CJC -1295 acetateTau txais kev sib tw tseem ceeb rau hauv lub xeev Peptide kev tshawb fawb vim nws qhov kev ua haujlwm zoo ntawm kev nqis tes ua. Cov hluavtaws no peptide analog ntawm kev loj hlob muaj kev loj hlob-gormed hormone (ghrh) tau piqued zoo ib yam rau nws lub peev xwm los txhawb kev loj hlob hormone zais cia. Hauv txoj kev tshawb nrhiav no, peb yuav tshem tawm ua haujlwm intricate ntawm CJC {}} acitate, thiab kev ua kom muaj kev ua haujlwm ntawm cov kab kev loj cellular.
Khoom Code: BM -2-4-007
Lub npe Askiv npe: CJC -1295 acetate
CAS TSIS MUAJ.: 863288-34-0
Molecular Cov Qauv: C152H252N44O42
Molecular hnyav: 3367.89688
Eineecs tsis muaj.: 206-141-6
HS code: /
Analysis items: HPLC>99. {{0%, lc-ms
Kev Lag Luam Tseem Ceeb: Tebchaws Asmeskas, Australia, Nyij Pooj, Tebchaws Yelemees, Indonesia, Tebchaws Askiv, Canada, thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM Tech Changzhou Hoobkas
Kev Pab Technology: R & Dept. {-3
Peb muab CJC -1295 acetate CAS {}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}}} Cov vev xaib no kom cov ncauj lus qhia ntxaws ntxaws thiab cov ntaub ntawv.
Khoom:https://www.bloomtechz.com/synthetic adcjc@tnepci611}} ait ay ubtml
CJC {{{{{0} х etate khi rau ghrh receptors?
Cov txheej txheem khi ntawm CJC -1295 acetate rau ghrh receptors yog qhov ntxim nyiam seev cev ntawm molecular paub thiab sib cuam tshuam. Cov qauv peptide no tau ua kom pom tseeb ua kom pom kev ua kom pom tseeb nrog cov khoom siv uas pom ntawm cov npoo ntawm Somatophrophs nyob rau hauv lub caj qaum anterior.
ThaumCJC -1295 acetateMus kom ze lub ghrh receptor, nws pib ua kev hloov pauv hloov. Qeb cov amino acid leigns nrog cov chaw khi tshwj xeeb nrog cov chaw khi tshwj xeeb ntawm cov receptor, sib sau lub xauv-thiab-tseem ceeb haum. Qhov kev sib tw no ua rau cov txheej txheem ntawm cov xwm txheej ntawm intracellular, teeb tsa theem rau peptide cov teebmeem.
Qhov kev khi lus ntawm CJC -1295 acetate rau ghrh receptors yog qhov tseem ceeb, tshaj tawm tias ntawm haiv neeg ghrh. Qhov kev txhim kho ib puag ncig yog ntaus nqi rau cov qauv Peptide hloov kho, uas muaj cov tswv yim hloov kho tshiab thiab ntxiv cov kev txhim kho nrog lub receptor. Qhov tshwm sim yog qhov ruaj khov dua thiab ntev dua kev sib txuas, uas ua rau muaj kev pab txhawb nqa peptide ncua ib nrab-lub neej thiab lub sijhawm ntev.
Ib qho ntawm cov txiaj ntsig tseem ceeb uas teeb CJC {{-1295 acetate sib nrug yog nws kev tshwm sim ntawm cov tshuaj affinity complex (dac) thev naus laus zis. Txoj kev tshiab no cuam tshuam nrog kev sib ntxiv ntawm Lysine Moiety, uas tso cai rau peptide rau khi rau cov hlab ntshav. Qhov no albumin khi tau cuam tshuam ntau dua txuas lub sij hawm peptide peptide ncig, ua rau nws muaj txiaj ntsig zoo thiab ntev ntawm kev nqis tes ua.
Cov txheej txheem khi tsis yog qhov xwm txheej zoo li qub tab sis kev sib txuam zoo. Raws li CJC {-1295 acetate koom nrog ghrh receptor, nws induces hloov maj mam hloov hauv cov receptor txoj cai. Cov kev hloov pauv no los ntawm cov qauv receptor, thaum kawg ua rau kev ua kom lub zog ntawm cov phiajcim ntawm cov kev teeb tsa. Qhov no molecular chaoreograph tau teeb tsa theem rau peptide txoj hlab kav, suav nrog kev ua kom muaj kev loj hlob ntawm cov kev loj hlob ntau synthesis thiab tso tawm.
