Parasites zoo li dev mub thiab zuam yog ntau tshaj qhov tsis txaus siab - lawv ua phem rau kev noj qab haus huv ntawm cov tsiaj phooj ywg. Cov tswv tsiaj nce nrhiav kev daws qhov ncauj uas sib txuas nrog kev tiv thaiv ntev nrog kev yooj yim ntawm kev tswj hwm. Fluralaner ntsiav tshuajformulations tau tshwm sim raws li kev soj ntsuam validated kev xaiv uas muab systemic, ntev -kev pab them nqi tiv thaiv ib tug dav spectrum ntawm lwm yam kab mob. Kab lus no taug kev los ntawm kev tshawb fawb, cov txiaj ntsig tau zoo, thiab qhov tiag -kev cuam tshuam hauv ntiaj teb ntawm qhov kev kho mob no rau kev tswj xyuas tsiaj txhua hnub.
Fluralaner ntsiav tshuaj
1. General Specification (hauv Tshuag)
(1) Kev daws teeb meem
(2) Tablet
(3) Txhaj tshuaj
(4) Txau
(5) Poob
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
Tus Qauv Zauv: BM-2-079
Fluralaner CAS 864731-61-3
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Yuav Ua Li Cas Fluralaner Tablets Txhawb Flea thiab Tick Control hauv Tsiaj?
Targeting Parasite Nervous System nrog Precision
Cov ntsiav tshuaj fluralaner ua nws txoj haujlwm los ntawm kev txuas rau GABA receptors ntawm phab ntsa ntawm tes ntawm kab thiab zuam. Qhov kev sib khi no txwv tsis pub cov chloride ion channel qhib. Qhov no ua rau cov neurons hluav taws tawm ntawm kev tswj hwm, ua rau lawv tuag tes tuag taw, thiab tua cov kab mob cab. Tib lub sijhawm, nws thaiv glutamate-gated chloride channels, uas ua rau cov nyhuv neurotoxic ntawm lub hom phiaj lub cev muaj zog. Cov tshuaj tsis muaj txiaj ntsig zoo ib yam rau cov dev lossis miv vim tias cov tsiaj txhu GABA receptors nyob rau hauv lub hauv nruab nrab lub paj hlwb, tom qab cov ntshav - hlwb barrier. Qhov no ua rau kev kho mob xaiv heev. Niaj hnub nimno isoxazoline-cov tshuaj hauv chav kawm txawv ntawm yav dhau los broad-spectrum agents vim tias lawv tsis muaj qhov txwv tsis pub muaj -channel dual.
Cov txiaj ntsig kho mob: Kev nrawm thiab sijhawm ua haujlwm
Cov kev tshawb fawb kws kho tsiaj uas tau ua rau pej xeem pom tau hais tias ib koob tshuaj ntawm qhov ncauj ntawm cov ntsiav tshuaj fluralaner tau tshem tawm ntau dua 98% ntawm cov miv dev nyob hauv 12 teev thiab tag nrho lawv hauv 48 teev. Kev tiv thaiv cov zuam tseem ceeb, xws li Ixodes scapularis, Dermacentor variabilis, thiab Rhipsephalus sanguineus, yuav kav li ntawm 12 lub lis piam tom qab noj ib zaug xwb. Lub qhov rais ua haujlwm ntev dua no ua rau nws yooj yim dua rau cov tswv tsiaj kom taug qab ntau npaum li cas lawv cov tsiaj tau txhaj tshuaj, uas ncaj qha txhim kho kev ua raws cai. Kev npog zoo ib yam kuj txwv lub sijhawm uas cov zuam tuaj yeem txuas tau ntev txaus los kis kab mob xws li kab mob Lyme- ua rau cov kab mob Borrelia burgdorferi.
