Ipamorelinpeptide (qhov txuas:https://www.bloomtechz.com/synthetic-chemical/peptide/lpamorelin-powder-cas-170851-70-4.html). peb tus neeg muag khoom ntawm Ipamorelin, peb muaj Ipamorelin muag. Cov khoom dawb, yooj yim soluble nyob rau hauv polar solvents xws li dej thiab methanol. Nws muaj pKa tus nqi ntawm 9.76 thiab nws lub xeev them nqi yog cationic hauv pH 7.4 tsis muaj tshuaj. Tsis tas li ntawd, Ipamorelin muaj kev sib hloov kho qhov muag ntawm ntxiv rau 79 degree (c=1, dej cawv tsis muaj dej), qhia tias nws yog optically active peptide.
Chemical structure:
Cov tshuaj formula ntawm Ipamorelin yog C38H49N9O5, tus txheeb ze molecular loj yog 711.86, thiab nws muaj 17 amino acid residues. Nws cov qauv yog:
H2N-(His-D-2-Nal-Ala-Trp-D-Phe-Lys)-NH2
Ntawm lawv, D-2-Nal sawv cev D-2-naphthylalanine, thiab D-Phe sawv cev D-phenylalanine. Tsis tas li ntawd, peptide kuj muaj ob yam amino acids tsis zoo, uas yog D-2-naphthylalanine thiab D-phenylalanine. Kev qhia txog cov amino acids tsis zoo no ua rau Ipamorelin tiv taus ntau dua rau kev degradation los ntawm proteases, yog li ua rau nws cov bioavailability thiab ib nrab-lub neej.
Ipamorelin yog ib qho kev loj hlob hormone tso tawm peptide (GHRP) uas tau kawm dav thiab siv los kho ntau yam kab mob. Nws lub luag haujlwm tseem ceeb yog txhawm rau txhim kho cov protein synthesis, pob txha ceev, cov leeg nqaij thiab lwm yam haujlwm hauv lub cev los ntawm kev txhawb nqa kev tso tawm ntawm kev loj hlob hormone hauv lub cev. Daim ntawv thov ntawm Ipamorelin nyob rau hauv ntau yam kab mob yuav qhia nyob rau hauv kom meej hauv qab no.
1. Txhim khu kev tiv thaiv thiab tiv thaiv kev laus:
Ipamorelin tuaj yeem txhim kho kev tiv thaiv kab mob thiab tiv thaiv kab mob los ntawm kev txhawb nqa kev tso tawm ntawm kev tiv thaiv kab mob xws li thymosin thiab tib neeg thymosin (hT 1). Tsis tas li ntawd, Ipamorelin tuaj yeem ua tiav cov teebmeem kev laus los ntawm kev nce qib ntawm antioxidants thiab txo qhov kev puas tsuaj ntawm cov dawb radicals rau lub cev.
2. Txhim kho kev nco, pw tsaug zog thiab mus ob peb vas:
Ipamorelin kuj muaj kev ua haujlwm ntawm kev txhim kho kev nco, pw tsaug zog thiab mus ob peb vas. Cov kev tshawb fawb tau pom tias Ipamorelin tuaj yeem txhawb qhov tshwm sim thiab kev loj hlob ntawm hippocampal neurons, thiab nce cov neurons hauv cheeb tsam hippocampal. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam rau neurotransmitters hauv lub hlwb, xws li dopamine, norepinephrine, thiab serotonin, yog li txhim kho kev pw tsaug zog thiab mus ob peb vas.
3. Txo cov tsos mob ntawm cov kab mob plawv:
Ipamorelin tuaj yeem txo cov tsos mob ntawm cov kab mob plawv los ntawm kev txhawb nqa kev loj hlob ntawm cov hlwb endothelial, ntxiv dag zog rau kev ua haujlwm ntawm cov hlwb endothelial thiab txo cov ntshav siab thiab lwm yam. Cov kev tshawb fawb tau pom tias Ipamorelin tuaj yeem txhim kho vascular endothelium-dependent so so, txo cov ntshav siab systolic thiab diastolic, thiab tau txais qee yam kev tiv thaiv atherosclerotic.
4. Kev kho mob rog:
Ipamorelin kuj tau kawm dav dav thiab siv los kho kev rog. Nws lub luag haujlwm tseem ceeb yog txo lub cev hnyav thiab lub cev rog thaum tswj cov leeg nqaij los ntawm kev txhawb nqa glycogen synthesis thiab kev siv fatty acid. Tsis tas li ntawd, Ipamorelin tseem tuaj yeem txhawb nqa qhov tso tawm ntawm cov tshuaj insulin zoo li kev loj hlob (IGF-1), yog li txhim kho insulin receptor rhiab heev thiab metabolism.
5. Txhim kho pob txha pob txha thiab pob txha pob txha:
Ipamorelin kuj tseem siv los txhim kho pob txha pob txha thiab mob xws li pob txha pob txha. Cov kev tshawb fawb tau pom tias Ipamorelin tuaj yeem txhawb kev loj hlob thiab kev sib txawv ntawm osteoblasts, thaum inhibiting cov haujlwm ntawm osteoclasts, yog li ua rau pob txha loj thiab pob txha ceev. Tsis tas li ntawd, nws tuaj yeem txhim kho calcium nqus thiab khaws cia, yog li txo qhov mob ntawm pob txha.
6. Txhim kho cov leeg nqaij thiab kev ua kis las:
Ipamorelin tseem tuaj yeem txhim kho cov leeg nqaij thiab kev ua kis las. Cov kev tshawb fawb tau pom tias Ipamorelin tuaj yeem txhawb kev tsim cov protein ntau thiab cov leeg nqaij ntawm tes, thaum inhibiting protein degradation thiab nqaij atrophy. Tsis tas li ntawd, nws txhim kho cov leeg lub zog thiab kev ua siab ntev, yog li txhim kho kev ua kis las thiab kev tawm dag zog.
