Tsis zoo siv: Mglumine, tseem hu ua n-methyl-d-glucamine lossis methyllucamine, yog qhov sib txuas nrog cov ntawv thov sib txawv hauv cov ntawv thiab cov kev kho mob. Cov ntawv sau no tshawb txog lub luag haujlwm ntawm Meggumeine hauv cov tshuaj kuaj mob, tshwj xeeb yog ib qho kev sib xyaw ua ke ntawm cov neeg sawv cev sib txawv, thiab cov nqi hluav taws xob ua cov qauv ntawm cov neeg sawv cev no. Cov tshuaj lom neeg, cov txheej txheem ntawm kev nqis tes ua, thiab chaw kuaj mob ntawm cov mugbumine tau sib tham, nrog nws cov txiaj ntsig thiab kev txiav txim siab rau kev siv.
Khoom Code: BM -2-5-020
Lus Askiv Lub Npe: Mugbumine
CAS TSIS MUAJ.: 6284-40-8
Molecular cov mis: C7h17No5
Molecular hnyav: 195.21
Eineecs tsis muaj.: 228-506-9
MDL No.:MFCD00004707
HS code: 29221980
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-4
Peb muab cov hmoov muggumine cas? 6284-40-8, thov saib mus rau lub vev xaib hauv qab no rau cov ncauj lus kom ntxaws ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomtechz.com/synthetic adapi-researching/api-RIbeearching-
Lo lus tseem ceeb: Mugbumine; Kev kuaj mob tshuaj; Cov neeg sawv cev sib txawv; Solubizer; Cov Ntaub Ntawv Siv Khoom Siv
Lub hauv paus rau phau ntawv
Mglumine(C7h17No5) yog cov amino suab thaj muab los ntawm sorbitol, nrog molecular hnyav ntawm 195.21 g / mol. Nws yog hmoov dawb huv uas yog soluble hauv dej thiab me ntsis soluble hauv ethanol. Meglumine tau tau siv dav hauv kev lag luam tshuaj uas nws muaj feem ntau, suav nrog cov khoom siv ntau yam ntawm cov tshuaj sib txawv thiab ua ib qho yeeb tshuaj zoo.
Meglumumine hauv cov tshuaj kuaj mob
Lub luag haujlwm hauv cov neeg sawv cev sib txawv
Cov khoom siv sib txawv yog cov tshuaj uas siv los txhim kho qhov pom ntawm cov txheej txheem sab hauv xws li cov duab kos, thiab cov duab sib nqus (MRI). Cov sawv cev no ua haujlwm los ntawm kev hloov cov teeb liab siv ntawm cov ntaub so ntswg lossis cov kua hauv cov qauv sib txawv ntawm cov qauv sib txawv thiab pab pawg hauv kev kuaj mob.
Meglumine yog feem ntau siv los ua kev tawm tsam lossis cov neeg sawv cev ntsev rau hauv cov qauv ntawm iodinated sib txawv cov neeg sawv cev. Iodinated sib txawv cov tshuaj tiv thaiv yog qhov dav tshaj plaws siv hom kev sib piv sib txawv, tshwj xeeb rau xoo hluav taws xob thiab ct kev xav. Iodine atoms nyob rau hauv cov neeg sawv cev no muaj cov lej atomic siab, uas ua rau lawv muaj txiaj ntsig zoo ntawm cov x-rays thiab nce qhov sib piv ntawm cov ntaub so ntswg.
Mechanism ntawm Kev Ua
Thaum Mugbumine yog koom ua ke nrog iodinated compound, nws ua ntsev uas yog ntau soluble hauv dej dua li iodinated compound nyob ib leeg. Qhov kev nce qib no tau nce solubility yog qhov tseem ceeb rau kev ua haujlwm zoo ntawm cov neeg sawv cev sib luag, raws li nws tso cai rau kev npaj cov kev daws teeb meem uas tuaj yeem txhaj rau tus neeg mob. Thaum txhaj tshuaj, tus neeg sawv cev sib piv ntawm cov ntshav thiab yog coj los ntawm cov ntaub so ntswg lossis siv cov kev txaus siab ntawm cov qauv no ntawm cov duab kho mob.
