Nkag siab Roundworm Control Nrog Milbemycin Oxime Powder

Roundworm kab mob tseem yog ib qho kev txhawj xeeb tshaj plaws ntawm cov kab mob parasitic nyob rau hauv cov tsiaj phooj ywg thoob ntiaj teb. Cov dev, tshwj xeeb tshaj yog, ntsib cov kab mob nematode uas tuaj yeem cuam tshuam lawv txoj kev noj qab haus huv, kev loj hlob, thiab kev loj hlob tag nrho. Raws li cov tswv tsiaj thiab cov kws kho tsiaj nrhiav kev ntseeg siab, kev tshawb fawb-cov kev daws teeb meem, milbemycin oxime hmoovtau tshwm sim los ua ib qho tseem ceeb tshaj plaws nyob rau hauv parasite tswj raws tu qauv.

Qhov blog no taug kev los ntawm lub hauv paus pharmacological ntawm milbemycin oxime hmoov, nws cov hom phiaj tshwj xeeb ntawm cov kab mob canine roundworm, thiab yuav ua li cas nws koom ua ke rau hauv cov tswv yim tiv thaiv.

Milbemycin Oxime hmoov

1. General Specification (hauv Tshuag)
(1) API (Ntshiab hmoov)
(2) Cov ntsiav tshuaj
Rau dev: 2.3mg / 5.75mg / 11.5mg / 23.0mg
Rau miv: 5.75mg / 11.5mg / 23.0mg
(3) Pill press machine
https://www.achievechem.com/pill-xwm
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-1-112
Milbemycin Oxime CAS 129496-10-2
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R&D Dept.-4

Lub Mechanism Qab Paralysis hauv Parasites

Hauv cov paj hlwb thiab cov leeg nqaij, milbemycin oxime hmoov txuas rau glutamate-gated chloride ion channels. Lawv cia ntau cov chloride ions rau hauv lub cell thaum lawv qhib rau hauv txoj kev coj txawv txawv. Qhov no ua rau daim nyias nyias muaj peev xwm tsis zoo, uas txwv tsis pub lub xov tooj ntawm tes xa xov hluav taws xob tsis tu ncua.

Cov kab mob parasite cov leeg thiab cov hlab ntsha sai sai nres ua haujlwm thiab tsis tuaj yeem zoo dua. Tus kab mob roundworm tuag vim nws tsis tuaj yeem npaj nws txav, noj, lossis ua ntau yam ntawm nws. Cov tshuaj tiv thaiv kab mob no tshwm sim tau zoo heev ntawm qib cellular thiab tsom mus rau biology ntawm invertebrates thaum tsis muaj kev cuam tshuam rau cov tsiaj txhu tsiaj txhu.

Vim li cas Mammals thiaj li muaj kev nyab xeeb ntawm Kev Kho Mob

Cov tsiaj nyeg muaj glutamate{0}}gated chloride channels, tab sis lawv feem ntau nyob hauv lub hlwb thiab qaum qaum. Cov ntshav- lub hlwb thaiv tiv thaiv lawv. Milbemycin oxime hmoov muaj lub sijhawm nyuaj los ntawm phab ntsa no hauv cov tsiaj uas haum. Qhov no yog vim li cas cov tshuaj kho tau zoo kom tshem tawm cov kab mob tsis ua mob rau lub hlwb. Qhov kev nyiam no tau lees paub ntau dua thiab ntau dua hauv cov ntaub ntawv kws kho tsiaj veterinary. Qhov no txhawb lub compound lub keeb kwm ntev ntawm kev nyab xeeb nyob rau hauv dev thiab miv ntawm tag nrho cov theem ntawm lub neej.

Channel Binding thiab Ion Flux Dynamics

GluCl yog tsiaj-tsuas yog channel uas cia chloride hla dhau. Qhov no ua rau nws lub hom phiaj zoo rau cov tshuaj. Channel nyob twj ywm qhib thaum lubmilbemycin oxime hmoovkhi rau GluCl subunit. Cov kab mob roundworm tsis tuaj yeem nres lossis qeeb ntawm cov chloride ions mus rau hauv lub cell. Hyperpolarization nres acetylcholine los ntawm kev xa lub cev muaj zog thaum qhov no tshwm sim. Qhov no txwv tsis pub cov leeg ua haujlwm ua ke.

Txoj kev tshawb no ntawm nematodes tau pom tias cov kab mob rhiab heev tuaj yeem ua rau tuag tes tuag taw tag nrho tom qab raug rau nanomolar cov nyiaj ntawm macrocyclic lactones rau lub sijhawm luv luv.

Txawm tias me me, cov khoom muaj zog txaus los siv los ua cov khoom muaj nyob hauv ob qho tib si tiv thaiv thiab kho cov khoom.

