Dab tsi yog Methylergonovine siv los kho?
Methylergonovine txiv neejntsevFeem ntau yog siv los tiv thaiv thiab tswj cov ntshav tom qab yug me nyuam, uas yog hais txog cov ntshav ntau dhau tom qab yug menyuam. Raws li ib tug semisynthetic ergot alkaloid, nws ua hauj lwm raws li ib tug uterotonic tus neeg saib xyuas, stimulating lub contraction ntawm uterine nqaij. Los ntawm inducing uterine contractions, methylergonovine pab tswj los ntshav los ntawm compressing cov hlab ntsha uas muab lub tsev menyuam.
Nquag tswj intramuscularly lossis intravenously tom qab kev xa khoom ntawm cov placenta, methylergonovine tuaj yeem tau txais prophylactically thaum lub sijhawm thib peb ntawm kev ua haujlwm kom tsis txhob cuam tshuam tom qab cev xeeb tub, tshwj xeeb tshaj yog nyob rau hauv cov poj niam uas muaj kev phom sij vim muaj kev hloov pauv xws li yav dhau los uas muaj cov kua dej tom qab cev xeeb tub lossis uterine atony ( tsis muaj uterine nqaij laus).
Tshaj li nws thawj daim ntawv thov kev xeeb tub, methylergonovine kuj tseem tuaj yeem siv tawm daim ntawv lo rau lwm yam mob, suav nrog:
Migraine mob taub hau:Methylergonovine lub peev xwm los tswj cov hlab ntsha cranial tuaj yeem pab txo qhov mob migraine. Nws yog feem ntau txiav txim siab nyob rau hauv cov ntaub ntawv uas lwm yam kev kho mob migraine tsis tau zoo.
Uterine los ntshav:Nyob rau hauv cov xwm txheej ntawm lub uterine los ntshav tsis cuam tshuam txog kev yug me nyuam, xws li menorrhagia (mob khaub thuas hnyav), yuav raug muab tshuaj methylergonovine los pab tswj cov ntshav los ntawm kev txhawb nqa uterine contractions.
Mob plab los ntshav:Methylergonovine's vasoconstrictive zog ua rau nws muaj txiaj ntsig zoo hauv kev txo cov ntshav los ntawm plab lossis hnyuv. Nws tuaj yeem pab txo cov hlab ntsha, yog li txo qis ntshav los ntawm cov hnyuv.
Thaum cov tshuaj methylergonovine tseem ceeb rau cov xwm txheej no, kev siv nws yuav tsum tau ua tib zoo xav txog, tshwj xeeb tshaj yog nyob rau hauv cov neeg muaj mob tshwj xeeb lossis noj tshuaj sib txawv, vim yog kev twv txiaj tsis zoo. Nws yog ib qho tseem ceeb rau cov kws kho mob los soj ntsuam txhua tus neeg mob cov keeb kwm kho mob thiab tag nrho cov kev noj qab haus huv ua ntej yuav tshuajMethylergonovine txiv neejntsevrau tej yam qhia.
Methylergonovine Maleate ua haujlwm li cas?
Methylergonovine txiv neejntsev, ib tug derivative ntawm ergot alkaloid ergonovine, feem ntau yog siv nyob rau hauv obstetrics rau nws uterotonic zog, pab nyob rau hauv kev tiv thaiv los yog kev kho mob ntawm postpartum hemorrhage thiab kev tswj ntawm uterine atony tom qab yug me nyuam los yog rho menyuam. Nws cov txheej txheem ntawm kev ua cuam tshuam nrog ntau yam kev sib cuam tshuam hauv lub cev, tshwj xeeb nrog serotonin thiab dopamine receptors.
Stimulation ntawm Serotonin Receptors: Methylergonovine mus txog raws li ib tug agonist ntawm serotonin receptors, tshwj xeeb tshaj yog cov 5-HT2A thiab 5-HT2B subtypes, taug qab nyob rau hauv uterine smooth nqaij hlwb. Kev ua haujlwm ntawm cov receptors no ua rau muaj kev nthuav dav hauv cov calcium hauv cov leeg hauv cov leeg nqaij.
Nce Calcium Levels: Lub ascent nyob rau hauv intracellular calcium tsom teeb tawm ib tug ciav ntawm lub sij hawm, nws thiaj li coj txog kev tshem tawm ntawm uterine smooth nqaij strands. Qhov kev cog lus no yog qhov tseem ceeb rau kev tswj cov ntshav tom qab yug me nyuam thiab txhawb kev cuam tshuam ntawm lub tsev menyuam tom qab yug menyuam.
Direct Action ntawm Smooth Muscle Cells:Ntxiv nrog rau nws cov teebmeem serotonergic, methylergonovine tseem cuam tshuam ncaj qha rau lub tsev menyuam cov leeg nqaij. Qhov kev txiav txim ncaj qha no ntxiv txhim kho uterine contractions, ua rau nws cov txiaj ntsig zoo li tus neeg sawv cev uterotonic.
Vasoconstrictor Properties:Methylergonovine kuj nthuav tawm cov teebmeem vasoconstrictor, feem ntau los ntawm nws kev cuam tshuam nrog dopamine receptors, tshwj xeeb tshaj yog D2 subtype, muaj nyob rau hauv cov hlab ntsha. Los ntawm stimulating cov receptors, methylergonovine ua rau constriction ntawm cov hlab ntsha, uas yuav pab tau nyob rau hauv tej yam kev kho mob scenarios.
