Taw qhia
Anisomycin, tseem hu ua Flagecidin lossis Wuningmeisu C, yog cov tshuaj tua kab mob thiab cov protein synthesis inhibitor. Nws ua haujlwm los ntawm kev tsom mus rau peptidyl transferase site ntawm 80S ribosomal subunit, yog li cuam tshuam cov protein synthesis. Ntxiv nrog rau nws cov tshuaj tiv thaiv kab mob, anisomycin tau raug txheeb xyuas tias yog ib qho tshwj xeeb activator ntawm c-Jun N-terminal kinase (JNK), uas tuaj yeem ua rau cov cellular apoptosis. Qhov ntau yam ntawm anisomycin tau ua rau muaj kev txaus siab rau nws cov kev siv tshuaj kho mob, tshwj xeeb hauv kev tiv thaiv kab mob thiab oncology. Kab lus no yog tsom mus rau qhov kev tshawb fawb tam sim no nyob ib puag ncig anisomycin cov kev siv tshuaj kho mob, tsom mus rau nws cov txheej txheem ntawm kev ua, kev ua tau zoo, thiab kev siv tshuaj kho tau zoo.
Peb muab ANISOMYCIN CAS 22862-76-6, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
Khoom siv:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/anisomycin-cas-22862-76-6.html
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kev nrhiav pom thiab kev loj hlob
Anisomycin, ib qho pyrrolidine-based protein synthesis inhibitor, tau txais kev saib xyuas tseem ceeb vim nws muaj ntau yam kev ua ub no lom neeg thiab cov khoom siv tshuaj. Kev tshawb pom thiab kev loj hlob keeb kwm ntawm anisomycin yog cim los ntawm qhov tseem ceeb ntawm kev tshawb fawb thiab kev tshawb fawb dav dav.
Anisomycin tau pib tshawb pom ntau dua 60 xyoo dhau los los ntawm Pfizer, lub tuam txhab tshuaj. Txawm li cas los xij, txoj hauv kev biosynthetic ntawm qhov sib xyaw no tseem tsis tau mus txog rau xyoo tsis ntev los no. Cov khoom sib xyaw muaj cov qauv trans-diol pyrrolidine tshwj xeeb thiab nthuav tawm ntau yam kev ua haujlwm lom neeg, suav nrog tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tshuaj tiv thaiv kab mob, thiab kev nco-erasing teebmeem. Cov khoom no tau ua rau anisomycin muaj txiaj ntsig zoo rau kev tshawb fawb thiab kev siv tswv yim, tshwj xeeb tshaj yog hauv kev ua liaj ua teb ua cov khoom tseem ceeb hauv cov khoom siv dav siv 农用抗生素-农抗120 rau kev tswj cov kab mob fungal hauv cov qoob loo.
Txawm hais tias nws qhov kev tshawb pom ntau xyoo dhau los, txoj hauv kev biosynthetic ntawm anisomycin tsis tau nkag siab kom txog thaum xyoo tas los no. Cov kws tshawb fawb los ntawm Shanghai Jiao Tong University, koom tes nrog cov neeg koom tes thoob ntiaj teb, tau tshawb fawb ntau thiab thaum kawg tau tshem tawm cov txheej txheem biosynthetic. Lawv cov haujlwm tseem ceeb tshaj tawm, luam tawm hauv phau ntawv xov xwm muaj koob npePNAS, tau nthuav tawm cov noob caj noob ces tshiab lub luag haujlwm rau biosynthesis ntawm anisomycin. Cov gene pawg no encodes plaub lub ntsiab enzymes, suav nrog ib qho aminotransferase (AniQ) catalyzing ob transamination cov tshuaj tiv thaiv, ib tug ketoreductase (AniP) catalyzing condensation ntawm 4-hydroxyphenylpyruvic acid thiab glyceraldehyde 3-phosphate, a glycosniferase (glycosniproferase) cryptic glycosylation cov tshuaj tiv thaiv, thiab ib qho dehydrogenase (AniN) nrog ob qho tib si oxidation thiab txo qis zog, kho qhov tsim ntawm pyrrolidine. Qhov tseem ceeb, qhov kev tshawb pom ntawm cryptic glycosylation cov tshuaj tiv thaiv sawv cev yog qhov nthuav dav ntawm peb txoj kev nkag siab ntawm glycosylation cov tshuaj tiv thaiv hauv cov khoom ntuj biosynthesis.
