Dab tsi ua rau cov tshuaj Fipronil poob zoo tiv thaiv fleas?

Fleas yog cov kab tsuag uas muaj zog. Lawv txav nrawm, rov tsim dua sai, thiab txhim kho kev tiv thaiv rau ntau yam kev kho mob. Tseemcompound fipronil poob tau nyob twj ywm ib qho ntawm kev ntseeg siab tshaj plaws hauv kev tswj flea rau xyoo lawm. Dab tsi ua rau qhov sib xyaw no nws lub zog nyob ruaj khov? Cov lus teb nyob tob rau hauv cov fleas lub paj hlwb - thiab nkag siab tias cov txheej txheem qhia tias yog vim li cas fipronil - raws li cov formulations tseem ua tau zoo dua li lwm txoj hauv kev.

Compound Fipronil Thiab Praziquantel Spot On Solution

1. General Specification (hauv Tshuag)
(1) Kev daws teeb meem
2.Customization:
Peb yuav sib tham tus kheej, OEM / ODM, Tsis muaj hom, rau kev tshawb nrhiav kev ruaj ntseg nkaus xwb.
PIB: BM-9-022
Compound Fipronil thiab Praziquantel Spot On Solution
Lub khw tseem ceeb: Tebchaws Asmeskas, Australia, Brazil, Nyiv, Lub Tebchaws Yelemees, Indonesia, UK, New Zealand, Canada thiab lwm yam.
Chaw tsim tshuaj paus: BLOOM TECH Xi'an Hoobkas
Kev tshuaj xyuas: HPLC, LC-MS, HNMR
Kev them nyiaj yug Technology: R & D Dept.-4

Txhua yam uas muaj sia nyob xav tau lub paj hlwb uas ua haujlwm zoo kom muaj sia nyob. Cov kab mob paj hlwb qhia cov kab xws li fleas txav, noj, thiab ua txhua yam lawv xav tau ua. Compound fipronil tee yog qhov zoo heev ntawm kev ntaus cov kab ke no vim tias lawv tau txais txiaj ntsig los ntawm kev ua kom tsis muaj zog lom neeg uas muaj zog ntau dua hauv cov tsiaj txhu hauv cov tsiaj txhu.

Lub luag haujlwm ntawm Neurotransmitter Inhibition hauv Flea Control

Fipronil yog ib qho tshuaj tua kab hauv pawg phenylpyrazole. Yog hais tias ib yam dab tsi nkag mus rau hauv daim tawv nqaij los yog noj thaum nws noj, nws sai sai txav los ntawm hemolymph, uas zoo li ntshav rau kab, thiab tau mus rau paj hlwb. Ntawm cov paj hlwb synapses, nws messes li GABA neurotransmitter, uas yog ib qho calming neurotransmitter. GABA txoj haujlwm yog kom tsis txhob muaj lub paj hlwb los ntawm kev ua kom muaj zog thiab ua kom nws siab. Cov teeb liab so no tsis ua haujlwm thaum fipronil blocks GABA receptor chaw, thiab paj hlwb pib teb tsis raug yam tsis muaj kev txwv.

 

Vim li cas xaiv qhov tseem ceeb rau kev ua tau zoo

Kev xaiv ntawm receptors yog ib feem loj ntawm vim li cas cov tshuaj fipronil tee ua haujlwm zoo heev tiv thaiv dev mub thaum tseem zoo nkauj zoo nkauj rau cov tsiaj thaum siv cov nqi tsim nyog. Fipronil khi ntau zog rau GABA-gated chloride channels hauv kab ntau dua li cov receptors hauv vertebrates. Kev tshawb fawb tshiab hauv thaj tsam ntawm kab mob kab mob qhia tau hais tias cov qauv sib txawv ntawm arthropod thiab tib neeg GABA receptors ua rau lawv zoo dua ntawm kev khi fipronil hauv kab. Qhov kev xaiv no ua rau cov khoom lag luam muaj txiaj ntsig zoo dua rau cov kab tsuag uas nws txhais tau tias tua tsis tas yuav tsum muaj ntau yam khoom xyaw.