Selectivity hla Nematode Hom

Tsis yog txhua yam tshuaj tua kab mob ua haujlwm tib yam rau txhua tus ntawm lawv. Milbemycin oxime hmoov zoo tiv thaiv ntau yam nematodes vim tias txhua hom kab cab muaj GluCl raws uas zoo sib xws. Txawm hais tias lub hom phiaj yog Toxocara canis lossis Ancylostoma caninum, milbemycin oxime tseem khi rau cov channel no. Qhov no yog qhov tseem ceeb hauv kev kho mob. Nws tuaj yeem siv tau rau ntau qhov xwm txheej uas muaj ntau tshaj ib tus kab mob tshwm sim vim nws ua haujlwm ntawm ntau hom.

Common Nematode Targets hauv Canine Tshuaj

Muaj pov thawj los ntawm kev kuaj tsiaj uas milbemycin oxime hmoov tuaj yeem tua ntau hom kab mob sib txawv. Toxocara canis, tus dev roundworm, thiab Toxascaris leonina yog ob hom tsiaj uas pom muaj nyob hauv cov dev thoob plaws ntiaj teb. Ntawm cov ntsiab lus sib txawv hauv lawv lub neej voj voog, milbemycin oxime nres lawv. Nws tua ob tus neeg laus cab thiab lig -stage larvae (L4).

Ancylostoma caninum thiab Ancylostoma braziliense yog ob hom kab nuv ntses uas noj ntshav thiab tuaj yeem ua rau mob ntshav qab zib thiab enteritis. Cov hmoov no ua los ntawm milbemycin oxime ua haujlwm zoo heev tiv thaiv cov tsiaj no.

Cov tshuaj no kuj tseem siv tau los kho tus kab mob whipworm (Trichuris vulpis), uas tuaj yeem ua rau dev tau mob plab ntau dua.

Larval Stage Coverage thiab Life Cycle Interruption

Ib qho nthuav uas cov kws tshawb fawb tau pom txog milbemycin oxime yog tias nws tua cov theem pib. Nws yuav tsum tau muab txhua lub hlis kom ntes cov larvae tshiab ua ntej lawv loj hlob tuaj thiab pib nyob hauv lub plab zom mov vim tias cov tshuaj tsis tua cov qe ncaj qha. Tus nab npawb ntawm cov cab nyob hauv tus dev ib puag ncig maj mam nqis nrog txoj kev no, uas yuav pab ua kom qhov chaw huv huv rau tus dev.

Txhua hli Dosing thiab Sustained Protection

Raws li cov ntaub ntawv pharmacokinetic, qhov loj tshaj plaws ntawm milbemycin oxime pom nyob rau hauv cov ntaub so ntswg plaub mus rau yim teev tom qab nws noj los ntawm qhov ncauj. Cov tshuaj tau yooj yim coj los ntawm cov ntaub so ntswg rog thiab nyob ntawd rau 30 hnub ntawm tus nqi uas ua haujlwm. Cov tshuaj yuav tsum tau muab ib hlis ib zaug, uas tam sim no yog txoj hauv kev niaj hnub rau ntau tus kws kho tsiaj kom tsis txhob muaj kab mob plawv thiab plab hnyuv nematodes raws li cov tshuaj pharmacokinetic profile.

Hauv 48 teev, kwv yees li 90% ntawm cov tshuaj tau ntws tawm ntawm lub cev hauv tib daim ntawv uas nws tau tsim nyob rau hauv.Qhov no ua rau nws los ntawm kev tsim thiab tso siab rau daim siab,

uas yog qhov zoo rau cov dev uas tau txais tshuaj kom lawv noj qab nyob zoo rau lub sijhawm ntev.

Combination Protocols for Comprehensive Coverage

Sib tovmilbemycin oxime hmoovnrog rau lwm cov khoom xyaw nquag yog ib txoj hauv kev los ua kom cov kab mob cab ua haujlwm zoo dua. Yog tias koj muab nws nrog praziquantel, nws tuaj yeem tua cov kab mob plawv, kab mob sib kis, thiab kab mob qog noj ntshav txhua lub sijhawm. Qhov kev sib xyaw ua ke no ua rau nws yooj yim rau cov tswv tsiaj uas muaj ntau tshaj ib tus tsiaj los saib xyuas thiab ua rau nws tsis tshua muaj cov tshuaj yuav ploj. Siv nws ib hlis ib zaug tau pom tias txiav cov kab mob cab hauv tsev ntau dua 90%.

Kev Ntsuam Xyuas Kev Nyab Xeeb Kev Nyab Xeeb rau Cov dev

Roundworm qe tuaj yeem nkag mus rau hauv tus dev lub cev los ntawm cov quav, cov av tsis huv, lossis cov tswv tsev uas cov qe hla dhau. Qhov no yog vim niam muaj peev xwm muab tus kab mob no rau lawv cov menyuam los ntawm cov kua mis thiab thaum lawv tseem nyob hauv plab. Qee qhov chaw uas muaj kev cuam tshuam ntau yog dev khiav, chaw ua si, thiab qhib qhov chaw sab nraud. Cov kev uas tus kab mob no kis tau tuaj yeem pab cov tswv tsiaj thiab cov kws kho tsiaj kom nkag siab zoo dua vim li cas cov tshuaj tiv thaiv zoo dua li kev saib xyuas zoo dua.

