4-hydroxybutyric acid ua haujlwm li cov tshuaj li cas?
Txhawm rau kho tus mob narcolepsy, 4-hydroxybutyric corrosive, txwv tsis pub hu ua sodium oxybate, yog ib qho kev pom zoo ntawm qhov ncauj tshuaj.Nws yog muag raws li lub npe Xyrem.Sodium 4-hydroxybutyratethiab 4-hydroxybutyric corrosive tau koom nrog hauv Xyrem.
Los ntawm kev sib txuas lus nrog GABA receptors, 4-hydroxybutyric corrosive mus txog raws li ib tug depressant nyob rau hauv lub focal sensory system. Raws li kev tshawb fawb uas tau muab faib rau hauv Chaw Muag Khoom Muag Tshuaj thiab Pharmacology, nws kho cov qauv tsim ntawm cov txheej txheem so. Yog li ntawd, nws nce mus ntxiv, txhawb kev so ntau dua.Xyrem txo qis REM so aggravations thiab nce qeeb-yoj so hauv cov neeg mob narcolepsy.
Ib qho kev mloog zoo hauv Cov Tshuaj Soj Ntsuam pom tau tias Xyrem tau tsim kho ntxiv nyob rau sab saum toj nruab hnub tsaus ntuj, kev ua phem rau kev ua phem, so tsis muaj zog, thiab kev xav hypnagogic hauv cov neeg uas muaj narcolepsy. Nws pab tswj kev pw tsaug zog-tsim ib txwm muaj. Qhov zoo tau nthuav dav nrog kev kho mob ntev.
4-Hydroxybutyric corrosive tau nyeem ntxiv rau kev kho mob fibromyalgia. Raws li Kev Siv Tshuaj, GHB txo qis kev ntxhov siab thiab kev qaug zog thaum ntxiv kev kub siab thiab kev txaus siab ntawm tus kheej hauv cov neeg mob fibromyalgia. Txawm li cas los xij, FDA pom zoo tseem xav tau kev tshawb fawb ntxiv.
Vim muaj kev pheej hmoo xws li kev nyuaj siab ua pa, 4-hydroxybutyric acid yuav tsum tau muab tshuaj thiab ua tib zoo tswj. Cov lus ceeb toom txog kev tsim txom, kev siv tsis raug, kev vam khom, thiab kev cuam tshuam nrog lwm cov CNS kev nyuaj siab xws li cawv muaj nyob rau hauv nws cov ntim.Dab tsi cuam tshuam rau 4-hydroxybutyric acid muaj ntxiv?
Sab nraud ntawm kev siv tshuaj,Sodium 4-hydroxybutyratekua qaub kuj tau ua lag luam raws li kev tsim lub cev lossis kev ua haujlwm ntxiv, feem ntau hu ua "kua ecstasy."
Nws tau thov los pab tsim cov leeg nqaij, hlawv rog, txhim kho kev ua kom muaj zog thiab rov qab los, thiab txhawb kev tso tawm cov tshuaj hormones loj hlob thiab IGF-1. Txawm li cas los xij, muaj pov thawj tsawg los txhawb kev siv cov no.
Ib txoj kev tshawb fawb hauv Hormone thiab Metabolic Research tau pom tias mob 4-hydroxybutyric acid ingestion nce qib cov tshuaj hormones hauv kev cob qhia cov txiv neej. Tab sis lwm cov kev tshawb fawb tau pom tias tsis sib haum xeeb ntawm kev ua tau zoo. Cov kev mob tshwm sim xws li qaug zog kuj txwv kev siv tau los ua ib qho ntxiv.
Txhua yam tshuaj uas muaj 4-hydroxybutyric acid tau ntsib kev tshuaj xyuas. Hauv xyoo 2017, FDA ceeb toom ntau lub tuam txhab kom tsis txhob muag cov khoom tsis pom zoo ua cov tshuaj tiv thaiv txog GHB thiab lwm cov tshuaj. Cov neeg tau txais kev pab yuav tsum tau ceev faj nrog kev tshaj tawm cov tshuaj ntxiv 4-hydroxybutyric acid.