Muaj ntau dua rau GABA receptor dua li qhov hloov pauv ntawm / tawm. Nws yog ib qho nyuaj ion channel protein complex uas pom nyob rau hauv daim nyias nyias ntawm cov neurons, thiab fipronil cuam tshuam nrog nws nyob rau hauv ib txoj kev uas tshwj xeeb thiab kav ntev.

Nkag siab GABA-Gated Chloride Ion Channels

Nws yog ib qho tseem ceeb kom nco ntsoov tias nyob rau hauv ib tug noj qab haus huv flea paj hlwb, GABA khi rau nws receptor thiab qhib ib tug channel uas cia chloride ions (Cl⁻) nkag mus rau hauv lub cell. Cov ions tsis zoo ntxiv ua rau lub cell membrane them ntau dua, uas ua rau nws nyuaj rau cov neuron xa tawm qhov ua tau zoo. Qhov no ua rau inhibition, uas yog "pause" teeb liab hauv lub hlwb. Compound fipronil cov kauj ruam ncaj qha rau ntawm qhov chaw no los ntawm kev coj mus rau tib qhov chaw khi uas GABA feem ntau yuav siv. Qhov no txwv tsis pub chloride nkag mus thiab tshem tawm tag nrho inhibitory tswj. Txij li thaum cov hlab ntsha tsis muaj txoj hauv kev ua kom qeeb, nws pib ua siab dhau.

Duration ntawm Receptor Binding thiab Vim Li Cas Nws Tseem Ceeb

Ib yam uas ua rau fipronil tshwj xeeb yog tias nws nyob ruaj khov rau receptors ntev. Fipronil nyob twj ywm txuas nrog GABA receptor complex rau lub sijhawm ntev, thaum qee cov tshuaj tua kab sib cais sai. Cov kws tshawb fawb kawm txog neuropharmacology ntawm arthropods tau pom tias fipronil thaiv cov chloride channel hauv txoj kev uas tsis sib tw nrog GABA. Qhov no txhais tau tias nws lub cev thiab mus tas li thaiv cov channel. Txoj hauj lwm ntev no - lub sij hawm ua kom paub tseeb tias cov hlab ntsha hyperexcitation kav ntev txaus los ua kom puas cov dev mub lub paj hlwb nyob rau hauv ib txoj kev uas kho tsis tau, txawm tias nws tsuas yog los rau hauv kev sib cuag nrogcompound fipronil poobrau lub sijhawm luv luv.

Fipronil cov tshuaj tseem ceeb yog kom tsis txhob muaj kab mob. Thaum koj nkag siab nws, koj tuaj yeem pom yog vim li cas txawm tias me me ntawm cov tshuaj muaj zog zoo li no rau cov kab.

Lub Mechanism of Non{0}}Competitive Channel Block

Fipronil ua ntau dua li tsuas yog so rau saum GABA receptor. Nws nkag mus rau hauv cov tshuaj chloride ion channel pore, nyob twj ywm nyob rau hauv lub transmembrane domain, thiab lub cev nres ions ntawm tsiv. Cov txheej txheem tsis yog - kev sib tw yog qhov tseem ceeb heev vim nws txhais tau tias qhov nce GABA yuav tsis thim rov qab qhov thaiv; cov channel yuav nyob twj ywm tsis muaj teeb meem ntau npaum li cas ntawm ib qho inhibitory neurotransmitter cov flea lub paj hlwb tso tawm. Compound fipronil tee, ntawm qhov tod tes, ua rau muaj kev cuam tshuam ntawm cellular uas yog qhov tseem ceeb mus tas li, depriving cov neuron ntawm cov kev cai ionic nws yuav tsum ua haujlwm kom raug.