Nws tsim nyog ceeb toom tias qhov kev khi ntawm CJC -1295 acetate rau ghrh receptors yog reversible. Qhov kev thim rov qab no yog qhov tseem ceeb rau kev tswj hwm lub cev sib npaug thiab tiv thaiv overerstimulation ntawm txoj kev loj hlob muaj axis. Thaum cov peptide dissetfiates los ntawm lub receptor, nws tuaj yeem tshem tawm los ntawm cov kab ke lossis cov kev xav tau mus rau lwm txoj kev xav thiab muaj kev tiv thaiv lub cev.
Qhov tshwj xeeb ntawm CJC -1295 acetate txoj hlua khi yog lwm qhov tseem ceeb ntawm nws cov tshuab. Thaum nws thawj lub hom phiaj ghrh ghrh ghrh gheptors, kev tshawb fawb tau pom tias nws kuj yuav muaj qee qhov kev sib txawv rau lwm tsev neeg hauv cov zais cia hauv tsev neeg. Qhov kev cuam tshuam dav dav no yuav pab tau qee qhov peptide qhov kev cuam tshuam rau kev loj hlob hormones feem ntau tsawg dua li nws ua thawj zaug ntawm ghrh receptors.
Nkag siab cov lus qhuab qhia ntawm CJC -1295 acetate txoj kev khi khi yog qhov tseem ceeb rau kev txaus siab rau nws cov kev ua. Qhov kev paub no tsis tsuas yog teeb meem peptide cov teebmeem tam sim no tab sis kuj tau txais kev nkag siab txog nws cov txheej txheem kev loj hlob thiab muaj feem xyuam ntawm cov txheej txheem kev loj hlob.
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CJC {-1295 acetate lub luag haujlwm hauv kev txhawb nqa GH Secition
Tub ntxhais mechanism ntawm kev nqis tes ua
CJC -1295 acetateUa tau kom muaj kev loj hlob muaj kev loj hlob muaj (Gh) Kev zais cia los ntawm kev sib txuas ua ke cov nraus-tso tawm (GHRH) kev ua yeeb yam nrog kev ua yeeb yam tshuaj yeeb (DAC). Qhov no ua rau thim rov qab albumin khi hauv kev ncig, tsim cov nyhuv reservoir uas tau ua haujlwm ntev peptide. Tsis zoo li luv luv-ua yeeb yam ghrh analogs, nws muaj cov ntshav siab sib luag ntawm cov ntshav, muab kev txhawb nqa cov khoom lag luam tsis tu ncua ntawm cov pa pituitary somatop.
Physiological Gh Tso Qauv
Lub peptide mimics ntuj ingatatile g recdion los ntawm kev zam cov hormonal ntse. Qhov no khov kho li lub cev nrog lub cev cov kab ke ntawm lub cev, txhawb cov txheej txheem ntawm qhov muag pom, cov txheej txheem anabolism, thiab cov txheej txheem indabolism. Xws li cov profile txo cov kev pheej hmoo ntawm cov kev mob tshwm sim zoo li cov dej ua kom muaj dej lossis cov tshuaj insulin tiv thaiv kom zoo rau abrosed grges g s surges.
Txhim Kho Cellular rhiab
Ntev ntev li CJC {{{acetate Upregulates ghrh receptor qhia thiab ua kom zoo tshaj plaws intracellular taw tes hauv Somatrotrophraph hlwb. Qhov kev xav tau zoo tshaj plaws ua kom pom tseeb lub pituitary cov lus teb rau Endogenous G-tso tawm cov cim kev lag luam uas tsis muaj kev tswj hwm lub ntuj.
Kev Sib Tham ntawm Somatostatin Kev Sib Tham
CJC {-1295 acetate yuav indirection suppress somatostatin lub chaw tsis pub muaj ntawm GH Secition. Los ntawm kev sib npaug ntawm ghrh-somatostatin axis, nws txuas ntxiv lub sijhawm tawm ntawm gh tso tawm thaum ua rau muaj kev kho hypothalic-pituitary tswv yim ntau dhau qib.
Ruaj khov igf -1 ntau lawm
Kev txhawb nqa GH Secition tsav insulin zoo li kev loj hlob 1 (i}}}}) synthesis hauv lub siab. Qhov kev ruaj ntseg txhim kho cov ntaub so mos cov ntaub so ntswg, lpholysis, thiab cov leeg kev loj hlob thaum tsis tshua muaj kev hloov pauv uas tuaj yeem cuam tshuam rau cov tswv yim sab nraud.
Kev Nyab Xeeb thiab Kev Tsim Kho Kev Nyab Xeeb
Lub cev peptide nyob rau hauv lub cev lub ntuj tswj hwm moj khaum. Nws cov txheej txheem albumin Qhov kev pheej hmoo no txo cov tsos mob ntawm lub tshuab hluav taws xob-zoo li cov tsos mob lossis tsis txaus ntseeg.
