Methylergonovine maleate yog ib tug semisynthetic ergot alkaloid derivative uas exerts nws thawj qhov kev kho mob los ntawm kev txhawb cov leeg nqaij contractions, tshwj xeeb tshaj yog nyob rau hauv lub tsev menyuam. Cov tshuaj txoj kev ntawm kev ua nyob rau hauv activating du nqaij contractions muaj ntau txoj kev, nrog rau kev sib cuam tshuam nrog sib txawv receptors thiab ncaj qha cuam tshuam rau cov leeg nqaij hlwb.
Nws yog ib hom serotonin receptor agonism. Cov leeg nqaij du muaj serotonin receptors ntawm 5-HT2A thiab 5-HT2B subtypes. Cov tshuaj no ua rau muaj zog agonists. Cov khoom khi rau cov receptors no. Thaum lub sij hawm ntawd, nws pib ua ib qho teeb meem nyuaj uas nws thiaj li ua rau muaj kev nce hauv cov calcium hauv cov cell.
Peb tuaj yeem ua cov kauj ruam ntxiv. Nws tuaj yeem nce cov calcium hauv lub cev. Lub compound txhawb kev tsim ntawm inositol triphosphate (IP3). Activating serotonin receptors yog ib txoj hauv kev. Yog li, calcium yog tso tawm los ntawm intracellular reserves. Nws suav nrog sarcoplasmic reticulum. Voltage-gated calcium channels tuaj yeem pab txhawb cov calcium ntxiv rau hauv cov leeg nqaij.
Nws txhawb nqa calcium-mediated smooth nqaij contraction. Ib qho calcium-calmodulin complex yog tsim thaum cov protein calmodulin khi rau cov calcium ntau ntxiv hauv cov cell uas coj los ntawmmethylergonovinecov dej num. Tom qab ntawd, qhov sib xyaw ua ke no ua rau myosin teeb saw kinase (MLCK). Nws yog ib qho enzyme uas phosphorylates myosin txoj kev tswj lub teeb chains.
Nws pab tsim cov actin-myosin cross-bridge. Lub phosphorylation ntawm myosin lub teeb chains los ntawm MLCK tso cai rau tsim cov actin-myosin cross-bridges, uas yog lub hauv paus ntawm cov leeg nqaij contraction. Cov ntoo khaub lig txuas txuas txuas, rub, thiab tshem tawm ntawm cov actin filaments, tsim kom muaj zog thiab ua rau cov nqaij leeg du kom luv thiab cog lus.
Nws cov teebmeem kho los ntawm serotonin receptors yog qhov tseem ceeb uas yuav tsum tau tham. Cov khoom lag luam kuj nthuav tawm ncaj qha ua haujlwm ntawm cov leeg nqaij leeg uas ua rau nws txoj haujlwm uterotonic. Lub compound tuaj yeem ncaj qha depolarize cov leeg nqaij daim nyias nyias. Lub compound ua rau qhib qhov hluav taws xob-gated calcium channel thiab influx ntawm calcium ions. Cov txheej txheem no yog ywj siab ntawm cov tshuaj serotonergic cov teebmeem thiab ntxiv dag zog rau cov lus teb ntawm cov leeg nqaij du.
Yuav Ua Li Cas Methylergonovine Tshwj Xeeb cuam tshuam rau Uterine Smooth Muscle?
MethylergonovineFeem ntau tiv thaiv thiab kho cov ntshav tom qab yug me nyuam los ntawm kev txhawb nqa cov leeg nqaij leeg hauv cov ntaub so ntswg sib txawv, tshwj xeeb tshaj yog nyob rau hauv cov leeg nqaij uterine.
Nws pab uterine smooth nqaij contraction. Thaum lub sij hawm cev xeeb tub, cov nqaij ntshiv ntawm lub tsev menyuam tau dhau los ua hypertrophy thiab hyperplasia hauv kev npaj rau kev ua haujlwm thiab kev yug menyuam. Cov khoom no ua rau lub tsev menyuam cov leeg nqaij leeg, txhawb kev sib koom ua ke ntawm kev sib koom tes los ntawm cov txheej txheem tau piav qhia saum toj no.
Nws yog qhov zoo rau compression ntawm cov hlab ntsha. Thaum cev xeeb tub, lub tsev menyuam muaj cov hlab ntsha dilation los txhawb kev loj hlob ntawm fetus. Cov tshuaj induces uterine contractions thiab constricts cov hlab ntsha. Tom qab ntawd, nws txo cov ntshav khiav thiab pab tswj cov ntshav tom qab yug menyuam.
