Chrysophanic acidyog ib tug natural organic compound nrog molecular mis C15H10O4, tseem hu ua anthraquinone-2-carboxylic acid. Nws yog daj crystalline hmoov nrog ib tug muaj zog aromatic thiab iab saj. Nws yog yooj yim soluble nyob rau hauv cov kuab tshuaj organic xws li ethanol, ether, benzene thiab chloroform nyob rau hauv me ntsis acidic tej yam kev mob, tab sis yuav luag insoluble nyob rau hauv dej. Cov qauv molecular ntawm Chrysophanic acid muaj ob lub nplhaib benzene thiab ib pawg carboxyl, thiab pawg carboxyl yooj yim los ua nws cov sodium, potassium ntsev lossis lwm yam dej-soluble derivatives. Nws yog thawj zaug cais tawm ntawm fern Rheum officinale, thiab tam sim no tau siv dav hauv tshuaj thiab tshuaj pleev ib ce.
1. Daim ntawv thov ntawm Chrysophanic acid:
(1) Daim ntawv thov hauv kev kho mob:
Chrysophanic acid yog ib qho tseem ceeb tshuaj compound, uas muaj kev lom zem zoo thiab siv tau los kho ntau yam kab mob. Piv txwv li, nws yog dav siv nyob rau hauv kev kho mob ntawm daim tawv nqaij kab mob, thiab yuav zoo kho alopecia areata, psoriasis, eczema, psoriasis thiab lwm yam kab mob. Tsis tas li ntawd, nws tseem tuaj yeem siv los kho cov kab mob sab hauv xws li colitis, kab mob raum, thiab mastitis.
(2) Kev siv tshuaj pleev ib ce:
Chrysophanic acid yog dav siv nyob rau hauv cov tshuaj pleev ib ce vim hais tias ntawm nws cov antioxidant, anti-inflammatory, thiab tawv-tightening teebmeem. Nws tuaj yeem siv los ua cov khoom siv hauv cov xim plaub hau, tshuaj dawb thiab tshuaj dawb, tuaj yeem txhim kho cov xim ntawm cov plaub hau thiab tawv nqaij, thiab muaj cov nyhuv antibacterial thiab moisturizing. Nyob rau tib lub sijhawm, nws tuaj yeem ua raws li cov khoom siv exfoliating thiab pob txuv-txo, uas tuaj yeem ntxuav thiab tiv thaiv.
(3) Lwm yam kev siv:
Ntxiv nrog rau cov ntawv sau tseg saum toj no, Chrysophanic acid kuj tuaj yeem siv los ua cov tshuaj xws li dyes, khoom noj khoom haus thiab tshuaj tua kab. Nws tseem tuaj yeem siv los ua cov txheej txheem organic ruaj khov, cov khoom siv optoelectronic thiab cov khoom siv hluav taws xob, thiab lwm yam.
2. Kev ua haujlwm lom neeg ntawm Chrysophanic acid
Chrysophanic acid muaj ntau yam kev ua ub no, xws li tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tua kab mob, tiv thaiv qog, thiab lwm yam. Cov hauv qab no yog cov lus qhia tshwj xeeb:
(1) Kev tiv thaiv kab mob: Chrysophanic acid tuaj yeem cuam tshuam kev loj hlob ntawm ntau yam kab mob xws li Escherichia coli, Staphylococcus aureus thiab Streptococcus.
(2) Antioxidant kev ua haujlwm: Chrysophanic acid tuaj yeem tshem tawm cov dawb radicals thiab lwm yam khoom tsis zoo, thiab muaj cov nyhuv antioxidative zoo.
(3) Anti-inflammatory kev ua: Chrysophanic acid tuaj yeem txo qhov mob thiab mob, thiab muaj kev kho mob zoo rau rheumatism thiab lwm yam kab mob.
(4) Kev tiv thaiv qog nqaij hlav: Chrysophanic acid muaj cov nyhuv tiv thaiv qog thiab tuaj yeem cuam tshuam kev loj hlob ntawm tib neeg lub mis, ntsws thiab cov qog nqaij hlav hauv plab.
3. Synthesis method of Chrysophanic acid:
Chrysophanic acid yog daj organic compound uas tuaj yeem muab rho tawm los ntawm cov hauv paus hniav rhubarb. Nws yog dav siv hauv tshuaj thiab kev lag luam. Raws li qhov kev thov rau nws cov ntawv thov dav dav ntxiv, tib neeg pib tshawb nrhiav txoj hauv kev tshiab los ua ke Chrysophanic acid. Feem ntau siv ntawm cov no yog cov khoom siv hluavtaws pib los ntawm cov kua qaub daj (emodin).
