Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm desmopressin acetate txhaj nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo desmopressin acetate txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Desmopressin acetate txhaj tshuajyog ib qho tshuaj sterile txhaj tshuaj npaj nrog desmopresin acetate ua cov khoom xyaw tseem ceeb (CAS: 16789-98-3). Raws li cov tshuaj synthesized antidiuretic hormone analogue thiab vasopressin derivative, nws muaj ib tug optimized molecular qauv uas xa muaj zog antidiuretic teebmeem nrog negligible vasoconstrictive phiv. Nws cov khoom siv raw yog dawb crystalline hmoov nrog cov dej zoo solubility, thiab cov kev npaj tiav yog ib qho ntshiab, tsis muaj xim tsis muaj kuab lom aqueous. Cov khoom lag luam tswj xyuas cov khoom siv tshuaj lom neeg ruaj khov thiab kev ua haujlwm lom neeg nyob rau hauv kev sib khi, tsaus thiab qis-kub ntawm -20 degree, thaum kub kub thiab av noo tej zaum yuav ua rau cov qauv degradation thiab txo cov nyhuv.
Cov tshuaj no ua haujlwm los ntawm kev tswj hwm tib neeg cov dej- ntsev metabolism, txo cov zis tso zis, ua kom cov zis osmotic siab thiab txo cov ntshav osmotic siab. Nws yog feem ntau qhia rau central polyuric syndrome, txhim kho cov neeg mob 'polyuria thiab nocturia cov tsos mob ntawm cov tshuaj hormone hloov kho thiab optimizing lawv lub neej zoo. Tsis tas li ntawd, nws tuaj yeem siv rau kev tswj ntshav los ntshav thiab kev tiv thaiv los ntshav ua ntej. Nws yog qhov tsim nyog rau cov neeg mob congenital los yog siv yeeb tshuaj-induced platelet dysfunction, uremia, cirrhosis thiab unexplained lub sij hawm los ntshav, thiab tseem yuav pab tiv thaiv thiab kho los ntshav thaum lub sij hawm me me kev phais nyob rau hauv cov neeg mob uas mob hemophilia A.
Peb Cov Khoom
Desmopressin Acetate COA
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| Certificate of Analysis | ||
| Compound npe | Desmopressin Acetate hmoov | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 16789-98-3 | |
| Ntau | 60g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090055 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.48% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.30% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.56% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 170 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Chemical Formula: | C50H72N14O16S2 |
| Exact Mass: | 1188 |
| Molecular Luj: | 1189 |
| m/z: | 1188 (100.0%), 1189 (49.8%), 1070 (12.1%), 1070 (9.0%), 1069 (5.2%), 1071 (4.5%), 1070 (2.6%), 1070 (2.5%), 1069 (1.6%), 1071 (1.2%), 1071 (1.1%), 1072 (1.1%) |
| Elemental Analysis: | C, 51.67; H, 6.03; N, 18.34; O, 17.96; S, 6.00 |
Txoj kev tswj hwm suav nrog kev txhaj tshuaj intravenous, subcutaneous, lossis txhaj tshuaj intramuscular, thiab cov koob tshuaj yuav tsum tau hloov kho raws li qhov xwm txheej tshwj xeeb thiab cov lus qhia ntawm tus neeg mob. Piv txwv li, nyob rau hauv kev kho mob ntawm central polyuric syndrome, cov koob tshuaj niaj hnub rau kev txhaj tshuaj rau cov neeg laus yog 1-4 micrograms ib zaug, 1-2 zaug hauv ib hnub; Thaum siv los tswj los ntshav lossis tiv thaiv los ntshav ua ntej kev phais, qhov ntau npaum li cas yog xam raws li lub cev hnyav, feem ntau yog 0.3 micrograms ib kilogram ntawm lub cev hnyav.
