Albendazole Capsules

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm albendazole capsules hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo albendazole capsules rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

Albendazole ntsiav tshuajyog ib qho tshuaj anthelmintic siv los kho kab mob cab kab mob. Cov khoom xyaw nquag, albendazole, belongs rau chav kawm benzimidazole thiab ua haujlwm los ntawm inhibiting microtubule tsim nyob rau hauv cov cab, ua rau lawv immobilization thiab tuag.

Kev siv:
Albendazole muaj txiaj ntsig zoo tiv thaiv ntau yam kab mob helminth, suav nrog neurocysticercosis (ua los ntawm nqaij npuas tapeworm larvae), kab mob hydatid (los ntawm dev tapeworm larvae), thiab kab mob plab hnyuv xws li pinworms, roundworms, thiab hookworms.

Dosage & Administration:
Kev noj tshuaj sib txawv raws li hom kab mob thiab tus neeg mob qhov hnyav, feem ntau noj nrog zaub mov los txhim kho kev nqus. Kev kho mob yuav xav tau ntau lub voj voog.

Cov teebmeem:
Cov kev mob tshwm sim muaj xws li xeev siab, mob plab, mob taub hau, thiab kiv taub hau. Tsis tshua muaj tab sis muaj kev cuam tshuam loj xws li lub siab enzyme nce siab, kev tiv thaiv pob txha pob txha, thiab kev tsis haum tshuaj.Albendazole yog ib qho dav -spectrum antiparasitic, tab sis kev saib xyuas kev kho mob yog qhov tseem ceeb rau kev siv nyab xeeb.

Nyob rau tib lub sijhawm, peb lub tuam txhab tsis yog tsuas yog muab cov hmoov ntshiab, tab sis kuj muaj cov ntsiav tshuaj thiab kev ncua. Yog tias xav tau, thov koj xav tiv tauj peb txhua lub sijhawm.

 

Peb Cov Khoom

Albendazole hmoov

Albendazole ntsiav tshuaj

Albendazole Ncua tseg

Albendazole COA

Albendazole ntsiav tshuaj, raws li dav -spectrum antiparasitic tshuaj, yuav tsum tau desiccants kom nws ruaj khov thaum lub sij hawm cia thiab tsheb thauj mus los. Txawm li cas los xij, silica-raws li desiccants (tshwj xeeb tshaj yog silica gel desiccants) tuaj yeem cuam tshuam cov tshuaj tiv thaiv vim lawv lub cev adsorption zog, ua rau txo qis hauv cov ntsiab lus zoo ntawm kev tsim. Cov kev soj ntsuam hauv qab no yog ua los ntawm peb yam: cov xwm txheej zoo ib yam, cov txheej txheem adsorption, thiab kev tiv thaiv kev pheej hmoo.

Cov xwm txheej zoo: Kev tsis pom zoo ntawm cov tshuaj muaj txiaj ntsig hauv Sheep Deworming Experiment hauv South Africa

 

 

Hauv xyoo 2013, pab pawg tshawb fawb hauv South Africa tau soj ntsuam cov txiaj ntsig deworming ntawm kev tswj hwm - tso tawmalbendazole ntsiav tshuaj(CRCs) ntawm Trichuris trichiura. Lawv pom tias qhov txo qis ntawm fecal qe nyob rau hauv cov pab pawg neeg sim ntawm yaj tsis sib txawv ntawm pawg tswj, thiab qhov hnyav nce ntawm pawg sim yog 12% qis dua li ntawm pawg tswj. Kev tshawb nrhiav ntxiv tau pom tias muaj qhov tshwm sim ntawm adsorption ntau dhau ntawm silica gel desiccant hauv batch ntawm cov tshuaj ntsiav: cov seem ntawm albendazole kuaj pom nyob rau saum npoo ntawm cov desiccant yog 0.8mg / g, thaum cov ntsiab lus ntawm cov tshuaj nyob rau hauv cov ntsiab lus capsule ib txwm yog 200mg ib ntsiav tshuaj.

