Tirzepatide(link:https://www.bloomtechz.com/synthetic-chemical/peptide/tirzepatide-powder-cas-2023788-19-2.html) yog ib qho tshiab biosimilar tsim los ntawm Lilly thiab Boehringer Ingelheim, uas belongs rau chav kawm ntawm dual hormone (GLP{0}}/GCG) receptor agonists. Cov tshuaj yog ib tug ntev-acting GLP-1 receptor agonist nrog agonistic teebmeem ntawm glucagon-zoo li peptide-1 (GLP-1) thiab glucagon tsev neeg peptide (GCG) tib lub sijhawm, thiab yog zoo hauv kev kho mob ntawm 2 Nws qhia tau hais tias muaj peev xwm loj hauv ntshav qab zib, kab mob uas tsis yog-coholic fatty siab (NAFLD), nonalcoholic steatopancreatitis (NAPCD), rog rog thiab kab mob plawv.
1. Txo cov ntshav qab zib:
Tirzepatide yog GLP ua haujlwm ntev -1 receptor agonist uas tau pom muaj peev xwm zoo hauv kev kho mob ntshav qab zib hom 2. Nws txhawb kev tsim cov tshuaj insulin, txo glucagon thiab insulin tsis kam, thiab pab tswj cov ntshav qab zib. Hauv kev sim tshuaj hauv Tsev Kho Mob General ntawm Tianjin Medical University, qib HbA1c ntawm pab pawg kho mob Tirzepatide tau txo qis los ntawm 2.29 feem pua, tab sis txo qis rau cov neeg mob ntshav qab zib tsis zoo, hypercholesterolemia thiab hypertriglyceridemia loj heev.
2. Txhim kho cov kab mob uas tsis yog-alcoholic fatty siab (NAFLD):
Tirzepatide kuj qhia tau hais tias muaj peev xwm zoo hauv kev kho NAFLD. Hauv kev tshawb fawb Lilly-sponsored, cov neeg mob kho nrog Tirzepatide pom 59 feem pua ntawm cov rog hauv siab txo qis piv nrog cov placebo, thiab nws kuj muaj txiaj ntsig zoo rau cov neeg mob NASH. Tirzepatide txhim kho fatty acid metabolism thiab txo cov insulin tsis kam thiab o, yam uas tau txuas rau kev loj hlob ntawm NAFLD.
3. Txo kev rog:
Tirzepatide kuj tau kawm dav dav rau kev tswj hwm kev rog. Hauv kev sim, ob-dig muag, tshuaj placebo-tswj, cov neeg mob kho nrog Tirzepatide poob qhov nruab nrab ntawm kwv yees li 11.3 feem pua ntawm lawv lub cev qhov hnyav. Hauv lwm txoj kev tshawb fawb, Tirzepatide tuaj yeem ua ke nrog lwm cov tshuaj tiv thaiv kev rog los txhim kho lawv cov teebmeem yuag.
4. Txo txoj kev pheej hmoo ntawm kab mob plawv:
Ntau cov kev tshawb fawb tau pom tias Tirzepatide muaj txiaj ntsig zoo rau cov kab mob plawv. Hauv kev tshawb fawb txhawb nqa los ntawm Lilly, pab pawg kho mob Tirzepatide tau txo qis 40 feem pua ntawm kev pheej hmoo plawv, feem ntau yog vim txo qis tag nrho cov roj (cholesterol) thiab qis lipoprotein cholesterol (LDL-C) qib, tab sis kuj txo cov ntshav siab systolic.
5. Txo cov uas tsis yog-alcoholic steatopancreatitis (NAPCD):
Tsis ntev los no tau pom tias GLP-1 thiab nws cov analogues kuj muaj txiaj ntsig los txhim kho NAPCD. Hauv kev kawm ntawm NAPCD nas qauv, nws tau ua pov thawj tias Tirzepatide tuaj yeem tsis tsuas yog txo cov kev hloov pauv pathological los ntawm GLP-1/GCG dual agonist txoj hauv kev, tab sis kuj txo qis insulin tsis kam, thiab cuam tshuam rau kev tswj hwm txoj cai ntawm kev tuag teeb liab uas ua rau. apoptosis. mus rau txoj kev kho mob.
