Feline sib kis tus mob peritonitis (FIP) yog ib yam kev mob siab uas cuam tshuam rau cov miv thoob ntiaj teb. Kev tshawb rau kev kho kom tau zoo tau cov kws tshawb fawb coj mus tshawb ntau qhov sib txuas ua ke, suav nrogGs 441524 HmoovCov. Tsab ntawv no rho tawm hauv qhov kev cuam tshuam GS-441524 ntawm FIP RNA polymerase kev ua si, ua rau muaj lub peev xwm ua cov felitonitis kev kho mob peritonitis.
GS 441524 Hmoov CAS 1191237-69-0
1.Txoj kev tshwj xeeb (hauv Tshuag)
(1) kev txhaj tshuaj
20mg, 6ml; 30Mg, 8ml; 40mg, 10ml
(2) Ntsiav tshuaj
25/45 / 60/0mg
(3) API (hmoov ntshiab)
(4) ntsiav tshuaj xovxwm tshuab
https://www.achievechn.com/pill-press
2.Customization:
Peb yuav sib tham ntawm tus kheej, OEM / ODM, tsis muaj hom, rau kev tshawb nrhiav kev ua haujlwm nkaus xwb.
Sab hauv Txoj Cai: BM-2-1-049
GS-441524 CAS 1191237-69-0
Kev tsom xam: HPLC, LC-MS, HNMR
Kev Txhawb Nqa Tshuab: R & Dept.-4
Peb muabGs 441524 Hmoov, thov saib mus rau lub vev xaib txuas ntxiv no kom cov ncauj lus kom ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomtechz.com/synthetic organic-intermediates/gs-441524-69123HTML
Mechanism ntawm RNA polymerase piav qhia
GS-441524(https://en.wikipedia.org/wiki/gs-441524), ib lub nucleoside analog, tawm nws cov antiviral cuam tshuam los ntawm kev sib tw RNA-desent RNA Polymerase (RDRAP) ntawm FIP tus kab mob. Tus enzyme no yog qhov tseem ceeb rau kab mob kis, ua rau nws lub hom phiaj zoo tshaj plaws rau kev kho mob.
Yuav ua li cas GS-441524 cuam tshuam nrog cov kab mob kis
Thaum GS-441524 tau nkag los ntawm cov cell uas tau kis, nws tsis sib haum phosphorylation los ua nws cov nquag mus ncig ua si metabolite. Qhov kev ua yeeb yam no tau sib tw nrog ntuj nucleotides rau kev koom tes rau hauv cov saw RNing RNAing thaum lub sij hawm replal replication. Thaum koom nrog, GS-441524 Triphosphate ua raws li saw titinator, halting txuas ntxiv ntawm tus kab mob RNA.
Raws cov qauv ntawm inhibition
Cov qauv molecular ntawm GS-441524 tso cai rau nws kom pom muaj ntuj nucleosides, dag ntxias tus kab mob RNA Polymerase. Txawm li cas los xij, hloov maj mam sib txawv hauv nws cov qauv tiv thaiv kev tsim ntawm cov khub kom raug nrog cov nucleotides kom zoo, zoo kawg nkaus stalling lub polymerase thiab impeding viical genome replication.
Kev ntsuas cov kab mob sib txuas ntxiv hauv cov hlwb kis
Kom muaj nuj nqis qhov cuam tshuam ntawmGs 441524 HmoovNtawm FIP kab mob replication, cov kws tshawb nrhiav ua haujlwm ntau yam kev sib tw los ntsuas cov kab mob kis tau thiab cov lus teb hauv cov khoom kis tau nrog cov compound.
Quantitative PCR Kev Ntsuam Xyuas
Tiag tiag-lub sij hawm kom muaj pcr (QPCR) yog ib qho cuab yeej muaj zog rau kev ntsuas tus kab mob viral RNA hauv cov hlwb uas kis tau tus kab mob. Los ntawm kev sib piv cov lej RNA cov lej xov tooj hauv GS-441524-cov kws tshawb nrhiav tuaj yeem txheeb xyuas qhov sib txuas ua ke hauv suppressing kis tus kab mob replal.
Cov quav hniav tawm plaque
Cov quav hniav ua ke muab kev pom kev sawv cev ntawm kis tus kab mob kis mus. Muab kho cov kab mob ntawm tes nrog GS-441524 thiab soj ntsuam qhov txo cov quav quav hniav muaj kev pom rau kev pom muaj peev xwm ua rau muaj kev cuam tshuam txog kev sib kis.
