Procaine hydrochloride (hcl)yog ib qho ruaj khov hydrochloride, feem ntau nyob rau hauv daim ntawv ntawm dawb crystalline hmoov los yog tsis muaj xim pob tshab siv lead ua. Nws cov xim feem ntau cuam tshuam los ntawm cov tshuaj purity thiab ntau lawm txheej txheem. Lub solubility hauv dej yog heev. Nws tseem tuaj yeem yaj lossis tawg hauv qee cov kuab tshuaj organic, xws li ethanol, ether, chloroform thiab benzene. Lub melting point ntawm 154-158 degree . Qhov no melting point yuav siv tau raws li ib tug ntawm cov qauv rau kev ntsuam xyuas nws zoo. Nws yog ib qho tshuaj loog ruaj khov. Nws tuaj yeem khaws cia ruaj khov ntawm chav tsev kub. Nws tseem tiv taus oxidation hauv huab cua thiab tsis cuam tshuam los ntawm lub teeb.
Procaine hydrochloride yog ib qho tshuaj loog uas feem ntau siv hauv cov tshuaj loog hauv zos thiab dav dav, thiab kuj tseem siv los kho qhov mob, txo kev ntxhov siab thiab kev puas tsuaj ntawm lub paj hlwb. Kev siv ntau yam ntawm procaine hydrochloride yuav qhia meej hauv qab no.
1. Tshuaj loog hauv zos:
Procaine hydrochloride tuaj yeem siv rau tshuaj loog hauv zos los ntawm inhibiting paj hlwb. Nws tuaj yeem siv rau qee cov txheej txheem qis hauv chav ua haujlwm me me, xws li kev tshem tawm cov hniav lossis cov tawv nqaij suturing. Nws yog ib qho tsim nyog yuav tsum ntsuas qhov dav dav ntawm tus neeg mob ua ntej cov txheej txheem tswj hwm, suav nrog kev ua xua lossis yav dhau los cov tshuaj loog hauv zos thiab contraindications.
2. Tus kab mob Parkinson:
Hauv kev kho mob Parkinson tus kab mob, procaine hydrochloride feem ntau yog siv los ua kev kho mob ntawm L-dopa los txhim kho nws cov nyhuv. Nws ua haujlwm los ntawm kev nce qib ntawm cov neurotransmitters hauv nruab nrab paj hlwb los txo cov tsos mob ntawm Parkinson tus kab mob xws li tuag tes tuag taw, tshee hnyo thiab ceg tawv.
3. Mob myocardial infarction:
Kev kho mob myocardial infarction nrog procaine hydrochloride tuaj yeem txhim kho myocardial kev ua haujlwm los ntawm kev ua kom cov ntaub so ntswg thiab cov pa oxygen kom txo tau cov tsos mob ntawm cov kab mob plawv. Nws tuaj yeem txo qhov kev puas tsuaj ntawm cardiomyocyte los ntawm inhibiting sodium influx mus rau hauv daim nyias nyias cardiomyocyte.
4. Mob hlwb:
Procaine hydrochloride kuj tseem siv tau los kho ntau yam kev puas hlwb xws li kev ntxhov siab, kev nyuaj siab thiab neurosis. Nws tuaj yeem txo cov neeg mob cov kab mob los ntawm kev txo lawv cov tsos mob thiab txhim kho kev kho mob.
5. Epilepsy:
Procaine hydrochloride kuj ua lub luag haujlwm hauv kev kho mob vwm. Nws tuaj yeem txo cov tsos mob ntawm qaug dab peg los ntawm kev txo cov excitability ntawm neurons.
6. Mob neuropathic:
Procaine hydrochloride tuaj yeem txo cov tsos mob ntawm tus mob neuropathic los ntawm kev thaiv cov hlab ntsha. Tej zaum nws yuav raug txhaj rau ntawm qhov chaw mob kom txo lossis tshem tawm cov leeg mob.
7. Mob plab:
Procaine hydrochloride kuj tseem siv tau los kho mob plab mob. Nws tuaj yeem txo cov tsos mob ntawm qhov mob plab los ntawm kev txo qis spasms thiab txo qis gastric acid secretion.
8. Rheumatism, mob caj dab rheumatoid:
Procaine hydrochloride tuaj yeem txo cov tsos mob ntawm rheumatism thiab mob caj dab rheumatoid los ntawm kev txo qhov mob thiab txo qhov mob.
9. Ua npaws:
Procaine hydrochloride tuaj yeem txo cov tsos mob ntawm kub taub hau los ntawm kev txo lub cev kub. Nws tuaj yeem txhim kho cov tsos mob tshwm sim thaum tib neeg lub cev kub taub hau los ntawm kev txo qis cov kab mob inflammatory thiab cov as-ham hauv lub cev.