Hom kev sib txawv ntawm cov neeg muaj suab paj nruag
Ntau hom iodinated sib xws muaj cov meglumine raws li ib tug. Cov no suav nrog:
Ionic Cov Tshuaj Tiv Thaiv Ionic
Cov no yog cov hom ib txwm muaj ntawm iodinated sib txawv cov neeg sawv cev thiab suav nrog cov chaw sib txuas xws li mugbumine diatrizoate thiab mugbumine iotroxate. Ionic cov neeg sawv cev ntawm cov dej ntws yog cov dej-soluble thiab tau nrawm nrawm los ntawm ob lub raum. Txawm li cas los xij, lawv muaj qhov ntau dua ossolality piv rau cov neeg sawv cev tsis zoo, uas tuaj yeem ua rau muaj kev pheej hmoo ntawm cov kev tsis zoo.
Cov Tshuaj Tiv Thaiv-ionic
Cov no yog cov hom tshiab ntawm iodinated sib txawv cov neeg sawv cev uas muaj qis dua osymolity thiab tsis tshua muaj feem yuav ua rau muaj kev phiv tsis zoo. Cov neeg sawv cev tsis yog-ionic nrog cov mugbumine feem ntau yog kev tawm tsam, txawm hais tias lwm yam kev sib tawm xws li sodium thiab calcium kuj siv.
Gadolinium-Raws li cov neeg sawv cev sib txawv
Txawm hais tias tsis yog iodinated, gadolinium-raws li cov neeg sawv cev sib txawv yog siv hauv MRI IRGING. Qee tus ntawm cov neeg sawv cev, xws li gadopentetate Dimeglumine, muaj Moglumine ua ib qho kev sib koom ua ke. Gadolinium-Raws li cov neeg sawv cev sib txawv los ntawm kev hloov cov khoom sib nqus ntawm cov nqaij uas lawv tau qhia rau hauv, li kev txhim kho qhov sib piv ntawm MRI cov duab.
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Meglumumine ua ib hnub
Ntxiv rau nws lub luag haujlwm hauv kev sib txawv ntawm cov neeg sawv cev, Meglumine tseem siv los ua cov yeeb yaj kiab rau cov tshuaj soluble tsis zoo. Solubilizers muaj cov lus sib xyaw uas ua kom muaj cov tshuaj solubility ntawm cov tshuaj aqueous, yog li kev txhim kho lawv cov peev xwm thiab kev ua tau zoo. Meglumbumine yog qhov tshwj xeeb yog ua haujlwm rau cov khoom siv amphipilic, uas tso cai rau nws cuam tshuam nrog ob qho tib yam hydeculic molecules.
Mechanism ntawm solubilization
Lub solubilization ntawm cov tshuaj los ntawm mlougbumine tshwm sim los ntawm ntau cov tshuab, suav nrog:
Ion Sib Npaug
Meglumine tuaj yeem tsim ion khub nrog cov tshuaj ionic, yog li nce lawv solubility hauv dej. Qhov no yog tshwj xeeb rau cov tshuaj acidic tsis muaj zog lossis qaug zog cov tshuaj uas tsis muaj zog, uas tuaj yeem tsim cov ntsev nrog cov mugbumine.
Micelle Ua
Meglumine tuaj yeem ua tau micelles tshuaj ib puag ncig cov tshuaj hydrophobic, encapsulating lawv thiab nce lawv solubility hauv dej. Micelles tau sib sau ua ke ntawm amphiphilic molecules uas tsim spherical cov qauv nrog cov tub ntxhais Hydrophobic thiab ib txheej hydrophilic sab nraud.
Nyuaj
Meglumine tuaj yeem tsim cov complexes nrog hlau ions lossis lwm yam lwg me, hloov lawv solubility thiab bioavailability. Qhov no muaj txiaj ntsig tshwj xeeb rau cov tshuaj uas tsis zoo soluble vim lawv lub siab molecular hnyav lossis cov qauv nyuaj.