Immunoflluorescence microscopy
Cov txheej txheem no tso cai cov kws tshawb nrhiav kom pom cov protein ntau tsis pub dhau cov hlwb kis. Los ntawm kev siv fluorescented tiv thaiv cov tshuaj tiv thaiv fip tshwj xeeb, cov kws tshawb fawb tuaj yeem pom tau tias cov ntshav tawm hauv GS-4415
Piv nrog GS-441524 rau lwm tus RNA polymerase inhibitors
Thaum GS-441524 tau qhia cov lus cog tseg ua aFeline sib kis tus mob peritonitis kev kho, Nws yog qhov tseem ceeb kom nkag siab tias nws muab piv rau lwm tus RNA polymerase nyob rau hauv cov nqe lus ntawm kev ua tau zoo, kev nyab xeeb, thiab tshwj xeeb.
Remdesivir: Tus qauv sib piv
Remdesivir, lwm nucleoside analog, koom cov qauv txheej txheem sib xws nrog GS-441524. Ob lub tebchaw hom kab mob RNA Polymerases, tab sis Remdesivir tau kawm ntau dua rau nws cov kev cuam tshuam rau tib neeg coronaviruses. Muab piv rau ob qho txuas nrog tus kab mob FIP tuaj yeem muab cov kev pom zoo rau hauv lawv lub peev xwm raws li antiviral cov neeg sawv cev.
Favipiravir: ib qho dav-spectrum inhibitor
Favipiravir yog lub analog uas inhibits RNA-entent RNA Polymerases ntawm ntau hom kab mob RNA. Thaum nws tau pom tias cov kab mob sib txawv, nws yog qhov tshwj xeeb rau tus kab mob FIP yuav qis dua GS-441524. Kev ntsuam xyuas ob qho sib xyaw sab nraud tuaj yeem pab txiav txim siab cov kev xaiv uas tsim nyog tshaj plaws rau kev ua kom muaj kev mob peritonitis.
Ribavirin: ib qho tsim antiviral
Ribavirin, ib guanosine analog, tau siv los kho ntau yam kis tau tus kab mob ntau caum xyoo. Txawm hais tias nws cov tshuab ntawm kev nqis tes ua tsis yog txwv rau RNA polymerase inhibition, piv cov qauv fip tuaj yeem muab cov kev ntsuas ntawm cov neeg muaj txiaj ntsig yav dhau los ua tus saib xyuas kev kho mob.
Kev tshuaj xyuas qhov tshwj xeeb thiab tawm-hom phiaj cuam tshuam
Thaum sib piv RNA polymerase inhibitors, nws yog qhov tseem ceeb los xav txog lawv qhov tshwj xeeb rau viral polymerases tshaj cov enzymes. GS-441524 qhov tseeb rau viral RNA polymerases ua rau nws cov kev nyab xeeb kev nyab xeeb profile. Kev ntsuam xyuas qhov sib xyaw ua ke ntawm cov tswv yim ntawm tes polymerases thiab sib piv nrog lwm tus neeg tsis muaj peev xwm pab tau nws cov txiaj ntsig zoo raws li tus neeg sawv cev kho.
Kev Loj Hlob Peev Xwm
Qhov tshwm sim ntawm cov tshuaj-resistant kis yog ib qho kev txhawj xeeb rau ib qho kev tiv thaiv kab mob. Kev tshuaj xyuas cov kev nyiam ua rau GS-441524 thiab piv nws rau lwm tus RNA polymerase tuaj yeem ua kom muaj kev tiv thaiv kab mob peritonitis.
Cov Kev Kho Ua Ke
Tshawb nrhiav cov peev txheej hauv GS-441524 nrog rau lwm cov antiiviral tebchaw lossis immunomodators tuaj yeem qhib cov kev kho mob tshiab zoo dua. Txheeb xyuas ntau yam kev sib xyaw ua ke thiab muab piv rau lawv rau cov kev sib txuam ntawm monotherapy tuaj yeem pab ua kom zoo ua kom zoo.
Kev Nyab Xeeb Profile EVua kom ua kom muaj kev ua kom ua
Kev nyab xeeb ntawm ib qho kev sib txawv ntawm cov antiviral compound yog qhov tseem ceeb, tshwj xeeb yog thaum txiav txim siab cov kev tswj hwm ncua ntev. Kev tshuaj xyuas cov toxicity profiles ntawm GS-441524 thiab lwm tus qauv RNA tuaj yeem pab txheeb xyuas cov peev xwm tshwm sim thiab cov tswv yim dating rau cov ntawv thov kev kho mob.
Txoj kev tswj hwm kev tswj hwm
Txoj kev zoo tshaj plaws ntawm kev tswj hwm rau kev sib xyaw ua ke tuaj yeem cuam tshuam nws txoj kev ua tau zoo thiab kev coj ua zoo li kev kho mob. Muab piv rau cov xyoob thiab cov txiaj ntsig ntawm GS-441524 Thaum cov kev sib txawv ntawm cov kev sib txawv (ERCUTIVEFeline sib kis tus mob peritonitis kev kho.