Cov ntaub ntawv no nthuav tawm ob qhov teeb meem loj:

Lub desiccant tuaj rau hauv kev sib cuag ncaj qha nrog cov tshuaj:Lub ntim tsim tsis tau txais cov qauv kev sib cais ywj pheej, uas ua rau cov desiccant thiab cov tshuaj ntsiav tshuaj txhuam rau ib leeg thaum lub sijhawm thauj mus los, thiab cov tshuaj hmoov adhering rau saum npoo ntawm desiccant.

Adhesion kinetics imbalance:Ntawm 25℃thiab txheeb ze av noo ntawm 60%, lub sij hawm sib npaug ntawm adsorption ntawm silica gel desiccant rau albendazole yog 72 teev, tab sis lub sij hawm thauj mus los tiag tiag yog ntev li 14 hnub, deb tshaj lub sij hawm adsorption saturation.

Kev soj ntsuam ntawm cov txheej txheem ntawm cov tshuaj adsorption los ntawm silica gel desiccants

 

 

Surface monolayer adsorption: Cov pab pawg silanol (-Si-OH) ntawm silica nto ua ke nrog cov amino pawg (-NH₂) hauv albendazole molecules los ntawm hydrogen bonds, tsim thawj txheej adsorption. Thaum lub sij hawm no, tus nqi adsorption yog ceev, tab sis tus nqi adsorption tsawg (li 0.1mg / g).

Multilayer adsorption: Thaum cov chaw adsorption nto saturated, cov tshuaj molecules txuas ntxiv mus ntxiv rau ntawm cov adsorbed txheej twb dhau los ntawm van der Waals rog, tsim ib tug multi- txheej txheej. Lub sijhawm no, tus nqi adsorption nce ntxiv, tab sis lub zog adsorption txo qis.

Capillary condensation: Nyob rau hauv lub microporous qauv, cov tshuaj molecules condense nyob rau hauv ib tug kua lub xeev, tsim ib tug "adsorption-dissolution" equilibrium. Thaum lub sij hawm no, tus nqi adsorption tuaj yeem ncav cuag ntau dua 80% ntawm qhov siab tshaj plaws theoretical, uas yog qhov tseem ceeb ntawm kev siv tshuaj tsis ua haujlwm.

Cov yam ntxwv adsorption ntawm albendazole raug cuam tshuam los ntawm cov hauv qab no:

Molecular polarity:Lub molecule ntawm albendazole muaj sulfur atoms (nrog ib tug electronegativity ntawm 2.58) thiab nitrogen atoms (nrog rau ib tug electronegativity ntawm 3.04), uas yog nquag cuam tshuam nrog cov polar pawg nyob rau saum npoo ntawm silica gel.

Crystal qauv:Cov khoom siv raw ntawm albendazole yog - hom siv lead ua, thiab nws lub zog lattice (120 kJ / mol) qis dua li ntawm - hom (145 kJ / mol), ua rau nws yooj yim dua adsorbed.

Environmental humidity:Thaum cov txheeb ze av noo ntau dua 60%, cov dej molecules hauv silica gel micropores tsim cov kav dej ua kua, txhawb kev tawg thiab adsorption ntawm cov tshuaj molecules. Cov txiaj ntsig kev sim qhia tau hais tias ntawm 80% av noo, qhov adsorption ntawm albendazole yog 3.2 npaug ntau dua li ntawm 40% av noo.

Kev Tswj Xyuas Kev Nyab Xeeb: Los ntawm kev tsim khoom ntim rau kev ua kom zoo ntawm cov qauv kev sim

Kev txhim kho cov qauv ntsuas: Tom qab muab tso rau ntawm 40℃/ 75% RH rau 6 lub hlis, cov ntsiab lus ntawm cov tshuaj ntsiav thiab tus nqi adsorption ntawm cov desiccant tau kuaj tsis tu ncua. Tus nqi adsorption tau teev tseg yuav tsum tsis pub tshaj 0.5% ntawm cov ntawv sau npe ntawm cov tshuaj ntsiav; txwv tsis pub, nws raug txiav txim tias tsis tsim nyog.

Kev txhim kho kev ntim khoom

 Kev ywj pheej compartment tsim: Siv ob - txheej aluminium foil ntim, nrog cov tshuaj ntsiav tso rau hauv txheej sab hauv thiab ib lub desiccant compartment nyob rau hauv txheej txheej, kev sib cais ntawm lub cev txo qhov kev pheej hmoo ntawm kev sib cuag. Tom qab qhov kev tsim no tau thov los ntawm lub tuam txhab kws tshuaj, tus nqi desiccant adsorption poob ntawm 0.8 mg / g rau 0.02 mg / g.

