1. Tshuaj formula:
Cov tshuaj formula ntawmOrphenadrine citrate(https://www.bloomtechz.com/synthetic-chemical/api-researching-only/orphenadrine-citrate-powder-cas-4682-36-4.html) yog C18H23NO·C6H8O7. Cov qauv tshuaj no qhia peb tias cov khoom sib xyaw ua ke yog tsim los ntawm ntau yam, suav nrog carbon (C), hydrogen (H), oxygen (O), thiab nitrogen (N).
2. Daim duab kos duab:
Los ntawm daim duab kos duab, peb tuaj yeem nkag siab ntau ntxiv txog cov qauv molecular ntawm Orphenadrine citrate thiab kev sib txuas ntawm cov atoms. Hauv qab no yog daim duab duab ntawm Orphenadrine citrate:
Nws tuaj yeem pom los ntawm daim duab kos duab uas cov qauv molecular ntawm Orphenadrine citrate feem ntau yog tsim los ntawm ob ntu: Orphenadrine ib feem thiab citrate ib feem.
- Orphenadrine seem: seem ntawm sab laug ntawm daim duab duab. Qhov no yog ib tug qauv uas muaj benzene rings thiab spiro rings, ua los ntawm ntau yam carbon atoms thiab ib tug nitrogen atom. Muaj ib pawg methylbenzyl ntawm lub nplhaib benzene. Lub atom nitrogen txuas nrog cov pa roj carbon atom ntawm lub nplhaib spiro, thiab tseem muaj hydrogen atom thiab hydroxyl (OH) atom ntawm nitrogen atom.
- Citrate seem: seem nyob rau sab xis ntawm daim duab kos duab. Qhov no yog citrate, ua los ntawm ntau cov pa roj carbon, hydrogen thiab oxygen atoms. Nws cov qauv muaj peb pawg carboxyl (COOH) thiab ib pawg hydroxyl (OH), uas tsim ntau cov ester bonds nrog carbon atoms.
Lub orphenadrine ib feem thiab citrate ib feem yog ua ke los ntawm ionic bonds lossis ionic kev sib cuam tshuam los tsim cov qauv molecular tag nrho ntawm orphenadrine citrate.
Orphenadrine citrate yog ib qho tshuaj uas feem ntau siv los txo cov leeg nqaij thiab mob.
1. Relieve nqaij spasms:
Orphenadrine citrate yog dav siv los kho ntau yam kab mob thiab tej yam kev mob uas ua rau cov nqaij ntshiv xws li cov nqaij ntshiv, nqaij ntshiv, caj dab spasms, teeb meem ntawm tus txha caj qaum, thiab lwm yam.
2. Cov nyhuv analgesic:
Ntxiv nrog rau kev txo qis cov leeg nqaij, Orphenadrine citrate kuj muaj cov khoom ua kom muaj zog. Nws tuaj yeem txo qhov kev nkag siab ntawm qhov mob los ntawm kev cuam tshuam rau hauv nruab nrab paj hlwb. Qhov no ua rau nws muaj txiaj ntsig zoo rau kev kho mob nrog rau cov leeg nqaij, nrog rau lwm yam mob xws li mob taub hau, neuralgia, thiab lwm yam.
3. Anticholinergic kev ua haujlwm:
Orphenadrine citrate belongs rau cov tshuaj anticholinergic. Nws txo cov cholinergic neurotransmission los ntawm inhibiting qhov kev txiav txim ntawm cholinergic receptors, yog li tsim cov nyhuv anticholinergic. Qhov kev txiav txim no ua rau Orphenadrine citrate muaj txiaj ntsig hauv qee yam mob los kho cov teeb meem tshwm sim los ntawm kev ua haujlwm cholinergic paj hlwb, xws li Parkinson's kab mob, tshee, thiab qee qhov kev txav tsis zoo.
4. Raws li ib qho tshuaj kho mob ntxiv:
Orphenadrine citrate kuj tseem siv tau los ua ib qho ntxiv rau lwm cov tshuaj hauv qee yam mob. Piv txwv li, qee zaum nws tuaj yeem siv ua ke nrog cov tshuaj uas tsis yog tshuaj tiv thaiv kab mob (NSAIDs) lossis lwm cov leeg nqaij so kom pab tau zoo dua ntawm cov leeg nqaij thiab mob.