Cov yam ntxwv nta uas pab kom tob Channel nkag mus

Cov qauv tshuaj ntawm fipronil ua rau qhov kev sib sib zog nqus channel nkag tau. Cov pab pawg trifluoromethylsulfinyl thiab qhov tseeb tias cov molecule feem ntau lipophilic ua rau nws yooj yim rau nws nkag mus rau hauv cov tub ntxhais hydrophobic ntawm cov channel protein uas yog kos rau hauv daim nyias nyias. Lub cev profile koj pom tsis yog ib qho xwm txheej; nws yog qhov tshwm sim ntawm kev ua tib zoo npaj molecular. Yog li ntawd, lub compound tau txais mus rau nws lub hom phiaj sai sai thiab nyob twj ywm nyob rau hauv lub sij hawm ntev. Qhov no ua rau kev sib xyaw fipronil tee ib qho cuab yeej muaj zog rau txhua txoj kev npaj tshuaj tua kab.

Thaum cov chloride ions nkag tsis tau rau hauv, cov neurons hauv cov dev plam lawv lub peev xwm los tswj lwm cov neurons. Yog li ntawd, ib tug series ntawm lub hlwb tshwm sim uas sai heev overload tus kab lub cev.

Los ntawm Inhibition Poob mus rau Uncontrolled firing

Yog tsis muaj kev tswj hwm los ntawm GABA, cov lus zoo siab yuav txuas ntxiv mus los ntawm cov dev mub lub paj hlwb yam tsis tau nres. Thaum lub cev muaj zog neurons hluav taws kub nyhiab txhua lub sijhawm, cov kev hnov ​​​​mob tau txhaws nrog cov cim tsis tseeb, thiab cov kab hluav taws xob hauv nruab nrab ntawm lub paj hlwb nres ua haujlwm ua ke. Cov kev ntxhov siab sab hauv no tuaj yeem pom nyob rau hauv cov flea qhov kev txav tsis tu ncua, kev ua tsis taus pa, thiab co cwj pwm. Qhov no overexcitation ntawm neurons tsis yog ib qho kev mob tshwm sim; Nws yog dab tsi compound fipronil tee yuav tsum ua. Nws yog qhov tshwm sim ntawm lub cev ncaj qha ntawm qhov ntev - lub sij hawm GABA channel thaiv.

Hyperexcitation raws li qhov xwm txheej Systemic

Nws tsis yog ib qho kev sib txuas paj hlwb uas cov dev mub neurons tau txais kev zoo siab heev. Vim tias muaj GABA receptors nyob rau hauv kab paj hlwb, nrog rau hauv lub hlwb, lub ventral paj qaum, thiab peripheral ganglia, fipronil cov teebmeem tau hnov ​​thoob lub cev. Kab muaj peev xwm los txhim kho kev txav mus los, noj, thiab rov tsim dua tshiab ua rau tib lub sijhawm hauv ntau lub cev. Qhov no systemic xwm piav qhia vim li cas cov teebmeem ntawmcompound fipronil poobtshwm sim sai heev; lawv feem ntau tshwm nyob rau hauv cov sij hawm ntawm daim ntawv thov.

Los ntawm ib qho ion channel uas raug kaw rau cov dev mub tuag, muaj ntau cov txheej txheem molecular uas ua haujlwm ua ke kom ceev cov txheej txheem.

Lub zog poob qis thiab Cellular Failure

Neurons uas tas li overexcited xav tau ntau lub zog ntawm tes. Neurons uas niaj hnub siv lawv cov khw muag khoom adenosine triphosphate (ATP) tsis tuaj yeem tau txais lub zog ntau dua sai sai. Raws li ATP qib poob sai dua, cov twj tso kua mis ion tsis ua haujlwm, cellular equilibrium tawg, thiab paj hlwb pib poob lawv cov qauv hauv txoj kev uas kho tsis tau. Tus kab mob no tau mus txog qhov chaw ntawm lub cev uas nws tsis tuaj yeem rov zoo dua. Compound fipronil tee ua kom cov kab mob ua haujlwm txhua lub sijhawm, uas ua rau nws noj nws tus kheej los ntawm sab hauv.