 Daim ntawv thov ntawm breathable membrane: Embedding ib tug 0.45 μm pore txoj kab uas hla polytetrafluoroethylene membrane ntawm lub desiccant compartment thiab capsule compartment tso cai rau cov dej molecules mus txog thaum thaiv cov tshuaj hmoov. Cov thev naus laus zis no tuaj yeem txo tus nqi adsorption los ntawm 95% thaum tuav cov dej noo- pov thawj.

Optimization ntawm desiccant xaiv

 Hloov kho silica gel hloov pauv: Siv cov amino- hloov kho silica gel (xws li NH₂-SiO₂), cov amino pawg saum npoo ntawm cov hloov silica gel sib tw rau adsorption nrog albendazole molecules, txo tus nqi adsorption. Cov txiaj ntsig kev sim qhia tau hais tias tus nqi adsorption ntawm hloov kho silica gel rau albendazole yog 78% qis dua li cov silica gel zoo tib yam.

 Daim ntawv thov ntawm cov tshuaj desiccant: Siv cov silica gel -chloride calcium composite desiccant, tshuaj hygroscopicity ntawm calcium chloride (nrog lub peev xwm hygroscopic txog li 300% ntawm nws tus kheej qhov hnyav) txo cov nqi ntawm silica gel siv, yog li txo qhov kev pheej hmoo adsorption. Tom qab daim ntawv thov los ntawm ib qho kev lag luam, tag nrho qhov loj ntawm cov desiccant poob los ntawm 40%, thiab tus nqi adsorption poob los ntawm 65%.

Kev Tshawb Fawb Kev Lag Luam thiab Cov Lus Qhia Yav Tom Ntej

 

Qhov teeb meem ntawm cov tshuaj adsorption los ntawm silica gel tsis yog ib qho kev sib cais; nws cov ntsiab lus yog qhov tsis sib xws ntawm kev ruaj ntseg tshuaj thiab kev sib raug zoo ntawm cov khoom ntim. Kev tshawb fawb yav tom ntej tuaj yeem tsom mus rau cov lus qhia hauv qab no:

Kev loj hlob ntawm ntse desiccants

Tsim kom muaj qhov kub thiab av noo- cov khoom siv tshuaj tiv thaiv uas tswj hwm lawv cov haujlwm hygroscopic thaum lub sijhawm khaws cia thiab cia li kaw lub pore qauv thaum thauj.

Kev suav simulation- pab tsim

Siv molecular dynamics simulation los kwv yees kev sib cuam tshuam ntawm cov tshuaj thiab desiccants, thiab optimize ntim cov ntaub ntawv thiab cov txheej txheem tsis.

Blockchain traceability system

Tsim kom muaj tag nrho -chain database rau desiccant ntau lawm thiab siv, ua kom muaj tseeb - sij hawm saib xyuas thiab ceeb toom ntxov ntawm adsorption txaus ntshai.

Los ntawm kev sib koom tes tsim kho tshiab hauv cov ntaub ntawv tshawb fawb, ntim engineering, thiab cov cuab yeej siv tshuaj, qhov teeb meem ntawm cov tshuaj adsorption los ntawm cov tshuaj desiccants tuaj yeem daws tau, muab kev lees paub zoo rau lub ntiaj teb kev muab tshuaj tiv thaiv -cov tshuaj parasitic xws li albendazole.

Albendazole ntsiav tshuaj, raws li ib tug dav - spectrum deworming tshuaj, lub bioavailability ntawm nws capsule formulation yog ho cuam tshuam los ntawm lub capsule plhaub khoom. Gelatin capsules thiab neeg tsis noj nqaij capsules (xws li hydroxypropyl methylcellulose capsules, starch capsules, thiab lwm yam) nthuav tawm cov yam ntxwv sib txawv ntawm cov tshuaj tso tawm, ruaj khov thiab nqus tau zoo vim qhov sib txawv ntawm cov khoom siv, yog li cuam tshuam rau bioavailability.