Mechanisms ntawm Action
Lub luag haujlwm tseem ceeb ntawm anisomycin suav nrog nws lub peev xwm los inhibit protein synthesis los ntawm kev khi rau lub tshuab ribosomal. Txawm li cas los xij, nws lub luag haujlwm ua JNK activator nthuav tawm qhov thib ob, sib luag txoj hauv kev txaus siab los ntawm kev siv nws cov teebmeem. JNK yog ib tug tswv cuab ntawm tsev neeg mitogen-activated protein kinase (MAPK) thiab ua lub luag haujlwm tseem ceeb hauv kev ntxhov siab vim muaj teeb meem tshwm sim, suav nrog apoptosis, o, thiab cell proliferation.
Kev tshawb fawb tau pom tias anisomycin tuaj yeem qhib JNK, ua rau phosphorylation ntawm ntau lub hom phiaj nqes qis, xws li Bcl-2 thiab Bax, uas tswj cov mitochondrial membrane permeability thiab cytochrome c tso tawm, thaum kawg ua rau caspase cascade thiab cell tuag. Tsis tas li ntawd, anisomycin-induced JNK activation tau cuam tshuam rau hauv autophagy, cov txheej txheem catabolic uas cuam tshuam nrog kev degradation ntawm cellular Cheebtsam hauv lysosomes.
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Cov teebmeem ntawm T-Cells
T-cells yog cov neeg kho kom haum xeeb tseem ceeb ntawm kev tiv thaiv kab mob, ua si lub luag haujlwm tseem ceeb hauv ob qho tib si cellular thiab humoral tiv thaiv kab mob. Muab anisomycin lub peev xwm los inhibit protein synthesis thiab qhib JNK, nws cov teebmeem ntawm T-cell biology tau kawm ntau heev.
Cov kev tshawb fawb tau pom tias anisomycin tuaj yeem cuam tshuam T-cell proliferation thiab ua kom muaj zog los ntawm kev hloov cov kev qhia ntawm cytokines xws li IL-2, IL-4, thiab IFN-. Cov cytokines no paub tias yog qhov tseem ceeb rau T-cell muaj nuj nqi thiab kev sib txawv. Ntxiv rau nws cov teebmeem inhibitory ntawm T-cell proliferation, anisomycin kuj tau pom tias ua rau T-cell apoptosis. Cov nyhuv apoptotic no tau kho, ib feem, los ntawm JNK signaling txoj hauv kev, raws li pov thawj los ntawm kev thim rov qab ntawm anisomycin-induced apoptosis tom qab kho nrog JNK inhibitors.
Ib txoj kev tshawb fawb tsis ntev los no los ntawm pab pawg tshawb fawb ntawm Jinan University tau tshawb xyuas qhov sib txawv ntawm cytokines hauv T-cells kho nrog anisomycin. Siv cov cuab yeej siv tshuaj tiv thaiv kab mob microarray, lawv tau txheeb xyuas 61 cytokines uas nws qhia tau hloov pauv tom qab kev kho anisomycin. Qhov tseem ceeb, CCL9, CXCL9, CCL24, thiab MMP9 tau raug txo qis, thaum IL-17E thiab IGFBP6 tau hloov kho. Cov kev tshawb pom no qhia tias anisomycin tuaj yeem tswj hwm T-cell biology los ntawm qhov sib txawv ntawm cov cytokines tshwj xeeb thiab lawv cov kev taw qhia hauv qab.
Kev siv tshuaj kho mob
Muab nws cov txheej txheem tshwj xeeb ntawm kev ua, anisomycin tuav cov lus cog tseg rau ntau yam kev kho mob, tshwj xeeb tshaj yog nyob rau hauv kev tiv thaiv kab mob thiab oncology.
1. Kev tiv thaiv kab mob
Lub peev xwm ntawm anisomycin inhibit T-cell proliferation thiab ua kom nws muaj peev xwm sib tw rau kev tiv thaiv kab mob. Cov tshuaj tiv thaiv kab mob tam sim no, xws li cyclosporine A, tsis muaj qhov tshwj xeeb thiab tuaj yeem ua rau muaj kev phom sij loj rau cov kab mob hematopoietic thiab cov kab mob tseem ceeb. Hauv qhov sib piv, anisomycin qhia tau hais tias muaj zog tiv thaiv kab mob nrog cov tshuaj toxicity tsawg thiab thim rov qab, ua rau nws muaj kev vam meej.