Hauv kev xyaum kho mob, methylergonovine yog siv los ntawm qhov ncauj lossis los ntawm kev txhaj tshuaj, nyob ntawm qhov qhia tshwj xeeb thiab tus neeg mob. Nws txhais tau hais tias muaj ntau yam uas yuav tsum nco ntsoov tias thaum methylergonovine ua tiav rau nws lub hom phiaj npaj, nws yuav tsum tau siv tsis tu ncua thiab nyob rau hauv kev saib xyuas vim tias nws muaj peev xwm ua rau vasoconstriction, uas tuaj yeem ua rau muaj kev cuam tshuam tsis zoo xws li kub siab thiab ischemia, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob. mob plawv lossis kub siab.
Zuag qhia tag nrho,Methylergonovine txiv neejntsev's multifaceted mechanism ntawm kev txiav txim, koom nrog serotonin thiab dopamine receptors, ua rau nws yog ib qho tseem ceeb kho tus neeg saib xyuas hauv obstetrics rau kev tswj cov ntshav tom qab yug me nyuam thiab uterine atony. Tsis tas li ntawd, nws cov khoom vasoconstrictor txuas ntxiv nws cov txiaj ntsig rau lwm yam mob xws li mob taub hau thiab mob plab hnyuv, txawm hais tias nws siv hauv cov ntsiab lus no yuav tsum tau ua tib zoo xav txog cov kev mob tshwm sim thiab contraindications.
Dab tsi yog qhov cuam tshuam thiab ceev faj ntawm Methylergonovine?
ThaumMethylergonovine txiv neejntsevyog ib qho tshuaj zoo rau kev tiv thaiv thiab kho mob ntshav qab zib, nws muaj feem cuam tshuam nrog ntau yam kev mob tshwm sim thiab kev ceev faj uas yuav tsum tau xav txog.
Cov teebmeem thib ob:
Cov tsos mob pom dav tshaj plaws ntawm methylergonovine suav nrog:
- Mob thiab regurgitating
- Cerebral mob
- Wooziness
- Mob ntshav siab (hypertension)
- Lub hauv siab torment los yog snugness
- ob txhais ceg
- Flushing los yog hnov qhov sov so
Tsis tshua muaj tshwm sim, txawm li cas los xij ntau qhov kev cuam tshuam loj thib ob yuav muaj xws li:
- Cov kab mob vasospasm, ua rau myocardial localized necrosis (ua pa tsis ua haujlwm)
- Cerebral vasospasm, tej zaum yuav ua rau mob stroke lossis qaug dab peg
- Gangrene lossis loj fringe ischemia (tsis txaus ntshav txaus rau cov ntsiab lus nyob deb tshaj)
- Hypertensive xwm txheej (ua rau mob hnyav heev)
- Aspiratory edema (kua kua hauv lub ntsws)
Kev ceev faj:
Vim tias muaj peev xwm ua rau muaj kev cuam tshuam loj heev, methylergonovine yuav tsum tau koom nrog kev ceeb toom hauv cov xwm txheej nrog:
- Mob plawv:Methylergonovine yog contraindicated nyob rau hauv cov neeg mob uas muaj ntshav siab, kab mob ntawm txoj hlab ntsws, los yog lwm yam mob plawv plawv.
- Fringe vascular mob:Cov tshuaj yuav tsum tau khaws cia kom deb ntawm cov neeg mob uas ua rau nce kev twv txiaj ntawm fringe ischemia, xws li Raynaud's mob lossis thromboangiitis obliterans.
- Hepatic lossis raum tsis zoo:Kev kho koob tshuaj yuav tsim nyog rau cov neeg mob uas muaj lub siab lossis lub raum tsis ua haujlwm.
- Hyperthyroidism:Methylergonovine tuaj yeem ua rau cov tsos mob ntawm hyperthyroidism ntau dua.
-Kev pub niam mis:Cov tshuaj yuav txwv tsis pub lactation thiab yuav tsum tau siv nrog ceev faj hauv cov niam uas pub niam mis.
Cov kws kho mob yuav tsum ua tib zoo ntsuas cov txiaj ntsig zoo ntawm cov tshuaj methylergonovine tiv thaiv cov kev pheej hmoo, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas muaj mob hauv qab los yog muaj feem cuam tshuam rau cov kev tsis zoo.
Cov ntaub ntawv:
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2. Methylergonovine Maleate. Hauv: IBM Micromedex [Internet]. Greenwood Village (CO): IBM Corporation; [hloov kho 2023 Mar 10; los ntawm 2023 Mar 21]. Muaj los ntawm: https://www.micromedexsolutions.com
3. Bouwmeester FW, Bolte AC, van Geijn HP. Pharmacological thiab hlab plawv cov teebmeem ntawm methylergometrine thiab methylergonovine hauv cov poj niam uas muaj tus kab mob hypertensive thaum cev xeeb tub. Eur J Obstet Gynecol Reprod Biol. 1988; 29(1):{4}}.
4. Derry S, Sven-Åke R, Moore RA. Methylergonovine maleate hauv kev tiv thaiv thiab kev kho mob ntshav qab zib: kev tshuaj xyuas. J Obstet Gynaecol. 2005; 25(8): 751-757.
5. Briggs GG, Freeman RK, Yaffe SJ. Tshuaj nyob rau hauv cev xeeb tub thiab lactation: Phau Ntawv Qhia rau Fetal thiab Neonatal Risk. 10 ed ib. Philadelphia, PA: Lippincott Williams & Wilkins; 2015.
6. Methylergonovine Maleate. Hauv: DrugBank Online [Internet]. Edmonton (AB): University of Alberta; [hloov kho 2023 Feb 13; los ntawm 2023 Mar 21]. Muaj los ntawm: https://go.drugbank.com/drugs/DB00847