Tsim ib lub sijhawm tiv thaiv ib puag ncig Milbemycin Oxime

Nws yog ib qho nyuaj rau mob tam sim ntawd yog tias koj pib tiv thaiv kev kho mob ua ntej lub caij yoov tshaj cum thiab kab mob phem.

 

 

Milbemycin oxime hmoov tiv thaiv ntau hom kab mob khaub thuas tam sim ntawd, yog li cov dev uas tau txais yuav tshiab, tshwj xeeb tshaj yog cov neeg uas tsis paub txog keeb kwm kev kho mob, tsis tas yuav nyob ib leeg thiab saib xyuas kom ntev. Nws muaj kev nyab xeeb dua rau cov dev uas nkag siab rau cov tshuaj siv milbemycin oxime es tsis txhob siv tshuaj avermectin-raws li tshuaj. Qhov no yog qhov tseeb tshwj xeeb rau cov yug me nyuam nrog MDR1 gene variation.

Milbemycin Oxime hmoovtau pom tias muaj txiaj ntsig tau tshem ntawm roundworms hauv dev. Nws ua haujlwm los ntawm kev txwv glutamate-gated chloride channels, uas ua rau nws dav -spectrum nematocidal kev txiav txim thiab muaj kev nyab xeeb zoo. Vim li no, nws yog ib qho kev xaiv zoo rau ob qho tib si kev noj qab haus huv thiab teeb meem kev noj qab haus huv. Nws ua rau cov dev muaj kev nyab xeeb nyob rau ntau lub sijhawm ntawm lawv lub neej thiab theem ntawm kev sib cuag thaum siv tsis tu ncua raws li ib feem ntawm cov phiaj xwm tswj kab mob parasite.

Thaum nws los txog rau kev noj tshuaj rau tsiaj, Bloomtechz paub tias koj yuav tsum tau txais qhov zoo tshaj plaws. Peb yog ib lub koob npe nrovmilbemycin oxime hmoovtus neeg muag khoom nrog ntau tshaj 12 xyoo ntawm kev paub hauv cov organic synthesis thiab tshuaj intermediates. Peb GMP-cov chaw tsim khoom tau lees paub tau raug tshuaj xyuas los ntawm US FDA, EU GMP, PMDA, thiab CFDA, thiab nws ua API- qib hmoov thiab cov ntsiav tshuaj tiav. Nws yog peb txoj haujlwm kom paub tseeb tias koj tau txais raws nraim qhov koj xav tau, raws sijhawm thiab raws li tau npaj tseg. Peb pab pawg tshawb fawb thiab kev tsim kho mob siab rau, tus qauv tsim nqi meej, thiab triple -txuas kev tswj xyuas qhov zoo tag nrho ua haujlwm ua ke los ua qhov no. Tsis muaj teeb meem yog tias koj xav tau Tshuag API, OEM ntsiav tshuaj, lossis cov zaub mov ua rau koj xwb, peb pab neeg tau npaj los pab koj kom ncav cuag koj cov hom phiaj kev tsim khoom.

Hu rau peb hnub no ntawmSales@bloomtechz.comthov cov lus qhia tshwj xeeb, qauv, lossis cov lus hais.

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2. Prichard, RK, & Geary, TG (2019). Kev pom ntawm kev siv hluav taws xob ntawm moxidectin thiab milbemycin oxime rau kev tswj cov kab mob parasitic nematodes nyob rau hauv lub ntsej muag ntawm kev txhim kho macrocyclic lactone kuj. International Journal for Parasitology: Tshuaj thiab Tshuaj Tiv Thaiv, 10, 69–83.

3. Paul, AJ, Tranquilli, WJ, & Hutchens, DE (2000). Kev nyab xeeb ntawm milbemycin oxime hauv kev sib tsoo nrog ABCB1-1Δ (MDR1) noob hloov. American Journal of Veterinary Research, 61(6), 635–637.

4. Bowman, DD, & Atkins, CE (2009). Heartworm biology, kho, thiab tswj. Veterinary Clinics of North America: Small Animal Practice, 39(6), 1127–1158.

5. Sasaki, T., Takagi, M., Yaguchi, T., Miyadoh, S., Okada, T., & Koyama, M. (1992). Ib tug tshiab anthelmintic milbemycin oxime: Discovery, pharmacology thiab hom kev ua. Phau ntawv Journal of Antibiotics, 45(5), 692–697.

6. Lok, JB, & Knight, DH (1995). Kev kuaj thiab kev kho mob ua tau zoo ntawm milbemycin oxime tiv thaiv Dirofilaria immitis. Veterinary Medicine, 90(7), 660–667.