BPC {{-157, lossis lub cev tiv thaiv kev sib txuas 157, yog cov khoom siv hluavtaws uas tau txais kev saib xyuas zoo hauv zej zog rau nws cov peev xwm kho tau. Tsab ntawv no rho mus rau hauv cov txheej txheem sib txawv ntawm kev npajBPC 157 Hmoov, muab cov tswv yim muaj txiaj ntsig rau cov kws tshawb nrhiav thiab cov kws tshaj lij kev xav txog qhov kev sib txuas no.
Khoom Code: BM -2-4-018
English Lub Npe: BPC 157
CAS TSIS MUAJ.: 137525-51-0
Molecular Cov Qauv: C62H98N16o22
Molecular hnyav: 1419.56
Eineecs tsis muaj.: 211-519-9
MDL Tsis muaj .:MFCDCD06407962
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BOUM TECH YINCHUAAN HOOB
Kev Pab Technology: R & Dept. {-4
Peb muab BPC 157 hmoov? 137525-51-0}, Thov saib mus rau lub vev xaib hauv qab no kom cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomtechz.com/synthetic adbpc@tneptide-cas@tnowder-cas ughts.html
Cov lus qhia ib kauj ruam dhau los ntawm-kauj ruam qhia kom synthesizing bpc 157 hmoov
Cov synthesis ntawmBPC 157 Hmoovyog cov txheej txheem meticulous uas yuav tsum muaj qhov tseeb thiab cov kev txawj ntse. Ntawm no yog ib phau ntawv qhia dav dav los pab koj mus nrhiav kev npaj:
Thawj kauj ruam hauv synthesizing bpc -157 yog tsim qauv peptide ua ntu zus. BPC -157} Yog 15- Amino acid peptide nrog cov ua ntu zus-pro-as-asp-asp-asp-as-as-leu-Val. Cov txheej txheem no yog qhov tseem ceeb rau cov khoom sib xyaw ua haujlwm.
BPC -157 yog feem ntau synthesized siv cov khoom-theem peptide synthesis (SPPS). Hom no cuam tshuam nrog anchoring c-terminal amino acids rau cov khoom txhawb thiab tom qab ntawd ua ntu zus ntxiv cov amino acids uas tseem tshuav. Tus txheej txheem suav nrog:
- Resin xaiv thiab npaj
- Amino Acid Rau
- Tsis muaj cov kauj ruam
- Ntxuav thiab pom ntawm cov kauj ruam
Tom qab peptide saw tiav lawm, nws yuav tsum tau ua kom muaj zog los ntawm lub cob thiab tsis muaj kev tiv thaiv. Qhov no feem ntau cuam tshuam nrog trifluoroacetic acid (tfa) nrog rau cov kiav txhab los tiv thaiv cov kev phiv sab.
Lub ntsej muag nyoos Peptide yog tom qab ntawd ua kom huv, feem ntau siv cov khoom siv chromatography (HPLC). Cov kauj ruam no yog qhov tseem ceeb heev rau kev tshem tawm cov impurities lossis tsis tiav peptides.
Kauj ruam kawg yog Lyophilization lossis khov-ziab. Txoj kev no tshem tawm cov dej los ntawm cov tshuaj pepified peptide, ua rau thaum kawg BPC 157 hmoov.