Fluralaner ntsiav tshuaj ua haujlwm tom qab kev nqus dej
Kev faib tawm thoob plaws lub cev
Thaum noj los ntawm qhov ncauj, cov khoom xyaw nquag hauv cov ntsiav tshuaj fluralaner yog nqus los ntawm lub plab zom mov thiab tom qab ntawd kis thoob plaws lub cev los ntawm cov hlab ntsha. Qhov kev kis kab mob no txhais tau hais tias cov tshuaj nkag mus rau ntawm daim tawv nqaij thiab nkag mus rau hauv cov qib uas ua rau tuag taus rau arthropods uas pub ntshav. Vim tias nws yog lipophilic, fluralaner tuaj yeem tsim nyob rau hauv cov roj txheej hauv qab ntawm daim tawv nqaij, uas ua rau thaj chaw cia ntev - tso tawm. Cov tshuaj pharmacokinetic no qhia tau hais tias yog vim li cas cov khoom sib xyaw tuaj yeem khaws cov ntshav plasma siab ntev ntev yam tsis tas yuav tsum tau txhaj tshuaj ntau dua thaum lub sijhawm ntawd.
Vim li cas Systemic Action Surpasses Topical Alternatives
Cov tshuaj pleev ib ce- ntawm cov khoom muaj qee qhov teeb meem, xws li ntxuav tawm lossis tsis sib npaug ntawm lub tsho loj. Lawv kuj ua rau muaj kev pheej hmoo ntawm kev noj los ntawm cov menyuam yaus lossis lwm yam tsiaj. Cov teeb meem no tsis tuaj yeem nrog kev tswj xyuas qhov ncauj. Covfluralaner ntsiav tshuajmuab cov tshuaj tswj uas nkag mus rau tus tsiaj cov hlab ntsha sib npaug, txawm tias nws lub tsho ntev npaum li cas los yog nws da dej ntau npaum li cas. Kev kho lub qhov ncauj yog ib txoj hauv kev zoo tshaj thiab tswj tau los kho cov tsiaj uas muaj tawv nqaij rhiab lossis nyob hauv tsev nrog lwm tus tsiaj. Veterinary obedience kev tshawb fawb tas li qhia tau hais tias cov tswv muaj feem ntau yuav ua raws li los ntawm qhov ncauj chewable los yog ntsiav tshuaj cov ntaub ntawv piv rau cov tshuaj pleev ib ce.
Vim Li Cas Qhov Qhov Ncauj Fluralaner ncav cuag ntshav -Pib yoov thiab zuam?
Lub Mechanism ntawm Exposure Thaum Ntxov Ntshav
Qhov ncauj fluralaner ua haujlwm los ntawm kev cuam tshuam ncaj qha nrog ectoparasites hauv kev lom neeg. Thaum ib tug yoov los yog zuam tom tus miv uas tau kho, nws yuav siv cov ntshav uas muaj cov khoom xyaw hauv nws. Cov kab mob hauv lub paj hlwb tom qab ntawd nkag mus rau hauv kev sib cuag nrog fluralaner ntawm qib siab txaus kom nres cov tshuaj chloride ion, uas ua rau tuag tes tuag taw sai thiab tuag. Txoj kev kis tus kab mob no txhais tau hais tias tus kab mob yuav tsum pib noj kom tau txais koob tshuaj tuag, tab sis kev tshawb fawb ntawm zuam txuas qhia tias feem ntau, kev tuag tshwm sim ua ntej cov kab mob kis tau zoo heev. Koj ua sai npaum li cas tom qab noj cov ntshav yog qhov tseem ceeb hauv kev txwv tsis pub lub voj voog ntawm cov kab mob sib kis.
