Niaj hnub no veterinary parasitology tau txhim kho canine ectoparasite thiab endoparasite tswj.Afoxolaner thiab Milbemycin Oxime Chewable Tabletsrevolutionize parasite tswj. Afoxolaner-isoxazoline chemistry- tau hloov pauv cov kws kho tsiaj thiab cov tswv tsiaj tiv thaiv kev cia siab. Dual- kev tsim tawm ua kom dhau cov kev txwv ntawm cov tshuaj laus thiab muab kev tiv thaiv ntev -. Nkag siab txog kev tshawb fawb tom qab lub tswv yim kho mob no piav qhia nws qhov muaj koob meej hauv kev ua tsiaj. Isoxazoline tebchaw hloov kho ectoparasiticide tsim. Isoxazolines tsom rau arthropod lub hlwb txoj hauv kev, tsis zoo li lwm cov chav kawm tshuaj nrog sib xyaw ua haujlwm thiab tshuaj lom. Nrog macrocyclic lactones zoo li milbemycin oxime, koob tshuaj txhua hli txo cov kab mob sab nraud thiab sab hauv. Cov thev naus laus zis no ua tiav qhov kev xav tau loj zuj zus ntxiv rau cov txheej txheem kho kom yooj yim uas ua rau kom ua tau raws thiab ua tau zoo.
Afoxolaner Thiab Milbemycin Oxime Chewable Tablets
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Tablet
9.375+1.875mg: 2-3.5 kg
18.75+3.75mg: 3.5-7.5kg
37.5+7.5mg:＞7.5-15kg
75+15mg:＞15-30kg
150+30mg: 30-60kg
(3) Ointment
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-2-117
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Dab tsi ua rau Afoxolaner hauv Afoxolaner thiab Milbemycin Oxime Chewable Tablets txawv ntawm cov khoom siv tshuaj Parasite Control?
Qhov txawv Chemical Architecture thiab Selectivity
Ib txwm ectoparasiticides feem ntau yog organophosphates, carbamates, los yog pyrethroid chemicals, uas yog neurotoxic feem ntau thiab yuav ua tau txaus ntshai rau tsiaj. Afoxolaner txawv ntawm cov tshuaj laus no vim tias nws muaj cov qauv isoxazoline uas ua haujlwm zoo heev ntawm cov hlab ntsha ntawm cov pob txha. Cov qauv tsim molecular ua rau nws ua tau rau siab -affinity khi rau chloride channels uas tau qhib los ntawm gamma-aminobutyric acid (GABA) thiab tsuas yog pom nyob rau hauv arthropods. Qhov rhiab heev no txhais tau hais tias nws muaj me ntsis tsis muaj kev cuam tshuam rau GABA receptors hauv cov tsiaj nyeg, uas piav qhia txog kev nyab xeeb zoo uas pom hauv kev kuaj mob.
Lub hom phiaj meej no pab cov dev uas tau kho nrog Afoxolaner thiab Milbemycin Oxime Chewable Tablets vim tias nws txo qis kev pheej hmoo ntawm cov teeb meem hauv lub paj hlwb uas feem ntau nrog cov tshuaj tua kab mob tsawg dua.
Ncua Sijhawm Ua Haujlwm Tshaj Tawm piv rau Cov Kev Xaiv Xaiv
Ntau qhov kev kho mob yoov tshaj cum thiab zuam yuav tsum tau muab tshuaj ntau dua los yog ua tsis tau zoo tom qab dej los yog hnub raug. Afoxolaner's pharmacokinetic profile qhia tau hais tias nws tau tawg thoob plaws hauv lub cev tom qab kev tswj hwm qhov ncauj, daws cov teeb meem no. Cov molecule ncav cuag nws cov ntshav siab tshaj plaws nyob rau hauv ob mus rau plaub teev thiab nyob twj ywm rau ib hlis, muab cov txiaj ntsig kho mob.