Cov yam ntxwv bioavailability ntawm gelatin capsules

Gelatin capsules yog tsim los ntawm hydrolyzing tsiaj collagen. Cov amino thiab carboxyl pawg nyob rau hauv cov saw hlau molecular ntawm cov tshuaj ntsiav muab lawv yooj yooj yim thiab sealing zog, tab sis kuj tseem muaj kev pheej hmoo ntawm tus ntoo khaub lig- txuas cov tshuaj tiv thaiv. Cov lysine thiab arginine residues nyob rau hauv gelatin yog nquag oxidation nyob rau hauv high kub thiab high humidity tej yam kev mob los tsim aldehyde pawg, uas ntxiv ua ke nrog cov amino pawg uas nyob ib sab los tsim amine acetal lug, ua rau lub capsules harden. Tus ntoo khaub lig- txuas cov tshuaj tiv thaiv no txo ​​qhov o thiab solubility ntawm cov tshuaj ntsiav, yog li ncua kev tso tshuaj. Piv txwv li, tom qab kev ntsuas nrawm ntawm 40℃/ 75%RH rau 8 hnub, qhov kev sib cais ntawm tus ntoo khaub lig- txuas gelatin capsules poob los ntawm 40% piv rau cov qauv uas tsis yog -cross- txuas, uas tuaj yeem ua rau qeeb ntawm kev nqus tshuaj hauv plab.

Tsis tas li ntawd, bioavailability ntawm gelatin capsules kuj cuam tshuam los ntawm cov ntsiab lus ntawm cov khoom. Yog tias cov ntaub ntawv raw lossis cov khoom ntxiv ntawm albendazole muaj aldehyde compounds (xws li qee cov tshuaj stabilizers), lawv yuav ncaj qha cuam tshuam nrog cov amino pawg ntawm gelatin, ua kom tus ntoo khaub lig- txuas cov txheej txheem. Qhov kev sib cuam tshuam no tuaj yeem hloov kho cov tshuaj tso tawm nkhaus, txo cov ntshav siab tshaj plaws tshuaj concentration (Cmax) lossis ncua sijhawm kom ncav cuag qhov siab tshaj plaws (Tmax), tshwj xeeb tshaj yog rau cov tshuaj nrog lub qhov rai nqaim (xws li cov metabolite ntawm albendazole uas yuav tsum tau nqus rau hauv ib feem ntawm cov hnyuv), cov nyhuv tseem ceeb dua.

Qhov zoo ntawm bioavailability ntawm cov neeg tsis noj nqaij capsules

Cov neeg tsis noj nqaij capsules yog tsim los siv cov nroj tsuag -raws li cov ntaub ntawv xws li hydroxypropyl methylcellulose (HPMC), starch, thiab pullulan polysaccharide. Tsis zoo li gelatin, lawv cov qauv molecular tsis muaj cov amino pawg, uas yog tsim los tshem tawm txoj kev pheej hmoo ntawm tus ntoo khaub lig- txuas cov tshuaj tiv thaiv uas tuaj yeem cuam tshuam cov tshuaj ruaj khov thiab kev ua haujlwm tawg. Noj HPMC capsules ua piv txwv tus neeg sawv cev, lawv cov txheej txheem tshwj xeeb ntawm lub plhaub o thiab tso tshuaj tso tawm los ntawm kev tsim cov hydrogen bond network thaum sib cuag nrog cov kua dej hauv plab, ua kom muaj kev tswj hwm thiab kwv yees tso tawm profile.

Cov neeg tsis noj nqaij capsules yog ua los ntawm cov nroj tsuag- cov ntaub ntawv raws li (xws li hydroxypropyl methylcellulose, starch, pullulan polysaccharide, thiab lwm yam), thiab lawv cov qauv molecular tsis muaj cov amino pawg, hauv paus tsis txhob tshwm sim ntawm tus ntoo khaub lig- txuas cov tshuaj tiv thaiv. Piv txwv li, HPMC capsules txhawb qhov o thiab tshuaj tso tawm ntawm lub plhaub capsule los ntawm hydrogen bond networks, thiab muaj hygroscopicity tsawg. Lawv tsis tshua muaj kev tawg nyob rau hauv qhov chaw uas tsis muaj av noo thiab tsis tshua muaj peev xwm los ua ke nyob rau hauv high humidity ib puag ncig, kom ntseeg tau qhov sib xws ntawm cov tshuaj tso tawm. Kev tshawb fawb qhia tau hais tias HPMC capsules tuav ruaj khov npaum li cas nyob rau hauv kev ntsuam xyuas ceev, nrog ib tug txo ntawm 5% -8% tom qab 6 lub hlis, ho superior rau gelatin capsules.