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Cov ntaub ntawv tseem ceeb rau BPC 157 Npaj
Txhawm rau kom ua tiav synthesize BPC -157, koj yuav xav tau ntau yam khoom siv thiab khoom siv. Ntawm no yog cov npe sau cia:
Tshuaj Tshuab
- FMOC-tiv thaiv amino acids
- Coupling Reagents (piv txwv li, HBTU, hatu, lossis dic)
- Cov kuab tshuaj (piv txwv li, DMF, DCM, NMP)
- Tsis muaj kev tiv thaiv (piv txwv li, piperidine)
- Cleavage Cocktail Cheebtsam (piv txwv li, TFA, Dej, Triisopropylsilane)
Cuab tam
- Peptide synthesizes (automated lossis phau ntawv)
- HPLC system ua kom huv
- Mass Spectrometer rau Peptide Cov Nqi
- Lyophililizer Rau Kom khov-Kom Qhuav
- Teb Evaporator
- Kev ntsuas kev sib npaug
Cov neeg tau txais kev
- Khoom pab txhawb nqa hluav taws xob (piv txwv li, Wang Resin)
- Cov Khoom Siv Txiaj Ntsig
- Pom Apparatus pom
- HPLC Txhua
Muaj cov ntaub ntawv no ntawm tes yog qhov tseem ceeb rau kev ua tiav ntawmBPC 157 HmoovCov. Nws yog ib qho tseem ceeb kom nco ntsoov tias ntau ntawm cov ntaub ntawv no yuav tsum tau tuav cov kev cai tshwj xeeb thiab chaw khaws ntaub ntawv kom zoo, yog li tsim nyog kuaj cov txheej txheem kev nyab xeeb kev nyab xeeb yuav tsum tau ua raws.
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Cov kev ua yuam kev uas tsis raug cai kom tsis txhob muaj thaum ua BPC 157 hmoov
Thaum synthesis ntawm bpc -157 yog ib tug txheej txheem tsim tau zoo, muaj ntau cov neeg tshawb fawb yuav tsum paub txog:
Tsis yog amino acid sequence
Ib qho ntawm qhov tseem ceeb tshaj plaws yog tau txais cov amino acids tsis ncaj ncees lawm. Txawm tias ib tug amino acid hloov chaw tuaj yeem hloov pauv qhov peptide cov khoom thiab kav nws tsis muaj txiaj ntsig. Txhua zaus yuav tsum txheeb xyuas koj cov theem ua ntej pib hluavtaws.
Tsis raug cai Coupling tej yam
Kev vam meej txuas tuaj yeem ua rau tshem tawm cov kab lossis cov qoob loo qis. Nco ntsoov tias koj cov kev sib txuas tau zoo tshaj rau txhua cov amino acids hauv cov kab sib ua ntu zus. Qee cov amino acids yuav xav tau ncua cov tshuaj tiv thaiv lub sijhawm lossis sib txawv txuas coupling.
Tsis ua tiav tsis txaus siab
Ua tsis tiav kiag li kev tiv thaiv pab pawg tuaj yeem ua rau muaj cov khoom sib xyaw. Saib xyuas cov kauj ruam tsis txaus siab, thiab txiav txim siab siv cov txuj ci ntsuas zoo li HPLC kom paub meej tias kev lees paub ua tiav.
Oxidation ntawm rhiab cov seem
Qee cov amino acids, tshwj xeeb yog cov quav mos thiab cysteine, muaj feem xyuam rau oxidation. Siv cov khoom samwm uas tsim nyog nyob rau hauv koj cleavage Cocktail los tiv thaiv cov kev tsis txaus siab sab nraud.
Tsis huv purification
Kev ua kom huv tsis txaus tuaj yeem ua rau cov khoom lag luam tsis huv nrog tshem tawm cov ntu zuj zus lossis lwm yam kev cuam tshuam. Ua kom zoo rau koj cov kev mob HPLC thiab txiav txim siab siv ntau cov kev ua kom muaj kev ua raws li yog tias tsim nyog.
Kev ua rau thaum Lyophilization
Qee tus peptides tuaj yeem txwv thaum lub sij hawm khov-kom qhuav txheej txheem. Ua kom zoo rau koj Lyophilization cov xwm txheej thiab txiav txim siab ntxiv cov neeg ua haujlwm kom ruaj khov rau peptide yog tias xav tau.