Bioavailability thiab Plasma Concentration Maintenance
Fluralaner yog bioavailable nyob rau hauv cov dev thiab miv thaum muab los ntawm qhov ncauj los yog tom qab noj mov. Feem ntau, cov ntshav plasma siab tshaj plaws tau mus txog hauv cov xuab moos tom qab noj cov tshuaj. Qhov tseem ceeb, cov nqi kho mob nyob twj ywm tib lub sijhawm 12 lub lis piam. Qhov no txhais tau hais tias cov tshuaj txuas mus txog cov kab mob uas pub ntshav rau lub sijhawm tiv thaiv yam tsis tas yuav tsum tau txhaj tshuaj ntxiv. Qhov kev hloov kho pharmacokinetic nkhaus no yog qhov ua rau nws ua tau rau ib koob tshuaj fluralaner los tswj ectoparasites rau lub sijhawm ntev es tsis txhob siv sijhawm luv luv.
Fluralaner Tablets thiab Broader Ectoparasite Management
Kev Pabcuam Tiv Thaiv Kabmob thiab Kabmob Secondary ntawm daim tawv nqaij
Covfluralaner ntsiav tshuajua haujlwm tawm tsam ntau tshaj li cov yoov thiab zuam. Nws kuj tau pom tias ua haujlwm tiv thaiv sarcoptic mange (Sarcoptes scabiei) thiab pob ntseg mites (Otodectes cynotis). Ib koob tshuaj ntawm qhov ncauj tau txuas mus rau 80% poob hauv cov qhab nia pruritus nyob rau hauv ob lub lis piam thiab 95% rov qab tus nqi nyob rau hauv plaub lub lis piam hauv dev nrog sarcoptic mange. Kev kho qhov ncauj tshem tawm ntau dua 90% ntawm Otodectes cynotis hauv 72 teev rau pob ntseg kab mob. Vim nws muaj ntau yam teebmeem, fluralaner zoo dua siv los ua ib feem ntawm kev ua tiav kev tswj hwm ectoparasite dua li kev kho mob rau ib hom kab mob cab xwb.
Lub luag haujlwm Adjunctive hauv Kev Tswj Flea Allergic Dermatitis
Flea allergic dermatitis (FAD) yog tshwm sim los ntawm kev ua xua rau flea salivary antigens, tsis yog muaj ntau ntawm fleas. Kev tshem tawm cov yoov sai sai yog li ntawd qhov ncaj qha rov ua haujlwm tshaj plaws. Raws li cov ntaub ntawv los ntawm cov kev tshawb fawb, cov dev thiab miv nrog FAD muaj 70% khaus khaus hauv 72 teev tom qab tau txais cov tshuaj fluralaner, thiab 85% ntawm cov tawv nqaij kho tsis pub dhau ob lub lis piam. Qhov ncauj fluralaner pab cov tawv nqaij zoo yam tsis muaj kev vam khom tsuas yog corticosteroids lossis antihistamines ua tshuaj tua kab mob. Nws ua qhov no los ntawm kev tshem tawm cov tshuaj tiv thaiv kab mob sai sai thiab ua kom cov kab mob ntawm daim tawv nqaij -dawb rau 12 lub lis piam.
Los ntawm kev tswj qhov ncauj mus rau Parasite Elimination: Yuav Ua Li Cas Fluralaner Tablets Ua Haujlwm
Txoj Kev Tag Nrho: Kev Noj Qab Haus Huv rau Parasite Tuag
Thaum tus tsiaj nqos cov ntsiav tshuaj, cov txheej txheem pib. Lub active tshuaj yog absorbed nyob rau hauv cov hnyuv thiab xa mus rau lub portal ncig. Tom qab ntawd nws tau ua tiav hauv daim siab thiab xa mus thoob plaws lub cev. Dermal catabletary networks coj cov ntshav uas muaj cov tshuaj mus rau saum npoo ntawm daim tawv nqaij, qhov twg ectoparasites pub. Thaum tus kab mob noj cov ntshav no, nws cov GABA receptors tau qhib, nws cov tshuaj chloride channel conductance raug thaiv, thiab nws cov paj hlwb excitatory teeb tsa tsis tau nres. Tsis pub dhau ob peb feeb, cov dev mub yuav tuag tes tuag taw, thiab cov cab tuag ua ntej nws tuaj yeem pib tso qe dua. Qhov no yog lub ntsiab lus tseem ceeb rau kev tiv thaiv kev kis tus kab mob dev mub thiab qe rau hauv ib puag ncig.