6. Txhim kho insulin rhiab heev:
Tirzepatide's dual hormone (GLP-1/GCG) receptor agonist mechanism ua kom cov tshuaj insulin rhiab heev. Cov tshuaj no nce insulin secretion los ntawm txiav txiav thiab txo glucagon thiab insulin tsis kam, pab tswj cov ntshav qab zib.
7. Txo qhov mob:
Kev kho cov nyhuv ntawm Tirzepatide tsis yog tsuas yog tswj cov kab mob xws li ntshav qab zib los ntawm kev txhim kho cov txheej txheem metabolic, tab sis kuj txo qis cov lus teb. Cov nyhuv no tshwj xeeb tshaj yog tshwm sim hauv kev kho mob rog thiab kab mob plawv, vim tias cov kab mob no muaj feem cuam tshuam nrog cov lus teb inflammatory.
8. Txhim kho insulin secretion:
Cov txiaj ntsig muaj zog ntawm Tirzepatide ntawm insulin secretion kuj tau kawm ntau heev. Los ntawm kev txhawb kev tso tawm ntawm insulin-zoo li peptides hauv plab hnyuv thiab ua rau muaj kev cuam tshuam ntawm cov tshuaj insulin, cov tshuaj pab tswj cov ntshav qab zib thiab txhim kho cov kev cai metabolic.
9. Txo qab los noj mov:
Cov teebmeem kev kho mob ntawm Tirzepatide kuj tseem cuam tshuam nrog txo qis qab los noj mov. Kev sim tau pom tias cov tshuaj tuaj yeem txo cov zaub mov noj, qab los noj mov thiab xav tau cov khoom noj uas muaj calorie ntau ntau, pab tswj qhov hnyav thiab txo kev rog.
10. Kho ntau yam kab mob:
Zuag qhia tag nrho, Tirzepatide yog cov tshuaj muaj ntau yam uas tuaj yeem siv rau hauv kev kho mob ntawm hom 2 mob ntshav qab zib, kab mob uas tsis yog-coholic fatty siab (NAFLD), nonalcoholic steatopancreatitis (NAPCD), rog rog thiab kab mob plawv, thiab lwm yam. Txawm hais tias xav tau kev tshawb fawb ntxiv kom paub meej tias nws txoj kev nyab xeeb thiab kev ua tau zoo, Tirzepatide cov kev tshawb fawb hauv cov cheeb tsam saum toj no tau ua rau tib neeg muaj kev cia siab.
Tirzepatide yog ib qho tshuaj uas muaj cov ntawv thov dav dav thiab tuaj yeem siv los kho mob ntshav qab zib hom 2, kab mob uas tsis yog-coholic fatty siab (NAFLD), nonalcoholic steatopancreatitis (NAPCD), rog rog thiab kab mob plawv. Txawm hais tias kev tshawb fawb ntxiv tseem xav tau los lees paub nws txoj kev nyab xeeb thiab kev ua tau zoo, cov txiaj ntsig kev tshawb fawb ntawm hom tshiab biosimilar hauv cov teb saum toj no tau ua rau tib neeg muaj kev cia siab.
Tirzepatide yog polypeptide molecule uas muaj ntau yam amino acid residues, thiab nws cov tshuaj tiv thaiv muaj feem cuam tshuam los ntawm ntau yam, xws li kub, pH tus nqi, lub teeb, thiab lwm yam. Cov nram qab no yuav piav qhia txog cov tshuaj tiv thaiv ntawm Tirzepatide los ntawm cov yam ntxwv ntawm cov tshuaj tiv thaiv, cov tshuaj tiv thaiv redox. , acid-base cov tshuaj tiv thaiv, hydrolysis cov tshuaj tiv thaiv, ntxiv cov tshuaj tiv thaiv thiab lwm yam.
1. Tshuaj tiv thaiv:
Cov qauv polypeptide ntawm Tirzepatide ua rau nws chemically reactive thiab tuaj yeem hnov mob nrog qee cov reagents. Piv txwv li, Tirzepatide tuaj yeem raug txo qis cov tshuaj tiv thaiv carbonyl nrog cov pa roj carbon monoxide (CO) nyob rau hauv lub xub ntiag ntawm palladium catalyst los tsim cov tshuaj steroid intermediate. Tsis tas li ntawd, Tirzepatide kuj tseem tuaj yeem qhia ntau pawg ua haujlwm los ntawm kev hloov pauv, xws li qhia cov pab pawg alkyl, pawg cawv, pawg acyl, thiab lwm yam. Cov tshuaj tiv thaiv no feem ntau yuav tsum tau ua raws li qhov tsim nyog reagents, catalysts thiab cov tshuaj tiv thaiv kom tau txais cov txiaj ntsig zoo thiab cov khoom lag luam. kev huv.