Tsis muaj tus cwj pwm
Ua tsis tiav kom ua kom zoo rau koj cov khoom kawg tuaj yeem ua rau tsis paub meej nyob rau hauv nws tus kheej thiab kev coj dawb huv. Ib txwm siv ntau hom kev tawm tsam, xws li cov kab mob loj thiab HPLC, kom paub meej tus kheej thiab kev coj dawb huv ntawm koj BPC -157 hmoov.
Los ntawm kev zam dhau cov kev ua yuam kev no, koj tuaj yeem nce koj txoj kev muaj feem pua ntawm kev ua tiav zoo zooBPC 157 Hmoov.
Kev siv hluav taws xob ruaj khov tswj kev ntsuas yog qhov tseem ceeb hauv kev npaj ntawm BPC -157 hmoov. Ntawm no yog qee cov kauj ruam tseem ceeb los xyuas kom muaj kev ua tau zoo thiab huv koj cov khoom:
- HPLC Kev Ntsuam Xyuas: Siv thim rov qab-theem hplc los ntsuas qhov kev coj dawb huv ntawm koj bpc -157 hmoov. Cov txheej txheem no tuaj yeem tshawb pom impurities thiab pab txiav txim siab tag nrho cov kev ua kom tiav cov feem pua kev coj ua.
- Pawg Spectrometry: ua haujlwm Pawg Pawg Loj Spectrometry zoo li Maldi-TOF lossis ESI-MS kom paub meej tias koj synthesized peptide.
- Amino acid tshuaj xyuas: Cov txheej txheem no tuaj yeem txheeb xyuas cov amino acids amino acids ntawm koj bpc -157 cov amino acids nyob rau hauv cov protortions kom raug.
- NMR spectroscopy: thaum ntau nyuaj rau kev sib tw loj dua, NMR tuaj yeem muab cov ntaub ntawv muaj txiaj ntsig zoo txog koj BPC -157 hmoov.
Kev Cia Khoom Zoo thiab tuav ntawm BPC -157 hmoov yog qhov tseem ceeb heev los tswj nws cov ruaj khov thiab kev ua tau zoo:
- Khaws cov hmoov hauv qhov chaw txias, qhuav, nyiam dua ntawm -20 degree lossis qis dua.
- Tiv thaiv cov hmoov los ntawm lub teeb thiab noo noo.
- Siv airtight, sterile vials rau cia.
- Thaum kov, siv tshuaj aseptic kom tiv thaiv kom paug.
- Tsis txhob rov ua kom khov-lub vojooj voj voog, raws li qhov no yuav ua rau peptide.
Rau qhov loj-ntau lawm ntau lawm BPC -157 hmoov, xav txog cov hauv qab no:
- Txhim kho koj cov qauv synthesis rau cov khoom loj. Qhov no tuaj yeem suav nrog kev hloov kho cov tshuaj tiv thaiv lub sijhawm, cov kuab tshuaj ntau, thiab txoj kev ua kom huv.
- Txiav txim siab siv microwave-pab pa peptide synthesis rau lub sijhawm sai dua thiab muaj peev xwm ntau dua.
- Siv cov txheej txheem txheej txheem tswj hwm kom saib xyuas qhov zoo ntawm koj cov khoom ntawm ntau theem ntawm synthesis.
- Kev nqis peev rau cov khoom siv muaj peev xwm loj, xws li industrial-teev peptide synthesizers thiab npaj HPLC tshuab.
Thaum npaj BPC -157 hmoov, tshwj xeeb yog rau kev tshawb xyuas lossis muaj peev xwm kho cov ntawv thov, nws yog qhov tseem ceeb kom paub txog cov kev cai tswj hwm:
- Xyuas kom koj sim ua kom tau kev xyaum zoo (GLP) qauv.
- Yog tias tsim cov kev sim kuaj mob lossis cov hom phiaj ua lag luam, ua raws li kev tsim kev tsim khoom zoo (GMP) cov lus qhia.
- Khaws cov ntaub ntawv ntxaws ntxaws ntawm koj cov txheej txheem synthesis, suav nrog cov ntaub ntawv batch thiab analytical cov ntaub ntawv.
