5-Methoxytryptamine, rau feem ntau hu ua 5-MeO-tryptamine lossis 5-MeO-T, yog ib qho tshwm sim tsis tu ncua uas muaj qhov chaw nrog tryptamine alkaloids tsev neeg. dej haus. Remarkably, nws imparts loj cheeb tsam ntawm lub zog rau ib tug mus rau serotonin, ib tug synapse fundamentally taug qab nyob rau hauv lub cerebrum ntawm lub siab.
5-Methoxytryptamine mus txog raws li ib tug muaj zog agonist (activator) ntawm serotonin receptors nyob rau hauv lub paj hlwb thiab fringe ntaub so ntswg. Nws yog lub npe hu rau nws cov kev puas siab puas ntsws thiab kev puas siab puas ntsws, feem ntau ua rau muaj kev xav tsis thoob thiab hloov pauv ntawm kev paub. Nws yog suav hais tias yog ib yam khoom psychedelic.
Thaum 5-Methoxytryptamine tshwm sim ib txwm nyob hauv cov nroj tsuag tshwj xeeb, nws tuaj yeem sib xyaw ua ke hauv cov chaw sim rau kev tshawb fawb thiab kev siv kis las. Kev coj ntawm sab ntsuj plig thiab kev kho mob qee zaus siv nws, raws li kev tshawb fawb txog nws cov teebmeem ntawm tus cwj pwm thiab lub hlwb ua haujlwm.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev siv ntawm 5-Methoxytryptamine qhia qhov yuav muaj kev phom sij, ob qho tib si tiag tiag thiab lub hlwb.Nws siv kev ua si tsis raug cai hauv ntau lub tebchaws, thiab txawm tias kev tshawb fawb nrog cov tshuaj no yuav tsum tau ua raws li cov lus qhia nruj thiab kev tswj hwm. saib xyuas. Nws raug nquahu kom ua raws li kev siv 5-Methoxytryptamine nrog ceev faj thiab ua qhov tseem ceeb rau kev nyab xeeb ntawm tus kheej thiab kev txiav txim siab raws cai.
Cov qauv tshuaj thiab cov khoom ntawm 5-methoxytryptamine yog dab tsi?
5-Methoxytryptamine(5-MT), feem ntau hu ua mexamine, yog cov yam ntxwv sib xyaw uas muaj qhov chaw nrog cov chav kawm tryptamine. Nws tsim kev txhim kho suav nrog lub nplhaib indole koom nrog ethylamine pob, nrog rau kev hloov pauv methoxy pob ntawm 5 txoj haujlwm.
5-MT muaj sub-atomic load ntawm 190.24 g / mol thiab ib daim ntawv qhia atomic ntawm C11H14N2O. Cov khoom tseem ceeb ntawm 5-methoxytryptamine suav nrog:
① 5-Methoxytryptamine yog cov khoom sib xyaw uas zoo li cov iav dawb zoo li hmoov ntawm chav tsev kub. Nws muaj qhov ntsuas qhov ntsuas qhov ntsuas ntawm 148-150 degree, qhov twg nws hloov pauv los ntawm thaj chaw loj ntawm lub zog rau lub xeev ua kua. Nws muaj qhov nruab nrab ntawm li 10 milligrams rau txhua milliliter (mg / mL) hauv dej, tuaj me ntsis dissolvable. Txawm li cas los xij, nws qhia tau tias muaj kev sib cais ntau dua hauv cov kuab tshuaj li niaj zaus xws li ethanol thiab CH3) 2CO.
② Ib qho yeeb yam ntawm 5-Methoxytryptamine yog nws lub peev xwm los ua kom lub teeb ci (UV) ci. Nws qhia txog kev tuav tuav ntawm cov zaus ntawm 226 nanometers (nm) thiab 287 nm. Qhov kev tuav pov hwm ntawm UV teeb no feem ntau siv los paub txog thiab rhuav tshem qhov sib xyaw hauv chav kuaj.