Cov txheej txheem rau synthesizing Chrysophanic acid pib los ntawm cov kua qaub daj muaj qhov zoo ntawm kev ua haujlwm siab, kev lag luam, thiab kev tiv thaiv ib puag ncig. Cov hauv qab no yog cov ncauj lus kom ntxaws txog cov txheej txheem synthesis pib los ntawm cov kua qaub daj:
3.1 Cov tshuaj tiv thaiv oxidation:
Thaum xub thawj, cov kua qaub daj tau koom nrog hauv cov concentrated nitric acid, thiab tswj qhov kub ntawm 10-15 degree , thiab lub sijhawm tshuaj tiv thaiv yog 5 teev. Tom qab cov tshuaj tiv thaiv tiav, xanthic acid hloov mus rau 3-methoxy-1,6, 8-trinitronaphthalene (MTN), uas yog neutralized los ntawm cov dej ntau dhau.
3.2. Txo cov tshuaj tiv thaiv:
Tshem tawm MTN hauv qhov chaw hydrogen, ntxiv rau cov hlau hlau lossis hlau pob, thiab do nws. Raws li cov xwm txheej zoo li no, MTN raug txo mus rau 1,6,8-trimethoxynaphthalene (1,6,{5}}trimethoxynaphthalene, TMN luv luv).
3.3. Stereochemical cov tshuaj tiv thaiv:
Dissolve TMN hauv acetone thiab cyanogen iodide, thiab hnov mob hauv qab cua sov qeeb, co thiab tsaus ntuj los npaj ib qho ntawm ob lub stereoisomers ntawm Chrysophanic acid, uas yog 4,5-dimethoxy 4,5-dimethoxy{{4} }hydroxybenzoic acid (DMHBA luv luv).
3.4. Heterocyclic tshuaj tiv thaiv:
Ntxiv DMHBA rau acetone, ntxiv sodium nitrite nyob rau hauv lub xub ntiag ntawm ferric chloride, ces ntxiv sulfuric acid, boil thiab cia sawv ntsug kom tau ib tug maub daj graphite zoo li tshuaj. Tom qab yaug, lim, thiab ziab cov khoom zoo li graphite, Chrysophanic acid nrog purity siab dua tuaj yeem tau.
Cov txheej txheem hluavtaws ntawm Chrysophanic acid pib los ntawm cov kua qaub daj, thiab dhau los ntawm ntau cov kauj ruam xws li oxidation, txo, stereochemical thiab heterocyclic tshuaj tiv thaiv, thiab kev xaiv tsim nyog ntawm cov tshuaj tiv thaiv hauv txhua kauj ruam yog qhov tseem ceeb heev. Tam sim no, txoj kev sib txuas no tau tsim los ua ib qho ntawm cov kev siv ntau tshaj plaws Chrysophanic acid synthesis.
4. Cov tshuaj lom thiab kev nyab xeeb ntawm Chrysophanic acid
Chrysophanic acid yog ib qho organic tebchaw, uas yog ib puag ncig zoo thiab nyab xeeb dua. Tom qab kev tshawb fawb txog kev toxicity thiab kev nyab xeeb, nws ntseeg tau tias Chrysophanic acid kuj muaj kev nyab xeeb hauv kev kho mob. Txawm li cas los xij, kev siv tsis raug kuj yuav muaj qee yam kev mob tshwm sim, xws li kev siv ntau dhau yuav ua rau tawv nqaij ua xua thiab kub hnyiab. Yog li ntawd, thaum siv, nws yuav tsum tau siv nruj me ntsis raws li tus kws kho mob los yog cov chaw tsim khoom cov lus pom zoo.
Nyob rau hauv xaus, Chrysophanic acid yog ib tug compound nrog ib tug tseem ceeb lom kev ua si, uas muaj antibacterial, antioxidative, anti-inflammatory, antitumor thiab lwm yam teebmeem. Nws yog siv nyob rau hauv teb xws li tshuaj thiab tshuaj pleev ib ce. Los ntawm cov kev tshawb fawb nruj thiab kev nyab xeeb, nws ntseeg tau tias Chrysophanic acid kuj muaj kev nyab xeeb hauv kev kho mob.