7. Kho Mob thiab mob:
Ipamorelin kuj tseem siv los kho cov mob xws li mob thiab mob. Cov kev tshawb fawb tau pom tias Ipamorelin tuaj yeem txhawb lub apoptosis thiab tshem tawm cov hlwb inflammatory, thaum txo cov theem ntawm cov kab mob inflammatory. Tsis tas li ntawd, nws tuaj yeem txhim kho kev ua haujlwm ntawm lub cev tiv thaiv kab mob, yog li nws kuj muaj qee yam cuam tshuam rau cov kab mob tua kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob.
Hauv kev xaus, Ipamorelin yog dav siv los ua ghrelin hauv ntau qhov chaw. Nws lub luag haujlwm tseem ceeb yog los txhawb kev tso tawm ntawm kev loj hlob hormone hauv lub cev, yog li txhim kho cov haujlwm ntawm cov protein synthesis, pob txha ceev, thiab cov leeg nqaij hauv lub cev, thiab txhim kho kev tiv thaiv, tiv thaiv kev laus, nco, pw tsaug zog, kab mob plawv, rog, thiab pob txha ceev. , cov leeg nqaij, kev ua kis las, mob thiab mob txhua yam ua lub luag haujlwm. Nyob rau tib lub sijhawm, txhawm rau kom ntseeg tau tias cov haujlwm saum toj no, cov khoom lag luam kuj muaj ntau yam khoom sib xws, uas tau qhia raws li hauv qab no tsis hais qhov xwm txheej.
Chemical stability:
Ipamorelin yog qhov ruaj khov hauv vivo thiab feem ntau cuam tshuam los ntawm cov yam ntxwv xws li gastric acid, digestive enzymes thiab proteases. Cov kev tshawb fawb tau pom tias ib nrab lub neej ntawm peptide yog li 2 teev, thiab nws cov metabolites tseem ceeb yog amino acids thiab peptide saw fragmentation khoom.
Pharmacokinetics:
Ipamorelin muaj cov tshuaj pharmacokinetic zoo. Tom qab kev txhaj tshuaj subcutaneous lossis intravenous, nws nkag mus rau hauv cov hlab ntshav sai sai thiab ncav cuag qhov siab tshaj plaws hauv 30 feeb. Nws bioavailability yog kwv yees li 90 feem pua, thaum Tmax thiab T1/2 yog 15 thiab 120 feeb, feem. Tsis tas li ntawd, peptide feem ntau yog metabolized los ntawm lub siab, uas CYP450 enzyme system plays lub luag haujlwm tseem ceeb.
Pharmacodynamics:
Ipamorelin, raws li ghrelin, muaj ntau yam tshuaj pharmacodynamic. Nws lub luag haujlwm tseem ceeb yog los txhawb kev tsim tawm thiab tso tawm cov tshuaj hormone-tso tawm (GHRH) nyob rau hauv lub caj pas pituitary, yog li ua rau lub caj pas anterior pituitary secrete loj hlob hormone (GH). Kev loj hlob hormone feem ntau ua rau lub siab thiab lwm yam ntaub so ntswg hauv lub cev, txhawb lub cev kev loj hlob thiab kho cov txheej txheem.
Cov teebmeem pharmacodynamic ntawm Ipamorelin tuaj yeem muab faib ua cov hauv qab no:
1. Txhawb nqa protein synthesis:
Ipamorelin tuaj yeem txhawb kev sib txuas ntawm cov protein, yog li ua kom cov leeg nqaij, txhim kho pob txha ceev thiab kho qhov mob, thiab lwm yam. Cov kev tshawb fawb tau pom tias peptide txhawb kev noj qab haus huv thiab kev siv, nce oxidative metabolism thiab ATP synthesis, yog li txhawb cov txheej txheem protein synthesis.
2. Txhim kho kev tiv thaiv:
Ipamorelin tuaj yeem txhim kho kev tiv thaiv, yog li ua kom lub cev tiv thaiv kab mob. Cov kev tshawb fawb tau pom tias cov peptide no tuaj yeem txhawb kev tso tawm ntawm lub cev tiv thaiv kab mob xws li thymosin thiab tib neeg thymosin, thiab txhim kho kev tiv thaiv kab mob.
3. Txhim kho cov metabolism:
Ipamorelin tuaj yeem nce qib metabolic, yog li txhawb kev txo qis hauv lub cev thiab kev kho mob rog. Cov kev tshawb fawb tau pom tias peptide tuaj yeem txhawb nqa glycogen synthesis thiab fatty acid siv, txo fatty acid synthesis thiab cia, yog li txo lub cev hnyav thiab lub cev rog.
4. Txhim kho kev ua kis las:
Ipamorelin tuaj yeem txhim kho kev ua kis las, yog li ua kom muaj zog xws li cov leeg nqaij thiab kev ua siab ntev. Cov kev tshawb fawb tau pom tias peptide tuaj yeem txhawb kev loj hlob thiab sib txawv ntawm cov leeg nqaij, ua kom cov leeg nqaij thiab lub zog.
Hauv kev xaus, Ipamorelin muaj cov tshuaj pharmacokinetic zoo thiab ntau yam tshuaj muaj txiaj ntsig, thiab tuaj yeem siv los kho ntau yam kab mob. Nws cov tshuaj lom neeg ruaj khov thiab lub cev muaj zog kuj ua rau nws zoo tagnrho rau kev npaj cov tshuaj hormones loj hlob.