Cov kab mob parasitic txuas ntxiv mus rau plague veterinary xyaum, ua phem rau tus khub tsiaj thoob ntiaj teb. Raws li cov tshuaj tiv thaiv kab mob sophisticated nrog rau qhov zoo -txhais molecular mechanism,milbemycin oxime hmoovsawv tawm ntawm kev tsim kho tshuaj los daws qhov teeb meem no. Qhov no macrocyclic lactone molecule paub txog kev tiv thaiv kab mob plawv thiab tswj cov hnyuv nematodes hauv dev thiab miv.
Lub hauv paus kev tshawb fawb ntawm milbemycin oxime hmoov qhia tau hais tias yog vim li cas cov kws kho tsiaj thiab kws kho mob xav tias nws tseem ceeb heev rau kev kho mob parasitology niaj hnub no. Targeted antiparasitic kev kho mob tau nce siab vim lub compound qhov tshwj xeeb cuam tshuam rau invertebrate neuromuscular systems thiab mammalian kev nyab xeeb. Nplooj ntawv no tham txog txoj hauv kev molecular, kev ua ub no, thiab kev siv tshuaj thiab kev tshawb fawb ntawm cov tshuaj no.
Milbemycin Oxime hmoov
1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
Rau dev: 2.3mg / 5.75mg / 11.5mg / 23.0mg
Rau miv: 5.75mg / 11.5mg / 23.0mg
(3) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-1-112
Milbemycin Oxime CAS 129496-10-2
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4
Chemical Structure thiab Binding yam ntxwv
Milbemycin oxime hmoov tua kab mob vim nws 16-tus tswvcuab macrocyclic lactone qauv.
Cov tshuaj nkag mus rau cov cab cab phab ntsa ntawm tes thiab ua rau lub hom phiaj ntawm lub paj hlwb vim nws cov qauv molecular. Ob lub ntsiab lus tseem ceeb, milbemycin A3 thiab A4, ua haujlwm sib koom ua ke los txhim kho cov txiaj ntsig kho. Tshaj li 30 xyoo dhau los, kev tshawb fawb tau tsim kom pom tias cov txheej txheem no khi zoo rau glutamate-gated chloride channels tsuas yog nyob rau hauv lub cev tsis muaj zog hauv cov hlab ntsha. Tib neeg thiab cov kab mob parasite ion tau tsim sib txawv, ua rau muaj kev xaiv tshuaj. Tsis zoo li vertebrates 'GABA receptors, worms' thiab arthropods 'glutamate-gated chloride channels suav nrog milbemycin- cov chaw tshwj xeeb khi. Qhov kev paub xaiv no piav qhia vim li cas cov tshuaj tua kab mob kom zoo thaum tiv thaiv tsiaj.
Cov kev tshawb fawb ntawm kev khi kinetics qhia tau hais tias cov tshuaj tsim kom muaj kev sib txuas ntawm cov channel ruaj khov nyob rau hauv feeb ntawm kev sib cuag ntawm tes, ua rau cov tshuaj tiv thaiv kab mob uas rhuav tshem cov kab mob hauv lub paj hlwb.
Pharmacokinetic Properties cuam tshuam rau kev siv tshuab
Tom qab kev tswj hwm qhov ncauj, milbemycin oxime hmoov yog nkag tau yooj yim thiab ua tiav cov ntshav ntshav siab tshaj plaws hauv plaub mus rau yim teev. Qhov sib xyaw ua ke lipophilia tso cai rau nws nkag mus rau cov ntaub so ntswg adipose, tsim kom muaj cov nyhuv reservoir uas txuas ntxiv nws cov haujlwm. Cov tshuaj pharmacokinetic no tso cai rau noj txhua hli thaum tswj cov tshuaj kom tiv thaiv kab mob cab.Cov molecule feem ntau raug tshem tawm hauv daim siab tom qab me me biotransformation. Cov quav tso tawm 90% ntawm cov tshuaj tsis hloov pauv.