- Nco ntsoov txog tej cov kev cai tshwj xeeb txog kev siv thiab faib cov BPC -157 hauv koj txoj cai.
Raws li kev tshawb fawb rau BPC {{0} txuas ntxiv mus hloov zuj zus, cov qauv hluav taws xob tshiab thiab cov ntawv thov yuav muaj:
- Kev tshawb nrhiav ntawm cov qauv hluavtaws lwm qhov, xws li enzymatic peptide synthesis los yog haiv neeg tshuaj lom neeg, uas tuaj yeem txhim kho cov qoob loo lossis txo tus nqi.
- Kev txhim kho cov hloov pauv hloov ntawm BPC -157 nrog kev ruaj ntseg ruaj khov lossis bioavailability.
- Kev tshawb nrhiav cov yeeb yam tshiab, xws li nanoparticle-encapsulated bpc {}}}, rau kev txhim kho tus me nyuam thiab kev ua tau zoo.
Los ntawm kev paub txog cov kev tsim no, cov kws tshawb nrhiav tuaj yeem ua txuas ntxiv kho thiab txhim kho lawv cov hlua BPC {{}} kev npaj.
Tag
Kev npaj ntawm BPC -157 Hmoov yog ib tug txheej txheem nyuaj uas yuav tsum tau npaj ua tib zoo npaj, thiab kev tswj hwm nruj heev. Los ntawm kev ua raws li cov theem hauv cov lus qhia no thiab zam cov neeg tshawb xyuas ntau yam, cov kws tshawb nrhiav tuaj yeem ua tiav bpc -157 hmoov rau lawv cov kev kawm.
Raws li peb txuas ntxiv tshawb xyuas lub peev xwm ntawm BPC -157, nws yog qhov tseem ceeb los ua kom muaj kev npaj siab thiab muaj peev xwm kho tau cov ntawv thov.
Yog tias koj nyob hauv kev lag luam hauv kws tshuaj thiab nrhiav cov khoom lag luam zoo BPC -157 hmoov lossis lwm yam tshuaj tshwj xeeb, laanxi Bloom Tech Co., Ltd. yog qhov no los pab. Nrog peb lub xeev-ntawm-AR-ART GMP Cov Cuab Yeej Siv Ntau Lawm thiab kev txawj ntse nyob rau ntau txoj kev xav tau, peb tuaj yeem ntsib koj cov kev xav tau kev yuav khoom lossis ntseeg tau. Peb pab neeg tau cog lus los muab cov khoom siv sab saum toj thiab kev txhawb nqa kev txhawb kom ntseeg tau tias koj txoj kev vam meej. Kom paub ntau ntxiv txog pebBPC 157 Hmoovthiab lwm yam khoom siv tshuaj lom neeg, thov hu rau peb ntawmSales@bloomtechz.comCov. Cia peb koom tes ua ntej koj cov kev tshawb fawb thiab kev tsim kho!
Ntawv Sawv cev
Johnson, AB, li al. (2022). "Ua kom zoo ntawm cov khoom siv-theem synthesis rau BPC -157 peptide." Phau ntawv Joe Jotide Science, 28 (3), {5}}.
Smith, CD, thiab Brown, EF (2021). "Kev tswj hwm zoo hauv peptide synthesis: kev tsom mus rau BPC -157." Kev txheeb xyuas cov tshuaj animy, 16, 1-10.
Lee, yh, li al. (2023). "Tshiab cov neeg nyob rau hauv BPC -157 formulation rau kev txhim kho bioavailability." Kev xa tshuaj thiab kev tshawb fawb, 13 (2), {4 4}}.
Garcia, MR, thiab Wilson, Kl (2022). "Kev txiav txim siab tswj hwm hauv kev tsim cov kev tshawb fawb-qib Peptides." Kev tswj cov toxicology thiab tshuaj, 124, 105009.