Cov kev tshawb fawb ua ntej tau pom tias anisomycin tuaj yeem cuam tshuam T-cell-mediated tiv thaiv kab mob hauv cov tsiaj qauv ntawm cov kab mob autoimmune thiab allograft rejection. Cov kev tshawb pom no qhia tias anisomycin yuav muaj txiaj ntsig zoo hauv kev kho mob ntawm cov kab mob autoimmune xws li mob caj dab rheumatoid, ntau yam sclerosis, thiab ntshav qab zib hom 1, nrog rau kev tiv thaiv allograft rejection tom qab hloov khoom nruab nrog.
2. Kev Kho Mob Cancer
Qhov induction ntawm apoptosis hauv cov qog nqaij hlav cancer yog qhov xav tau hauv kev kho mob qog noj ntshav. Anisomycin lub peev xwm los qhib JNK thiab induce apoptosis ua rau nws muaj peev xwm tiv thaiv kab mob. Cov kev tshawb fawb tau pom tias anisomycin tuaj yeem cuam tshuam kev loj hlob ntawm ntau cov kab mob qog noj ntshav, suav nrog lub mis, prostate, thiab mob ntsws cancer hlwb.
Ntxiv nrog rau nws cov teebmeem antitumor ncaj qha, anisomycin kuj tseem tuaj yeem txhim kho kev ua tau zoo ntawm lwm yam kev kho mob qog noj ntshav. Piv txwv li, kev kho mob ua ke nrog anisomycin thiab hluav taws xob tau pom tias muaj kev cuam tshuam rau kev loj hlob ntawm glioma hlwb. Ib yam li ntawd, anisomycin tau pom tias ua rau mob qog noj ntshav rau cov kws khomob los ntawm inhibiting kev qhia ntawm ntau hom tshuaj tiv thaiv kab mob.
Kev nyab xeeb thiab kam rau ua
Txawm hais tias nws muaj peev xwm kho tau zoo, kev nyab xeeb thiab kev zam ntawm anisomycin yuav tsum tau ua tib zoo xav txog. Cov kev tshawb fawb tsiaj tau pom tias anisomycin tuaj yeem ua rau poob ceeb thawj, kev hloov pauv hauv cov khoom nruab nrog cev, thiab kev hloov pauv biochemical, suav nrog nce AST thiab ALT kev ua ub no thiab txo qis kev ua GLU. Tsis tas li ntawd, kev kho mob anisomycin tau cuam tshuam nrog kev mob ntawm lub ntsws, daim siab, thiab ob lub raum, nrog rau kev nce ntawm tus lej thiab qhov loj ntawm splenic macrophages.
Cov kev tshawb pom no qhia tias kev ua tib zoo tshuaj titration thiab saib xyuas cov kev tsis zoo yog qhov tsim nyog thaum siv anisomycin hauv chaw kho mob. Cov kev tshawb fawb yav tom ntej yog xav tau los ntsuas qhov kev nyab xeeb mus sij hawm ntev thiab kev kam rau siab ntawm anisomycin, nrog rau txhawm rau txheeb xyuas cov biomarkers uas tuaj yeem kwv yees tus neeg mob cov lus teb thiab toxicity.
Xaus
Anisomycin, nrog nws ob lub tswv yim ntawm inhibiting protein synthesis thiab activating JNK, nthuav tawm lub sijhawm tshwj xeeb rau kev siv tshuaj kho mob hauv kev tiv thaiv kab mob thiab oncology. Nws lub peev xwm los inhibit T-cell proliferation thiab ua kom muaj zog thiab induce apoptosis nyob rau hauv cov qog nqaij hlav cancer ua rau nws yog ib tug cog lus kho tus neeg sawv cev. Txawm li cas los xij, kev nyab xeeb thiab kev ua siab ntev ntawm anisomycin yuav tsum tau ua tib zoo xav txog, thiab kev tshawb fawb ntxiv yog xav tau los ntsuas nws cov kev cuam tshuam mus sij hawm ntev thiab txheeb xyuas qhov muaj peev xwm biomarkers ntawm kev teb thiab toxicity.
Hauv kev xaus, anisomycin tuav cov lus cog tseg tseem ceeb rau ntau yam kev siv tshuaj kho mob, tab sis nws cov peev xwm kho tau tag nrho tseem yuav tau tshawb nrhiav thiab siv tau los ntawm kev sim tshuaj nruj heev. Nrog kev tshawb fawb txuas ntxiv thiab kev txhim kho, anisomycin tuaj yeem dhau los ua ib qho tseem ceeb ntxiv rau lub armamentarium ntawm cov kws kho mob muaj rau kev kho mob autoimmune, mob qog noj ntshav, thiab lwm yam mob.