Qhov no txo qis lub siab enzyme metabolic load. Cov qauv kev tshem tawm no ua rau cov tshuaj muaj kev nyab xeeb rau ntau tus neeg, txawm tias cov neeg mob plab me me. Lub sij hawm ncua cov ntaub so ntswg nyob txuas ntxiv raug rau migratory parasite larvae, tshwj xeeb tshaj yog thaum lub sij hawm tseem ceeb tshaj plaws tiv thaiv kab mob plawv.
Molecular Interactions ntawm Lub Hom Phiaj
Milbemycin oxime hmoov allosterically modulates glutamate -gated chloride channels hauv hlwb. Qhov kev tshwm sim khi hloov pauv cov channel protein cov qauv, ua rau nws muaj peev xwm qhib thiab txuas ntxiv chloride ntws. Qhov no alters parasites 'neural signaling, uas tswj cov leeg ua haujlwm.
Cov tshuaj ua kom cov tshuaj chloride ion txaus txaus los ntawm ntau qhov kev txiav txim ntawm qhov loj, raws li kev ntsuam xyuas electrophysiological.
Thaum ib qho molecule txuas, nws pab txuas rau lwm cov molecules rau cov chaw nyob sib ze channel complex vim muaj kev koom tes zoo. Qhov kev sib koom ua ke no txhim kho cov tshuaj muaj txiaj ntsig ntawm cov ntaub so ntswg qis. Cov kws tshawb fawb tau txheeb xyuas cov kev paub txog cov amino acid residues ntawm qhov chaw - qhia mutagenesis. Qhov no qhia meej cov tshuaj -receptor kev sib cuam tshuam. Cov yam ntxwv molecular no yuav txhim kho lub zog ntawm cov tshuaj tiv thaiv kab mob yav tom ntej.
Milbemycin Oxime Powder Hom Kev Ua Los Ntawm Glutamate-Gated Chloride Channels
Kev ua kom Channel thiab chloride Ion Flux
Ligand-gated glutamate-gated chloride channels muaj nyob rau hauv invertebrate neuromuscular junctions thiab interneurons.Milbemycin Oxime hmoovkhi rau cov channel no, qhib cov channel pore kom cia cov chloride ions nkag mus rau hauv lub cell raws lawv cov electrochemical gradient. Tsis zoo them ions hyperpolarise lub cellular daim nyias nyias, tawm hauv nws qis dua qhov ua tau zoo.
Cov tshuaj chloride conductance yog khaws cia, tsis zoo li ib txwm glutamate signaling. Milbemycin oxime hmoov qhib cov channel ntev dua li endogenous glutamate, uas qhib lawv luv luv. Raws li kev sib xyaw ua ke, thaj chaw-kev sim ntsuas hluav taws xob electrophysiological tau sau cov channel qhib lub sijhawm ntau lub vib nas this,
piv rau milliseconds thaum lub sij hawm ib txwm synaptic kis tau tus mob.Qhov no txawv txav ntawm inhibitory signaling silences parasite paj hlwb neuronal kis tau tus mob.
Neuromuscular Junction Disruption
Milbemycin oxime hmoov cuam tshuam rau neuromuscular junctions ntau dua vim lawv glutamate-gated chloride channels. Somatic nqaij contraction yuav tsum raug excitation thiab inhibition sij hawm los ntawm lub cev muaj zog neurones. Cov tshuaj tiv thaiv cov leeg nqaij fiber ntau los ntawm kev nce chloride conductance ntawm cov junctions. Parasites afflicted los ntawm cov txheej txheem no maj mam poob motility thiab ua flaccid.Qhov no neuromuscular cuam tshuam cuam tshuam rau parasite ciaj sia taus.
Peristaltic txav tsis tu ncua tshem tawm cov plab hnyuv nematodes, uas poob lawv lub peev xwm los tuav txoj haujlwm hauv tus tswv lub plab. Kev tuag tes tuag taw pib hauv ib teev. Kev ua sai sai ua rau cov tshuaj muaj txiaj ntsig zoo hauv kev kho thiab tiv thaiv cov ntsiab lus.
