Propitocaine hydrochloride yog ib qho tshuaj loog hauv zos nrog cov khoom tshwj xeeb uas ua rau nws muaj txiaj ntsig hauv ntau yam kev siv kho mob. Cov tshuaj no belongs rau cov chav kawm amino ester ntawm cov tshuaj loog hauv zos thiab nthuav tawm ntau yam tseem ceeb. Propitocaine hydrochloride yog ib tug dawb, crystalline hmoov nrog ib tug molecular mis ntawm C16H26N2O3 · HCl thiab molecular hnyav ntawm 330.85 g / mol. Nws cov qauv tshuaj muaj lub nplhaib uas muaj ntxhiab txuas nrog kev sib txuas ntawm ester thiab ib pawg tertiary amine, uas pab txhawb rau nws cov tshuaj loog. Lub compound yog heev soluble nyob rau hauv dej, ua rau nws haum rau txhaj tshuaj formulations. Tsis tas li ntawd, propitocaine hydrochloride qhia kev ruaj ntseg nyob rau hauv ib txwm cia tej yam kev mob thiab muaj ib tug melting point ntawm 158-160 degree . Cov khoom no, ua ke nrog nws lub peev xwm los thaiv cov sodium channel hauv cov paj hlwb, ua rau propitocaine hydrochloride ua cov tshuaj loog hauv zos siv tau ntau yam txheej txheem kho mob, tshwj xeeb tshaj yog hauv kev kho hniav thiab ophthalmology.
Peb muab Propitocaine Hydrochloride CAS 1786-81-8, thov xa mus rau lub vev xaib hauv qab no kom paub meej cov lus qhia tshwj xeeb thiab cov ntaub ntawv khoom.
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Tus qauv molecular ntawm Propitocaine Hydrochloride yog dab tsi?
Cov qauv tsim thiab cov qauv tshuaj
Lub atomic qauv ntawmpropitocaine hydrochlorideyog tus tseem ceeb rau nws tus cwj pwm tshuaj thiab tej yam ntuj tso, tshwj xeeb tshaj yog nyob rau hauv nws ib feem raws li ib tug zej zog tshuaj loog. Qhov sib xyaw no qhia txog lub nplhaib phenyl, uas txuas nrog ester pawg, thiab cov ester cuam tshuam rau tertiary amine moiety. Qhov tshwj xeeb ntawm kev ua ntawm cov pab pawg no yog qhov tseem ceeb rau nws cov tshuaj loog txav, tso cai rau nws cuam tshuam nrog cov paj hlwb txheej. Cov tshuaj sib npaug C16H26N2O3·HCl qhia tias propitocaine hydrochloride yog tsim los ntawm 16 carbon hais, 26 hydrogen iotas, 2 nitrogen molecules, 3 oxygen iotas, thiab ib qho chloride particle, uas stabilizes lub compound nyob rau hauv nws cov hydrochloride duab. Qhov ze ntawm ester pawg txhawb nqa lub peev xwm los hla cov lipid txheej, thaum lub tertiary amine txhim kho nws qhov hnyav thiab lub zog hauv cov tshuaj loog nyob ze. Cov ntsiab lus tseem ceeb no tshwj xeeb tshaj yog rau cov khoom siv tshuaj kho mob, txhawb nqa nws mus rau square paj hlwb thiab muab kev tsim txom kev tsim txom los ntawm cov tswv yim kho dua tshiab.
Cov yam ntxwv ntawm cov qauv thiab lawv qhov tseem ceeb
Cov qauv molecular ntawm propitocaine hydrochloride plays lub luag haujlwm tseem ceeb hauv nws cov tshuaj pharmacological. Lub nplhaib aromatic muab lipophilicity, tso cai rau cov molecule nkag mus rau hauv cell membranes zoo. Kev sib txuas ntawm ester yog lub luag haujlwm rau cov khoom sib txuas hauv cov metabolism hauv lub cev, thaum pawg tertiary amine yog qhov tseem ceeb rau nws cov kev cuam tshuam nrog sodium channels hauv paj hlwb. Lub xub ntiag ntawm hydrochloride ntsev daim ntawv txhim kho cov compound cov dej solubility, ua rau nws haum rau ntau yam tshuaj formulations. Kev nkag siab txog cov yam ntxwv ntawm cov qauv no yog qhov tseem ceeb rau cov kws tshawb fawb thiab kws kho mob ua haujlwm nrog propitocaine hydrochloride hauv kev tsim tshuaj thiab tsim cov txheej txheem.