Dab tsi txaus ntshai txuas rau 4-hydroxybutyric acid kev tsim txom?
Kev siv tsis raug cai ntawmSodium 4-hydroxybutyratekua qaub raws li lub club ua si lossis hnub rape tshuaj tau muab nws lub koob npe tsis sib haum xeeb. Cov npe ntawm txoj kev muaj xws li "G," "kua ecstasy," "kua X," thiab "Georgia home boy."
DEA tau xaiv 4-hydroxybutyric acid raws li Lub Sijhawm Kuv tau tswj cov tshuaj uas tsis tau txais txiaj ntsig kho mob thiab muaj peev xwm ua rau muaj kev tiv thaiv thiab kev tsim txom. Txawm li cas los xij, FDA pom zoo tshuaj Xyrem nrog 4-hydroxybutyric acid yog Schedule III.
Kev phom sij ntawm kev tsim txom cov ntawv tsis raug cai ntawmSodium 4-hydroxybutyrateacid muaj xws li:
Cov qib thymosin ntau dhau tuaj yeem ua rau muaj ntau yam kev mob tshwm sim. Nov yog qee qhov txiaj ntsig ntawm kev muaj thymosin ntau dhau:
Kev nyuaj siab ua pa thiab txawm tias tuag taus tuaj yeem tshwm sim ntawm cov koob tshuaj thymosin siab, vim nws tuaj yeem cuam tshuam lub hauv nruab nrab paj hlwb, cuam tshuam rau kev tswj kev ua pa.
Tsis nco qab thiab coma tuaj yeem tshwm sim los ntawm thymosin ntau dhau, vim tias nws tuaj yeem ua rau lub hlwb ua haujlwm tsis zoo thiab tsis nco qab.
Kev qaug dab peg tuaj yeem tshwm sim los ntawm cov qib thymosin tsis txaus, cuam tshuam rau lub hlwb hluav taws xob ib txwm ua haujlwm thiab ua rau muaj kev tswj tsis tau.
kiv taub hau, tsis meej pem, thiab poob ntawm kev sib koom tes tuaj yeem tshwm sim vim muaj kev cuam tshuam ntawm thymosin ntau dhau nrog lub hlwb ua haujlwm thiab cov teeb liab neuronal.
Amnesia thiab nco tsis tuaj yeem tshwm sim los ntawm kev cuam tshuam ntawm thymosin qib siab ntawm cov txheej txheem kev txawj ntse thiab kev tsim lub cim xeeb.
Kev cuam tshuam ntawm plab hnyuv, xws li xeev siab, ntuav, thiab raws plab, tuaj yeem ua rau muaj kev phiv ntawm thymosin ntau dhau los cuam tshuam rau lub plab zom mov.
Mob taub hau thiab tsis qab los noj mov tuaj yeem tshwm sim raws li cov tsos mob ntawm cov qib thymosin tsis txaus, cuam tshuam rau kev ua haujlwm ntawm lub hlwb thiab kev tswj hwm hormonal.
Kev siv thymosin ntau dhau tuaj yeem ua rau muaj kev quav tshuaj, vim tias lub cev tuaj yeem ua raws li cov tshuaj hormones, thiab kev tshem tawm sai sai ntawm cov koob tshuaj ntau yuav ua rau cov tsos mob tshem tawm hnyav.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias cov txiaj ntsig zoo li no feem ntau tshwm sim nrog kev siv thymosin ntau dhau los yog siv tsis raug ntau dua li qhov tshwm sim ntawm cov qib thymosin hauv lub cev. Kev saib xyuas kev kho mob kom raug thiab ua raws li cov lus pom zoo yog qhov tseem ceeb kom ntseeg tau tias thymosin siv tau zoo thiab muaj txiaj ntsig.