Selectivity rau Invertebrate Channels
Milbemycin oxime hmoov muaj kev nyab xeeb hauv cov tsiaj txhu vim tias cov kab mob vertebrate thiab invertebrate chloride channel coj txawv txawv. Macrocyclic lactones tsom glutamate-gated chloride channels, tsis yog tsiaj txhu. Hloov chaw, lawv qeeb cov kab mob neuronal siv GABA thiab glycine.
Cov tshuaj kho cov tshuaj khi tsis muaj zog rau cov tsiaj txhu GABA receptors.Qhov no piav qhia qhov sib txawv loj ntawm cov kab mob parasite-tua thiab tsiaj- noj tshuaj.Rau tsiaj, cov ntshav- lub paj hlwb muaj kev tiv thaiv ntxiv. Ntau yam khoom tsis tuaj yeem nkag mus rau CNS vim qhov kev xaiv permeability barrier. Txawm tias muaj cross-reactivity, milbemycin oxime hmoov tsis tuaj yeem ncav cuag lub hlwb inhibitory receptors. Qee tus dev yug nrog ntau yam tshuaj - tiv thaiv cov noob hloov pauv yuav muaj qhov cuam tshuam tsawg dua, txawm hais tias cov tshuaj muaj kev nyab xeeb ntawm qib pom zoo. Qhov kev xaiv tshuaj lom neeg no yog qhov zoo dua li kev xaiv tsawg dua thiab muaj kev phom sij ntau dua cov tshuaj tiv thaiv kab mob.
Milbemycin Oxime Powder cuam tshuam li cas Parasite Nervous System Function?
Kev cuam tshuam ntawm Neurotransmission Patterns
Txhawm rau tswj tus cwj pwm, noj mov, kev yug me nyuam, thiab ib puag ncig cov lus teb, cov kab mob parasitic neural yuav tsum sib npaug excitatory thiab inhibitory impulses. Milbemycin oxime hmoov artificially boosts inhibitory neurotransmission, hloov qhov equilibrium. Cov tshuaj persistently hyperpolarises glutamate-gated chloride channels, txwv tsis pub muaj kev ua haujlwm neuronal. Parasites tsis tuaj yeem teb tau raws li qhov tsim nyog vim qhov no cuam tshuam rau kev ua haujlwm ntawm lub cev thiab lub cev muaj zog. Thaum xub thawj, cov kab mob cuam tshuam muaj teeb meem tsiv teb tsaws thiab noj los ntawm lawv lub caj pas. Raws li kev sib xyaw ua ke txuas ntxiv mus,
Cov kev puas tsuaj no zuj zus mus txog rau thaum tus kab mob tuag tes tuag taw.Parasitic larvae muaj teeb meem txav mus los thiab nrhiav cov tswv tshiab vim qhov teeb meem neurological, txwv lawv qhov peev xwm kis tau. Nws ntau yam khoom ua rau cov tshuaj muaj txiaj ntsig zoo tiv thaiv lub neej sib txawv thiab cov kab mob cab.
Kev cuam tshuam rau Parasitic Muscle Function
Milbemycin oxime hmoov cuam tshuam rau cov leeg nqaij physiology nrog rau lub paj hlwb. Hyperpolarisation los ntawm chloride conductance tiv thaiv cov leeg nqaij los ntawm kev cog lus. Peb cov leeg locomotor tsis muaj zog thiab tawm ntawm kev ua rau lub cev muaj zog neuron impulses. Immobility tua cov kab mob uas yuav tsum tau txav mus rau noj, yug me nyuam, lossis nyob twj ywm hauv lawv tus tswv tsev.
Parasites 'cov leeg nqaij tshwj xeeb raug cuam tshuam.
