Semaglutide(txuas:https://www.bloomtechz.com/synthetic-chemical/peptide/semaglutide-powder-cas-910463-68-2.html) yog ib qho tshuaj rau kev kho mob ntshav qab zib hom 2 thiab koom nrog cov tshuaj insulin zoo li peptide-1 receptor agonist (GLP-1 RA). Cov tshuaj formula C187H291N45O59, CAS CAS 910463-68-2. Nws yog ib tug dawb mus rau-dawb hmoov. Nws yog soluble nyob rau hauv dej thiab tsim ib tug ntshiab rau me ntsis cloudy tov nrog ib tug solubility nyob rau hauv dej ntawm txog 10 mg / mL, thiab kuj yuav yaj nyob rau hauv ib co organic solvents xws li cawv thiab dimethyl sulfoxide. Nws yog ib qho hluavtaws zoo sib xws peptide. Hauv cov qauv tshuaj ntawm semaglutide, kuj tseem muaj cysteine residue, uas txuas nrog lwm cov amino acid residues los ntawm disulfide bonds. Nyob ruaj khov nyob rau hauv ib txwm tshuaj cia tej yam kev mob. Nws tuaj yeem khaws cia rau lub sijhawm ntev hauv cov tub yees txias (2-8 degrees Celsius). Cov tshuaj tiav ntawm cov khoom siv tshuaj no muaj ntau yam kev kho mob, tab sis cov khoom tsim los ntawm Shaanxi Chuchan Chemical Co., Ltd. yog cov khoom siv tshuaj thiab tsuas yog siv rau kev tshawb fawb tshawb fawb.
Semaglutide yog ib qho tshuaj insulin zoo li peptide-1 receptor agonist (GLP-1 RA), feem ntau yog siv los kho mob ntshav qab zib hom 2. Ntxiv nrog rau kev kho mob ntshav qab zib mellitus, semaglutide tau raug tshawb xyuas rau ntau lwm yam kev siv.
1. Kev kho mob ntshav qab zib:
Semaglutide yog GLP ua haujlwm ntev -1 receptor agonist uas txo cov ntshav qab zib los ntawm kev ua raws li kev ua ntawm insulin zoo li peptide-1 (GLP-1) uas tsim tawm hauv lub cev. Nws nkoos lub secretion ntawm insulin, inhibits lub secretion ntawm glucagon, thiab slows lub plab zom mov, yog li txo cov ntshav qab zib tom qab noj mov. Qhov ua haujlwm ntev ntawm semaglutide tso cai rau nws muab kev tswj hwm glycemic ruaj khov raws li kev txhaj tshuaj ib zaug ib lim tiam.
2. Kev tswj qhov hnyav:
Ntxiv nrog rau kev kho mob ntshav qab zib, semaglutide kuj tseem siv rau kev tswj qhov hnyav. Kev sim tshuaj ntsuam xyuas tau pom tias cov neeg mob rog rog tau kho nrog semaglutide tuaj yeem ua tiav qhov hnyav hnyav piv rau cov placebo. Semaglutide ua haujlwm los ntawm suppressing qab los noj mov thiab ua kom satiety, yog li txo lub zog kom tsawg. Yog li ntawd, nws yog suav hais tias yog ib qho cuab yeej kho mob rau kev rog rog.
3. Kev tiv thaiv kab mob plawv:
Semaglutide kuj tau qhia txog kev tiv thaiv kab mob plawv. Hauv kev sim tshuaj tiv thaiv kab mob plawv, cov neeg mob ntshav qab zib tau kho nrog semaglutide muaj qhov pheej hmoo tsawg dua ntawm cov xwm txheej hauv plawv (xws li mob plawv, mob stroke) piv nrog cov placebo. Qhov no qhia tau hais tias semaglutide tuaj yeem ua rau txo qis kev pheej hmoo ntawm cov kab mob plawv, uas tuaj yeem cuam tshuam txog kev txhim kho cov tshuaj insulin, txo qis insulin tsis kam thiab txhim kho cov ntshav rog metabolism.
4. Kev kho mob raum mob:
Cov kev sim tshuaj tsis ntev los no tau pom tias semaglutide kuj qhia tau tias muaj peev xwm kho mob raum mob. Cov neeg mob ntshav qab zib hom 2 tau kho nrog semaglutide tsis tsuas yog tswj cov ntshav qab zib kom zoo, tab sis kuj tseem muaj kev txhim kho tseem ceeb hauv lub raum kev ua haujlwm. Tsis tas li ntawd, semaglutide txo qis cov zis albumin, qhov qhia txog kab mob raum.
