Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm bivalirudin txhaj tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo bivalirudin txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Hauv kev kuaj mob thiab kev kho mob, muaj ntau qhov xwm txheej tshwj xeeb uas yuav tsum muaj kev tswj hwm ntawm cov ntshav coagulation. Ntawm lawv, qee qhov kev ua haujlwm muaj qhov yuav tsum tau muaj zog thiab nruj rau inhibiting ntshav txhaws vim lawv tus yam ntxwv. Cov haujlwm zoo li no feem ntau xav tau kev hloov pauv tau zoo, kev ua haujlwm meej meej ntawm kev ua haujlwm, kev tswj tau zoo, thiab kev txhawb nqa qis ntawm lub cev los muab kev pabcuam pabcuam.Bivalirudin Txhaj, nrog nws cov yam ntxwv tshwj xeeb ntawm kev nqis tes ua, tau dhau los ua ib qho kev daws teeb meem zoo tshaj plaws hauv cov xwm txheej zoo li no.
Peb Cov Khoom
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Bivalirudin COA
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| Certificate of Analysis | ||
| Compound npe | Bivalirudin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 128270-60-0 | |
| Ntau | 38g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090086 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C98H138N24O33 |
| Exact Mass | 2178.99 |
| Molecular Luj | 2180.32 |
| m/z | 2179.99 (100.0%), 2178.99 (94.3%), 2180.99 (40.3%), 2182.00 (17.5%), 2180.99 (12.1%), 2180.99 (8.9%), 2179.98 (8.4%), 2181.99 (6.8%), 2180.99 (6.4%), 2181.99 (4.7%), 2183.00 (4.6%), 2183.00 (2.7%), 2181.00 (1.6%), 2179.99 (1.5%), 2180.99 (1.3%), 2179.99 (1.2%), 2184.00 (1.2%) |
| Elemental Analysis | C, 53.99; H, 6.38; N, 15.42; O, 24.22 |
Tshwj xeeb, nws daim ntawv thov txheej txheem hauv qee qhov kev ua haujlwm ntawm cov hlab ntsha ntsig txog kev ua haujlwm thiab cov txheej txheem ntshav purification (feem ntau hemodialysis) tsis yog tsuas yog ua tau raws li qhov tseem ceeb ntawm kev thov kom muaj txiaj ntsig zoo inhibition ntawm cov ntshav coagulation hauv cov haujlwm no, tab sis kuj ua kom muaj kev ruaj ntseg ntawm inhibition cuam tshuam thaum txiav txim siab txog kev nyab xeeb ntawm cov txheej txheem kev ua haujlwm thiab tus neeg mob lub siab ntev, ua kom tsis txhob muaj kev cuam tshuam ntawm cov ntshav coagulation. Txhawm rau kom paub meej ntxiv txog nws daim ntawv thov kev xav thiab tus nqi hauv cov xwm txheej saum toj no, cov hauv qab no yuav tsom mus rau ob qhov xwm txheej tseem ceeb no thiab ua cov kev tshuaj xyuas tshwj xeeb los ntawm ntau qhov ntev, tsom mus rau lawv cov ntaub ntawv thov, cov ntsiab lus hloov kho, thiab cov txiaj ntsig kho mob.
Siv rau hauv peripheral vascular kev ua haujlwm
Hauv kev ua haujlwm ntawm cov hlab ntsha peripheral, kev tsim cov vascular pathways, kev kho mob ntawm cov hlab ntsha, thiab lwm yam txheej txheem tuaj yeem ua rau cov ntshav txhaws tau yooj yim, uas tuaj yeem cuam tshuam cov txiaj ntsig ntawm kev ua haujlwm thiab txawm tias ua rau tsis zoo. Yog li ntawd, nws yog ib qho tsim nyog yuav tsum tau siv cov tshuaj muaj zog thiab mob me me los pab txhawb. Kev xaiv ntawmBivalirudin TxhajHauv cov xwm txheej zoo li no muaj lub hom phiaj meej thiab qhov zoo, uas tuaj yeem ua los ntawm cov hauv qab no:
Muaj feem xyuam ua haujlwm hom:
Tsis yog txhua qhov kev ua haujlwm vascular peripheral yuav tsum tau siv qhov kev npaj no. Nws cov tub ntxhais yog tsim rau cov xwm txheej uas muaj siab coagulation nyiam los yog kev ua haujlwm siab, xws li kev kho mob plab aortic aneurysm, mesenteric vascular kab mob vascular reconstruction phais, thiab qis qis arterial sclerosis thiab occlusion ntsig txog vascular reconstruction phais. Nyob rau hauv xws li kev khiav hauj lwm, ntau yam ntawm vascular puas tsuaj yog loj, lub sij hawm ua hauj lwm yog kuj ntev, thiab lub zais txaus ntshai ntawm cov ntshav txhaws yog ho nce. Kev cuam tshuam zoo los tiv thaiv cov ntshav coagulation yog xav tau kom ua haujlwm zoo. Tsis tas li ntawd, rau qee cov txheej txheem kev cuam tshuam cuam tshuam nrog peripheral venous thrombosis, qhov kev npaj no kuj tuaj yeem siv los ua ib qho ntxiv thaum cov pa roj coagulation inhibition regimen tsis zoo.