Daim ntawv thov nyob rau hauv kev kho mob ntawm central polyuric syndrome
Central polyuric syndrome yog ib qho mob tshwm sim los ntawm qhov tsis txaus ntawm cov tshuaj antidiuretic hormone (ADH) nyob rau hauv lub caj pas pituitary, uas yog nqhis dej thiab tso zis ntau zaus. Kev tso tawm tsis txaus ntawm cov tshuaj antidiuretic hauv tus neeg mob lub cev lossis qhov tsis txaus ntseeg ntawm lub raum rau nws tuaj yeem ua rau muaj kev ua haujlwm tsis zoo hauv cov dej rov qab los ntawm lub raum tubules, ua rau cov tsos mob xws li polyuria, nqhis dej, thiab haus dej ntau dhau. Tus kab mob no cuam tshuam rau lub neej zoo ntawm cov neeg mob, yog li cov kev kho mob zoo yuav tsum tau ua kom txo tau cov zis tso zis, nce cov zis osmotic siab, txo cov ntshav osmotic siab, thiab txo cov tsos mob.
(2) Cov txheej txheem thov tshwj xeeb
Daim ntawv xaiv ntau npaum li cas: Muaj ntau ntau hom tshuajKev txhaj tshuaj desmopressin acetatemuaj, suav nrog cov ntsiav tshuaj ntawm qhov ncauj, tshuaj tsuag qhov ntswg, subcutaneous lossis txhaj tshuaj intravenous, thiab lwm yam. Ntawm lawv, cov ntsiav tshuaj ntawm qhov ncauj yog qhov yooj yim siv thiab yog ib qho ntawm cov ntawv siv ntau npaum li cas; Kev nqus pa ntawm qhov ntswg tuaj yeem siv tau sai; Kev txhaj tshuaj intramuscular thiab intravenous yog tsim rau cov neeg mob uas xav tau kev tswj cov tsos mob sai lossis tsis tuaj yeem noj ntawm qhov ncauj.Kev ceev faj txog tshuaj: Vim nws txwv tsis pub tso zis, kev haus dej yuav tsum nruj me ntsis thaum kho, tshwj xeeb tshaj yog rau cov menyuam yaus thiab cov neeg laus, kom tsis txhob haus dej ntau dhau ua rau dej lom thiab hyponatremia.
Kev haus dej cawv thiab hyponatremia yog qhov tshwm sim tsis zoo tshaj plaws hauv kev kho cov tshuaj no, thiab thaum mob hnyav, lawv tuaj yeem ua rau qaug dab peg, coma, thiab txawm tuag. Nyob rau tib lub sijhawm, nws raug txwv tsis pub siv cov tshuaj no rau cov neeg mob uas muaj lub raum tsis ua haujlwm hnyav (creatinine clearance rate).<50 mL/min) and a history of hyponatremia, and it is also not suitable for patients with renal polyuric syndromes. In addition, newborns should be alert to the toxicity risk of benzyl alcohol, as some preparations contain benzoic acid (a metabolite of benzyl alcohol), and should be highly vigilant when used in low birth weight infants or premature infants.
(3) Cov nyhuv kho mob thiab cov ntaub ntawv tshawb fawb
Cov kev tshawb fawb txog kev kho mob thiab cov ntaub ntawv kho mob qhia tau hais tias tom qab siv tus qauv, kwv yees li 83% ntawm cov neeg mob uas muaj cov kab mob hauv nruab nrab polyuric tuaj yeem txhim kho lawv cov tsos mob, txo cov zis tso zis, thiab txhim kho lawv lub neej zoo. Piv txwv li, nyob rau hauv kev xyaum kho mob, ntau tus neeg mob muaj ib tug tseem ceeb txo nyob rau hauv lub sij hawm tso zis ntau zaus thiab ib tug nyem ntawm nqhis dej tom qab kev kho mob, thiab muaj peev xwm rov qab tau lawv li qub pace ntawm lub neej thiab kev ua hauj lwm.
