Lidocaineyog ib qho tshuaj loog hauv zos uas siv dav rau kev kho mob thaum phais, kho hniav, txheej txheem ntawm daim tawv nqaij, thiab lwm yam. Ntxiv nrog rau kev siv tshuaj loog, Lidocaine tau pom tias muaj ntau yam kev kho mob thiab tsis siv tshuaj kho mob.
1. Tshuaj loog:
Kev siv tseem ceeb ntawm Lidocaine yog ua tshuaj loog. Nws tuaj yeem txo qhov mob los ntawm inhibiting Na plus channels ntawm tus kheej neurons. Lidocaine feem ntau yog siv rau tshuaj loog hauv zos thaum phais, kho hniav, txheej txheem ntawm daim tawv nqaij, thiab lwm yam. Tsis tas li ntawd, Lidocaine kuj tseem siv tau los ua sedative hauv cov xwm txheej xws li kev phais plawv uas yuav tsum tau siv tshuaj loog.
Thib ob, kev kho mob ntawm arrhythmia:
Lidocaine kuj tseem siv los kho plawv arrhythmias. Txij li thaum Lidocaine tuaj yeem inhibit Na plus channel hauv lub plawv hlwb, nws tuaj yeem txo lossis tshem tawm qhov tsis xis nyob los ntawm arrhythmia. Vim Lidocaine muaj cov yam ntxwv ntawm kev ua haujlwm sai thiab cov nyhuv luv luv, nws muaj txiaj ntsig zoo hauv kev kho mob arrhythmia.
3. Kev kho mob qaug dab peg:
Lidocaine kuj tseem siv tau los ua ib qho ntawm cov tshuaj kho mob vwm, tshwj xeeb tshaj yog rau cov neeg uas muaj kev nyuaj siab ntxhov plawv. Cov nyhuv antiepileptic ntawm Lidocaine yog suav tias yog cuam tshuam nrog nws thaiv cov sodium ion channel hauv neurons. Qhov kom zoo dua ntawm Lidocaine nyob rau hauv nws qhov pib sai ntawm kev ua, kev hloov kho tau yooj yim, thiab muaj kev phiv tsawg.
Plaub, kev kho mob:
Ntxiv nrog rau kev ua tshuaj loog, Lidocaine kuj tuaj yeem siv los kho qhov mob ntawm lub hauv paus sib txawv. Piv txwv li, kev txhaj tshuaj Lidocaine hauv zos tuaj yeem txo cov tsos mob xws li mob neuropathic thiab mob leeg, thiab tib lub sijhawm txo qis kev tsis xis nyob xws li mob los ntawm kev kis kab mob lossis kev raug mob.
5. inhibit qhov tshem tawm cov tsos mob ntawm kev puas siab puas ntsws yeeb tshuaj:
Lidocaine kuj tau pom los pab txo qis cov tsos mob ntawm cov neeg quav yeeb quav tshuaj, haus cawv, cov neeg haus luam yeeb, thiab lwm yam. Lidocaine tau xav tias yuav txo qis cov tsos mob tawm los ntawm inhibiting neuronal kev ua haujlwm, thaum tseem txo qis kev xav tsis zoo xws li kev pom thiab hnov lus hnov.
6. Kev kho mob ntawm lwm yam kab mob:
Lidocaine kuj tseem siv tau los ua tshuaj los kho lwm yam mob, xws li cov leeg nqaij, tshee, thiab lwm yam mob. Nyob rau tib lub sijhawm, kev kho mob, Lidocaine kuj tau siv dav hauv kev tswj qhov mob ua ntej, thaum lub sijhawm thiab tom qab phais, nrog rau kev kho mob ntawm lub plawv, lub paj hlwb, thiab ua pa.
Tag nrho hauv tag nrho, raws li ib qho tshuaj loog hauv zos, Lidocaine tau siv dav hauv kev kho mob. Nws cov kev siv tseem ceeb suav nrog tshuaj loog, kev kho mob arrhythmia, kev kho mob vwm, kev kho mob, tshem tawm cov tsos mob ntawm kev puas siab puas ntsws, thiab kev kho mob ntawm lwm yam kab mob. Txawm hais tias Lidocaine muaj kev phiv me me, nws tseem yuav tsum tau siv nrog ceev faj thiab ua raws li cov lus qhia ntawm tus kws kho mob.
Thaum siv Lidocaine, peb yuav tsum xav txog tag nrho nws cov khoom reactive, uas yuav pab peb nkag siab thiab siv nws zoo dua. Hauv qab no yog cov lus piav qhia ntxaws ntxaws ntawm tag nrho cov reactive zog ntawm Lidocaine:
1. Acidity thiab alkalinity:
Lidocaine yog ib qho amine compound, yog li nws yog alkaline hauv kev daws. Lidocaine molecule muaj ob lub hauv paus nitrogen atoms, uas tuaj yeem txais cov protons los ua cov ntsev. Hauv dej, Lidocaine ntsev yog yooj yim soluble hauv dej thiab muaj zog electrolytic zog. Thaum Lidocaine ua ke nrog cov kua qaub muaj zog, nws tuaj yeem tsim cov ntsev hydrochloride, uas yog li cas cov tshuaj loog siv lidocaine tau npaj.