2. Cov tshuaj tiv thaiv Redox:
Tirzepatide muaj ntau yam amino acid residues thiab unnatural amino acids nrog ib co redox reactivity. Piv txwv li, Tirzepatide tuaj yeem raug oxidation nyob rau hauv lub xub ntiag ntawm oxygen los yog oxidizing tus neeg sawv cev los tsim ib co oxidation khoom. Tsis tas li ntawd, nyob rau hauv lub xub ntiag ntawm kev txo cov neeg ua hauj lwm los yog nyob rau hauv txo cov kev mob, Tirzepatide kuj yuav txo tau cov tshuaj tiv thaiv, yog li txo qhov hnyav molecular thiab lom lom. Cov tshuaj tiv thaiv no muaj qhov cuam tshuam tseem ceeb rau kev ruaj ntseg thiab kev ua tau zoo ntawm Tirzepatide, yog li yuav tsum tau saib xyuas kom tsis txhob muaj cov tshuaj tiv thaiv no thaum khaws cia thiab siv.
3. Cov tshuaj tiv thaiv acid-base:
Txij li Tirzepatide muaj ntau yam amino acid residue, nws muaj qee yam acid-puag zog thiab tuaj yeem ua rau muaj kev cuam tshuam tsis zoo nrog qee cov kua qaub lossis cov hauv paus. Piv txwv li, ntawm qhov qis pH qhov tseem ceeb, cov amino pawg ntawm Tirzepatide yog protonated los tsim cov ions zoo, thaum nyob rau ntawm pH ntau dua, lawv raug deprotonated los tsim cov ions tsis zoo. Cov kev hloov no yuav cuam tshuam rau kev solubility, stability thiab kev ua tau zoo ntawm Tirzepatide, yog li nws yuav tsum tau khaws cia thiab siv Tirzepatide ntawm qhov tsim nyog pH.
4. Hydrolysis cov tshuaj tiv thaiv:
Txij li Tirzepatide muaj ntau yam peptide bonds, nws kuj muaj qee qhov hydrolytic reactivity. Thaum muaj dej los yog hydrolytic enzymes, peptide bonds ntawm Tirzepatide tuaj yeem hydrolyzed los ntawm dej los yog hydrolytic enzymes kom decompose rau hauv monomeric amino acids. Cov tshuaj tiv thaiv no yuav txo qis kev lom neeg thiab kev ruaj ntseg ntawm Tirzepatide, yog li yuav tsum tau saib xyuas kom tsis txhob muaj cov tshuaj tiv thaiv no thaum khaws cia thiab siv.
5. Ntxiv cov tshuaj tiv thaiv:
Txij li thaum Tirzepatide muaj ntau daim ntawv cog lus ob npaug (xws li Pro thiab Gln residues), nws kuj muaj qee qhov kev sib txuas ntxiv. Piv txwv li, Tirzepatide tuaj yeem raug ntxiv cov tshuaj tiv thaiv nrog qee cov electrophiles (xws li sodium nitrite, diazomethane, thiab lwm yam) los qhia cov pab pawg sib txawv thiab cov haujlwm ua haujlwm. Cov tshuaj tiv thaiv no yuav tsum tau ua raws li qhov tsim nyog reagents, catalysts, thiab cov tshuaj tiv thaiv kom tau txais cov txiaj ntsig zoo thiab cov khoom purity.
Hauv cov ntsiab lus, Tirzepatide yog polypeptide molecule uas muaj ntau yam amino acid residues, thiab nws cov khoom reactivity cuam tshuam los ntawm ntau yam. Tirzepatide muaj qee yam tshuaj reactivity, redox reactivity, acid-base reactivity, hydrolysis reactivity thiab ntxiv reactivity, thiab yuav tsum tau saib xyuas kom tsis txhob muaj cov tshuaj tiv thaiv thaum lub sij hawm cia thiab siv los xyuas kom meej nws cov kev ua tau zoo thiab kev nyab xeeb.