Scopolamine butylbromide(feem ntau hu ua Buscopan txuas:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/scopolamine-butylbromide-cas-149-64-4.html) yog ib qho tshuaj siv los kho cov tsos mob ntawm plab hnyuv thiab belongs rau ib chav kawm ntawm cov tshuaj anticholinergic. Cov tshuaj no tsuas yog ua kom cov leeg du thiab txo qis kev zais cia los ntawm kev thaiv qhov kev txiav txim ntawm acetylcholine, thiaj li ua tiav lub hom phiaj ntawm kev kho thiab txo cov teeb meem hauv plab. Tam sim no, Scopolamine butylbromide tau siv dav hauv kev kho mob, thiab nws cov kev siv yuav raug qhia kom ntxaws hauv qab no.
1. Mob plab thiab plab hnyuv spasms:
Scopolamine butylbromide feem ntau ua rau cov nqaij ntshiv ntawm lub plab zom mov, thiab tuaj yeem txo cov tsos mob xws li mob plab los ntawm spasms thiab contractions ntawm txoj hnyuv. Yog li ntawd, nws yog feem ntau siv los kho ntau yam kab mob uas muaj feem xyuam rau txoj hnyuv, xws li mob plab, plab hnyuv ulcers, biliary ascariasis (kab tom), colitis, cholecystitis, plab hnyuv, thiab lwm yam.
1.1 Mob plab:
Lub plab cramping yog ib qho mob ntawm qhov mob thiab qhov tsis xis nyob uas tshwm sim los ntawm qhov txawv txav ntawm lub plab zom mov. Scopolamine butylbromide muaj cov nyhuv ntawm kev so cov leeg du ntawm txoj hnyuv, uas tuaj yeem txo qhov mob thiab tsis xis nyob.
1.2 Cov kab mob hauv plab:
Gastrointestinal ulcer yog ib qho kev raug mob ntawm lub plab hnyuv mucosa, feem ntau tshwm sim los ntawm cov kua qaub ntau dhau. Scopolamine butylbromide tuaj yeem ua lub luag haujlwm hauv kev kho mob ntawm plab hnyuv ulcers los ntawm kev txo qis ntawm cov kua qaub kom txo qis kev ua xua thiab cov tsos mob ntawm txoj hnyuv.
1.3 Biliary ascariasis:
Biliary ascariasis yog ib yam kab mob ntawm biliary obstruction los ntawm roundworms parasitizing nyob rau hauv lub kua tsib duct. Scopolamine butylbromide txo cov tsos mob los ntawm kev so / txo cov leeg nqaij hauv daim siab, txiav, duodenum, thiab gallbladder.
1.4 Colitis:
Colitis yog ib qho mob ntawm phab ntsa ntawm cov hnyuv, cov tsos mob tseem ceeb ntawm cov mob plab thiab raws plab. Scopolamine butylbromide txo cov tsos mob no los ntawm kev txo qis qhov contractions thiab spasms ntawm lub plab.
1.5 Cholecystitis:
Cholecystitis yog ib qho mob ntawm lub gallbladder, cov tsos mob tseem ceeb uas yog mob plab thiab kub taub hau. Scopolamine butylbromide txo cov tsos mob no los ntawm kev ua kom cov leeg du ntawm lub gallbladder thiab txo cov zais zis.
1.6 Kev mob plab hnyuv:
Txoj hnyuv plab yog ib yam mob tshwm sim los ntawm kev txhaws hauv plab hnyuv. Cov tsos mob muaj xws li mob plab, ntuav, thiab cem quav. Scopolamine butylbromide tuaj yeem txo cov tsos mob no los ntawm kev ua kom cov leeg du ntawm lub plab zom mov.