2. Redox khoom:
Lidocaine molecules muaj cov qauv resonance ntawm methylene thiab benzene rings, thiab cov nqi hloov ntawm lawv ua rau Lidocaine muaj qhov txo qis. Hauv lub cev, Lidocaine kuj feem ntau txo rau nws cov metabolites monoethylglycinexylidide (MEGX) thiab glycinexylidide (GX). Cov metabolites no muaj cov haujlwm tshuaj sib txawv, uas tuaj yeem cuam tshuam rau bioavailability thiab kev ua tau zoo ntawm Lidocaine hauv vivo.
3. Thermal stability:
Lidocaine muaj thermal stability zoo. Tom qab ob peb lub hlis ntawm chav tsev kub, tsis muaj qhov pom tseeb decomposition tshwm sim. Lidocaine tuaj yeem decompose nyob rau hauv qhov kub thiab txias, ua rau nws cov tshuaj loog txo qis. Yog li ntawd, peb yuav tsum tau saib xyuas kom muaj cov xwm txheej zoo thaum khaws cia thiab siv Lidocaine.
4. Kev tsis haum tshuaj:
Kev tsis haum rau Lidocaine yog qhov tshwm sim tsis tshua muaj tshwm sim, tab sis nws tsis tuaj yeem txiav txim siab tag nrho. Tsis txhob siv Lidocaine thiab nrhiav kev kho mob tam sim yog tias koj muaj cov tsos mob ua xua xws li o, ua tsis taus pa, ua pob liab liab, lossis mob plab.
5. Hloov cov nyhuv:
Lidocaine cuam tshuam cov metabolism thiab hloov pauv hauv lub cev, thiab cov txheej txheem metabolic tseem ceeb tshaj plaws suav nrog N-deethylation thiab hydroxylation hauv lub siab. Cov khoom siv hloov dua siab tshiab MEGX thiab GX muaj cov kev ua haujlwm tshuaj sib txawv thiab tuaj yeem siv los ua cov cim ntsuas los ntsuas cov metabolism ntawm Lidocaine. Kev hloov pauv muaj qhov cuam tshuam tseem ceeb rau kev ua tau zoo thiab kev zam ntawm Lidocaine.
6. Hydrolysis cov tshuaj tiv thaiv:
Lidocaine tuaj yeem ua rau cov tshuaj tiv thaiv hydrolysis hauv dej. Nyob rau hauv acidic tej yam kev mob, Lidocaine yooj yim hydrolyzed rau 2, 6-diethylaminophenol thiab formaldehyde. Yog li ntawd, yuav tsum tau saib xyuas kom tsis txhob muaj acidic thaum npaj lidocaine tshuaj loog.
7. Photochemical cov tshuaj tiv thaiv:
Lub nplhaib aromatic nyob rau hauv Lidocaine molecule muaj zog ultraviolet absorption yam ntxwv, yog li nws yog ib qho yooj yim rau undergo photochemical tshuaj tiv thaiv nyob rau hauv ultraviolet irradiation. Cov khoom tsim los ntawm cov tshuaj tiv thaiv photochemical tuaj yeem txo qhov ua tau zoo ntawm Lidocaine. Yog li ntawd, zam lub teeb thaum npaj thiab siv Lidocaine.
8. Kev sib cuam tshuam nrog lwm yam tshuaj:
Lidocaine tuaj yeem cuam tshuam nrog lwm cov tshuaj hauv lub cev. Piv txwv li, kev sib koom ua ke ntawm Lidocaine nrog hepatic microsomal enzyme inducers xws li phenolamine lossis phenobarbital tuaj yeem txo qhov ua tau zoo ntawm Lidocaine. Thaum ua ke nrog -blockers xws li propranolol, cov nyhuv ntawm Lidocaine tuaj yeem txhim kho.
Txhua yam, Lidocaine yog cov tshuaj siv ntau yam, thiab nws cov tshuaj tiv thaiv muaj xws li acid-base zog, redox zog, thermal stability, kev tsis haum tshuaj, transformation, hydrolysis tshua, photochemical tshua, thiab kev cuam tshuam nrog lwm yam tshuaj, thiab lwm yam. Cov khoom no yuav tsum tau ceev faj. tuav thaum siv Lidocaine kom ntseeg tau tias nws muaj kev nyab xeeb thiab ua haujlwm tau zoo.