Tswv yim kev nyab xeeb Profile hauv dev thiab miv
US Food and Drug Administration (FDA) thiab European Union (EU) cov tub ceev xwm tau saib xyuas cov ntaub ntawv kev nyab xeeb rau isoxazoline-cov tshuaj hauv chav kawm. Vim yog qhov kev xaiv ntawm fluralaner thoob plaws cov ntshav- lub hlwb thaiv, nws tsis cuam tshuam rau cov tsiaj hauv tib txoj kev uas nws cuam tshuam rau cov kab mob hauv lub hom phiaj thaum muab ntawm cov tshuaj pom zoo. Muab nws nrog zaub mov ua rau lub cev muaj peev xwm tuav tau thiab nqus tau zoo dua. Veterinary cov kws tshaj lij qhia txog kev tshuaj ntsuam xyuas kev noj qab haus huv rau cov tsiaj uas twb muaj lub paj hlwb rhiab heev. Qhov no yog nyob rau hauv txoj kab nrog kev saib xyuas ib txwm muaj uas yuav tsum tau ua thaum muab tshuaj rau txhua yam tshuaj.
Xaus
Kev siv ntawmfluralaner ntsiav tshuajkev kho mob yog ib kauj ruam loj rau kev tswj cov kab mob hauv cov tsiaj. Nws ob txoj kev ua haujlwm -txoj kev ua haujlwm, kev faib tawm, dav -spectrum ectoparasite npog, thiab ntev dua 12 lub lis piam tiv thaiv qhov rais tag nrho ua haujlwm ua ke los daws cov teeb meem tseem ceeb ntawm cov tswv tsiaj thiab cov kws kho tsiaj lub ntsej muag. Fluralaner tau pom nyob rau hauv cov ntawv luam tawm cov kws kho tsiaj cov kev tshawb fawb los pab cov tsiaj txhu uas muaj kab mob dermatitis tau zoo dua, tswj cov kab mob nquag, thiab txwv tsis pub kis kab mob los ntawm zuam mus rau lwm yam tsiaj.
FAQ
1. Lub ntsiav tshuaj fluralaner tua hma tau sai npaum li cas?
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Tsab ntawv tshaj tawm hais tias ib koob tshuaj ntawm qhov ncauj ntawm cov ntsiav tshuaj fluralaner tua ntau dua 98% ntawm cov dev mub hauv 12 teev thiab tag nrho cov fleas hauv 48 teev. Daim ntawv tshaj tawm kuj hais tias txoj hauv kev nrawm no yuav pab tau kom txo tau cov kab mob dev vwm.
2. Lub ntsiav tshuaj fluralaner muab kev tiv thaiv flea thiab zuam ntev npaum li cas?
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Raws li tsab ntawv ceeb toom, ib koob tshuaj ntawm cov ntsiav tshuaj fluralaner yuav tiv thaiv cov zuam loj rau ntev txog 12 lub lis piam. Cov qib kho mob kuj tseem khaws cia nyob rau lub sijhawm no, kom cov ntshav - pub cov dev mub thiab cov zuam tuaj yeem ntsib nrog fluralaner yam tsis tas yuav tsum tau txhaj tshuaj rov ua dua thaum lub sijhawm tiv thaiv.
3. Lwm yam kab mob dab tsi tuaj yeem pab tswj cov ntsiav tshuaj fluralaner?
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Ntxiv nrog rau cov yoov thiab zuam, fluralaner ntsiav tshuaj kho kuj tau pom tias muaj txiaj ntsig zoo tiv thaiv sarcoptic mange (Sarcoptes scabiei) thiab pob ntseg mites (Otodectes cynotis), raws li tsab xov xwm. Tsab ntawv xov xwm hais txog nws siv ntxiv rau kev tshem tawm ntawm cov dev mub induced khaus thiab rov qab los ntawm flea allergic dermatitis.