Thaum lawv cov leeg pharyngeal tawm haujlwm, nematodes tshaib plab. Txawm hais tias tus kab mob parasite tseem nyob hauv plab, qhov no tshwm sim.Parasite cov neeg poob qis thaum cov txheej txheem ua me nyuam uas yuav tsum tau tswj cov leeg los tsim cov qe los yog tso tawm microfilariae tawm haujlwm. Cov physiological kev puas tsuaj ua ke los muab cov tshuaj nws cov tshuaj tiv thaiv kab mob tag nrho hauv kev kho mob. Cov tshuaj cuam tshuam cov leeg nrawm, thiab tuag tes tuag taw tshwm sim hauv 24 teev.
Kev cuam tshuam nrog Parasitic Sensory Systems
Parasites xav tau kev nkag siab dav kom muaj sia nyob. Cov sensors no ntes tus tswv tsev cov lus tshuaj, kev hloov ib puag ncig, thiab kev loj hlob stimuli.
Milbemycin Oxime hmoovimpairs neuronal sensory processing, cuam tshuam rau cov kev txawj no.Cov tshuaj overactivates glutamate-gated chloride channel-muaj chemosensory neurons.Qhov no dej nyab lub neural system nrog inhibitory impulses, thaiv sensory inputs.Parasites poob lawv kev nkag siab thiab tawm tsam mus traverse host cov ntaub so ntswg. Thaum cov larvae txav mus, lawv nco lawv txoj kev thiab tsis ncav cuag lawv qhov kev loj hlob. Cov neeg laus cov kab mob tsis tuaj yeem nrhiav qhov chaw pub mis zoo lossis cov koom tes tsim tawm. Dhau li cuam tshuam rau lub cev muaj zog, cov tshuaj kuj cuam tshuam rau kev hnov mob, uas pab tshem tawm cov kab mob cab. Electrophysiological kaw los ntawm parasite sensory neurones pom tias cov tshuaj drastic hloov cov qauv teb.
Milbemycin Oxime Powder Antiparasitic Pathways thiab Kev Tshawb Fawb Daim Ntawv Thov piav qhia
Lifecycle Stage Susceptibility
Raws li glutamate-gated chloride channel txoj kev loj hlob, cov kab mob cab hauv lub neej muaj ntau dua los yog tsawg dua rau milbemycin oxime hmoov. Cov tshuaj yog tshuaj lom rau larvae, tshwj xeeb tshaj yog cov migrating thoob plaws hauv cov ntaub so ntswg. Cov tshuaj muaj txiaj ntsig zoo rau kev tiv thaiv kab mob los ntawm kev sib deev vim nws cuam tshuam kev loj hlob. Cov kws tshawb fawb tau pom tias nematodes muaj cov kab ntau tshaj plaws thaum lub sij hawm larval theem, uas sib phim cov kev soj ntsuam soj ntsuam.
Txawm hais tias lawv xav tau me ntsis ntau dua li cov larvae, cov neeg laus cov kab mob teb rau cov tshuaj. Hauv cov tsiaj laus, qhov ntom ntom ntawm cov channel yuav qis dua vim lub cev loj thiab cuticle thickness. Txawm hais tias cov teeb meem no, cov koob tshuaj kho mob cuam tshuam rau cov tsiaj tsis muaj zog 'cov neeg laus.
Qe thiab embryos thaum ntxov yog resistant vim hais tias lawv lub paj hlwb tseem tab tom tsim. Hauv cov chaw kho mob, qhov tshwj xeeb ntawm lub neej muaj feem cuam tshuam rau koob tshuaj thiab kev kho mob.
Spectrum ntawm Parasitic Target
Milbemycin oxime hmoov tua ntau yam tsiaj sib luag - kis nematode genera. Tshuaj- cov kab mob hauv plab hnyuv muaj xws li Toxocara canis thiab Toxascaris leonina. Ib qho - kev kho koob tshuaj muaj peev xwm tshem tawm ntau dua 95% hauv kev sim tshuaj. Hookworms zoo li Ancylostoma caninum teb zoo ib yam, ua rau cov tshuaj muaj txiaj ntsig zoo rau kev tswj cov kab mob hauv plab. Nws tswj cov kab mob (Trichuris vulpis); Txawm li cas los xij, lawv yuav xav tau ntau koob.