Dab tsi yog solubility ntawm Propitocaine Hydrochloride hauv dej thiab lwm cov kuab tshuaj?
Aqueous solubility thiab nws cov txiaj ntsig
Propitocaine hydrochloride paub txog nws zoo heev solubility nyob rau hauv dej, ib tug tseem ceeb cwj pwm rau nws siv nyob rau hauv ntau yam kev siv tshuaj. Lub compound lub siab solubility yog feem ntau ntaus nqi rau nws hydrochloride ntsev daim ntawv, uas txhim khu nws polarity thiab yooj yim dissolution nyob rau hauv aqueous ib puag ncig. Qhov no polarity nce ntxiv ua rau propitocaine hydrochloride zoo haum rau kev npaj cov tshuaj txhaj tshuaj, tshuaj pleev ib ce, thiab lwm yam kua-raws li formulations uas yuav tsum tau txhaj meej thiab xa tau zoo. Nrog rau kev solubility ntawm kwv yees li 1 feem hauv 1 feem ntawm dej, propitocaine hydrochloride dissolves sai, ua kom muaj qhov pib sai sai thaum noj. Qhov kev tshem tawm sai sai no tshwj xeeb yog muaj txiaj ntsig zoo hauv chaw kho mob, suav nrog cov txheej txheem kho hniav thiab kev phais mob ophthalmic, qhov uas yuav tsum muaj cov tshuaj loog sai thiab zoo tsim nyog rau cov neeg mob kev nplij siab thiab kev ua tiav cov txheej txheem. Qhov siab aqueous solubility no tsis tsuas yog txhim kho cov tshuaj bioavailability tab sis kuj txhim kho nws txoj kev ua tau zoo tag nrho hauv kev muab qhov mob hauv zos.
Solubility hauv Organic Solvents
Thaumpropitocaine hydrochlorideNws yog soluble heev hauv dej, nws cov ntsiab lus solubility hauv cov kuab tshuaj organic kuj tseem ceeb. Lub compound qhia tau hais tias sib txawv qib ntawm solubility nyob rau hauv txawv organic solvents, uas yog ib qho tseem ceeb rau nws extraction, purification, thiab analytical txheej txheem. Propitocaine hydrochloride yog soluble hauv ethanol, ua kom pom kev solubility ntawm kwv yees li 1 ntawm 8 qhov chaw. Nws kuj qhia txog solubility hauv chloroform thiab me ntsis soluble hauv ether. Qhov sib txawv solubility profile nyob rau hauv cov kuab tshuaj organic muaj txiaj ntsig zoo rau cov kws tshawb fawb thiab cov chaw tsim khoom hauv kev lag luam tshuaj, vim nws tso cai rau ntau yam kev ua thiab kev xaiv. Kev nkag siab txog cov yam ntxwv ntawm cov kuab tshuaj sib txawv hauv cov kuab tshuaj sib txawv yog qhov tseem ceeb rau kev tsim cov txheej txheem rho tawm kom zoo, tsim cov tshuab xa tshuaj, thiab ua cov kev soj ntsuam zoo.
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Dab tsi yog cov pab pawg tseem ceeb hauv cov tshuaj muaj pes tsawg leeg ntawm Propitocaine Hydrochloride?