Koom tes nrog Bloomtechz rau hwm Fluralaner Tablet Supply
Peb ntawm Bloomtechz tau ua cov kws tshaj lij hauv cov organic synthesis rau 12 xyoo thiab peb cov khoom yog GMP- ntawv pov thawj, uas txhais tau hais tias nws tau pom zoo los ntawm US FDA, EU, Nyiv, thiab CFDA. Qhov no txhais tau tias peb tuaj yeem ua cov tshuaj - qib fluralaner ntsiav tshuaj formulations uas koj ntseeg tau. Peb lub Hoobkas hauv Xi'an tuaj yeem hloov pauv rau cov ntsiav tshuaj, tshuaj, tshuaj, tshuaj tsuag, thiab xa cov ntawv rau OEM thiab ODM cov neeg siv khoom. Txhua batch raug tshuaj xyuas peb zaug kom paub tseeb tias nws ua tau raws li cov qauv thoob ntiaj teb: hauv lub Hoobkas, los ntawm QA / QC sab hauv, thiab los ntawm peb lub koom haum -. Yog tias koj yog ib lub chaw tshawb fawb, tuam txhab tshuaj kws kho tsiaj, lossis tus muag khoom tab tom nrhiav kev ntseeg siabfluralaner ntsiav tshuajtus neeg muag khoom, Bloomtechz tuaj yeem pab. Lawv muab cov nqi sib tw, lub sijhawm ua haujlwm raug, thiab tag nrho cov ntaub ntawv koj xav tau kom tshem tawm kev lis kev cai. Hu rau peb tam sim ntawd, thiab peb pab pawg R & D yuav ua cov lus teb uas haum rau koj lub khw.
Xa lus rau peb ntawmSales@bloomtechz.com.
Cov ntaub ntawv
1. Kilp, S., Ramirez, D., Allan, MJ, & Schneider, MJ (2014). Pharmacokinetics ntawm fluralaner hauv dev tom qab kev tswj hwm qhov ncauj ib leeg. Parasites & Vectors, 7, 85.
2. Dryden, MW, Smith, V., Bennett, G., Math, L., de Vos, C., Mahabir, SP, & Guerino, F. (2013). Kev ua tau zoo ntawm fluralaner flavored chews tiv thaiv induced infestations ntawm Ctenocephalides felis ntawm dev. Veterinary Parasitology, 193(1–3), 105–110.
3. Rohdich, N., Roepke, RKA, & Zschiesche, E. (2014). Ib qho randomized, qhov muag tsis pom, tswj thiab ntau-kev kawm hauv cheeb tsam sib piv cov kev ua tau zoo thiab kev nyab xeeb ntawm bravecto (fluralaner) tiv thaiv pem hauv ntej (fipronil/(S)-methoprene) hauv flea- thiab zuam- dev kis. Parasites & Vectors, 7, 83.
4. Wengenmayer, C., Williams, H., Zschiesche, E., Moritz, A., Langenstein, J., Roepke, RKA, & Pfister, K. (2014). Qhov ceev ntawm tua ntawm fluralaner (Bravecto ™) tawm tsam Ixodes ricinus zuam ntawm dev. Parasites & Vectors, 7, 525.
5. Fourie, JJ, Liebenberg, JE, Horak, IG, Taenzler, J., Heckeroth, AR, & Frénais, R. (2015). Kev ua tau zoo ntawm qhov ncauj tshuaj fluralaner (Bravecto™) los yog siv tshuaj pleev ib ce imidacloprid/moxidectin (Advocate®) tiv thaiv kev demodicosis hauv dev. Parasites & Vectors, 8, 187.
6. Taenzler, J., de Vos, C., Roepke, RKA, & Heckeroth, AR (2014). Kev ua tau zoo ntawm fluralaner tiv thaiv Otodectes cynotis kab mob hauv dev thiab miv. Parasites & Vectors, 7 (Suppl 1), O26.