim siab ua lag luam xwb; Nws yog raws li kev tshawb fawb zoo ntawm ob qho tib si cov tshuaj pharmacokinetic profile thiab lub sijhawm lub sijhawm uas cov kab mob plawv loj hlob. Cov tshuaj mus txog nws qib siab tshaj plaws hauv cov ntaub so ntswg adipose 4 mus rau 8 teev tom qab noj los ntawm qhov ncauj. Cov tshuaj no ua haujlwm ntev txaus los tua cov larvae uas tau muab tso rau hauv lub hli dhau los ua ntej lawv dhau mus rau theem L4, uas yog qhov tsis zoo.

Lub qhov rais retroactive kev ua tau zoo no tau raug pov thawj los ua haujlwm hauv kev tswj xyuas kev ua tau zoo,

qhov twg koob tshuaj txhua hli tiv thaiv ntau dua 99% ntawm cov dev nyob hauv thaj chaw uas Dirofilaria immitis feem ntau kis los ntawm tus kab mob.

Ua raws li kev teem caij txhua hli yog tib txoj hauv kev kom paub tseeb tias kev nyab xeeb nyob hauv qhov chaw. Txawm tias luv luv ntawm ob peb hnub tuaj yeem cia cov larvae txav mus rau theem tom ntej, qhov twg milbemycin oxime ua haujlwm zoo tshaj plaws.

Lub Sijhawm Sijhawm Sijhawm thiab Ua Ntej- Kev Tswj Xyuas Lub Caij Mosquito

Milbemycin Oxime hmoovyuav tsum tau siv ib hlis ua ntej lub caij yoov tshaj cum. Qhov no ua rau muaj qhov tsis zoo ntawm kev ua tau zoo uas tua cov larvae uas raug xa mus rau thaum ntxov tshwm sim ua ntej lawv mus txog cov ntaub so ntswg tiv thaiv. Veterinary parasitology cov cai hais tias nyob rau hauv sov thiab subtropical cheeb tsam uas yoov tshaj cum muaj zog txhua xyoo, kev kho mob yuav tsum tau muab ib lub hlis ib zaug tsis muaj so rau hnub so.

Yuav Ua Li Cas Milbemycin Oxime Powder Fits Rau Hauv Kev Tiv Thaiv Kab Mob Kabmob niaj hnub

Broad -Spectrum Coverage Beyond Heartworm

Milbemycin oxime hmoov txawv ntawm ib leeg -cov tshuaj tiv thaiv kab mob vim tias nws ua haujlwm tawm tsam ntau hom kab mob plab hnyuv tib lub sijhawm. Roundworms (Toxocara canis), hookworms (Ancylostoma caninum), thiab whipworms (Trichuris vulpis) tuaj yeem kho nrog ib koob tshuaj txhua hli. Qhov dav -spectrum kev txiav txim siab no txo ​​qis ntawm cov kev kho mob sib txawv uas xav tau thiab ua rau lub sijhawm tswj kab mob cab yooj yim dua rau cov tsev uas muaj ntau dua ib tus dev lossis miv.

Cov qauv sib xyaw ua ke uas ua ke nrog milbemycin oxime nrog praziquantel npog tapeworms zoo li, ua kom tiav cov kab mob parasite tswj los ntawm ib qho kev tshwm sim ib zaug.

Dose Precision hla lub neej theem thiab lub cev hnyav

Milbemycin oxime hmoov tuaj yeem raug txhaj tshuaj raws li qhov hnyav, thiab qhov kev hloov pauv yog 0.1 mg / kg. Qhov kev nthuav dav no yog qhov tseem ceeb rau txhua tus neeg mob, txij li cov menyuam yaus hnub nyoog qis dua 6 lub lis piam mus rau loj - yug me nyuam dev uas nws cov metabolism hloov nrog lub hnub nyoog. Hauv 48 teev, kwv yees li 90% ntawm cov tshuaj tau tawm hauv lub cev raws li nws cov tshuaj tsis hloov pauv niam txiv. Qhov no ua rau lub siab txoj haujlwm yooj yim dua.

Hepatic enzymes zoo li GOT thiab GPT tsis tau nce siab ntawm kev tiv thaiv ib txwm nyob hauv cov tsiaj uas nws lub siab ua haujlwm tsis muaj zog. Qhov no ua rau milbemycin oxime yog ib qho kev xaiv zoo ntev - lub sij hawm xaiv, txawm rau cov tsiaj uas muaj lub sij hawm ntev -.

Los ntawm Heartworm Larvae mus rau Kev Tiv Thaiv Kev Kho Mob: Lub luag haujlwm ntawm Milbemycin Oxime Powder

Kaw qhov sib txawv ntawm kev pheej hmoo kis kab mob thiab kev tiv thaiv kev ua haujlwm

Kab mob Heartworm kis mus ntsiag to, yog li ntau tus tswv tsiaj tsis paub tias nws txaus ntshai npaum li cas. Tus dev tuaj yeem khaws cov larvae ciaj sia tau ntau lub hlis yam tsis muaj tsos mob tshwm sim. Thaum lub sij hawm arterial hypertension los yog txoj cai - pom kev nyuaj siab ntawm lub plawv, nws lig dhau los pib kho. Qhov kev tiv thaiv ntawm milbemycin oxime hmoov tau tshem ntawm qhov teeb meem qeeb no los ntawm kev txwv cov larvae ua ntej lawv tuaj yeem nyob hauv plawv thiab lub ntsws cov ntaub so ntswg.