Starch capsules (xws li cassava starch-raws li capsules) muab kev tiv thaiv ruaj khov rau cov hmoov av lossis cov kua dej vim lawv cov qauv hmoov txhuv nplej siab thiab cov dej tsis zoo. Lawv muaj cov ntsiab lus tsis tshua muaj dej noo (4% -6%) thiab muaj zog tshuaj lom neeg ruaj khov, kom ntseeg tau tias albendazole cov khoom xyaw nquag tsis txo qis thaum khaws cia. Tsis tas li ntawd, cov txheej txheem tsim khoom ntawm cov tshuaj ntsiav tsis tas yuav tsum tau ntxiv cov tshuaj preservatives los yog siv ethylene oxide sterilization, tsis txhob muaj cov tshuaj residues uas yuav cuam tshuam rau kev ruaj ntseg ntawm cov tshuaj, thiab ntxiv kom muaj bioavailability.

Txheej txheem Optimization thiab yav tom ntej Trends

 

Txhawm rau hais txog tus ntoo khaub lig- txuas qhov tsis xws luag ntawm gelatin capsules, cov tuam txhab tau txhim kho bioavailability los ntawm kev ntxiv cov tshuaj antioxidants (xws li glycine, sodium metabisulfite) los yog siv cov txheej txheem enteric txheej. Txawm li cas los xij, cov txheej txheem no tuaj yeem ua rau cov txheej txheem nyuaj thiab cov nqi. Ntawm qhov tod tes, cov neeg tsis noj nqaij capsules, vim lawv cov tshuaj inertness, ib puag ncig adaptability, thiab cov txheej txheem controllability, yog maj mam dhau los ua cov kev xaiv rau siab -kawg npaj.

Kev lag luam thoob ntiaj teb rau cov nroj tsuag-raws li tshuaj ntsiav tau loj hlob ntawm tus nqi txhua xyoo ntawm 25%, thiab xav tias yuav muaj ntau dua $ 5 nphom hauv qhov loj los ntawm 2030. Lawv tshwj xeeb muaj txiaj ntsig zoo hauv kev npaj tshuaj suav tshuaj thiab biopharmaceuticals. Nyob rau hauv lub neej yav tom ntej, nrog rau kev siv cov ntaub ntawv tshiab xws li hloov cov hmoov txhuv nplej siab thiab nanotechnology, kev ua tau zoo ntawm kev sib tw thiab cov nqi sib tw ntawm cov neeg tsis noj nqaij cov tshuaj ntsiav yuav txhim kho ntxiv, muab cov kev daws teeb meem zoo dua rau kev tiv thaiv - cov tshuaj parasitic xws li albendazole thiab lwm yam.

FAQ

• Dab tsi yog albendazole siv rau?

Albendazole yog FDA- pom zoo tshuaj los kho ntau yam kab mob cab kab mob. Albendazole yog ib qho tshuaj antihelminthic nrog ntau qhov qhia xws li kab mob cystic hydatid ntawm daim siab, ntsws, thiab peritoneum uas tshwm sim los ntawm cov kab mob ntawm tus dev tapeworm, Echinococcus granulosus.

• Thaum twg yuav tsum tau noj albendazole?

Nws feem ntau yog noj nrog zaub mov ob zaug ib hnub. Thaum albendazole siv los kho neurocysticercosis, feem ntau nws yog noj rau 8 mus rau 30 hnub. Thaum albendazole siv los kho tus kab mob cystic hydatid, feem ntau nws yog noj rau 28 hnub, tom qab ntawd so 14 hnub, thiab rov ua dua rau tag nrho peb lub voj voog.

Cim npe nrov: albendazole capsules, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom