Sodium 4-phenylbutyrate(txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/sodium-phenylbutyrate-powder-cas-1716-12-7.html), yog ib qho organic compound uas muaj nyob rau hauv daim ntawv ntawm cov xim tsis muaj xim lossis dawb crystals. Cov tshuaj formula yog C10H11NaO2, qhov sib thooj molecular hnyav yog 186.19 g / mol, thiab nws feem ntau tsis muaj ntxhiab tsw. Nws muaj zoo solubility hauv dej. Nws kuj tseem tuaj yeem yaj hauv qee cov kuab tshuaj organic, xws li methanol, ethanol, chloroform, thiab lwm yam. Relatively ruaj ntawm qhov kub thiab txias. Txawm li cas los xij, nws tuaj yeem decompose yog tias raug tshav kub rau lub sijhawm ntev. Cov tshuaj aqueous yog alkaline thiab muaj pH siab. Nws yog cov khoom siv hluav taws xob uas tuaj yeem hlawv hauv qab nplaim taws los tsim cov pa roj carbon dioxide, dej thiab cov pa roj carbon monoxide. Nws tau siv dav hauv qee cov tshuaj pleev ib ce thiab cov khoom zoo nkauj. Nws muaj moisturizing, antioxidant thiab antibacterial zog thiab yog siv los txhim kho daim tawv nqaij kev ntxhib los mos, ncua kev laus ntawm daim tawv nqaij thiab tiv thaiv cov tawv nqaij teeb meem xws li pob txuv. Nws kuj tseem muaj qee qhov kev thov, xws li neuroprotection, anti-epilepsy, kev kho mob ntawm angiotensin-hloov enzyme deficiency, thiab lwm yam. Tsis tas li ntawd, nws kuj yog siv los ua cov tshuaj reagent thiab ua lub luag haujlwm hauv kev tshawb fawb biomedical.
Sodium 4-phenylbutyrate (4-phenylsodium phenylbutyrate) yog ib qho organic compound uas tuaj yeem npaj los ntawm ntau txoj kev hluavtaws. Cov hauv qab no yog ob peb txoj kev siv hluavtaws:
1. Nyob rau hauv situ tiam txoj kev:
Txoj kev no tsim tawm 4-phenylsodium phenylbutyrate hauv situ los ntawm cov tshuaj tiv thaiv.
- Cov kauj ruam tshuaj tiv thaiv: ntxiv benzoic acid thiab bromobutane rau hauv lub reactor, thiab nqa tawm condensation cov tshuaj tiv thaiv nyob rau hauv lub xub ntiag ntawm alkali los tsim 4-phenylbutyrate. Tom qab ntawd, 4-phenylbutyrate yog reacted nrog sodium hydroxide los ua 4-phenylsodium phenylbutyrate.
C7H6O2 plus C4H9Br → 4-phenylbutyrate
4-phenylbutyrate plus NaOH → C10H13NaO2
2. Reaction method:
- Reaction equation: C10H12O2 plus NaOH → C10H13NaO2
Synthetic cov kauj ruam:
1. Npaj reactants: 4-phenylbutyric acid (4-phenylbutyric acid) thiab base (xws li sodium hydroxide los yog sodium carbonate). Kuj npaj cov kuab tshuaj uas tsim nyog.
2. Kev npaj cov khoom siv tshuaj tiv thaiv: Nyob rau hauv qhuav tej yam kev mob, muab ib tug haum cov tshuaj tiv thaiv hlab ntsha, xws li ib tug puag ncig hauv qab khob. Xyuas kom lub reactor muaj ib qho inert cua.
3. Kev npaj cov tshuaj tiv thaiv sib tov: 4-phenylbutyric acid thiab ib qho tsim nyog ntawm lub hauv paus yog yaj nyob rau hauv ib qho hnyav hnyav los tsim cov tshuaj tiv thaiv sib tov. Feem ntau siv cov kuab tshuaj muaj xws li ethanol, methanol, thiab lwm yam.
4. Cov tshuaj tiv thaiv cua sov: cua sov cov tshuaj tiv thaiv sib xyaw kom haum rau qhov kub thiab txias, feem ntau nyob rau hauv thaj tsam ntawm 75-100 degree . Hauv cov kauj ruam no, cov tshuaj tiv thaiv tshwm sim li ob peb teev.
5. stirring cov tshuaj tiv thaiv: kom stirring cov tshuaj tiv thaiv sib tov nyob rau hauv tsim nyog stirring tej yam kev mob los txhawb txoj kev loj hlob ntawm cov tshuaj tiv thaiv.
6. Qhov kawg ntawm cov tshuaj tiv thaiv: Tom qab cov tshuaj tiv thaiv tiav lawm, cov tshuaj tiv thaiv sib tov yog txias rau chav tsev kub.
7. Acidification kho: Acidify cov tshuaj tiv thaiv sib tov los ntawm kev ntxiv cov kua qaub xws li hydrochloric acid. Qhov no yuav ua rau cov ntsev ntsev uas ua rau cov dej ntws tawm.
8. Crystal nag lossis daus: Sodium 4-phenylbutyrate crystals yog precipitated los ntawm txias cov tshuaj tiv thaiv sib tov, diluting los yog ntxiv ib tug tsim nyog hnyav.