5. Lipid metabolism tsis meej:
Semaglutide kuj tseem txhim kho lipid metabolism thiab txo cov ntshav triglyceride thiab cov roj cholesterol. Qhov no yog qhov tseem ceeb tshwj xeeb rau cov neeg mob ntshav qab zib, vim lawv feem ntau muaj cov metabolism hauv lipid tsis zoo.
Semaglutide yog ib yam tshuaj uas muaj nyob rau hauv chav kawm ntawm insulin-zoo li peptide -1 receptor agonists (GLP-1 RA). Tab sis nws kuj yog cov khoom siv tshuaj. Raws li lub tuam txhab kev lag luam tshuaj, peb kuj tau ua cov kev tshawb fawb ntxaws txog nws cov khoom siv tshuaj lom neeg thaum kawm txog kev siv cov khoom no. Tom qab ntau qhov kev ntsuam xyuas, peb muaj cov khoom nram qab no:
1. Tshuaj tiv thaiv:
- Hydrolysis: Semaglutide tau txais cov tshuaj tiv thaiv hydrolysis hauv dej, thiab nws cov saw peptide tau tawg rau hauv cov amino acid residue los ntawm cov dej molecules. Cov tshuaj tiv thaiv hydrolysis no tuaj yeem tshwm sim hauv vitro lossis hauv vivo.
- Protease Degradation: Semaglutide tuaj yeem degraded los ntawm proteases hauv vivo. Proteases ntxiv cleave cov peptide saw mus rau hauv me me fragments, nws thiaj li tsim cov amino acid residues.
- Oxidation: Semaglutide muaj ntau pawg sulfite (SS), uas yuav raug oxidized rau disulfide bonds (SS) nyob rau hauv oxidative tej yam kev mob.
- Acetylase-catalyzed cov tshuaj tiv thaiv: Cov acetate linkage (Ac-O-) hauv Semaglutide tej zaum yuav hydrolyzed rau cov sib txuas hydroxyl compound los ntawm acetate-catalyzed enzymes.
2. Pharmacokinetics thiab hauv vivo cov tshuaj tiv thaiv:
- Absorption: Semaglutide yog siv los ntawm kev txhaj tshuaj subcutaneous. Txoj kev ntawm kev tswj hwm no txhawb nqa kev nqus ntawm cov tshuaj thiab ua tiav qhov siab tshaj plaws hauv cov ntshav. Tom qab txhaj tshuaj, semaglutide tso tawm maj mam, muab kev ua haujlwm ruaj khov.
- Kev faib tawm: Hauv cov ntshav ncig, Semaglutide tuaj yeem khi rau plasma proteins. Nws tseem tuaj yeem ncav cuag cov ntaub so ntswg thiab lub cev los ntawm cov ntshav ncig.
- Metabolism: Semaglutide yog metabolized los ntawm lub siab thiab lwm yam ntaub so ntswg los ntawm cov metabolism ntawm insulinase thiab lwm yam enzymes. Cov enzymes no degrade peptide saw ntawm semaglutide thiab hloov mus rau hauv cov amino acid residues los yog me me fragments.
- Excretion: Semaglutide yog tawm los ntawm ob lub raum thiab quav. Semaglutide uas tsis tau metabolized los yog absorbed yog excreted unchanged nyob rau hauv cov zis.
3. Kev sib txuam tshuaj yeeb:
- Cov tshuaj insulin thiab qhov ncauj hypoglycemic: Thaum siv nrog cov tshuaj insulin thiab qhov ncauj hypoglycemic, semaglutide tuaj yeem txhim kho cov nyhuv hypoglycemic ntawm cov tshuaj no. Yog li ntawd, qhov ntau npaum ntawm cov tshuaj insulin thiab qhov ncauj hypoglycemic tshuaj yuav tsum tau ua tib zoo kho ua ntej siv semaglutide.
- Digestive Enzyme Inhibitors: Digestive enzyme inhibitors (xws li orlistat) tuaj yeem cuam tshuam rau kev nqus ntawm semaglutide. Yog li ntawd, tej zaum nws yuav tsim nyog los kho cov koob tshuaj los yog lub sij hawm ntawm semaglutide thaum cov tshuaj no siv concomitantly.