Lub ntsiab logic ntawm kev xaiv:
Qhov no yog xaiv rau hom kev ua haujlwm no, thiab nws txoj kev ua haujlwm yog ua raws li cov kev xav tau ntawm kev ua haujlwm. Piv nrog rau cov txheej txheem ntawm inhibiting ntshav coagulation, nws tsis cia siab rau lub cev tus kheej coagulation regulating tshuaj thiab tuaj yeem ua ncaj qha rau ntawm qhov txuas tseem ceeb ntawm cov ntshav txhaws, ua tiav sai, ruaj khov thiab muaj zog inhibitory teebmeem. Nws tuaj yeem zam tsis tau cov teeb meem xws li vascular pathway blockage thiab aggravated thrombus nyob rau hauv qhov chaw mob tshwm sim los ntawm cov ntshav coagulation thaum lub sijhawm ua haujlwm, thiab txo qis cov teebmeem tshwm sim los ntawm kev cuam tshuam ntau dhau lossis tsis txaus, thaum ntsuas kev ua tau zoo thiab kev nyab xeeb.
Qhov zoo ntawm kev siv tswv yim:
Hauv kev xyaum kho mob, kev siv cov kev npaj no rau kev ua haujlwm ntawm cov hlab ntsha tuaj yeem txo qhov tshwm sim ntawm cov teeb meem los ntshav ntawm qhov chaw ua haujlwm, tshwj xeeb tshaj yog qhov tshwm sim ntawm hematoma hauv zos, piv rau lwm cov ntshav coagulation inhibition schemes. Nyob rau tib lub sijhawm, nws tuaj yeem txo qhov ntev ntawm kev soj ntsuam hauv tsev kho mob tom qab kev phais thiab txhim kho kev rov ua haujlwm ntawm cov neeg mob. Qhov kom zoo dua no tau raug txheeb xyuas nyob rau hauv ntau qhov chaw soj ntsuam kev soj ntsuam, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kev zam txim tsis zoo los yog contraindications rau kev npaj cov ntshav coagulation inhibition.
Cov ntaub ntawv Source:
Kev siv hauv hemodialysis
Raws li ib qho tseem ceeb ntawm cov ntshav purification txoj kev hauv kev kho mob, hemodialysis cia siab rau lub extracorporeal ncig system kom tshem tawm cov metabolic pov tseg los ntawm cov ntshav.
Muaj feem cuam tshuam rau kev lim ntshav
Nws txoj kev xaiv yog tsom rau ob hom hemodialysis cov neeg mob. Ib hom yog cov neeg mob uas muaj contraindications rau kev siv cov pa ntshav txhaws inhibitors, xws li cov neeg uas tsis haum rau cov tshuaj npaj thiab muaj kev txawv txav platelet suav txo tom qab siv.Bivalirudin Txhajtuaj yeem siv los ua lwm txoj hauv kev los xyuas kom meej kev lim ntshav; Lwm hom yog cov neeg mob uas tau rov ua ntshav txhaws hauv cov txheej txheem lim ntshav. Cov neeg mob no muaj lub siab nyiam ua kom khov thiab cov txheej txheem ntawm kev tiv thaiv cov ntshav txhaws yog qhov nyuaj kom ua tiav cov txiaj ntsig zoo. Xaiv qhov kev npaj no tuaj yeem ua tiav qhov muaj zog thiab ruaj khov inhibitory cuam tshuam, txo qhov zaus ntawm cov raj txhaws.
Xaiv cov txiaj ntsig tseem ceeb
Qhov tseem ceeb ntawm kev sivBivalirudin Txhajrau hemodialysis nyob rau hauv nws controllability thiab kev nyab xeeb ntawm kev ua. Lub sijhawm ua haujlwm ntawm qhov kev npaj no yog luv luv. Tom qab txiav tawm, cov ntshav coagulation muaj peev xwm sai sai rov qab mus rau qhov qub, txo txoj kev pheej hmoo los ntshav los ntawm qhov seem inhibition ntawm cov ntshav coagulation tom qab kev lim ntshav. Nws yog tshwj xeeb tshaj yog haum rau cov neeg mob uas yuav tsum tau compress lub puncture site rau hemostasis tom qab dialysis, txo qhov nyuaj ntawm hemostasis thiab tej zaum yuav los ntshav txaus ntshai. Nyob rau tib lub sijhawm, nws cov txiaj ntsig tsis cuam tshuam loj heev los ntawm cov xwm txheej metabolic ntawm cov neeg mob, thiab qhov ntau npaum tuaj yeem hloov kho raws li lub sijhawm ntawm kev lim ntshav kom hloov mus rau qhov sib txawv ntawm cov neeg mob sib txawv.