③ Cov khoom siv lub cev thiab cov khoom siv hluavtaws no ntxiv rau ID thiab kev tshawb nrhiav ntawm 5-Methoxytryptamine, sau rau hauv cov yam ntxwv tseem ceeb rau nws qhov kev tshawb pom, kev piav qhia, thiab kev sib cais los ntawm cov khoom sib txawv. Lawv muab cov kws tshaj lij thiab cov kws tshuaj ntsuam xyuas nrog cov ntaub ntawv tseem ceeb rau tus ID thiab kev kwv yees ntawm qhov sib xyaw no hauv ntau daim ntawv thov, raws li kev ntsuas kev xav, kev tshawb fawb tshuaj, thiab kev ntsuas tshuaj.
④ 5-Methoxytryptaminemuaj ob qho tib si hydrophilic thiab lipophilic koog tsev kawm ntawv hauv nws txoj kev tsim kho atomic. Qhov no zoo kawg nkaus tivthaiv tso cai rau nws nkag mus rau hauv lipid films, zoo li cell txheej, txawj ntse. Lub cheeb tsam hydrophilic amine thiab lipophilic indole cheeb tsam ntxiv rau nws cov yeeb yaj kiab nkag mus rau cov khoom.
⑤ Ntawm physiological pH, 5-Methoxytryptamine muaj nyob rau hauv nws cov qauv cationic vim muaj ib qho tseem ceeb ethylamine pawg. Tus nqi pKa ntawm ethylamine pawg yog kwv yees li 9.8, npaj siab tias ntawm pH qib ze lossis tshaj qhov muaj nqis, feem ntau ntawm cov khoom sib xyaw yuav nyob hauv nws cov qauv txiav txim siab.
⑥ Lub hauv paus sub-atomic ntawm 5-Methoxytryptamine intently zoo li cov serotonin thiab melatonin, uas yog cov synapses tseem ceeb. 5-Methoxytryptamine tuaj yeem sib txuas lus nrog ntau yam monoamine receptors nyob rau hauv lub focal sensory system ua tsaug rau qhov kev sim ua ntej no. Cov kev sib koom tes no tuaj yeem cuam tshuam txog kev chij neural thiab tejzaum nws kho lub voj voog ntawm lub cev, piv txwv li, lub xeev ntawm lub siab cov lus qhia, so cycles, thiab lwm yam synapse cuam tshuam lub peev xwm.
⑦ Kev sib xyaw ntawm nws txoj kev nkag mus rau hauv cov yeeb yaj kiab lipid, cov qauv cationic ntawm lub cev pH, thiab cov hauv paus ze rau synapses ntxiv rau cov khoom siv tshuaj ntawm 5-Methoxytryptamine. Cov cwj pwm no txhawb nqa nws txoj kev koom tes nrog cov neeg txais kev paub meej thiab ua rau tweak ntawm neuronal zog, ua rau nws muaj kev txaus siab rau kev tshawb nrhiav ntxiv txog kev tshawb fawb txog neuroscience thiab kev qhia tshuaj.
Lub chaw indole muab cov tshuaj tsw qab hloov thaum lub methoxy thiab amine bunches ntxiv qhov kawg thiab hydrogen tuav peev xwm. Los ntawm loj thiab loj, tus qauv tsim tso cai rau 5-MT hla ciam teb ntshav siab.
Dab tsi yog txoj hauv kev biosynthesis thiab metabolism ntawm 5-methoxytryptamine?
5-Methoxytryptamine yog biosynthesized hauv pineal lub cev los ntawm serotonin hauv ob theem:
1. Hydroxylation: Serotonin (5-HT) yog hydroxylated ntawm 5 qhov xwm txheej los ntawm impetus tryptamine 5-hydroxylase, ntxiv ib pob hydroxy (- Goodness) .
2. Methylation: Qhov tshwm sim ntawm 5-hydroxytryptamine nruab nrab yog methylated ntawm 5-hydroxy tshwm sim los ntawm impetus hydroxyindole-O-methyltransferase (HIOMT), hloov dua hydroxy tau-ua ke rau hauv methoxy (- OCH3) bundle thiab outlineing5-methoxytryptamine.
Cov tshuaj Monoamine oxidase corrupt 5-MT rau kev zom:
1. Deamination: Los ntawm oxidative deamination, monoamine oxidase An los yog B tshem tawm cov ethylamine pawg los ntawm 5-MT, nqa txog aldehyde nruab nrab 5-methoxyindole-3-acetaldehyde.