Txawm hais tias huab cua los yog da dej ntau zaus, cov kab mob uas pub rau cov dev kho ib txwm ncav cuag qhov tsis zoo vim tias cov tshuaj no nyob hauv cov ntshav ntev ntev. Txoj kev daws teeb meem tshem tawm kev txhawj xeeb txog kev tsis sib xws lossis kev tshem tawm tsis txhob txwm ua, uas txo qhov ua tau zoo ntawm qhov chaw - ntawm kev kho mob. Cov kws tshawb fawb txog kev tiv thaiv kab mob parasite tau pom tias kev xa cov tshuaj hauv qhov ncauj ib hlis ib zaug tuaj yeem cuam tshuam cov neeg tiv taus.
Kev Ua Ntxiv Nrog Milbemycin Oxime rau Kev Tiv Thaiv Kev Tiv Thaiv
Cov khoom no txawv ntawm cov uas tsuas muaj ib qho khoom xyaw vim nws ua ke afoxolaner nrog milbemycin oxime hauv txoj kev ntse.
Milbemycin oxime ua haujlwm tawm tsam endoparasites los ntawm kev ua kom glutamate-gated chloride channels, thaum afoxolaner ua haujlwm tawm tsam ectoparasites los ntawm kev thaiv GABA receptors.Qhov ob -ib feem system nres ob qho tib si kab mob sab nraud thiab kab mob sab hauv, uas feem ntau tau kho ntau txoj hauv kev nrog cov khoom siv li niaj zaus. Veterinary kev coj noj coj ua uas cuam tshuam nrog cov kab mob plawv uas muaj nyob hauv thaj chaw zoo li yooj yim npaum li cas los tiv thaiv Dirofilaria immitis larvae thiab tswj plab hnyuv nematodes tib lub sijhawm. Kev tshem tawm ntawm kev kho qhov khoob uas tshwm sim thaum cov tswv tsis nco cov phiaj xwm deworming sib txawv yog qhov txiaj ntsig kho mob loj, tshwj xeeb tshaj yog nyob rau hauv qhov chaw uas muaj ntau tshaj li ib qho kab mob cab.
Isoxazoline Mechanism Qab Afoxolaner thiab Milbemycin Oxime Chewable ntsiav tshuaj piav qhia
Neurological Target thiab Ion Channel Modulation
Isoxazolines ua rau muaj kev cuam tshuam tsis zoo ntawm lub paj hlwb ligand -gated chloride channels. Afoxolaner muaj zog khi rau GABA receptors, thaiv cov neuronal excitation signaling. Thaum cov tshuaj chloride ions tso tseg, lub hom phiaj cov kab mob parasite tua hluav taws tsis muaj zog, ua rau qaug zog, tuag tes tuag taw, thiab tua lawv. Vim tias arthropod thiab vertebrate GABA receptors sib txawv. Kab thiab arachnid khi hnab ris haum rau isoxazolines zoo dua li tib neeg receptor isoforms. Cov kev ntsuas dav dav tau tshaj tawm thaum kuaj kev nyab xeeb yog vim muaj tshuaj rhiab heev.
Cov dev muab cov koob tshuaj kom raug ntawm Afoxolaner thiab Milbemycin Oxime Chewable Tablets rhuav tshem cov kab mob uas tsis ua mob rau lub hauv nruab nrab lub paj hlwb raws li cov tsiaj txhu receptors.
Kev tshwm sim sai thiab kev ua kom muaj kab mob parasiticide
Afoxolaner yog nqus tau zoo los ntawm lub cev tom qab noj los ntawm qhov ncauj, thiab 88% ntawm nws bioavailability tiav. Cov tshuaj no kis tau nyob rau hauv lub cev lub hlwb, txawm nyob rau hauv daim tawv nqaij, qhov twg ectoparasites yuav nrhiav tau qhov chaw noj. Fleas uas nkag mus rau hauv cov ntshav uas muaj afoxolaner ua rau tuag tes tuag taw hauv ob peb teev. Qhov no txwv tsis pub lawv los ntawm kev tso qe thiab nres cov kab mob cab lub neej ua ntej nws tuaj yeem kis mus rau lwm qhov ntawm ib puag ncig.