Luv luv qhia plaub txoj kev siv hluavtaws ntawm Orphenadrine citrate:
Txoj Kev 1: Cov txheej txheem hluavtaws ntawm Tropane alkaloid
Qhov no yog ib txoj kev siv hluavtaws siv tropane hauv paus ua cov khoom pib.
Kauj Ruam 1: React tropane bases nrog methanol los tsim cov alkoxides sib xws.
Kauj ruam 2: react alkoxide nrog isopropyl ammonium bromide los tsim quaternary ammonium ntsev.
Kauj Ruam 3: ua rau quaternary ammonium ntsev nrog phenylglycinium chloride los tsim cov phenylglycate ntawm quaternary ammonium ntsev.
Kauj ruam 4: reacting phenylglycate nrog citric acid los tsim cov hom phiaj khoom Orphenadrine citrate.
Txoj kev 2: cov txheej txheem hluavtaws ntawm amphetamine compound
Qhov no yog ib txoj kev hluavtaws siv cov tshuaj amphetamine zoo li cov khoom pib.
Kauj Ruam 1: Cov tshuaj tiv thaiv amphetamine compound nrog acid chloride los tsim cov amide sib xws.
Kauj Ruam 2: Cov tshuaj tiv thaiv ntawm amide nrog isopropylphosphorus trioxide tsim cov phosphoramidite sib raug.
Kauj Ruam 3: react phosphoramide nrog halogenated hydrocarbon los tsim quaternary ammonium ntsev.
Kauj Ruam 4: ua rau quaternary ammonium ntsev nrog phenylglycinium chloride los tsim cov phenylglycate ntawm quaternary ammonium ntsev.
Kauj Ruam 5: reacting phenylglycate nrog citric acid los tsim cov khoom lag luam Orphenadrine citrate.
Txoj Kev 3: Synthesis ntawm benzyl compounds
Qhov no yog ib txoj kev siv hluavtaws siv cov tshuaj benzyl ua cov khoom pib.
Kauj Ruam 1: Cov tshuaj tiv thaiv ntawm benzyl compound nrog formaldehyde los tsim N-benzyl lub cev qhuav dej Altokylmethylethylenediamine.
Kauj Ruam 2: Cov tshuaj tiv thaiv N-benzyl dehydroaltoxymethylethylenediamine nrog isopropylphosphorus trioxide los tsim cov phosphoramidite sib raug.
Kauj Ruam 3: react phosphoramide nrog halogenated hydrocarbon los tsim quaternary ammonium ntsev.
Kauj Ruam 4: ua rau quaternary ammonium ntsev nrog phenylglycinium chloride los tsim cov phenylglycate ntawm quaternary ammonium ntsev.
Kauj Ruam 5: reacting phenylglycate nrog citric acid los tsim cov khoom lag luam Orphenadrine citrate.
Txoj Kev Plaub: Synthesis of Orphenadrine Derivatives
Qhov no yog ib txoj kev siv hluavtaws siv cov khoom siv ntawm Orphenadrine ua cov khoom pib.
Kauj Ruam 1: Cov derivative ntawm Orphenadrine yog reacted nrog acetic anhydride los tsim cov acetate sib raug.
Kauj ruam 2: reacting acetate nrog citric acid los tsim cov hom phiaj khoom Orphenadrine citrate.
Cov no tsuas yog qee qhov ntawm plaub txoj kev siv hluavtaws, thiab cov txheej txheem hluavtaws tiag tiag yuav nyuaj dua thiab koom nrog lwm cov intermediates thiab cov kauj ruam tshuaj tiv thaiv. Thov nco ntsoov tias kev sib txuas ntawm Orphenadrine citrate yog qhov kev kawm tshwj xeeb ntawm kev tshawb fawb uas yuav tsum tau muaj chaw kuaj mob nrog kev cob qhia tshwj xeeb thiab cov chaw. Rau cov txheej txheem hluavtaws thiab cov ncauj lus kom ntxaws, thov xa mus rau cov ntaub ntawv tshawb fawb thiab cov peev txheej, thiab sab laj nrog tus kws tshaj lij hauv thaj chaw chemistry. Nyob rau tib lub sijhawm, txhua qhov kev sib xyaw tshuaj yuav tsum tau ua raws li cov cai hauv zos thiab cov kev cai thiab kev nyab xeeb, thiab kev ua haujlwm yuav tsum tau coj los ntawm cov kws tshaj lij.