Chaw ua yeeb yam zoo
Dac Technology txuas ntxiv CJC -1295 acetate lub neej ib nrab-lub neej mus rau 6-8 hnub, tso cai tsawg dua koob tshuaj (2-3 zaug txhua lub lim tiam). Qhov kev sib thooj nrog cov peptides niaj hnub, kev txhim kho kev ua raws thiab txo kev txhaj tshuaj tiv thaiv kev ntxhov siab hauv chaw kuaj mob.
Kho cov tshuaj
Cov teeb meem kev noj qab haus huv: Tsiv ntuj Gh / i {}} theem kev txhawb nqa cov roj oxidation thiab qabzib.
Kev Tshawb Fawb Kev Tshawb Fawb: Mim cov hluas nkauj Gh pulsatility yuav tiv thaiv cov hnub nyoog muaj hnub nyoog tsawg hauv cov ntaub so ntswg kho.
Kev Rov Mus Los Ua Si: Txhim Kho Protein Synthesis Aids Kev Kho Mob thiab Kev Tiv Thaiv Mob leeg.
Cov Kev Txiav Txim Siab
Thaum txhawb kom muaj kev txhawb nqa GH tso tawm, CJC {{0} ette etection khaws cia cov kab ke circadian. Nws cov kev cuam tshuam yog tshuaj-nyob nrog, nrog kev tshawb fawb uas qhia tawm cov linear nce hauv i6 {2}} ntau txog 60-90 tus sawv. Cov ntaub ntawv kev nyab xeeb kev nyab xeeb nyob rau hauv kev tshawb nrhiav, tshwj xeeb yog hais txog lub sijhawm ua haujlwm ntev.
Hauv cov ntsiab lus, CJC -1295 acetate lub luag haujlwm hauv kev tshaj tawm cov kev tshaj tawm hauv peptide-raws li kev loj hlob hormone kev hloov kho. Los ntawm kev txhawb nqa ib qho qauv ntau dua ntawm gh tso tawm, tus peptide no muaj peev xwm ua tau zoo rau kev ua tau zoo, sab kev ua haujlwm sab nrauv, thiab kev siv tshuaj lom zem. Raws li kev tshawb fawb hauv thaj chaw no txuas ntxiv mus, peb txoj kev nkag siab txog kev txhawb nqa ntev ntawm kev txhawb nqa, muaj peev xwm qhib cov ntawv thov tshiab hauv ntau daim tebendocrinologythiab kev tshawb nrhiav metabolic.
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Vim li cas CJC -1295 acetate qhib campifate?
Cov khoom siv rov qab los thiab kev pw hav zoov Induction:CJC -1295 acetateBinds rau GHRH receptors ntawm pituitary somatoph hlwb, ua kom zoo ua cov khoom siv g-proteins (gs). Qhov no ua rau adenylyl cyclase kom hloov ATP rau hauv cyclic amp (chaw pw hav zoov
Downstream kos npe Cascade: nce kev pw tsaug zog protein Kinase A (PKA), uas phosphorylates cov khoom siv hluav taws xob zoo li CREBHOR. Cov kev tswj hwm cov noob no muaj feem cuam tshuam hauv GH Synthesis thiab tso tawm, ua kom muaj cov tshuaj hormones kom muaj kev sib hloov pauv.
Kev txhawb nqa txoj kev ua kom muaj zog: tsis zoo li ntuj GHRH, CJC {{acetate lub caij nyoog ib nrab-lub neej (ntawm Dac Technology) tswj hwm kev nce qib sijhawm sijhawm. Nruam receptor stimulation txhawb kev ruaj khov g tso zis, kev dag ntxias lub cev pulsatility.
Synergistic cuam tshuam nrog lwm cov ntawv zais cia: CJC {{acetate lub chaw pw hav zoov ua ke GH-tso peptides (GHRP) uas ua ntawm cov kab mob calcium-basw. Kev siv sib xyaw ua ke yuav ua kom nrov dua gh tso tawm los ntawm kev ua kom ntau txoj kev.
Kev loj hlob ntawm kev loj hlob thiab ciaj sia: Camp txhawb nqa Somatotroph cell protanderation thiab muaj peev xwm nthuav dav lub pituitary lub peev xwm dhau sijhawm. Qhov no tuaj yeem txhim kho kev ua tau ntev ntev hauv GH-tsis muaj lub xeev.
Dhau GL: Cov xwm txheej pw hav zoov: Peptide lub chaw pw hav zoov cuam tshuam lwm cov txheej txheem pituitary (piv txwv li cov nqaij mos) thiab cov nqaij mos, cuam tshuam nws qhov kev cuam tshuam.