Nws lub hom phiaj kho mob tseem ceeb yog kho cov kab mob plawv. Nws tua cov ntaub so ntswg-theem larvae ua ntej lawv dhau los ua cov neeg laus hauv cov hlab ntsha pulmonary thaum noj txhua hli.Milbemycin oxime hmoov yog qhov tseem ceeb rau kev tswj cov kab mob plawv hauv cov cheeb tsam vim tias nws tiv thaiv kev sib kis. Cov tshuaj yuav ua kom puas demodectic thiab sarcoptic mange mites nrog rau helminths. Nws qhov dav txo qis qhov xav tau rau ntau yam tshuaj tiv thaiv kab mob, ua kom yooj yim txoj hauv kev kho.
Kev Tshawb Fawb Kev Siv thiab Kev Kawm Mechanistic
Milbemycin oxime hmoov yog siv nyob rau hauv cov tsiaj thiab los ntawm cov kws tshawb fawb los tshawb nrhiav invertebrate neurobiology thiab tshuaj receptor cuam tshuam.
Cov tshuaj cia cov kws tshawb fawb tshawb fawb glutamate-gated chloride channels 'cov qauv thiab kev ua haujlwm, uas pab peb nkag siab txog pawg tseem ceeb ntawm ion channels.Siv cov tshuaj hauv electrophysiological kev tshawb nrhiav tau pab peb nkag siab cov channel, ions, thiab allosteric kev cai nyob rau hauv ntau yam tshuaj. Kev tshawb nrhiav sib piv ntawm cov kab mob uas muaj kab mob thiab tiv taus tau qhia txog kev hloov caj ces uas txo cov tshuaj rhiab heev. Cov kev tshawb nrhiav no tau pom cov channel gene variants txuas nrog kev tiv thaiv. Qhov no pab tswj kev tiv thaiv kev npaj thiab saib xyuas. Milbemycin oxime hmoov muaj zoo- qauv qauv- kev sib raug zoo, ua rau nws muaj txiaj ntsig zoo rau kev tshawb fawb tshuaj chemistry uas lub hom phiaj los txhim kho cov tshuaj tiv thaiv kab mob.
Nws daim ntawv thov kev tshawb fawb ua rau nws muaj txiaj ntsig sab nraud cov tshuaj.
Kev Tshawb Fawb Txog Kev Tshawb Fawb Tom Qab Milbemycin Oxime Powder thiab Parasite Control
Kev koom ua ke nrog Kev Tswj Xyuas Kabmob
Kev tswj cov kab mob parasite zoo yuav tsum tau kho cov tshuaj pharmacological, kev tswj hwm ib puag ncig, thiab kev soj ntsuam xyuas.Milbemycin Oxime hmoovua haujlwm zoo hauv ntau-cov tswv yim tiv thaiv kab mob parasitic. Kev muab tshuaj tsis tu ncua ntawm daim ntawv lo ua ntu zus tswj cov tshuaj tiv thaiv thoob plaws lub caij nyoog siab - kis kab mob cab. Kev tiv thaiv yog kev noj qab haus huv thiab pheej yig dua li kev kho mob, tshwj xeeb tshaj yog rau cov mob hnyav xws li kab mob plawv.
Cov txheej txheem ib puag ncig txo cov kab mob parasite, pab tswj cov tshuaj. Faeces yuav tsum tau muab tshem tawm ntawm cov vaj thiab tsev kom sai li sai tau txhawm rau tiv thaiv cov qe thiab cov larvae los ntawm kev sib kis. Kev tswj yoov tshaj cum txo cov kab mob plawv.
Thaum ua ke nrog milbemycin oxime hmoov, cov txheej txheem no ua tau zoo dua kev kho tshuaj. Cov kws kho tsiaj tau nce ntxiv cov txheej txheem holistic uas hais txog cov kab mob sib txawv.