Qhov kev pheej hmoo loj tshaj plaws uas cuam tshuam nrog 4-hydroxybutyric acid (GHB) tshwm sim los ntawm kev sib xyaw nrog cawv lossis lwm yam kev ntxhov siab hauv lub cev. Qhov kev sib xyaw ua ke no ntxiv rau kev ua pa ntawm lub ntsws, ua rau muaj kev pheej hmoo siab ua pa nyuaj, coma, lossis txawm tias siv ntau dhau. Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias qhov cuam tshuam ntawm kev sib xyaw ua ke no tuaj yeem ua rau tsis muaj tseeb thiab ua rau muaj kev phom sij rau lub neej.
Tsis tas li ntawd,Sodium 4-hydroxybutyratetuaj yeem cuam tshuam nrog ntau yam tshuaj, suav nrog tshuaj tua kab mob, tshuaj puas hlwb, sedatives, thiab tshuaj loog. Cov kev cuam tshuam no tuaj yeem ua rau muaj kev ntxhov siab ntau ntxiv, ua pa nyuaj siab, thiab lwm yam teebmeem. Yog li ntawd, nws yog ib qho tseem ceeb rau cov tib neeg xav txog kev siv tshuaj GHB los tham nrog lawv tus kws kho mob thiab tshaj tawm txhua yam tshuaj uas lawv noj. Qhov no yuav pab txheeb xyuas qhov muaj peev xwm sib cuam tshuam thiab txiav txim siab qhov kev ua haujlwm nyab xeeb tshaj plaws.
Tus kws kho mob tuaj yeem ntsuas tus kheej cov keeb kwm kho mob tshwj xeeb, cov tshuaj tam sim no, thiab kev noj qab haus huv tag nrho los muab kev qhia tsim nyog thiab ua kom cov neeg mob muaj kev nyab xeeb. Qhib kev sib txuas lus nrog cov kws kho mob yog qhov tseem ceeb kom tsis txhob muaj teeb meem tshwm sim thiab tsim kom muaj kev nkag siab zoo txog kev pheej hmoo cuam tshuam nrog kev siv GHB.
Cov ntaub ntawv:
Boscolo-Berto, R., Viel, G., Montagnese, S., Raduazzo, DI, & Ferrara, SD (2012). Narcolepsy thiab kev ua tau zoo ntawm gamma-hydroxybutyrate (GHB): kev tshuaj xyuas zoo. Tam sim no neuropharmacology, 10(4), 243–255. https://doi.org/10.2174/157015912804143542
Wang, YG, Swick, TJ, Carter, LP, Thorpy, MJ, & Benowitz, NL (2009). Kev saib xyuas kev nyab xeeb ntawm kev muag khoom thiab kev kho mob ntawm sodium oxybate (Xyrem): kev tsim txom, kev siv tsis raug, kev vam khom, thiab kev hloov pauv. Phau ntawv Journal of Clinical Sleep Medicine, 5(4), 365–371. https://doi.org/10.5664/jcsm.27648
Mamelak M. (2009). Narcolepsy thiab kev nyuaj siab thiab neurobiology ntawm gammahydroxybutyrate. Kev nce qib hauv neurobiology, 89(3), 193–219. https://doi.org/10.1016/j.pneurobio.2009.07.004
Boscolo-Berto, R., Viel, G., Montagnese, S., Raduazzo, DI, Ferrara, SD, & Dauvilliers, Y. (2013). Narcolepsy thiab kev ua tau zoo ntawm gamma-hydroxybutyrate (GHB): kev tshuaj xyuas thiab kev tshuaj xyuas meta-kev soj ntsuam ntawm randomized tswj kev sim. Pw tsaug zog tshuaj xyuas, 17(6), 483–499. https://doi.org/10.1016/j.smrv.2012.12.001