9. Lim thiab ntxuav: Ntxuav thiab lim cov dej nag uas tshwm sim nrog cov kuab tshuaj tsim nyog. Qhov no yuav tshem tawm impurities.
10. Kev ziab thiab purification: Qhuav cov khoom mus rau qhov hnyav tas li los ntawm txoj kev ziab kom tsim nyog, thiab ua cov txheej txheem purification tsim nyog, xws li recrystallization, thiab lwm yam.
11. Kev txheeb xyuas thiab kev txheeb xyuas: Siv cov txheej txheem analytical tsim nyog, xws li huab hwm coj spectrometry, infrared spectroscopy, thiab lwm yam., txhawm rau txheeb xyuas thiab txheeb xyuas cov khoom tau txais.
3. Ammonification txoj kev:
Reaction sib npaug:
C10H12O2 plus NH3 → C10H13NaO2 synthesis cov kauj ruam:
1. Npaj reactants: 4-phenylbutyric acid (4-phenylbutyric acid) thiab ammonia (NH3). Kuj npaj cov kuab tshuaj uas tsim nyog.
2. Kev npaj cov khoom siv tshuaj tiv thaiv: Nyob rau hauv qhuav tej yam kev mob, muab ib tug haum cov tshuaj tiv thaiv hlab ntsha, xws li ib tug puag ncig hauv qab khob. Xyuas kom lub reactor muaj ib qho inert cua.
3. Dissolving reactants: Ntxiv 4-phenylbutyric acid, cov roj ammonia tsim nyog thiab cov kuab tshuaj tsim nyog rau hauv cov hlab ntsha. Feem ntau siv cov kuab tshuaj tuaj yeem yog methanol, ethanol, thiab lwm yam.
4. Cov tshuaj tiv thaiv cua sov: cua sov cov tshuaj tiv thaiv cov hlab ntsha mus rau qhov tsim nyog cov tshuaj tiv thaiv kub, feem ntau nyob rau hauv nruab nrab cua sov. Cov tshuaj tiv thaiv kub tuaj yeem hloov kho raws li kev sim, feem ntau ntawm 50-100 degree .
5. stirring cov tshuaj tiv thaiv: kom stirring cov tshuaj tiv thaiv sib tov nyob rau hauv zoo stirring tej yam kev mob los txhawb cov tshuaj tiv thaiv.
6. Qhov kawg ntawm cov tshuaj tiv thaiv: Nyob ntawm qhov kev nce qib ntawm cov tshuaj tiv thaiv, lub sij hawm cov tshuaj tiv thaiv feem ntau yuav siv sij hawm ob peb teev mus rau kaum teev. Thaum cov tshuaj tiv thaiv tiav, cov cua sov tau nres.
7. Txias: Txias cov tshuaj tiv thaiv sib tov rau hauv chav sov.
8. Acidification kho: Acidify cov tshuaj tiv thaiv sib tov los ntawm kev ntxiv cov kua qaub xws li hydrochloric acid. Qhov no yuav ua rau nag lossis daus ntawm 4-phenylammonium phenylbutyrate.
9. Crystal precipitation: Sodium 4-phenylbutyrate crystals yog precipitated los ntawm txias cov tshuaj tiv thaiv sib tov, diluting los yog ntxiv ib tug tsim nyog hnyav.
10. Lim thiab ntxuav: Ntxuav thiab lim cov dej nag uas tshwm sim nrog cov kuab tshuaj tsim nyog. Qhov no yuav tshem tawm impurities.
11. Qhuav thiab purification: Qhuav cov khoom mus rau qhov hnyav tas li los ntawm txoj kev ziab kom tsim nyog, thiab ua cov kauj ruam purification tsim nyog, xws li recrystallization, thiab lwm yam.
12. Kev txheeb xyuas thiab txheeb xyuas: Siv cov txheej txheem analytical tsim nyog, xws li huab hwm coj spectrometry, infrared spectroscopy, thiab lwm yam., txhawm rau txheeb xyuas thiab txheeb xyuas cov khoom tau txais.
4. Txoj kev Photocatalytic:
- Cov kauj ruam tshuaj tiv thaiv: hnov mob 4-phenylbutyric acid nrog rau cov photosensitive catalyst (xws li derivative ntawm stilbene) nyob rau hauv ultraviolet lub teeb los tsim 4-phenylsodium phenylbutyrate.
- Cov kab zauv sib piv: C10H12O2 ntxiv rau photosensitive catalyst ntxiv rau lub teeb irradiation → C10H13NaO2
Nws yuav tsum tau muab sau tseg tias thaum ua raws li cov txheej txheem synthesis saum toj no, kev sim ua haujlwm yuav tsum tau ua raws li cov cai tswj kev nyab xeeb, thiab cov xwm txheej ntawm cov tshuaj tiv thaiv, cov kuab tshuaj thiab cov catalysts yuav tsum raug xaiv nyob rau hauv qhov muaj feem xyuam. Nyob rau tib lub sijhawm, nws raug nquahu kom xa mus rau cov ntaub ntawv tshawb fawb txog kev tshawb fawb thiab phau ntawv qhia txog cov txheej txheem kev ua haujlwm kom ntxaws ntxiv thiab cov kev sim tshwj xeeb.