Pab nrog cov teebmeem synergistic ntawm oxytocin yog lwm qhov zoo dua. Cov khoom lag luam thiab oxytocin, ob qho tib si uterotonic cov neeg ua haujlwm, tuaj yeem ua haujlwm ua ke los txhim kho uterine contractions. Oxytocin tsom rau sab sauv ntawm lub tsev menyuam. Cov khoom lag luam muaj kev cuam tshuam zoo rau cov ntu qis. Nws ua rau muaj kev sib txuam thiab ua haujlwm zoo ntawm tag nrho lub tsev menyuam.
Nws kuj pab ntev lub uterine laus. Ntxiv nrog rau kev txhawb nqa kev cog lus muaj zog, cov khoom sib xyaw kuj tseem pab tswj lub tsev menyuam lub suab, uas yog qhov tseem ceeb rau kev tiv thaiv tom qab yug me nyuam. Los ntawm kev txhawb nqa uterine smooth nqaij contractions rau ib lub sij hawm ntev, cov khoom pab kom lub tsev menyuam nyob twj ywm nruj thiab tiv thaiv los ntshav ntau.
Dab tsi yog Cov Ntawv Kho Mob ntawm Methylergonovine's Effects on Smooth Muscle?
Methylergonovineyog siv nyob rau hauv obstetrics los kho postpartum hemorrhage. Nws lub peev xwm los txhawb cov leeg nqaij leeg tau nthuav dav nws daim ntawv thov rau ntau yam kev kho mob.
Ib qho ntawm cov kev siv yog kev kho mob ntshav qab zib. Peb cov khoom yog feem ntau txhaj tshuaj, xws li intramuscularly los yog intravenously, tom qab tso cov placenta. Lub hom phiaj yog kom muaj ntshav-tso-tswj uterine contractiles. Tsis tas li ntawd, nws tseem tuaj yeem siv rau kev kho mob ntshav qab zib tom qab yug me nyuam uas tau npaj los tshwm sim, xws li cov neeg uas muaj keeb kwm ntawm kev mob ntshav qab zib los yog lub tsev menyuam tuaj yeem kho nrog nws.
Nws pab tswj cov ntshav uterine. Cov khoom no qee zaum siv off-label rau kev tswj hwm ntawm atypical uterine los ntshav tsis cuam tshuam nrog cev xeeb tub. Qhov no tej zaum yuav muaj xws li hais txog tej yam mob xws li menorrhagia (feem ntau dhau lawm los ntshav) los yog los ntshav txuam nrog uterine fibroids los yog endometrial polyps.
Lwm qhov yog nws txoj kev kho mob migraine. Cov tshuaj tau tshawb pom raws li kev kho tsis tau zoo rau kev mob taub hau migraine vim nws cov yam ntxwv vasoconstrictive. Los ntawm kev txwv cov hlab ntsha cranial, cov tshuaj tuaj yeem pab txo qhov mob migraine thiab cov tsos mob tshwm sim.
Txoj hnyuv los ntshav kuj yog lwm daim ntawv thov. Cov khoom no yog siv off-label los kho plab hnyuv los ntshav vim nws muaj peev xwm mus constrict cov hlab ntsha thiab txhawb cov leeg nqaij contractions. Cov tshuaj tuaj yeem pab txo qis los ntshav los ntawm qhov ua rau muaj xws li peptic ulcers lossis mob qog noj ntshav hauv plab los ntawm kev txo cov ntshav ntws mus rau thaj chaw muaj kev cuam tshuam.
Nws muaj peev xwm siv tau rau lwm yam mob. Cov kev tshawb fawb tau saib txog kev siv cov khoom siv los kho cov kab mob ntxiv uas cuam tshuam rau cov leeg nqaij tsis zoo, suav nrog kev mob ntsws ntsws hauv qee hom, mob plab plob tsis so tswj, thiab zis incontinence. Txawm li cas los xij, kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj hauv cov ntsiab lus no tseem raug tshawb xyuas, yog li cov kev siv no tsis muaj pov thawj tag nrho.
Txawm hais tias nws muaj peev xwm los txhawb cov leeg nqaij leeg, yuav tsum ceev faj nrogmethylergonovinerau nws cov vasoconstrictive zog. Yog li, nws yog ib qho tseem ceeb kom muaj ib tus kws kho mob uas tsim nyog saib xyuas cov tshuaj. Kev tswj hwm ntawm cov tshuaj no ua tib zoo ntsuas qhov sib npaug ntawm cov txiaj ntsig thiab kev pheej hmoo rau txhua tus neeg mob.
Cov ntaub ntawv:
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