Ticks kuj tuag ua ntej lawv noj cov ntshav, uas txo qis kev pheej hmoo ntawm cov kab mob sib kis. Lub plasma ib nrab-lub neej ntawm li ob lub lis piam ua kom paub tseeb tias qhov kev siv tau zoo nyob siab ntawm cov koob tshuaj txhua hli, yog li txawm tias muaj kev ncua me me hauv kev noj tshuaj, kev nyab xeeb tseem nyob ruaj khov. Kev tshawb fawb Veterinary uas saib cov kab mob parasites hauv cov neeg kho mob tsis tu ncua pom kev txo qis ntau dua 95% rau cov hom phiaj ntawm lub sijhawm noj tshuaj.
Synergistic Effect Nrog Macrocyclic Lactone Component
Qhov sib txawv tseem sib piv, milbemycin oxime ua rau muaj kev cuam tshuam helminth thiab invertebrate larval membranes ntau permeable.
Cov tshuaj activates glutamate -gated chloride channels, uas tsub lub hlwb thiab cuam tshuam kev koom tes ntawm neuromuscular.Qhov no zoo heev tiv thaiv kab mob plawv microfilariae thiab lwm yam kab mob plab hnyuv. Thaum sib xyaw ua ke, afoxolaner's GABA-kev tawm tsam kev tawm tsam thiab milbemycin's glutamate-agonist cuam tshuam tiv thaiv kab mob ntawm ntau theem kev txhim kho. Milbemycin tua larvae thaum afoxolaner tua cov neeg laus ectoparasites. Hauv kev muaj tiag, cov kws kho tsiaj niaj hnub pom cov kab mob sib xyaw ua ke. Cov txheej txheem ntau- hom phiaj no txo qhov kev pheej hmoo ntawm kev kho tsis ua haujlwm.
Yuav Ua Li Cas Afoxolaner Txhawb Kev Tshawb Fawb Tshaj Plaws thiab Tick Control Hauv Cov dev?
Standardized Tool rau Kev Kawm Txuj Ci
Txhawm rau sib piv cov kev xaiv sim rau cov qauv kev kho mob, cov chaw tshawb fawb tshawb fawb uas tab tom nrhiav rau cov tshuaj tua kab mob tshiab yuav tsum tau kho kev sib piv. Vim tias nws qhov kev ua tau zoo tuaj yeem kwv yees tau thiab nws cov kws tshuaj tau nkag siab zoo, afoxolaner tau dhau los ua tus qauv hauv kev tswj hwm kev ua tau zoo. Afoxolaner yog siv los ua kev tswj xyuas zoo hauv kev tshawb fawb uas saib cov qauv tiv thaiv tshiab. Qhov no pab cov kws tshawb fawb qhia qhov sib txawv ntawm qhov txo qis ntawm kev sib cais ntawm thaj chaw thiab cov txheej txheem sib txawv.
Vim tias cov khoom xyaw hauv Afoxolaner thiab Milbemycin Oxime Chewable Tablets yeej ib txwm zoo ib yam, cov txiaj ntsig tuaj yeem rov ua dua ntawm qhov chaw kawm sib txawv. Qhov no ua rau nws yooj yim dua los ua meta- tshuaj ntsuam xyuas, uas yog siv los pab txiav txim siab txog cov cai thiab cov qauv kev kho mob.
Tus qauv rau kev nkag siab txog Acaricide Resistance Mechanisms
Cov tshuaj acaricides tsis tua ntau tus zuam raws li lawv tau siv los ua, uas ua rau cov tshuaj kho tsiaj thiab kev noj qab haus huv rau pej xeem nyuaj. Cov kws tshawb fawb tuaj yeem saib mus rau hauv tus ntoo khaub lig- qauv kev tiv thaiv thiab nrhiav cov hom phiaj molecular uas hloov pauv los ntawm kev xaiv lub siab ua tsaug rau afoxolaner txoj kev ua haujlwm tshwj xeeb. Thaum lub chaw soj nstuam raug cuam tshuam rau qib qis ntawm isoxazoline, lawv pom cov kev hloov pauv caj ces hauv GABA receptor subunits.
Cov ntaub ntawv no pab nrog kev txhim kho tshuaj thiab tswj kev tiv thaiv. Afoxolaner susceptibility test yog siv nyob rau hauv kev soj ntsuam cov kev pab cuam uas ua rau lub qhov muag ntawm cov zuam tsiaj qus kom pom tias cov genotypes resistant txav ntawm ib qhov chaw mus rau lwm qhov. Cov kev tshawb fawb no pab peb kawm paub ntau ntxiv txog neurobiology ntawm arthropods thiab muab cov ntaub ntawv tseem ceeb rau peb kom paub tseeb tias cov tshuaj tua kab mob muaj txiaj ntsig ntev dua.
Pharmacokinetic Cov ntaub ntawv txhawb nqa Dosing Optimization
Kev tshawb fawb Afoxolaner tsim cov ncauj lus kom ntxaws txog cov tshuaj pharmacokinetic uas pab cov neeg tshawb nrhiav pom txoj hauv kev zoo tshaj plaws los txhaj ntau hom dev.
Cov kev tshawb fawb uas saib seb cov dev sib txawv teb li cas rau cov tshuaj tau pom tias feem ntau cov dev muaj peev xwm tau txais cov tshuaj kho mob nyob rau hauv qhov kev tso cai ntawm 2.5 mus rau 6.9 mg / kg.Txawm li cas los xij, kev tshawb fawb ntawm qee cov dev, zoo li cov dev qub los yog dev uas muaj teeb meem rau daim siab, siv afoxolaner ua tus qauv isoxazoline kom pom kev nyab xeeb thiab ua tau hloov pauv. Cov kws kho tsiaj tuaj yeem tau txais cov ntaub ntawv pov thawj-raws li cov lus qhia uas txhim kho kev ua tau zoo thiab kev nyab xeeb los ntawm kev sau loj ntawm kev sim tshuaj uas tau ua tiav ntawm cov tshuaj no. Raws li cov ntaub ntawv tshuaj pharmacokinetic tshiab tuaj, cov chaw tshawb fawb ua haujlwm nrog cov tuam txhab tshuaj ua kom txhim kho txoj kev siv tshuaj. Qhov no ua kom paub tseeb tias cov lus qhia txog kev kho mob yog raws li kev paub txog kev tshawb fawb zaum kawg.
Afoxolaner thiab Milbemycin Oxime Chewable Tablets Daim Ntawv Thov hauv Kev Tswj Xyuas Kab Mob Niaj Hnub No
Kev sib koom ua ke rau Kev Tiv Thaiv Kev Noj Qab Haus Huv
Hauv kev coj noj coj ua niaj hnub no, kev tiv thaiv kab mob cab txhua xyoo yog qhov tseem ceeb tshaj li kev kho lawv tom qab lawv tau tshwm sim lawm. Txoj kev tiv thaiv no yog nyob rau hauv txoj kab nrog Afoxolaner thiab Milbemycin Oxime Chewable Tablets, uas muab kev tiv thaiv tag nrho ntawm cov kab mob parasitic txaus ntshai tib lub sijhawm. Cov chaw kho mob uas khiav cov kev pab cuam qoj ib xyoos ua rau muab cov qauv no rau cov dev ib hlis ib zaug yog qhov tseem ceeb ntawm kev ua kom lawv txoj kev noj qab haus huv zoo. Daim ntawv chewable, uas qab qab zoo dua, ua rau cov tswv yuav coj nws raws li kev qhia, uas yog qhov zoo dua li cov qauv tshuaj vim tias nws ua rau muaj qhov sib txawv ntawm kev tiv thaiv uas tsis muaj zog tiv thaiv tsiaj hauv tsev nrog ntau dua ib tus dev.
Thaum cov kws kho tsiaj tham nrog cov neeg siv khoom txog kev pheej hmoo parasite, lawv feem ntau tham txog qhov yooj yim npaum li cas kom muaj ib yam khoom uas tua cov dev mub, zuam, kab mob plawv, thiab kab mob plab. Cov lus no cuam tshuam hauv tsev nrog cov tswv uas xav ua kom lawv cov tsiaj tu cov txheej txheem yooj yim dua.
Lub luag haujlwm hauv Zoonotic Cov Tswv Yim Tiv Thaiv Kab Mob
Ntau cov kab mob uas kis tau los ntawm cov zuam thiab cuam tshuam rau dev kuj tuaj yeem tsim kev puas tsuaj rau tib neeg. Qhov no ua rau muaj kev tswj hwm zoo ntawm ectoparasites rau pej xeem kev noj qab haus huv tseem ceeb. Cov zuam uas nqa Borrelia burgdorferi, hom Anaplasma, thiab lwm yam zoonotic cov neeg ua haujlwm raug rau cov tshuaj lom afoxolaner, uas tua lawv ua ntej lawv tuaj yeem noj cov ntshav, uas yog qhov tsim nyog rau kev kis kab mob.
Kev tshawb fawb txog kev kis kab mob hauv thaj chaw uas zuam - kab mob kis tau tshwm sim tau txuas nrog kev siv ntau dua ntawm cov khoom uas muaj isoxazoline kom txo qis tus zuam - kis mob hauv tib neeg thiab dev. Cov kws kho tsiaj uas ua haujlwm rau pej xeem kev noj qab haus huv feem ntau txhawb nqa zej zog- cov kev tswj hwm kab mob thoob plaws thiab qhia cov tshuaj xws li Afoxolaner thiab Milbemycin Oxime Chewable Tablets ua txoj hauv kev zoo los tiv thaiv ob tus tsiaj thiab lawv tus tswv. Qhov tseeb tias cov tshuaj tua kab mob siab heev tuaj yeem txhim kho tsiaj kev noj qab haus huv thiab txo qis kev pheej hmoo ntawm cov kab mob zoonotic ua rau lawv qhov kev sib kis loj dua.
Kev siv hluav taws xob hauv cov neeg tshwj xeeb Canine
Cov dev ua haujlwm, tsiaj txhu hauv cov chaw nyob, thiab cov chaw yug me nyuam txhua tus muaj cov kab mob tshwj xeeb uas xav tau kev tswj xyuas kom muaj zog.
Cov khoom sib xyaw ua ke muaj kev tiv thaiv dav dav, uas muaj txiaj ntsig zoo rau cov tub rog thiab tub ceev xwm cov dev uas ua haujlwm hauv ntau qhov chaw. Cov vaj tse uas muaj kab mob ntau heev ntxuav lawv cov tsiaj ib hlis ib zaug kom tsis txhob muaj chaw nyob - muaj kev sib kis thoob plaws uas ua rau nws nyuaj nrhiav tsev rau cov tsiaj. Txhawm rau tiv thaiv kev laus kev noj qab haus huv thiab tiv thaiv kev sib kis ntsug ntawm qee tus kab mob, cov chaw yug me nyuam siv cov kev tiv thaiv. Afoxolaner muaj kev nyab xeeb vim nws tau siv ntau lab tus dev thoob ntiaj teb. Qhov no ua rau nws yog qhov kev xaiv zoo rau cov xwm txheej tshwj xeeb uas cov tshuaj txheem yuav ua rau muaj kev pheej hmoo ntau dhau. Cov kws kho tsiaj uas ua haujlwm nrog cov pab pawg no zoo li qhov sib tov tuaj yeem siv rau ntau hom thiab theem ntawm lub neej.
Tshawb nrhiav lub luag haujlwm ntawm Isoxazoline Technology hauv Afoxolaner thiab Milbemycin Oxime Chewable Tablets
Chemical Class Evolution thiab Structural Advantages
Cov tshuaj chemistry siv nyob rau hauv cov tsiaj cov tshuaj tau mus txog ib tug tseem ceeb lub sij hawm nrog lub nrhiav tau ntawm isoxazolines. Cov laus hom kab mob parasiticides feem ntau muaj teeb meem nrog metabolically tsis ruaj khov los yog tsis zoo nqus los ntawm lub cev thaum noj los ntawm qhov ncauj. Isoxazoline architecture tau txais ib puag ncig cov teeb meem no los ntawm kev siv cov qauv tsim qauv ntse. Lub tsib- koom nrog heterocyclic nplhaib nrog nitrogen thiab oxygen atoms ua rau cov lipophilic compound rau cov ntaub so ntswg tis thiab polar txaus rau nqus tau nyob rau hauv lub plab. Hloov pauv mus rau cov khoom siv txuas nrog cov tub ntxhais isoxazoline qauv ua rau nws ua tau zoo npaum li cas cov tshuaj khi rau receptors lub cev thiab nws txav mus li cas.
