Selank(link:https://www.bloomtechz.com/synthetic-chemical/peptide/selank-peptide-cas-129954-34-3.html) yog cov khoom siv kho mob adjuvant, nws cov teebmeem tseem ceeb yog kev tiv thaiv kev ntxhov siab, tiv thaiv kev nyuaj siab, txhim kho kev nco thiab ntxiv dag zog rau lub cev thiab lwm yam. Selank belongs rau kev loj hlob hormone tso tawm peptide (GHRP) tsev neeg, xya-amino acid polypeptide uas suav nrog cov txheej txheem tiv thaiv neuroprotective, muaj peev xwm txo qis cov tsos mob ntawm kev ntxhov siab thiab kev nyuaj siab, thiab kev txawj ntse.
Lub physiological muaj nuj nqi ntawm Selank:
1. Kev ntxhov siab thiab tshuaj tiv thaiv kev nyuaj siab:
Cov teebmeem neuromodulatory ntawm Selank ua rau nws muaj txiaj ntsig zoo rau kev ntxhov siab thiab tshuaj tiv thaiv kev ntxhov siab. Cov tshuaj no txo qis qhov pib ntawm kev ntxhov siab thiab kev nyuaj siab los ntawm kev txo qis ntawm gamma-aminobutyric acid (GABA) thiab txhawb kev tsim tawm ntawm cov neurons. Qhov no tuaj yeem pab tau zoo rau cov neeg uas tsis xis nyob hauv kev sib raug zoo lossis xav tias ntxhov siab thiab tsis nyob hauv lawv lub neej txhua hnub.
2. Txhim kho kev nco thiab kev kawm muaj peev xwm:
Selank tuaj yeem txhim kho kev nco thiab kev kawm los ntawm kev nce qib ntawm cov neurotransmitter acetylcholine hauv lub hlwb. Txij li thaum acetylcholine yog ib qho tseem ceeb tshaj plaws neurotransmitters nyob rau hauv tib neeg lub hlwb, Selank tuaj yeem pab tib neeg txhim kho lub sij hawm ntev thiab luv luv nco thiab ua kom cov txheej txheem thiab khaws cov ntaub ntawv los ntawm kev nce nws cov ntsiab lus.
3. Txhim kho kev tiv thaiv:
Selank kuj tau pom tias ua haujlwm hauv kev txhawb nqa lub cev tiv thaiv kab mob los ntawm ntau lub tshuab. Qee cov kev tshawb fawb tau pom tias Selank tuaj yeem txhawb nqa tib neeg lub cev tiv thaiv kab mob los tsim cov qe ntshav dawb, tshuaj tiv thaiv kab mob thiab cytokines, thiab lwm yam, thiab txhim kho lub cev tiv thaiv kab mob. Tsis tas li ntawd, nws txo qhov mob thiab oxidative kev nyuaj siab, uas tuaj yeem pab txo cov tsos mob tshwm sim los ntawm qee yam kab mob autoimmune.
Kev kho mob ntawm Selank:
Tam sim no, Selank tau kawm dav thiab siv rau kev kho mob ntawm ntau yam kab mob. Qee daim ntawv thov kev kho mob tau teev tseg hauv qab no:
1. Kev ntxhov siab thiab tshuaj tiv thaiv kev nyuaj siab:
Selank tau pom tias txhim kho cov tsos mob ntawm kev nyuaj siab thiab kev ntxhov siab, suav nrog kev phobia, agoraphobia, OCD, phobias, thiab ntau dua. Tsis tas li ntawd, nws tuaj yeem txo cov teeb meem kev xav uas tshwm sim los ntawm cov xwm txheej xws li dysmenorrhea thiab menstrual syndrome.
2. Txhim kho kev txawj ntse:
Selank tau siv dav los kho kev paub tsis meej, suav nrog Alzheimer's disease, Parkinson's disease, mob hlwb thiab lwm yam kab mob neurodegenerative. Los ntawm kev txhim kho neuronal viability, txo cov neuronal puas, thiab nce qib acetylcholine, Selank txhim kho kev txawj ntse thiab kev nco.
3. Txhim kho kev pw tsaug zog zoo:
Selank kuj tseem siv tau los txhim kho kev pw tsaug zog zoo thiab txo qis kev tsaug zog thaum hmo ntuj. Nyob rau hauv cov theem thaum ntxov ntawm kev kho mob, raws li ib tug tshuaj rau kev puas hlwb qaug zog thiab kev nyuaj siab, Selank feem ntau pom tau tias ua hauj lwm zoo rau pw tsaug zog.
4. Txo cov tsos mob ntawm lub cev lupus erythematosus:
Hauv kev sim tsiaj thiab kev sim tshuaj tib neeg, Selank tau pom tias txo cov tsos mob ntawm cov neeg mob uas muaj kab mob lupus erythematosus, xws li qaug zog, insomnia thiab ntxhov siab vim.
Ua kom tiav, cov teebmeem tseem ceeb ntawm Selank yog kev tiv thaiv kev ntxhov siab, tiv thaiv kev nyuaj siab, txhim kho kev nco thiab txhim kho kev tiv thaiv. Nws tau raug tshawb fawb thiab siv rau hauv kev kho mob ntawm ntau yam kab mob, xws li kev ntxhov siab, kev nyuaj siab, kev paub tsis meej, kab mob lupus erythematosus, thiab lwm yam. Txawm li cas los xij, kev siv Selank tseem yuav tsum tau ua raws li tus kws kho mob cov lus qhia thiab ua raws. cov qauv ntawm cov tshuaj tsis tu ncua.