Kev txiav txim siab rau Cov Neeg Tshwj Xeeb
Milbemycin oxime hmoov yuav tsum tau siv rau qee yam tsiaj uas siv cov txheej txheem hloov. Lub sijhawm kho mob thiab kev nyab xeeb kev nyab xeeb yog qhov tseem ceeb rau cov poj niam yug me nyuam. Txawm hais tias kev tshawb fawb txog kev ua me nyuam muaj tshuaj lom tau pom tau hais tias cov tshuaj noj tshuaj muaj kev nyab xeeb thaum cev xeeb tub thiab lactation, nws tseem yog qhov zoo tshaj plaws mus ntsib kws kho tsiaj rau txhua qhov xwm txheej. Puppies thiab kittens yuav pib tiv thaiv kab mob thaum muaj hnub nyoog 6 txog rau yim lub lis piam, tiv thaiv lawv thoob plaws hauv kev loj hlob thaum lawv raug mob.
Cov tsiaj txhu muaj ntau yam teeb meem kev noj qab haus huv tuaj yeem siv tshuaj lom neeg yam tsis muaj kab mob siab. yog li ntawd, nws tsis tshua muaj kev cuam tshuam nrog ntau yam tshuaj hauv cov tsiaj uas muaj kab mob ntev -. Kev yug me nyuam- tej teeb meem tshwj xeeb yuav tsum tau txiav txim siab, vim tias herding breeds muaj multidrug resistance gene mutations. Cov tshuaj muaj kev nyab xeeb dua li ob peb macrocyclic lactones hauv cov pab pawg no, txawm hais tias yuav tsum tau kuaj xyuas thiab hloov ntau npaum li cas.
Cov Qauv Zoo thiab Cov Khoom Siv Tshuaj
Milbemycin oxime hmoov yuav tsum ua tau raws li cov txheej txheem tshuaj zoo kom ua tau zoo thiab nyab xeeb.Txhim kho lub zog, purity, thiab ruaj khov,
Reputable producers ua nruj analytical xeem thoob plaws hauv manufacturing. HPLC thiab LC-MS yog txoj hauv kev tseem ceeb rau kev txheeb xyuas thiab ntsuas cov khoom xyaw nquag.Cov txheej txheem no tshawb pom cov kab mob sib kis thiab cov khoom puas tsuaj uas yuav cuam tshuam qhov zoo lossis kev nyab xeeb.FDA yuav tsum muaj cov ntaub ntawv ntxaws ntxaws txog yuav ua li cas cov khoom siv tshuaj kho tsiaj tsim, tshuaj xyuas kom zoo, thiab ruaj khov. Milbemycin oxime hmoov factories raug tshuaj xyuas tsis tu ncua rau kev ua raws li GMP. Cov kev tswj xyuas zoo no ua kom cov khoom ua tiav kev txheeb xyuas, lub zog, qhov zoo, thiab kev coj dawb huv los tiv thaiv cov neeg mob tsiaj thiab cov neeg siv kawg. Tsuas yog cov neeg tsim khoom ua tau raws li cov cai no yuav tsum muab cov ntaub ntawv.
Xaus
Milbemycin Oxime hmoovyog ib qho tshuaj tiv thaiv kab mob sib kis uas tshwj xeeb cuam tshuam nrog cov leeg pob txha, raws li kev tshawb fawb. Cov tshuaj xaiv inhibits glutamate-gated chloride channels thiab muaj cov tshuaj pharmacokinetics zoo dua thiab kev nyab xeeb, ua rau muaj txiaj ntsig zoo rau kev tshawb fawb tsiaj txhu. Kev nkag siab tias nws tua kab mob ua rau nws yooj yim dua los siv hauv chav kuaj thiab txhawb cov kws tshawb fawb kom nrhiav tau txoj hauv kev zoo dua.