Cov ntsiab lus tseem ceeb rau kev siv tswv yim
Thaum siv qhov kev npaj no hauv hemodialysis, cov koob tshuaj yuav tsum tau hloov kho raws li tus neeg mob qhov xwm txheej, tshwj xeeb tshaj yog rau cov neeg mob uas vam khom rau lub sijhawm ntev. Vim qhov tshwj xeeb metabolic ua haujlwm ntawm lub cev, tus nqi infusion yuav tsum raug txo kom tsim nyog kom tsis txhob muaj kev phiv los ntawm kev siv ntau dhau. Nyob rau tib lub sijhawm, nws yuav tsum tau ua tib zoo saib xyuas tus neeg mob cov cim tseem ceeb thiab cov xwm txheej ntawm cov tubing thaum lub sijhawm lim ntshav, saib xyuas cov ntshav coagulation ntsig txog cov cim raws sijhawm, xyuas kom meej tias qhov inhibition ntawm cov ntshav coagulation nyob rau hauv qhov zoo tagnrho, zam tubing coagulation, thiab tiv thaiv los ntshav txawv txav los ntawm kev inhibition ntau dhau.
Cov ntaub ntawv Source:
Wang Yan, Li Juan Kev soj ntsuam ntawm kev siv tshuaj bivalirudin hauv cov neeg mob hemodialysis [J]. Suav Journal of Blood Purification, 2020, 19 (5): 345-347
Olmedo W, Villablanca P, Weinreich M, et al. Bivalirudin piv rau Heparin nyob rau hauv Cov Neeg Mob Uas Muaj Kev Tiv Thaiv Percutaneous Peripheral Interventions: Kev Ntsuam Xyuas Txheej Txheem thiab Meta- tsom xam[J]. J Am Coll Cardiol, 2017, 70(18 Suppl): B298.
Cov ntaub ntawv
Zhang Min, Liu Yong Kev Ntsuam Xyuas ntawm daim ntawv thov cov nyhuv ntawm bivalirudin peripheral vascular intervention therapy [J]. Suav Journal of Practical Surgery, 2018, 38 (S1): 123-125
Tsu LV, Dager WE. Kev hloov tshuaj Bivalirudin rau txo qis lub raum ua haujlwm nrog lossis tsis muaj hemodialysis hauv kev tswj hwm ntawm heparin-induced thrombocytopenia[J]. Ann Pharmacother, 2011, 45(10): 1185-1192.
Liu Min, Zhao Jing Daim ntawv thov tus nqi ntawm bivalirudin hauv cov neeg mob hemodialysis nrog hypercoagulability nyiam [J]. Phau ntawv Journal of Clinical Nephrology, 2021, 21 (7): 589-592
Vascular Surgery Group ntawm Kev phais ceg ntawm Tuam Tshoj Medical Association Cov Lus Qhia rau Kev Tshawb Fawb thiab Kev Kho Mob Qis Qis Arteriosclerosis Occlusion (Part 1) [J]. Suav Journal of Vascular Surgery (Electronic Edition), 2015, 7 (3): 145-151
Kiser TH, et al. Kev nyab xeeb, kev ua tau zoo thiab kev noj tshuaj ntawm bivalirudin hauv cov neeg mob uas muaj heparin -induced thrombocytopenia[J]. Pharmacotherapy, 2008, 28(9): 1115-1124.
FAQ
- Qhov txawv ntawm bivalirudin thiab heparin yog dab tsi?
Heparin yog thawj qhov kev xaiv rau kev kho mob antithrombotic. Hauv qhov sib piv, bivalirudin yog tus tshiab ncaj qha thrombin inhibitor uas tau tshaj tawm tias muaj cov tshuaj tiv thaiv kab mob thiab txo qis kev pheej hmoo los ntshav thaum lub sijhawm PCI.
- Nws kav ntev npaum li cas?
Ib nrab-Lub neej ntawm Bivalirudin hauv cov neeg mob uas lub raum ua haujlwm zoo yog 25 feeb. Hauv nruab nrab thiab mob raum tsis zoo, kev tshem tawm raug txo los ntawm 21%, nrog rau ib nrab ntawm -lub neej ntawm 34 thiab 57 feeb, raws li. Hauv cov neeg mob dialysis, kev tshem tawm yog txo qis los ntawm 70% nrog ib nrab ntawm -lub neej ntawm 3.5 teev.
Cim npe nrov: bivalirudin txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom