Scopolamine butylbromide(link:https://www.bloomtechz.com/synthetic-chemical/api-researching-only/scopolamine-butylbromide-cas-149-64-4.htmlyog cov organic compound nrog cov tshuaj formula C21H30BrNO4 thiab molecular hnyav 440.3804 g/mol. Cov compound yog cov hmoov dawb crystalline, yuav luag insoluble hauv dej, nws tuaj yeem tsim cov kev daws teeb meem hauv qee cov organic solvents, thiab yooj yim soluble hauv ethanol, chloroform thiab benzene. yog ib qho ionic compound uas muaj qhov sib txawv ionization tas li hauv dej. Ntawm lawv, ionization tas li ntawm N (CH3) 3 pawg ntawm acetylcholine receptor yog 9.4 × 10-5; thiab ionization tas li ntawm Br-ion yog 7.3 × 10-17. Nws yog nyob rau hauv chav kawm ntawm acetylcholine receptor antagonists, thiab tuaj yeem so cov leeg du thiab txo qis kev zais cia los ntawm kev thaiv cov kev ua ntawm M1-M5 acetylcholine receptors.
Ntau yam tshuaj lom neeg ntawm Scopolamine butylbromide yuav qhia kom meej hauv qab no.
1. Thermal stability:
Scopolamine butylbromide yog qhov ruaj khov ntawm chav tsev kub, tab sis nws yooj yim rau decompose nyob rau hauv tej yam kev mob xws li kub, av noo thiab lub teeb. Yog li ntawd, yuav tsum tau saib xyuas kom tsis txhob muaj kev cuam tshuam ntawm cov xwm txheej no thaum npaj, khaws cia thiab siv.
2. Spectral zog:
Scopolamine butylbromide muaj cov yam ntxwv ntawm absorbing ultraviolet thiab infrared rays. Lub ntsiab nqus wavelength nyob rau hauv cheeb tsam ultraviolet yog 220-240 nm. Lub infrared spectrum qhia tau hais tias NH stretching vibration (3323 cm-1), C=O stretching vibration (1690 cm-1), COC stretching vibration (1090 cm-1) thiab lwm yam tus yam ntxwv ncov.
3. Kev ruaj ntseg:
Scopolamine butylbromide yog qhov ruaj khov ntawm chav tsev kub, tab sis nws yooj yim rau decompose nyob rau hauv tej yam kev mob xws li kub, av noo thiab lub teeb. Yog li ntawd, yuav tsum tau saib xyuas kom tsis txhob muaj kev cuam tshuam ntawm cov xwm txheej no thaum npaj, khaws cia thiab siv.
4. Solubility:
Scopolamine butylbromide yog xyaum insoluble hauv dej thiab yooj yim soluble hauv ethanol, chloroform thiab benzene. Xws li methanol, ethanol, thiab lwm yam.
Scopolamine butylbromide muaj solubility zoo thiab tuaj yeem yaj hauv ntau cov kuab tshuaj. Cov hauv qab no yog cov ntaub ntawv solubility ntawm Scopolamine butylbromide hauv qee cov kuab tshuaj:
Dej: 1 g ntawm Scopolamine butylbromide tuaj yeem yaj hauv li 10 ml dej;
Ethanol: 1 g ntawm Scopolamine butylbromide tuaj yeem yaj hauv li 3 ml ntawm ethanol;
Methanol: 1 g ntawm Scopolamine butylbromide yog soluble hauv li 4 ml ntawm methanol;
Dimethyl sulfoxide (DMSO): 1 g ntawm Scopolamine butylbromide tuaj yeem yaj hauv li 5 mL ntawm DMSO.
Nws yuav tsum tau muab sau tseg tias nyob rau hauv tej rooj plaub, solubility ntawm Scopolamine butylbromide tej zaum yuav cuam tshuam los ntawm lwm yam, xws li kub, pH, thiab lwm yam. Yog li ntawd, thaum ua tshuaj npaj thiab daim ntawv thov, nws yog tsim nyog los kho kom tsim nyog raws li tej yam kev mob. tau cov txiaj ntsig zoo tshaj plaws.
5. Ion tus naj npawb tsis tu ncua:
Scopolamine butylbromide yog ib qho ionic compound nrog sib txawv ionization tas li hauv dej. Ntawm lawv, ionization tas li ntawm N (CH3) 3 pawg ntawm acetylcholine receptor yog 9.4 × 10-5; thiab ionization tas li ntawm Br-ion yog 7.3 × 10-17.