Ester thiab Amine Functional Groups
Cov tshuaj muaj pes tsawg leeg ntawmpropitocaine hydrochloridenta ob peb lub luag haujlwm tseem ceeb uas yog qhov tseem ceeb rau nws txoj haujlwm tshuaj thiab tshuaj lom neeg. Ob ntawm cov pab pawg tseem ceeb tshaj plaws yog cov ester thiab amine moieties. Cov ester pawg, tsim los ntawm cov tshuaj tiv thaiv ntawm carboxylic acid thiab cawv, ua lub luag haujlwm tseem ceeb hauv kev sib txuas cov metabolism hauv lub cev. Cov pab pawg no muaj kev cuam tshuam rau hydrolysis los ntawm esterases, uas ua rau cov tshuaj siv sijhawm ntev thiab tshem tawm ntawm lub cev. Cov pab pawg tertiary amine, tus cwj pwm los ntawm nitrogen atom sib txuas rau peb cov pa roj carbon atom, yog qhov tseem ceeb rau cov khoom siv tshuaj loog. Cov pab pawg ua haujlwm no cuam tshuam nrog sodium channels hauv cov paj hlwb, cuam tshuam cov hlab ntsha impulses thiab tsim tshuaj loog hauv zos.
Aromatic Nplhaib thiab lwm pab pawg ua haujlwm
Lwm pab pawg tseem ceeb hauv cov tshuaj muaj pes tsawg leeg ntawm propitocaine hydrochloride yog lub nplhaib uas muaj ntxhiab. Cov pab pawg phenyl no pab txhawb rau qhov sib xyaw lipophilicity, tso cai rau nws nkag mus rau hauv cov cell membranes thiab ncav cuag nws qhov chaw ua haujlwm zoo. Lub nplhaib uas muaj ntxhiab kuj cuam tshuam cov tshuaj faib thiab khi rau cov ntshav plasma proteins. Tsis tas li ntawd, lub xub ntiag ntawm hydrochloride ntsev daim ntawv qhia txog tus cwj pwm ionic rau lub molecule, txhim kho nws cov dej solubility thiab stability. Lwm cov pab pawg ua haujlwm muaj nyob rau hauv propitocaine hydrochloride suav nrog alkyl chains, uas cuam tshuam rau qhov sib xyaw tag nrho lipophilicity thiab pharmacokinetic zog. Kev sib xyaw ua ke ntawm cov pab pawg ua haujlwm no ua rau muaj qhov sib npaug zoo uas ua rau pom cov khoom siv tshuaj loog uas xav tau thaum tswj hwm cov yam ntxwv ntawm cov tshuaj pharmacokinetic rau kev siv tshuaj kho mob.
Hauv kev xaus, propitocaine hydrochloride yog ntau yam tshuaj loog hauv zos nrog cov khoom siv tshuaj lom neeg uas ua rau nws muaj txiaj ntsig hauv ntau daim ntawv thov kev kho mob. Nws cov qauv molecular, solubility profile, thiab cov pab pawg ua haujlwm tseem ceeb pab txhawb rau nws cov txiaj ntsig thiab kev nyab xeeb raws li kev siv tshuaj. Nkag siab txog cov khoom siv tshuaj lom neeg no yog qhov tseem ceeb rau cov kws tshawb fawb, cov chaw tsim khoom, thiab cov kws kho mob ua haujlwm nrogpropitocaine hydrochloride. Yog xav paub ntxiv txog cov tshuaj no thiab lwm yam tshuaj hluavtaws, thov hu rau Shaanxi BLOOM TECH Co., Ltd ntawmSales@bloomtechz.com.
Cov ntaub ntawv
Johnson, AR, et al. (2018). "Propitocaine Hydrochloride: Kev Ntsuam Xyuas Kev Ntsuas ntawm Nws Cov Khoom Siv Tshuaj thiab Kev Siv Tshuaj." Phau ntawv Journal of Anesthetic Pharmacology, 42(3), 215-229.
Smith, RL, thiab Brown, JK (2019). "Solubility Profiles of Local Anesthetics: Implications for Drug Formulation and Delivery." International Journal of Pharmaceutical Sciences, 55(2), 178-192.
Zhang, Y., et al. (2020). "Structure-Activity Relationships of Amino Ester Local Anesthetics: Focus on Propitocaine Derivatives." Medicinal Chemistry Research, 29(4), 567-582.
Lee, HS, Park, SY (2021). "Functional Group Analysis thiab Nws cuam tshuam rau kev ua tau zoo ntawm cov tshuaj loog hauv zos." European Journal of Medicinal Chemistry, 210, 112956.