Cov ntaub ntawv pov thawj-raws li cov kws kho tsiaj muaj xws li siv milbemycin oxime hmoov nyob rau hauv parasite control regimens. Txhawm rau ua kom cov tshuaj tseem ceeb no pab tau ntau dua, kev tshawb fawb ntxiv yog xav tau rau hauv kev tiv thaiv, kev tswj hwm tshuaj, thiab kab mob kab mob hauv lub paj hlwb. Cov kws tshaj lij thiab cov kws tshaj lij tuaj yeem siv cov macrocyclic lactone no los tua cov kab mob cab los ntawm kev nkag siab nws cov kev tshawb fawb molecular.
FAQ
1. Yuav ua li cas txog milbemycin oxime hmoov ua kom nws tua kab zoo dua cov tsiaj?
Cov tshuaj tsom mus rau glutamate -gated chloride channels, uas tsuas yog pom nyob rau hauv lub paj hlwb ntawm invertebrates. Cov tsiaj txhu tsis muaj cov kab ke tshwj xeeb no. Hloov chaw, lawv siv GABA thiab glycine ua cov tshuaj uas ua rau cov paj hlwb qeeb. Milbemycin oxime hmoov tsis tuaj yeem khi rau cov hom phiaj tsiaj ntawm cov txiaj ntsig zoo vim tias cov qauv sib txawv ntawm glutamate channels hauv invertebrates thiab GABA receptors hauv cov tsiaj. Los ntawm kev khaws cov tebchaw los ntawm kev nkag mus rau qhov chaw ntawm lub hauv nruab nrab lub paj hlwb, cov ntshav - lub hlwb thaiv ntxiv rau kev nyab xeeb ntawm cov tsiaj uas tau kho.
2. Tsis yog tsuas yog kho tus kab mob rau cov neeg laus xwb, yuav ua li cas milbemycin oxime hmoov kom tsis txhob muaj kab mob plawv?
Muab milbemycin oxime hmoov ib hlis ib zaug ua rau cov ntaub so ntswg muaj siab txaus los tua cov kab mob plawv hauv lawv cov theem ntxov ntawm kev loj hlob ua ntej lawv loj hlob. Cov tshuaj ua haujlwm zoo tshwj xeeb tshaj yog tiv thaiv cov ntaub so ntswg - theem larvae (L3 thiab L4) uas txav los ntawm cov ntaub so ntswg tom qab kis los ntawm yoov tshaj cum. Cov tshuaj tiv thaiv kev loj hlob ntawm cov neeg laus cov kab mob uas ua rau mob plawv loj los ntawm kev tshem tawm cov ntaub ntawv tsis paub qab hau ua ntej lawv mus txog cov hlab ntsha thiab lub plawv. Rau qhov kev tiv thaiv no ua haujlwm, nws yuav tsum tau txhaj tshuaj txhua lub hlis thaum lub caij sib kis kom tiv thaiv cov kab mob tshiab.
3. Cov kab mob puas tuaj yeem tiv thaiv tau milbemycin oxime hmoov? Yog tias muaj, qhov no taug qab li cas?
Muaj kev pheej hmoo ntawm kev tiv thaiv kev tsim kho nrog cov tshuaj tiv thaiv kab mob, suav nrog milbemycin oxime hmoov. Cov kev hloov pauv hauv cov noob uas code rau glutamate-gated chloride channels yuav ua rau cov tshuaj tsis tshua khi, uas yuav ua rau cov tshuaj tsis zoo. Lub sijhawm tam sim no, kev saib xyuas cov kev pabcuam saib xyuas qhov feem pua ntawm cov kev kho mob uas tsis ua haujlwm thiab kuaj cov kab mob parasite cais hauv lub chaw kuaj mob kom pom cov qauv tshiab ntawm kev tiv thaiv. Kev siv lub luag haujlwm, xws li siv cov koob tshuaj kom raug thiab kev sib koom ua ke ntawm kev tswj cov kab mob parasite, pab kom cov tshuaj ua haujlwm zoo. Cov kws tshawb fawb tseem tab tom saib mus rau hauv yuav ua li cas tiv thaiv ua haujlwm kom lawv tuaj yeem ua txoj hauv kev taug qab thiab kev saib xyuas cov txheej txheem uas yuav ua rau tus neeg saib xyuas cov tshuaj tiv thaiv muaj txiaj ntsig ntev dua.