Thaum siv cov tshuaj tua yoov tshaj cum lossis cov kauj ruam los tswj ib puag ncig, qhov no tsim cov vets hu ua "internal kill, external protection" dual barrier.

Qhov no yog kev tiv thaiv multilayered uas ua rau nws nyuaj rau cov kab mob sib kis.

Kho Cov Txheej Txheem Kev Tiv Thaiv rau Cov Tsiaj Tshiab Tshiab

Cov tsiaj uas pom ntawm txoj kev lossis hauv cov chaw nyob feem ntau muaj cov kab mob xws li kab mob khaub thuas, kab ntsig, thiab hma uas tsis tau sau tseg. Thaum txais cov tsiaj thawj zaug coj los tsev, milbemycin oxime tau muab rau lawv. Qhov no ua rau lawv nthuav dav -spectrum deworming nyob rau hauv ib qho kev sib xyaw, uas txo qis lub sijhawm lawv yuav tsum tau khaws cia cais thiab ua kom lawv muaj kev nyab xeeb rau hauv cov tsiaj uas twb muaj lawm. Vim hais tias cov tshuaj muaj cov tshuaj toxicity tsawg, nws tuaj yeem siv tau txawm tias tus tsiaj lub cev hnyav lossis keeb kwm kev noj qab haus huv tseem tsis tau paub.

Xaus

Milbemycin Oxime hmoovyog ib txoj hauv kev zoo- paub thiab muaj pov thawj zoo los txwv tsis pub cov kab mob plawv thiab lwm yam kab mob sib kis. Nws tsuas yog ua haujlwm ntawm qee yam glutamate invertebrate-gated chloride channels, muaj kev nyab xeeb rau txhua hom tsiaj thiab theem ntawm lub neej, thiab muaj lub qhov rais ua haujlwm txhua hli uas ua rau nws yog ib qho tseem ceeb rau kev tu tsiaj niaj hnub. Qhov kev sib xyaw no ua haujlwm raws nraim qhov nws xav tau tshaj plaws, txawm tias lub hom phiaj yog los tiv thaiv tus menyuam dev Collie, khaws ib tus tsiaj - puv tsev nyob rau hauv kev tswj hwm, lossis xyuas kom meej tias cov tsiaj yug tshiab tsis muaj kab mob.

FAQ

Koom Tes Nrog Bloomtechz rau Kev Txhim Kho Milbemycin Oxime Powder Supply

Yog tias koj tab tom nrhiav rau kev vam khommilbemycin oxime hmoovtus neeg muag khoom, Bloomtechz xa cov khoom siv tshuaj- qib cov khoom txhawb nqa los ntawm kev nruj triple- txuas kev tswj hwm zoo - tshuaj xyuas ntawm qib Hoobkas, tshuaj xyuas los ntawm peb hauv- lub tsev QA / QC department, thiab tau lees paub los ntawm cov neeg pov thawj thib peb- cov tub ceev xwm. Peb GMP-cov chaw tsim khoom Xi'an tau lees paub muaj ntawv pov thawj los ntawm US FDA, EU GMP, PMDA, thiab CFDA, ua kom txhua pawg ua tau raws li cov qauv thoob ntiaj teb uas koj xav tau kev lag luam. Peb pab cov tuam txhab tshuaj, R & D cov koom haum, thiab cov kws kho tsiaj cov khoom lag luam thoob plaws hauv Asmeskas, Australia, Nyiv, Lub Tebchaws Yelemees, Canada, thiab tshaj. Nrog rau ntau tshaj 12 xyoo ntawm kev txawj ntse ntawm cov organic synthesis thiab tus qauv ruaj khov, pob tshab cov txiaj ntsig tau zoo, Bloomtechz tau tsim kom muaj kev koom tes ntev ntev. Nkag mus rau hnub no thiab tau txais cov lus hais meej, lub sijhawm ua haujlwm raug, thiab cov ntaub ntawv tag nrho rau kev lis kev cai.

📧 Hu rau peb:Sales@bloomtechz.com.

Cov ntaub ntawv

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3. Wolstenholme, AJ, Fairweather, I., Prichard, R., von Samson-Himmelstjerna, G., & Sangster, NC (2004). Tshuaj tiv thaiv nyob rau hauv veterinary helminths. Trends in Parasitology, 20(10), 469–476.

4. Geyer, J., Döring, B., Godoy, JR, Leidolf, R., Moritz, A., & Petzinger, E. (2005). Ntau zaus ntawm nt230 (del4) MDR1 kev hloov pauv hauv Collies thiab lwm yam dev yug hauv lub teb chaws Yelemees. Phau ntawv Journal of Veterinary Pharmacology thiab Therapeutics, 28(6), 545–551.

5. American Heartworm Society. (2020). Cov Lus Qhia Txog Canine tam sim no rau Kev Tiv Thaiv, Kev kuaj mob, thiab kev tswj hwm ntawm Heartworm (Dirofilaria immitis) Kab mob hauv dev. American Heartworm Society.

6. Paul, AJ, Tranquilli, WJ, & Hutchens, DE (2000). Kev nyab xeeb ntawm milbemycin oxime hauv avermectin-sensitive Collies. Phau ntawv Journal of the American Veterinary Medical Association, 217(6), 847–849.