Terminal Sequence: Paralysis thiab Mortality

Raws li qhov kev puas tsuaj ntawm neural zuj zus zuj zus, cov flea poob tag nrho cov kev txawj tsav tsheb. Neurons poob lawv lub peev xwm tua hluav taws tom qab hyperexcitation thiab ua rau tuag tes tuag taw. Tus neeg tsis noj mov thiab ua pa, thiab tag nrho lawv lub cev tsis ua haujlwm, uas yog qhov kawg ntawm cov saw hlau tuag. Los ntawm thawj channel blockade mus rau hyperexcitation thiab kev tuag, tag nrho cov txheej txheem tuaj yeem tshwm sim hauv 24 mus rau 48 teev ntawm qhov muaj txiaj ntsig zoo. Ib qho zoo tshaj plaws ntawm cov tshuaj fipronil tee yog tias lawv tua cov dev mub sai. Qhov no txhais tau hais tias cov kab mob fungal tau zoo dua sai sai, thiab fleas muaj sijhawm tsawg dua los tsim thiab kis dua.

Nws tsis yog coincidence uas ua kecompound fipronil poobua hauj lwm zoo tiv thaiv fleas. Nws los ntawm cov txheej txheem tshwj xeeb uas thaiv GABA-gated chloride ion channels, ua kom cov neurons siab dhau, thiab maj mam tso cov kab lub zog kom txog thaum nws ua rau tuag tes tuag taw thiab tuag. Fipronil yog ib qho ntawm cov khoom xyaw uas muaj kev ntseeg siab tshaj plaws hauv cov khoom siv tshuaj tua kab mob tam sim no vim tias nws txoj kev ua tau zoo nkag siab thiab txhawb nqa los ntawm kev tshawb fawb. Cov neeg tsim khoom, cov tsim qauv, thiab cov kws tsim khoom lag luam kws kho tsiaj uas xav siv cov tshuaj tua kab pov thawj yuav tsum nkag siab tias cov txheej txheem no ua haujlwm li cas thiaj li ua kom cov khoom lag luam txhim khu kev qha.

Bloomtechz tuaj yeem ua tau raws li koj cov qauv kev xav tau rau qhov raug, ruaj khov, thiab zoo uas tau kuaj xyuas. Bloomtechz yog tus tsim nyog muab kev pabcuamcompound fipronil poobnrog ntau tshaj 12 xyoo ntawm kev paub hauv organic synthesis thiab tshuaj intermediates. Lawv ua haujlwm tawm ntawm 100,000 m² GMP- cov nroj tsuag muaj ntawv pov thawj uas tau lees paub los ntawm US FDA, EU GMP, Nyiv, thiab CFDA. Muaj peb theem ntawm kev tswj xyuas zoo rau txhua pawg: ntawm qhov chaw tsim khoom, los ntawm peb tus kheej QA / QC cov neeg ua haujlwm, thiab los ntawm cov cai sab nraud. Ntau tshaj 24 lub tuam txhab txawv teb chaws loj ua haujlwm nrog peb hauv cov tshuaj agrochemical, tshuaj tshwj xeeb, thiab kev lag luam tshuaj. Txawm hais tias koj xav tau me me rau kev sim hauv chav kuaj lossis ntau yam khoom los ua, peb pab neeg tuaj yeem muab tus nqi them rau koj, sijhawm tos, thiab tag nrho cov ntaub ntawv kev lis kev cai uas koj xav tau. Hu rau peb tam sim ntawd los tham txog koj cov kev xav tau yuav khoom.

Xa lus rau peb ntawmSales@bloomtechz.com.

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5. Overmyer, SL, Rains, GC, & Buntin, GD (2005). Kev sib txawv ntawm cov dev mub rau fipronil: receptor pharmacology thiab residual kev tshawb fawb. Phau ntawv Journal of Economic Entomology, 98(3), 912–918.

6. US Environmental Protection Agency. (2011). Registration Eligibility Decision (RED) rau Fipronil. Office of Pesticide Programs, US EPA, Washington, DC