Koom tes nrog BLOOM TECH rau hwm Milbemycin Oxime Powder Supply
BLOOM TECH tau txais kev pom zoo milbemycin oxime hmoov khoom muag rau ntau tshaj 12 xyoo thiab muaj kev paub ntau yam ua cov organic tebchaw thiab tshuaj intermediates. Peb GMP- cov chaw tsim khoom muaj ntawv pov thawj khaws cov qauv zoo tshaj plaws, uas tau rov qab los ntawm cov ntawv pov thawj los ntawm US FDA, EU, thiab CFDA. Peb muab cov kws tshuaj -qib milbemycin oxime hmoov nrog tag nrho cov ntaub ntawv tshuaj ntsuam xyuas, uas suav nrog HPLC, LC-MS, thiab HNMR tsom xam. Qhov no ua kom ntseeg tau tias qhov zoo ib txwm zoo ib yam thiab ua tau raws li cov qauv thoob ntiaj teb rau kev tshawb fawb thiab kev siv tshuaj veterinary.
Peb tau cog lus rau ntau tshaj li kev muab khoom; peb kuj tseem muab kev pab cuam los ntawm peb pab pawg R&D uas mob siab rau, kev sib tw nqi qauv tsim rau kev sib koom ua haujlwm ntev -, thiab cov kev pabcuam thauj khoom txhim khu kev qha uas pabcuam kev lag luam thoob ntiaj teb. Peb ib qho -nres kev pabcuam platform muaj raws nraim li koj cov haujlwm xav tau, txawm tias koj xav tau kev tshawb fawb-qib cov ntaub ntawv rau kev tshawb fawb molecular lossis ntau npaum li cas los ua tshuaj. Peb paub tias cov khoom lag luam txhim khu kev qha tseem ceeb npaum li cas rau kev tsim cov tshuaj tshiab, yog li peb khaws cov khoom lag luam muaj zog kom ntseeg tau tias cov tshuaj muaj nyob ib txwm muaj.
Tiv tauj peb cov neeg ua haujlwm paub txog tam sim ntawd ntawm Sales@bloomtechz.com los tham txog kojmilbemycin oxime hmoovxav tau. Txhawm rau pab koj txiav txim siab yuav khoom, peb muab cov lus qhia rau koj tus kheej, tag nrho cov lus qhia, thiab cov ntaub ntawv tswj hwm. Koom nrog pab pawg ntawm 24 cov kev tshawb fawb thoob ntiaj teb thiab cov tuam txhab tshuaj uas ntseeg BLOOM TECH ua lawv cov khoom lag luam tshuaj tseem ceeb.
Cov ntaub ntawv
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2. Shoop WL, Mrozik H, Fisher MH. Cov qauv thiab kev ua haujlwm ntawm avermectins thiab milbemycins hauv tsiaj noj qab haus huv. Veterinary Parasitology. 1995;59(2):139-156.
3. Cully DF, Vasilatis DK, Liu KK, et al. Cloning ntawm avermectin-sensitive glutamate-gated chloride channel los ntawm Caenorhabditis elegans. Xwm . 1994;371(6499):707-711.
4. Prichard RK, Geary TG. Kev pom ntawm kev siv hluav taws xob ntawm moxidectin rau kev tswj cov kab mob parasitic nematodes nyob rau hauv lub ntsej muag ntawm kev txhim kho anthelmintic tsis kam. International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv . 2019; 10:69-83.
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6. Wolstenholme AJ, Rogers AT. Glutamate-gated chloride channels thiab hom kev ua ntawm avermectin/milbemycin anthelmintics. Parasitology. 2005;131(S1):S85-S95.