Cov tshuaj afoxolaner yog ib qho piv txwv zoo ntawm qhov tsim tshuaj tsim nyog yuav ua rau cov tshuaj muaj txiaj ntsig zoo tshaj plaws, xws li pib sai, ntev - cov teebmeem ntev, thiab ob peb cov kev mob tshwm sim uas tsis tau npaj tseg. Lub hauv paus tshuaj no thim rov qab cov txiaj ntsig kev kho mob uas cov kws kho tsiaj pom thaum lawv muab tshuaj Afoxolaner thiab Milbemycin Oxime Chewable Tablets.
Comparative Efficacy Against Emerging Parasite Threats
Qee hom zuam tam sim no tuaj yeem nyob hauv ntau thaj tsam thiab cuam tshuam nrog cov kab mob tshiab vim kev hloov pauv huab cua thiab tsiaj tsiv teb tsaws. Txawm tias muaj me ntsis isoxazoline raug, Amblyomma hom uas tau tsiv mus nyob rau hauv qhov chaw tshiab yog rhiab heev rau afoxolaner.
Qhov loj spectrum ntawm kev txiav txim tawm tsam ixodids txawv los ntawm yav dhau los acaricides nrog txwv kev ua tau zoo. Afoxolaner txoj kev tsim kho tshiab ua haujlwm rau cov neeg tawm tsam tshiab uas tuaj yeem tiv taus lwm cov tshuaj tua kab. Txawm tias tom qab xyoo ntawm kev siv, veterinary diagnostic labs tau pom cov khoom lag luam ua tau zoo. Qhov no qhia tau hais tias isoxazoline tsis kam txhim kho qeeb dua li cov tshuaj ua ntej. Cov txiaj ntsig no qhia tau hais tias yuav tsum muaj ntau yam sib txuas rau kev siv tshuaj tua kab mob zoo.
Regulatory Standards thiab Quality Assurance nyob rau hauv Manufacturing
Pharmaceutical -qib afoxolaner yuav tsum tau ua nruj me ntsis. Cov txheej txheem no ua kom batch zoo thiab ruaj khov.
Cov chaw tsim khoom rau cov khoom xyaw tshuaj nquag yuav tsum ua raws li GMP cov cai uas tau tshaj tawm los ntawm ntau lub tseem fwv. HPLC thiab huab hwm coj spectrometry yog siv rau hauv kev tswj kom zoo los txheeb xyuas cov tshuaj thiab kuaj cov kab mob. Precision dosing over weight-raws li specification range yog xav tau rau Afoxolaner thiab Milbemycin Oxime Chewable Tablets. Kev tsim kho tshuaj muaj zog thiab kev tshawb xyuas qhov tseeb yog xav tau. Veterinarians cia siab rau cov tuam txhab tsim khoom kom tswj tau cov qauv zoo yog li cov tshuaj no ib txwm ua raws li kev pom zoo. Thib peb-kev ntsuam xyuas tog thiab kev soj ntsuam kev tswj xyuas kom paub meej tias cov khoom npaj kho mob ua tiav cov txheej txheem kev nyab xeeb thiab kev ua tau zoo.
Xaus
Kev sib xyaw cov tshuaj tua kab mob nrog isoxazoline thev naus laus zis ntawm afoxolaner yog qhov ua ntej loj hauv cov tshuaj kho tsiaj. Afoxolaner thiab Milbemycin Oxime Chewable Tablets qhia tau li cas tam sim no kev tshawb fawb tshuaj thiab kev txhim kho kov yeej cov teeb meem kab mob parasitological los ntawm kev sib xyaw ua ke thiab cov tswv yim sib xyaw cov tshuaj. Cov txheej txheem sib txawv uas tsom GABA- thiab glutamate-gated chloride channels tiv thaiv exoparasites thiab endoparasites thaum tsis muaj teeb meem. Cov ntawv thov tshawb fawb pab peb nkag siab txog kab mob kab mob thiab kev tiv thaiv, uas yuav txhim kho kev kho mob yav tom ntej. Kev sib koom ua ke hauv kev kho mob hauv kev tiv thaiv kev tiv thaiv pab dev noj qab haus huv thiab tiv thaiv kab mob zoonotic. Raws li kws kho tsiaj tau nce qib los tiv thaiv tsiaj mob, isoxazoline- cov tshuaj raws li yuav tseem tseem ceeb rau cov kws kho tsiaj thoob ntiaj teb.