2. Oxidation: Oxidation: Lub aldehyde tseem oxidized los ntawm aldehyde dehydrogenase rau hauv 5-methoxyindole-3-acidic puas.
3. Conjugation: Lub carboxylic destructive ces zoo li tus nrog glucuronic destructive rau kawg ntawm kev tso zis.
Enzymatic hydroxylation thiab methylation cov lus teb tsim 5-MT los ntawm serotonin, uas tom qab ntawd siv los ntawm monoamine oxidases rau hauv cov khoom debasement thiab tso tawm.
Dab tsi yog cov teebmeem tshuaj thiab kev siv ntawm 5-methoxytryptamine?
5-Methoxytryptaminemus txog raws li ib tug agonist ntawm txawv serotonin thiab melatonin receptor subtypes, tsim ib tug Scope ntawm pharmacological kev tshwm sim:
1.- Mob siab rau agonist txav ntawm serotonin 5-HT1, 5-HT2, thiab 5-HT7 receptors. Nws tuaj yeem ua tus serotonin chij.
2.- Kev txwv loj heev rau melatonin MT1, MT2, thiab MT3 receptor hauv zos. tib yam li melatonin.
3.- Calming cuam tshuam los ntawm kev cuam tshuam cytokine thiab nitric oxide tsim nyob rau hauv cov hlwb resistant.
4.- Kev kho mob (kev tsim txom) cuam tshuam hauv cov qauv tsim, tshwm sim los ntawm serotonin receptor agonism.
5.- Vasoconstrictive cuam tshuam rau cov leeg nqaij zoo li aorta.
6.- Tswj cov circadian rhythms thiab so ntawm lub voj voog tsim, pom zoo siv rau kev pw tsaug zog.
7.- Cov kev cuam tshuam sab saud tshwm sim hauv cov kev tshawb fawb nas, kwv yees los ntawm kev nthuav dav serotonin neurotransmission.
Vim tias nws cov tshuaj polypharmacology zoo sib xws, 5-MT yog siv los ntsuas cov haujlwm ntuj ntawm serotonin thiab melatonin receptors. Nws qhia tau hais tias muaj kev lav phib xaub raws li kev kho mob, txo qis, ua kom muaj zog, thiab so tus kws kho mob tshwj xeeb, txawm li cas los xij xav tau kev tshawb nrhiav ntau ntxiv ntawm nws cov ntawv thov muaj txiaj ntsig.
Cov ntaub ntawv:
1. Chen, JJ, Ly, PV, & Ansermino, M. (2020). 5-Methoxytryptamine: Ib qho Endogenous Pineal Hormone uas hloov cov lus teb ua rau mob. Phau ntawv Journal of Endocrinology, 245(1), R1-R6.
2. Dray, A. (1981). 5-Hydroxytryptamine thiab analgesia. Neuropharmacology, 20(4), 311-315.
3. Silman, RE, Leone, RM, Hooper, RJ, Preece, NE, & Soper, CR (1979). Melatonin, 5-methoxytryptamine thiab 5-methoxytryptophol: synthesis, txheeb xyuas thiab kom muaj nuj nqis hauv tib neeg lub caj pas pineal. Phau ntawv Journal of neural transmission, 45(3-4), 313–326.
4. Tanaka, E., North, RA, & Tokimasa, T. (1997). Cov teebmeem ntawm 5-methoxytryptamine ntawm cov haujlwm neuronal hauv nas cingulate cortex hauv vitro. British phau ntawv Journal of Pharmology, 120(7), 1327–1330.
5. Torsney, KM, & McPherson, J. (2014). 5-Methoxy-N, N-dimethyltryptamine (5-MeO-DMT), ib qho Endogenous Psychedelic: Qhov Tseeb, Lus Nug, thiab Intoxication. Tshuaj thiab Dej Cawv Hnub No, 14(3), 5.
6. Ursin R. Serotonin thiab pw tsaug zog. Pw Tsaug Med Rev. 2002 Aug; 6(4):55-67. doi: 10.1053/smrv.2002.0174 ib. PIB: 125311455.