2. So uterine du nqaij:
Ntxiv nrog rau kev siv los kho cov kab mob hauv plab hnyuv, Scopolamine butylbromide kuj tseem siv tau los ua cov tshuaj ua ntej rau kev phais gynecological kom so cov leeg nqaij uterine. Nws tuaj yeem txo qhov nro thiab siab ntawm lub tsev menyuam, ua rau kev ua haujlwm smoother thiab muaj kev nyab xeeb.
3. Cov nyhuv tiv thaiv neuronal:
Ntxiv rau qhov kev kho mob saum toj no, Scopolamine butylbromide kuj muaj qee yam kev siv hauv kev kho mob hlwb. Cov kev tshawb fawb tau pom tias cov tshuaj muaj peev xwm tiv thaiv cov neurons los ntawm kev tswj cov neuronal membrane permeability thiab sodium tam sim no thiab lwm yam mechanisms, thiab txo cov tsos mob los ntawm cov kab mob thiab kev raug mob ntawm lub paj hlwb thiab cov leeg nqaij.
4. Relax airway smooth nqaij:
Scopolamine butylbromide tuaj yeem txo cov tsos mob tshwm sim los ntawm cov kab mob ua pa xws li mob hawb pob thiab bronchitis rau qee yam los ntawm kev so cov leeg nqaij ntawm txoj hlab ntsws. Lub mechanism ntawm kev txiav txim ntawm cov tshuaj tseem nyob rau hauv kev tshawb fawb thiab kev tshawb fawb ntxiv.
5. Inhibit qaub qaub secretion:
Scopolamine butylbromide kuj inhibits qaub ncaug ntau lawm nyob rau hauv lub qhov ncauj thiab larynx, yog li pab nyob rau hauv tej yam kev phais thiab kho cov txheej txheem. Tsis tas li ntawd, nws tuaj yeem txo cov tsos mob tsis xis nyob xws li qhov ncauj qhuav los ntawm salivation.
Hauv kev xaus, Scopolamine butylbromide tau dhau los ua ib qho ntawm cov tshuaj tseem ceeb hauv kev lag luam kho mob, thiab tau siv dav hauv ntau lub teb xws li kab mob plab, gynecology, neurology, thiab ua pa. Txawm hais tias cov tshuaj muaj qee qhov kev pheej hmoo thiab cov tsos mob tsis xis nyob thaum lub sijhawm kho, nws txoj kev kho mob yog qhov tseem ceeb heev thiab tsim nyog nyob rau hauv kev siv kom raug thiab saib xyuas.
Scopolamine Butylbromide yog cov organic compound nrog cov tshuaj formula C21H30BrNO4 thiab molecular hnyav ntawm 440.3804 g / mol. Nws belongs rau cov chav kawm ntawm acetylcholine receptor antagonists, thiab tuaj yeem so cov leeg du thiab txo qis kev zais cia los ntawm kev thaiv cov kev ua ntawm M1-M5 acetylcholine receptors. Tag nrho cov khoom reactivity ntawm Scopolamine Butylbromide yuav piav qhia meej.
1. Cov tshuaj tiv thaiv oxidation:
Scopolamine Butylbromide tuaj yeem oxidized rau ketones lossis aldehydes los ntawm oxidizing cov neeg ua haujlwm xws li hydrogen peroxide thiab potassium permanganate. Oxidizing agents xa mus rau ib chav reagents uas tuaj yeem pub cov pa oxygen atoms rau lwm cov tebchaw. Yog li, cov tshuaj tiv thaiv oxidation feem ntau yog nrog los ntawm kev tsim ntawm oxystarch. Tom qab Scopolamine Butylbromide dhau los ua cov tshuaj tiv thaiv oxidation, cov khoom ketone los yog aldehyde coj tau, thiab hom ntawm cov khoom tiag tiag nyob ntawm hom oxidizing reagent siv. Feem ntau, cov tshuaj tiv thaiv ntawm cov tshuaj tiv thaiv oxidation yog ceev heev.