FAQ
1. Dab tsi ua rau afoxolaner muaj kev nyab xeeb dua cov khoom qub qub uas siv los tua cov yoov thiab zuam?
Vim hais tias arthropod thiab mammalian receptor isoforms yog cov qauv sib txawv, afoxolaner yog xaiv heev rau invertebrate GABA receptors. Qhov kev xaiv no txhais tau hais tias ob peb lub hom phiaj vertebrate raug khi, uas piav qhia txog kev nyab xeeb loj uas pom hauv kev tshawb fawb soj ntsuam. Ib txwm organophosphates thiab carbamates tsis ua haujlwm zoo rau cov kab thiab vertebrate paj hlwb, thiab qee zaum lawv raug mob rau cov tsiaj uas tau kho nrog lawv. Cov qauv isoxazoline ua rau nws muaj peev xwm ua rau cov tshuaj ua haujlwm tiv thaiv kab mob thaum tsis muaj teeb meem rau cov tsiaj txhu.
2. Kev sib xyaw afoxolaner thiab milbemycin oxime ua kom yooj yim tshem tawm cov kab mob parasite li cas?
Ob -ib feem mis ua haujlwm ntawm ob qho tib si ectoparasites thiab endoparasites los ntawm kev thaiv GABA receptors thiab qhib glutamate channels. Vim tias cov txheej txheem no ua haujlwm ua ke, tsis tas yuav muaj cov phiaj xwm kev kho mob cais rau txhua hom kab mob cab. Tsuas yog txhaj tshuaj txhua hli xwb, cov dev tau tiv thaiv cov dev mub, zuam, cov qe plawv, thiab cov kab mob plab hnyuv txhua lub sijhawm. Txoj kev sib xyaw ua ke ua kom yooj yim rau tib neeg kom ua raws li cov cai thaum siv ntau yam khoom tiv thaiv, thiab nws kuj txo qis ntawm kev kho qhov khoob uas tuaj yeem ua rau tsiaj qhib rau kis.
3. afoxolaner -cov khoom siv puas tuaj yeem siv tau zoo hauv txhua hom dev?
Feem ntau hom dev tuaj yeem ua rau afoxolaner zoo nyob rau hauv qhov ntau npaum li cas uas tau pom zoo. Qee qhov tshwj xeeb yog collie- hom dev uas muaj kev hloov pauv hauv MDR1 noob uas cuam tshuam li cas cov tshuaj tawm hauv lub hauv paus paj hlwb. Afoxolaner yog ib qho kev xaiv heev rau invertebrates raws li nws lub hom phiaj, tab sis dev nrog MDR1 tsis xws luag tej zaum yuav muaj ntau dua ntawm cov tshuaj sib txawv nyob rau hauv lawv lub hlwb. Cov kws kho tsiaj feem ntau ua kuaj DNA lossis ceev faj thaum muab rau cov tsiaj uas paub tias muaj qhov hloov pauv no. Lawv hloov cov cai raws li qhov txaus ntshai npaum li cas txhua tus tsiaj.