Hauv cov ntsiab lus, Procaine hydrochloride yog ib qho tshuaj loog uas siv tau rau hauv kev kho mob ntawm ntau yam mob, nrog rau cov tshuaj loog hauv zos, Parkinson's disease, mob myocardial infarction, mob hlwb, qaug dab peg, mob neuropathic, mob plab mob, mob rheumatism, rheumatoid mob caj dab thiab kub taub hau. thiab lwm yam ntawm no tsuas yog ib qho kev piav qhia, thiab kev siv tshwj xeeb yuav tsum tau ua raws li tus neeg mob tus mob thiab kev txiav txim ntawm tus kws kho mob.
Cov tshuaj tiv thaiv ntawm Procaine hydrochloride:
1. Cov tshuaj tiv thaiv oxidation:
Procaine hydrochloride tuaj yeem cuam tshuam nrog oxygen. Cov tshuaj tiv thaiv no tuaj yeem suav tias yog cov tshuaj tiv thaiv oxidation, tsim cov pa roj carbon monoxide thiab lwm yam khoom. Cov tshuaj tiv thaiv no yog cov tshuaj tiv thaiv dawb radical, uas yog, oxygen dawb radicals yuav tshwm sim hauv cov tshuaj tiv thaiv, uas qee zaum tuaj yeem ua rau lwm yam tsis zoo. Kev tsim cov pa roj carbon monoxide tuaj yeem ua rau muaj tshuaj lom thiab lwm yam teeb meem kev noj qab haus huv.
2. Hydroxyl tshuaj tiv thaiv:
Procaine hydrochloride muaj cov pab pawg hydroxyl, yog li nws tuaj yeem dhau los ua cov tshuaj tiv thaiv hydroxyl. Feem ntau ntawm cov no yog esterification, qhov twg ib pawg hydroxyl hloov los ntawm ib pawg acyl. Cov tebchaw uas pib cov tshuaj tiv thaiv no feem ntau yog carboxylic acid derivatives. Cov khoom siv Esterification tuaj yeem siv rau hauv kev tsim cov tshuaj.
3. Amino cov tshuaj tiv thaiv:
Procaine hydrochloride muaj cov amino pawg, yog li muaj cov amino acids tuaj yeem tshwm sim. Feem ntau ntawm cov no yog amide tsim, qhov twg cov amino pawg hloov cov pab pawg carbonyl los ua ib daim ntawv cog lus amide. Tsis tas li ntawd, cov hauv paus muaj zog xws li sodium hydroxide tuaj yeem hloov cov carboxylamines mus rau cov pab pawg amine dawb, uas yog ib txoj hauv kev rau deactivate propionamide.
4. Halogenation cov tshuaj tiv thaiv:
Procaine hydrochloride kuj tuaj yeem raug cov tshuaj tiv thaiv halogenation. Cov tshuaj tiv thaiv zoo li no feem ntau suav nrog cov tshuaj halogenating thiab cov xwm txheej yooj yim. Hauv cov tshuaj tiv thaiv, tus neeg sawv cev halogenating hloov cov hydrogen atom ntawm hydroxyl lossis amino pawg los tsim cov khoom halogenated. Cov tshuaj tiv thaiv no tuaj yeem siv rau hauv kev tsim tshuaj los tsim ntau hom procaine hydrochloride.
5. Cov tshuaj tiv thaiv Alkynyl:
Procaine hydrochloride muaj cov pab pawg alkynyl, yog li nws tuaj yeem raug cov tshuaj tiv thaiv alkynyl. Cov tshuaj tiv thaiv no feem ntau cuam tshuam nrog cov tshuaj tiv thaiv arylation, nyob rau hauv uas ib pawg alkynyl hloov los ntawm ib qho atom los yog pab pawg ntawm atoms ntawm lub nplhaib uas muaj ntxhiab los tsim ib qho chaw tshiab. Cov lus teb no tuaj yeem siv los tsim cov tshuaj loog hauv zos tshiab.
6. Txo cov tshuaj tiv thaiv:
Procaine hydrochloride tuaj yeem raug txo qis. Hauv cov tshuaj tiv thaiv no, procaine hydrochloride tuaj yeem txo qis rau cov tsiaj qis xws li procaine. Kev txo cov tshuaj tiv thaiv tuaj yeem ua kom yooj yim los ntawm cov cua sov lossis tshuaj txo cov neeg ua haujlwm.
Hauv kev xaus, procaine hydrochloride muaj ntau yam reactivity zog. Cov khoom siv reactive no qiv lawv tus kheej mus rau ntau yam kev siv hauv thaj chaw tshuaj thiab chaw muag tshuaj. Txawm li cas los xij, cov kev cuam tshuam no tuaj yeem ua rau muaj kev cuam tshuam tsis zoo thiab teeb meem kev noj qab haus huv. Yog li ntawd, yuav tsum tau ceev faj heev thaum siv procaine hydrochloride, nruj me ntsis raws li cov lus qhia rau kev siv.