Qhov Zoo ntawm Meglumine Ua Ib Hnub
Txhim Kho Bioavailability
Los ntawm kev nce cov solubility ntawm cov tshuaj, cov tshuaj paum tuaj yeem txhim kho lawv cov peev xwm thiab kev ua tau zoo. Qhov no yog qhov tshwj xeeb tshaj yog rau cov tshuaj uas tsis zoo los ntawm lub plab zom mov lossis qhov uas muaj lub qhov rai nqaim.
Txo cov kuab lom
Meglumumine yog qhov tsis muaj tshuaj lom neeg uas tsis muaj tshuaj lom thiab yog feem ntau tau zam ntau ntawm cov neeg mob. Qhov no ua rau nws muaj ib tus neeg sib tw zoo tshaj plaws rau kev siv los ua cov yeeb ncuab zoo, raws li nws txo qhov kev pheej hmoo ntawm cov kev tsis zoo uas cuam tshuam nrog lwm cov kev lom zem.
Versatility
Meglumine tuaj yeem siv rau soluburilize ntau yam tshuaj, suav nrog ionic, tsis-ionic, thiab hydrophobic tebchaw. Cov versatility no ua rau nws muaj cov cuab yeej tseem ceeb hauv kev tsim cov tshuaj ntawm cov tshuaj.
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Cov ntawv thov kev kho mob ntawm Meglumine
Kev kuaj mob cov duab
Raws li tau hais ua ntej, Meggbumine yog qhov tseem ceeb ntawm ntau iodinated sib txawv cov neeg sawv cev siv hauv kev kuaj mob. Cov neeg sawv cev no tau siv los ua kom pom cov txheej txheem sab hauv thiab cov kua hauv lub cev, pab pawg hauv kev kuaj mob xws li:
- Kab Mob Cardiovases: Cov neeg sawv cev sib txawv yog siv los pom lub plawv thiab cov hlab ntsha, pab hauv kev kuaj mob xws li ntshav fab caj dab, lub plawv lub plawv mob, thiab Aortic aneurysms.
- Mob kha xaw: Cov neeg sawv cev sib txawv tuaj yeem pab tshawb xyuas thiab ntsuas cov teb, nrog rau saib xyuas cov lus teb rau kev kho mob.
- Neurological Decorders: Cov neeg sawv cev sib txawv yog siv los pom lub hlwb thiab tus txha caj qaum, pab hauv kev kuaj mob xws li mob hlab ntsha tawg, thiab ntau yam sclerosis thiab ntau yam sclerosis.
- Cov plab zom mov tsis zoo: Cov neeg sawv cev sib txawv tuaj yeem pab pom cov kab mob plab, pab hauv kev kuaj mob ntawm cov mob xws li kab qog, thiab mob hnyuv.
Kho cov ntawv thov
Ntxiv rau nws cov ntawv thov kev kuaj mob, Moggbumine kuj tau tshawb xyuas rau nws lub peev xwm kho. Piv txwv li, cov mellumine tau pom tias muaj cov tshuaj tiv thaiv thiab cov khoom siv tshuaj ye hauv cov kev tshawb fawb ua ntej. Txawm li cas los xij, xav tau kev tshawb fawb ntxiv los txiav txim siab nws cov kev ua tau zoo thiab kev nyab xeeb hauv chaw kuaj mob.
Txiav txim siab rau siv
Thaum lub sij hawm mugbumine yog feem ntau suav tias muaj kev nyab xeeb thiab kev ua tau zoo los xav txog cov kev sib raug zoo thaum siv lwm yam khoom siv hluav taws xob lossis lwm yam khoom siv tshuaj uas muaj cov meglumine. Cov kev tshwm sim uas cuam tshuam nrog iodinated sib xws li:
- Kev tsis haum: Cov no tuaj yeem muaj los ntawm cov tawv nqaij tawv nqaij tawm mus rau kev siv anaphylactical hnyav. Cov neeg mob uas muaj keeb kwm ua xua lossis hawb pob tuaj yeem muaj kev pheej hmoo siab.