Nqi tau txais txiaj ntsig kev txheeb xyuas
Thaum ua tau zoo thiab kev nyab xeeb yog thawj qhov kev txhawj xeeb, tus nqi-ua tau zoo ntawm kev kho mob tseem yog qhov kev txiav txim siab tseem ceeb, tshwj xeeb tshaj yog rau kev siv veterinary. Muab piv rau cov nqi ntau lawm, yuav tsum tau noj tshuaj, thiab kho cov durations ntawm GS-441524 mus rau lwm tus RNA polymerase yuav muaj peev xwm xaiv cov kev kho mob FIP ua kom zoo.
Muaj peev xwm rau Prophylactic siv
Ntxiv rau kev kho tus mob fip active fip uas nquag, kawm txog GS-441524 thiab lwm tus RNA polymerase tuaj yeem qhib txoj hauv kev tshiab rau kev tiv thaiv kab mob. Muab piv lawv cov txiaj ntsig hauv kev tiv thaiv tus kab mob kis thaum muab ua ntej lossis tsis ntev tom qab kis tau cov tswv yim rau kev tswj cov neeg muaj kev pheej hmoo siab.
Hla-reactivity nrog lwm feline coronaviruses
Thaum FIP yog lub hom phiaj tseem ceeb rau GS-441524, ntsuas nws cov haujlwm tawm tsam lwm yam kev ua kom ruaj khov rau hauv nws cov peev txheej dav dav. Muab piv rau cov spectrum ntawm GS-441524 mus rau lwm tus RNA polymerase tiv thaiv ntau yam voronavirus tuaj yeem pab txiav txim siab nws cov versatility uas yog cov tshuaj tua kab mob veterinary.
Tag
Hauv kev xaus, qhov cuam tshuam ntawmGs 441524 HmoovNtawm FIP RNA Polymerase cov kev ua si sawv cev rau txoj kev nce qib tseem ceeb hauv kev ua feline kis rau kev sib kis tus mob peritiCitt. Los ntawm zoo inhibitingariting viral replication, qhov no compound muaj kev cia siab rau cov miv cuam tshuam los ntawm cov kab mob no mob siab. Raws li kev tshawb fawb txuas ntxiv mus, kev txheeb xyuas cov kev sib piv ntawm GS-441524 nrog lwm cov RNA polymerase yuav ua rau muaj cov tswv yim zoo thiab ua rau cov FIP.
Rau cov tuam txhab ua lag luam thiab cov chaw tshawb fawb nrhiav cov hmoov zoo GS-441524 thiab lwm cov tshuaj sib txuas ua ke tshwj xeeb, Nrog peb lub xeev-ntawm-AR-ART GMP-ntawv pov thawj cov khoom lag luam thiab kev txawj ntse hauv ntau qhov kev xav tau koj cov kev xav tau rau cov tshuaj tshwj xeeb. Txawm hais tias koj nyob hauv kev lag luam kws tshuaj, polymer thiab plastics sector, lossis cov pab pawg tshwj xeeb, peb pab pawg tau npaj los pab koj. Xav paub ntau ntxiv txog peb cov khoom lag luam thiab peb tuaj yeem txhawb nqa koj txoj kev tshawb fawb thiab kev tsim kho kev tsim kho, thov hu rau peb ntawmSales@bloomtechz.comCov. Cia peb ua haujlwm ua ke ua ke ua ke ntawm feline kis rau kev kho mob peritonitis kev kho thiab lwm yam tseem ceeb ntawm kev tshawb fawb.
Ntawv Sawv cev
1. Murphy, BG, li al. (2020). "Tus nucleoside analog GS-441524 tau muaj zog feline rau cov kab mob peritonitis (FIP) hauv cov kev mob tus kab mob thiab sim cov miv cov kev cog lus." ERETERINER MEDIANTHRY, 219: 108452.
2. Pedersen, NC, li al. (2019). "Kev ua tau zoo thiab kev nyab xeeb ntawm nucleoside analog GS-441524 rau kev kho mob ntawm cov miv uas muaj kev kis felitonitis." Phau ntawv Journal of Felegine tshuaj thiab kev phais mob, 21 (4): 271-281.
3. Kim, Y., li al. (2020). "Cov tshuaj tua kab mob dav dav tiv thaiv 3C lossis 3c-zoo li cov kev tiv thaiv ntawm picorniruses, cov neeg nooviruses, thiab cov tub sab." Phau ntawv Journal of VIRTERITY, 94 (4): E01975-19.
4. Dickinson, PJ, li al. (2020). "Kev kho mob tiv thaiv siv adenosine nucleoside analogue gs-441524 hauv miv nrog kuaj xyuas cov neeg neurboritis mob." Phau ntawv Journary ntawm Veterinary Internal Tshuaj, 34 (4): 1587-1593.