2. Txo cov tshuaj tiv thaiv:
Scopolamine Butylbromide tuaj yeem txo qis rau cov dej cawv thiab amine tebchaw los ntawm kev txo cov neeg ua haujlwm xws li hydrogen, ferrous sulfate, thiab lwm yam. Kev txo cov tshuaj tiv thaiv yog hais txog ib chav reagents uas tuaj yeem pub hydrogen atoms lossis electrons rau lwm cov tebchaw. Hauv kev txo cov tshuaj tiv thaiv, ib daim ntawv cog lus nyob rau hauv cov molecule ntawm Scopolamine Butylbromide yog tawg thiab txo rau cawv thiab amine-based compounds.
3. Cov tshuaj tiv thaiv Alkylation:
Scopolamine Butylbromide tuaj yeem hnov mob nrog tus neeg sawv cev alkylating nyob rau hauv lub xub ntiag ntawm lub hauv paus muaj zog kom tau txais cov khoom sib xws alkylated. Cov tshuaj tiv thaiv no yog hu ua alkylation cov tshuaj tiv thaiv, nyob rau hauv uas tus neeg sawv cev alkylating ntxiv rau cov pa roj carbon atom hauv Scopolamine Butylbromide molecule los tsim cov tebchaw tshiab.
4. Kev tshem tawm cov tshuaj tiv thaiv:
Scopolamine Butylbromide tuaj yeem ua rau muaj kev cuam tshuam xws li deprotonation thiab hydroxyl tshem tawm los tsim cov khoom sib txawv. Kev tshem tawm cov tshuaj tiv thaiv yog hais txog kev rhuav tshem cov tshuaj lom neeg ntawm ob pawg ua haujlwm nyob rau hauv ib lub molecule uas tsawg kawg yog ib qho kev sib cog lus ntawm ib lub atom tau noj. Tshwj xeeb, hauv Scopolamine Butylbromide, hydroxyl tshem tawm cov tshuaj tiv thaiv ua rau poob ntawm hydroxyl pawg los tsim cov khoom sib xws.
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5. Cov tshuaj tiv thaiv Esterification:
Scopolamine Butylbromide tuaj yeem hnov mob nrog anhydrides lossis acids los tsim cov khoom lag luam esterification. Nyob rau hauv cov tshuaj tiv thaiv esterification, cov anhydride los yog acid reacts nrog cov hydroxyl pawg nyob rau hauv lub molecule ntawm Scopolamine Butylbromide los ua ib tug ester daim ntawv cog lus thiab tsim cov khoom sib xws.
6. Rearrangement cov tshuaj tiv thaiv:
Scopolamine Butylbromide tuaj yeem raug kho dua tshiab los tsim cov khoom sib txawv. Ib qho tshuaj tiv thaiv rov qab yog cov tshuaj tiv thaiv uas cov haujlwm ntawm atoms lossis pawg hauv kev hloov pauv molecule. Hauv Scopolamine Butylbromide, cov tshuaj tiv thaiv rov qab tuaj yeem ua rau muaj kev hloov pauv ntawm cov qauv molecular, yog li tsim cov khoom tshiab.
Raws li qhov tshwm sim, Scopolamine Butylbromide muaj ntau yam tshuaj tiv thaiv, suav nrog cov tshuaj tiv thaiv oxidation, txo cov tshuaj tiv thaiv, cov tshuaj tiv thaiv alkylation, tshem tawm cov tshuaj tiv thaiv, cov tshuaj tiv thaiv esterification, cov tshuaj tiv thaiv rov qab, thiab lwm yam.
Nws yog ib qho tsim nyog sau cia tias cov tshuaj tiv thaiv no feem ntau tshwm sim hauv cov tshuaj tiv thaiv ua raws li kev kuaj mob, yog li yuav tsum tau ua tib zoo tuav. Tsis tas li ntawd, thaum siv Scopolamine Butylbromide, yuav tsum tau them nyiaj tshwj xeeb rau nws txoj kev ruaj ntseg kom tsis txhob muaj kev cuam tshuam tsis tsim nyog.