Koom Tes Nrog BLOOM TECH rau Hwm Afoxolaner thiab Milbemycin Oxime Chewable Tablets Supply
BLOOM TECH stands raws li koj ntseeg siab Afoxolaner thiab Milbemycin Oxime Chewable Tablets tsum, combining tshaj 12 xyoo ntawm kev txawj ntse nyob rau hauv cov tshuaj intermediates nrog GMP- ntawv pov thawj peev xwm raug lees paub los ntawm US-FDA, EU, thiab CFDA tub ceev xwm. Peb qhov kev lees paub zoo tag nrho suav nrog peb theem ntawm kev txheeb xyuas qhov tseeb: kev sim hauv cov nroj tsuag, sab hauv QA / QC departments, thiab pom zoo thib peb- cov koom haum tog. Qhov no ua kom paub tseeb tias tag nrho peb cov khoom xyaw nquag muaj ntau dua 98% ntshiab, uas yuav tsum tau siv rau kev siv tshuaj. Peb pab cov tuam txhab tshuaj, cov chaw tshawb fawb, kev cog lus tsim kho thiab tsim cov koom haum (CDMOs), thiab cov neeg xa khoom los ntawm kev muab ntau yam khoom, los ntawm cov hmoov API ntshiab kom tiav cov ntsiav tshuaj chewable hauv tsib lub zog uas muaj kev nyab xeeb rau cov dev uas hnyav 2 txog 60 kg. Peb muab cov nqi sib tw yam tsis tau txo qis cov qauv zoo ua tsaug rau peb cov qauv nqi meej, uas tau txais kev txhawb nqa los ntawm cov nyiaj tau los ruaj khov thiab cov ntaub ntawv xov xwm ntxaws ntxaws khaws cia hauv peb lub platform ERP.
Cov kws kho tsiaj thiab cov neeg koom tes ua lag luam thoob plaws ntiaj teb nyob ntawm BLOOM TECH rau cov khoom siv ruaj khov, cov ntaub ntawv txheeb xyuas ntxaws (HPLC thiab MS profiles), thiab kev txhawb nqa kev cai lij choj rau kev tsim tshuaj tshiab. Peb pab pawg kws tshaj lij tuaj yeem pab koj nrog cov kev cai daws teeb meem uas txo lub sijhawm nws siv los tsim cov khoom tshiab thiab ua tau raws li cov qauv kev cai thoob ntiaj teb, txawm tias koj xav tau me me rau kev kawm lossis ntau yam khoom muag. Koj tuaj yeem xa email rau peb pab neeg muag khoom paub txog ntawmSales@bloomtechz.comtham txog koj cov kev xav tau tshwj xeeb rau afoxolaner formulations, nug rau daim ntawv pov thawj ntawm kev tshuaj xyuas, lossis kawm ntxiv txog peb cov kev cai sib xyaw ua ke uas yuav pab koj ncav cuag koj lub hom phiaj los tsim cov tshuaj tsiaj.
Cov ntaub ntawv
1. Dryden MW, Smith V, Bennett T, et al. "Kev ua tau zoo ntawm afoxolaner tiv thaiv kab mob dev mub hauv dev thiab miv: Kev tshuaj xyuas ntawm chav kuaj thiab kev tshawb fawb teb." Veterinary Parasitology, 2015, 212(3-4): 118-125.
2. Shoop WL, Hartline EJ, Gould BR, et al. "Discovery thiab hom kev ua ntawm afoxolaner, tus tshiab isoxazoline parasiticide rau dev." Veterinary Parasitology, 2014, 201(3-4): 179-189.
3. Letendre L, Huang R, Kvaternick V, et al. "Cov tshuaj tua kab mob hauv qhov ncauj thiab qhov ncauj ntawm afoxolaner siv los ua ib lub hlis chewable antiparasitic rau dev." Veterinary Parasitology, 2014, 201(3-4): 190-197.
4. Beugnet F, Halos L, Larsen D, de Vos C. "Kev ua tau zoo ntawm qhov ncauj afoxolaner rau kev kho mob ntawm canine generalized demodicosis." Tej zaum 2016, 23:14.
5. Cavalleri D, Murphy M, Gorbea RL, et al. "Kev soj ntsuam kev soj ntsuam ntawm tam sim thiab kev ua tau zoo ntawm afoxolaner tiv thaiv plaub hom zuam uas cuam tshuam rau dev hauv North America." Veterinary Parasitology, 2015, 214(1-2): 114-120.
6. Toutain CE, Seewald W, Jung M. "Pharmacokinetics ntawm afoxolaner tom qab txhaj tshuaj thiab qhov ncauj hauv cov dev." Veterinary Parasitology, 2016, 223: 15-18.