5.1. Ionization tas li: Lub ionization tas li ntawm Scopolamine butylbromide yog pKa=8.3, uas qhia tau hais tias nws muaj zog alkalinity nyob rau hauv aqueous kua thiab muaj peev xwm hnov mob nrog acid los tsim cov ntsev sib xws.
5.2. Degree ntawm dissociation: Cov degree ntawm dissociation ntawm Scopolamine butylbromide cuam tshuam los ntawm pH. Scopolamine butylbromide dissociates tsawg ntawm pH qis (ib puag ncig acidic) thiab siab dua ntawm pH siab dua (ib puag ncig). Piv txwv li, Scopolamine butylbromide dissociates txog 6.5 feem pua ntawm pH =7.4 (nyob rau hauv physiological mob).
Feem ntau, Scopolamine butylbromide yog cov khoom sib xyaw nrog cov khoom siv ionic, thiab nws cov ionization feem ntau yog siv los piav txog nws cov cwj pwm tshuaj thiab lub cev muaj zog hauv cov kua dej.
Hauv cov ntsiab lus, Scopolamine butylbromide yog cov hmoov dawb crystalline nrog UV thiab IR absorbing zog. Nws ua lub luag haujlwm tseem ceeb hauv kev tswj cov leeg nqaij thiab kev zais cia, tab sis nws yog ib qho yooj yim rau decompose nyob rau hauv tej yam kev mob xws li kub, av noo thiab lub teeb, yog li nws yuav tsum tau them sai sai rau kev cia thiab siv tej yam kev mob.
Xyoo 1893, tus kws muag tshuaj German Wilhelm Täufert tau rho tawm cov organic compound hu ua atropin los ntawm foxglove. Atropin yog cov tshuaj muaj zog anticholinergic uas muaj cov tshuaj anticholinergic xws li inhibition ntawm lub plawv thiab cov kab mob ua pa.
Xyoo 1894, tus kws muag tshuaj Askiv Askiv Skinton Burns (Henry Hallett Dale) tau tshawb pom ib qho neurotransmitter hu ua choline thaum kawm txog cov txheej txheem ntawm kev ua ntawm atropin, uas yog cov txheej txheem physiological ntawm kev tswj cov leeg nqaij contraction thiab secretion hauv tib neeg lub cev. yam tseem ceeb.
Txij thaum ntawd los, nyob rau hauv cov txheej txheem ntawm kev ntsuam xyuas anticholinergic ntawm ntau yam tshuaj, cov kws tshawb fawb tau tshawb pom ntau yam tshuaj anticholinergic zoo ib yam li atropin, suav nrog Scopolamine butylbromide.
Xyoo 1900, tus kws muag tshuaj German Heinrich Lefler tau tsim Scopolamine thawj zaug, tab sis tsis pom nws muaj txiaj ntsig zoo rau kev kho mob. Txog thaum xyoo 1917, tus kws muag tshuaj German Krusman tau coj txoj haujlwm tshawb fawb ntawm Rifingold, thiab txhim kho txoj kev sib xyaw ua ke raws li cov qauv tshuaj ntawm Scopolamine, thiab ua tiav kev npaj Scopolamine butylbromide. Txij thaum ntawd los, cov tshuaj tau kis tau sai heev nyob rau hauv lub teb chaws Yelemees thiab tau dhau los ua ib qho tshuaj tseem ceeb rau kev kho cov kab mob hauv plab thiab lwm yam kab mob.
Nrog rau kev tshawb fawb tob txog cov txheej txheem ntawm kev ua ntawm Scopolamine butylbromide, nws cov peev txheej ntawm daim ntawv thov kuj nthuav dav. Piv txwv li, nws tuaj yeem siv los ua ib qho tshuaj ntxiv rau cov tshuaj narcotic, uas tuaj yeem txo cov kev mob tshwm sim ntawm ntuav thiab qhov ncauj qhuav. Tsis tas li ntawd, nyob rau hauv cov nqe lus ntawm lub cev muaj zog, Scopolamine butylbromide tuaj yeem txo qhov mob thiab tsis xis nyob los ntawm lub cev muaj zog cov kab mob xws li cov leeg nqaij spasms thiab ankylosing spondylitis.
Feem ntau, Scopolamine butylbromide yog ib tug ntev-tsim thiab dav siv tshuaj anticholinergic, uas yog los ntawm kev tshawb fawb ntawm atropin thaum kawg ntawm lub xyoo pua 19th. Tom qab xyoo ntawm kev ua haujlwm nyuaj los ntawm cov kws tshawb fawb, nws tau maj mam paub thiab siv los ntawm tib neeg.