Hla-tham nrog lwm txoj hauv kev: Thaum lub chaw pw hav zoov yog thawj lub ntsej muag, pab txhawb nqa Mapkolic thiab anti-apoptotics-thaj chaw ntawm kev tshawb fawb.
Kho lub peev xwm: Lub hom phiaj Camp yuav tau txais txiaj ntsig thiab muaj hnub nyoog ntsig txog Ywj. Txawm li cas los xij, kev pleev xim zoo nkauj yog qhov tseem ceeb kom tsis txhob cuam tshuam hormonal equilibrium.
Hauv kev xaus, kev ua kom muaj zog ntawm Camp Txoj kev los ntawm CJC -1295 acetate yog qhov tseem ceeb ntawm nws cov tshuab ntawm kev nqis tes ua. Tus txheej txheem no tsis yog tsav lub peptide thawj cov nyhuv ntawm kev loj hlob hormone securdion tab sis kuj ua rau muaj cov lus teb dav dav ntawm lub dag zog ntawm lub cev. Raws li peb txoj kev nkag siab txog cov phiajcim no tseem hloov kho tshiab, nws yuav qhib cov kev tshawb fawb tshiab thiab muaj feem xyuam nrog kev tshawb fawb Biomedical thiab muaj peev xwm kho cov kev cuam tshuam.
Tag
Hauv cov ntsiab lus, CJC -1295 acetate lub tshuab ua haujlwm yog cov khoom plig loj heev uas cuam tshuam nrog kev tso pa tawm, thiab ua kom muaj kev ua kom muaj txiaj ntsig ntawm cov kab kev zoo cellular. Nws lub peev xwm los khi kom zoo rau ghrh receptors, txuas nrog nws cov ntaub ntawv ntiag tug tshwj xeeb, tso cai rau kev tshaj tawm lub caij nyoog ntawm kev loj hlob ntawm kev loj hlob. Kev ua kom muaj zog ntawm campacways txuas ntxiv nws cov kev cuam tshuam nws cov kev cuam tshuam, tsis muaj kev loj hlob tsuas yog tseem muaj kev loj hlob ntawm kev ua haujlwm ntawm tes.
Intricate olollay ntawm cov txheej txheem no underscores qhov nyuaj ntawm CJC {{acetate nws qhov tseem ceeb tshaj plaws hauv cov ntsiab lus tshawb fawb. Raws li peb txuas ntxiv mus unravel lub nuans ntawm nws cov tshuab, peb yuav tsis siv cov ntawv thov tshiab thiab kev nkag siab ntawm cov txheej txheem kev loj hlob thiab muaj feem xyuam ntawm cov txheej txheem kev loj hlob.
Rau cov neeg nyob hauv cov chaw lag luam kws tshuaj nrhiav cov kws tshaj lij kev tshawb fawb, lossis rau cov khoom tshwj xeeb ua kom nruj Nrog peb lub xeev-ntawm-AR-ART GMP-ntawv pov thawj cov chaw tsim khoom thiab kev txawj ntse nyob rau ntau yam kev qhia tawm, peb yog zoo-kev xav tau raws li koj cov kev xav tau tshwj xeeb. Kom paub ntau ntxiv txog pebCJC -1295 acetatethiab lwm yam khoom siv tshuaj lom neeg, thov tsis txhob ua siab deb mus cuag peb ntawmSales@bloomtechz.comCov. Peb pab neeg tau npaj txhij los pab koj nrog koj cov lus nug thiab muab cov kev daws teeb meem rau koj cov kev thov lossis kev siv khoom siv.
Ntawv Sawv cev
Teichman, SL, li al. (2006). Lub sijhawm ntev ntawm kev loj hlob hormones loj (GH) thiab insulin zoo li kev loj hlob ntawm gh-tso tawm, hauv cov neeg laus noj qab nyob zoo. Phau ntawv sau txog kev kho mob endocrminology & metabolism, 91 (3), 799-805.
Ionescu, M., & FROHMAN, LA (2006). Pulsatile zais ntawm kev loj hlob hormone (GH) mob siab thaum lub sijhawm ua kom nrawm nrawm los ntawm CJC {1}}} Phau ntawv Journal of Seccompinology & metabolism, 91 (12), {6}}.
Alba, M., li al. (2006). Thaum-txhua lub lim tiam ntawm CJC -1295, ghrh) analog, li qub kev loj hlob hauv GHRH KNOCKOUT nas. Miskas phau ntawv xov xwm ntawm physiology-endocrinology thiab metabolism, 291 (6), e 1290- e1294.
Jetté, L., li al. (2005). Kev loj hlob ntawm tib neeg kev loj hlob Endocrminology, 146 (7), 3052-3058.