- Lub raum puas tsuaj: Iodinated sib txawv cov tshuaj tiv thaiv tuaj yeem ua rau mob raum, tshwj xeeb rau cov neeg mob uas muaj kab mob raum lossis lwm yam kev pheej hmoo.
- Cov qog ua si tsis sib xws: Iodine-ntim cov neeg sawv cev sib xyaw tuaj yeem cuam tshuam nrog cov thyroid muaj nuj nqi, tshwj xeeb yog cov neeg mob thyroid tsis muaj xwm txheej.
Txhawm rau txo cov kev pheej hmoo ntawm kev phiv tsis zoo, nws yog ib qho tseem ceeb kom ua tib zoo cov neeg sawv cev thiab saib xyuas lawv ze rau tej yam tshwm sim ntawm kev cuam tshuam tsis zoo.
Meglumine tuaj yeem cuam tshuam nrog lwm cov tshuaj, muaj peev xwm hloov lawv cov kev ua tau zoo lossis kev nyab xeeb. Piv txwv li, cov melgbumine tuaj yeem cuam tshuam nrog kev nqus qee yam tshuaj, xws li cov tshuaj tiv thaiv tetraccium, thaum muab tshuaj sib thooj. Nws yog ib qho tseem ceeb uas yuav tau xav txog kev sib cuam tshuam kev ywg dej thaum tsim cov khoom siv tshuaj uas muaj cov megrumine.
Meglumine-muaj cov khoom lag luam tshuaj yuav tsum tau muab cia rau hauv qab cov xwm txheej tsim nyog los xyuas kom lawv ruaj khov thiab ua tau zoo. Yam xws li kub, lub teeb, thiab av noo tuaj yeem cuam tshuam rau qhov ruaj ntseg ntawm Mogguminine thiab cov tshuaj nws yog siv rau soluburilize. Nws yog ib qho tseem ceeb kom ua raws li cov chaw tsim khoom siv cov lus pom zoo rau kev khaws cia thiab tuav cov khoom lag luam no.
Tag
Meglumine yog ib qho kev sib txuas ntxiv nrog cov ntawv thov sib txawv hauv cov chaw kho mob thiab cov kws kho mob. Nws lub luag haujlwm hauv kev tsim ntawm cov neeg sawv cev sib txawv tau txhim kho cov txheej txheem kev kho mob, pub rau kev kho mob thaum ntxov thiab kho cov mob. Tsis tas li ntawd, nws cov nqi hluav taws xob ua ib qho stubilizer rau cov tshuaj tsis zoo tau txhim kho cov bioavailability thiab ua tau zoo ntawm cov neeg sawv cev.
Thaum lub sij hawm mugbumine yog feem ntau suav tias muaj kev nyab xeeb thiab kev ua tau zoo los txiav txim siab cov kev sib raug zoo thiab cov khoom siv tshuaj uas muaj cov tshuaj uas muaj cov khoom siv tshuaj uas muaj cov tshuaj no. Cov kev tshawb fawb ntxiv yog xav tau los tshawb txog qhov muaj peev xwm ntawm Moglumine thiab kom ua kom nws txoj kev ua kom zoo rau cov khoom ntawm cov tshuaj.
Hauv cov ntsiab lus, Meglumine yog ib qho cuab yeej tseem ceeb hauv kev ua haujlwm ntawm kev kuaj mob ntawm kev kuaj mob thiab kho cov neeg sawv cev rau cov neeg saib xyuas kev noj qab haus huv. Nws cov tshuaj tshwj xeeb thiab cov khoom lag luam rau cov neeg yuav tsum muaj kev sib tw thiab kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws cov kev txhim kho kev kho mob, thiab nws yuav pab txhawb rau kev txhim kho cov neeg mob thiab cov txiaj ntsig.