Selank yog polypeptide compound uas nws cov khoom muaj zog zoo ib yam li lwm cov polypeptides, feem ntau muaj kev cuam tshuam ntawm nws pawg thiab kev cuam tshuam nrog lwm cov molecules. Nyob rau hauv tus txheej txheem ntawm kev tshawb fawb thiab siv Selank, nws yog ib qho tseem ceeb heev kom to taub nws reactivity.
1. Hydrogen bond tsim:
Selank muaj 7 amino acid residues, 5 ntawm uas yog fatty amide pawg, 1 yog glycine thiab 1 yog alanine. Cov hydrogen thiab oxygen atoms nyob rau hauv cov residues tuaj yeem tsim kev sib cuam tshuam los ntawm hydrogen bonds, yog li tswj cov qauv spatial thiab stability ntawm polypeptide.
Nyob rau hauv Selank, acidic los yog yooj yim amino thiab carboxyl pawg tuaj yeem tsim kev cuam tshuam nrog hydrogen bonds hauv lwm cov amino acid residue. Piv txwv li, thaum cov amino pawg ntawm glycine residues tsim hydrogen bonds nrog cov amino pawg ntawm alanine residues, cov qauv spatial ntawm Selank hloov, uas yuav ua rau muaj kev hloov hauv nws cov tshuaj pharmacological.
2. Cov tshuaj tiv thaiv oxidation:
Lub molecule ntawm Selank muaj ntau carboxyl thiab amino pawg, uas yog yooj yim oxidized nyob rau hauv tej yam kev mob. Piv txwv li, nyob rau hauv lub xub ntiag ntawm oxygen, pawg carboxyl ntawm Selank tuaj yeem oxidized rau carboxylic acid, yog li hloov nws cov qauv spatial thiab pharmacological teebmeem.
Tsis tas li ntawd, sulfur oxides hauv Selank molecules kuj tuaj yeem raug oxidation tshwm sim. Nyob rau hauv lub xub ntiag ntawm oxygen, nws yuav ua rau sulfation thiab lwm yam alkylation tshuaj, yog li cuam tshuam rau nws pharmacological teebmeem.
3. Cov tshuaj tiv thaiv digestion:
Selank yog polypeptide uas yooj yim zom los ntawm cov enzymes xws li proteolytic enzymes. Cov enzymes no tuaj yeem hydrolyze peptide daim ntawv cog lus hauv Selank, yog li rhuav tshem nws mus rau hauv me me polypeptides lossis amino acid residues.
Hauv tib neeg lub cev, Selank feem ntau tawg los ntawm cov enzymes proteolytic hauv plab hnyuv. Yog li, cov tshuaj pharmacological ntawm Selank tuaj yeem cuam tshuam los ntawm kev zom zaub mov hauv qhov ncauj lossis kev txhaj tshuaj.
4. Cov tshuaj tiv thaiv condensation:
Lub molecule ntawm Selank muaj ntau yam amino acid residues, thiab condensation tshwm sim tuaj yeem tshwm sim ntawm cov residues. Piv txwv li, nyob rau hauv acidic los yog yooj yim tej yam kev mob, ib tug phosphite daim ntawv cog lus yuav tsim ntawm ib tug glycine residue thiab ib tug alanine residue, yog li tsim ib tug loj polypeptide molecule.
Qhov tshwm sim ntawm cov tshuaj tiv thaiv condensation feem ntau yuav tsum muaj qee yam mob, xws li acidic lossis alkaline ib puag ncig, kub kub thiab lwm yam. Yog li ntawd, nyob rau hauv lub chaw soj nstuam thiab daim ntawv thov, nws yog feem ntau tsim nyog los tswj cov kev mob thiab qhov npaum li cas ntawm cov condensation cov tshuaj tiv thaiv los xyuas kom meej qhov zoo thiab kev ua tau zoo ntawm cov khoom tau txais.
5. Lwm yam kev tshwm sim:
Ntxiv nrog rau cov tshuaj tiv thaiv saum toj no, Selank kuj tuaj yeem cuam tshuam nrog ntau yam ntawm lwm cov molecules. Piv txwv li, Selank tuaj yeem tsim kev sib koom ua ke nrog cov hlau ions, yog li cuam tshuam rau nws cov tshuaj pharmacological. Tsis tas li ntawd, Selank tuaj yeem cuam tshuam nrog lwm cov proteins los hloov lawv txoj haujlwm thiab cov qauv spatial.
Zuag qhia tag nrho, cov tshuaj tiv thaiv ntawm Selank zoo ib yam li lwm cov peptides, suav nrog hydrogen daim ntawv cog lus, cov tshuaj tiv thaiv oxidation, kev zom zaub mov, cov tshuaj tiv thaiv condensation, thiab cov tshuaj tiv thaiv nrog lwm cov molecules. Thaum ua ntawv thov thiab tshawb fawb Selank, nws yog ib qho tsim nyog yuav tsum xav txog cov kev cuam tshuam no thiab lawv cov teebmeem, thiab kho cov tshuaj tiv thaiv thiab cov txheej txheem kom tsim nyog los xyuas kom meej nws cov tshuaj pharmacological thiab zoo.