Cov ntsiav tshuaj ntawm qhov ncauj:
Raws li lub ntiaj teb thawj cov khoom siv qhov ncauj, lawv yog cov qauv kev kho mob rau lub hauv paus polyuric syndrome thiab muaj ntau tshaj 40 xyoo ntawm kev kho mob. Nws qhov zoo yog nyob rau hauv kev tswj hwm yooj yim, ua raws li tus neeg mob siab, thiab tsim nyog rau kev kho mob ntev -. Rau cov neeg mob uas muaj kev ruaj ntseg uas tuaj yeem noj tshuaj raws sijhawm, cov ntsiav tshuaj ntawm qhov ncauj yog qhov kev xaiv zoo tshaj plaws.
Cov tshuaj tsuag qhov ntswg: nws tuaj yeem siv tau sai thiab tsim nyog rau cov neeg mob uas xav tau tshem tawm cov tsos mob sai. Piv txwv li, thaum cov neeg mob dheev nqhis dej heev thiab polyuria, kev siv cov tshuaj tsuag qhov ntswg tuaj yeem ua rau kom cov dej rov qab los ntawm ob lub raum thiab txo cov zis tawm.
Hom Kev Txhaj Tshuaj: Subcutaneous lossis intravenous txhaj yog tsim rau cov neeg mob uas tsis tuaj yeem noj tshuaj hauv qhov ncauj, xws li cov neeg tsis nco qab lossis nrog kev ua haujlwm ntawm plab hnyuv. Hauv qee qhov xwm txheej kub ntxhov, xws li lub cev qhuav dej hnyav thiab qhov tsis txaus ntawm electrolyte tshwm sim los ntawm lub hauv paus polyuric syndrome, kev txhaj tshuaj hauv cov hlab ntsha tuaj yeem ua rau tus mob sai sai.
Tsis ntev los no, Eton Pharmaceuticals tshaj tawm tias US Food and Drug Administration (FDA) tau pom zoo nws tsim Desmoda acetate vasopressin qhov ncauj tshuaj rau kev kho mob ntawm central polyuric syndrome rau cov neeg laus thiab cov me nyuam. Lub Desmoda tau pom zoo rau lub sijhawm no yog thawj cov kua hauv qhov ncauj ntawm cov tshuaj kho tus qauv. Piv nrog rau cov ntsiav tshuaj ib txwm muaj, cov qauv ua kua tuaj yeem ua tiav cov kev hloov pauv hloov pauv ntau dua, tshwj xeeb tshaj yog tsim nyog rau kev kho mob ntshav qab zib insipidus uas yuav tsum tau titration meej los tswj cov dej ntsev sib npaug.
Cov tshuaj yog 0.05mg / mL npaj siv qhov ncauj, thiab pom zoo kom noj rau ntawm lub plab khoob (tsawg kawg 1 teev ua ntej lossis 2 teev tom qab noj mov). Thaum lub sijhawm kho, cov zis ntim thiab cov zis osmotic siab yuav tsum tau saib xyuas kom ntsuas qhov ua tau zoo. Qhov tshwm sim ntawm daim ntawv noj tshuaj tshiab no muab kev xaiv meej dua rau kev kho mob ntawm lub hauv paus polyuric syndrome, uas pab txhim kho kev kho mob zoo thiab txo qhov tshwm sim ntawm qhov tshwm sim tsis zoo.
Daim ntawv thov nyob rau hauv kev kho mob ntawm nocturnal enuresis
Nocturnal enuresis feem ntau tshwm sim hauv cov menyuam yaus, nrog qhov tshwm sim ntawm kwv yees li 2% -15%, thiab kev tso tawm tus kheej txhua xyoo ntawm 15%. Qhov tshwm sim tseem ceeb ntawm tus kab mob no yog pw tsaug zog thaum hmo ntuj thiab tso zis thaum nruab hnub, tsis muaj anatomical lossis kev ua haujlwm txawv txav hauv cov zis thiab lub paj hlwb. Txawm li cas los xij, yog tias tsis kho, qhov hnyav ntawm enuresis zuj zus tuaj nrog lub hnub nyoog, cuam tshuam rau lub cev thiab lub hlwb kev noj qab haus huv ntawm tus menyuam cuam tshuam. Cov menyuam yaus uas muaj kev puas siab puas ntsws feem ntau pom muaj kev ntshai, ua tsis taus pa, ua tsis taus pa, ntxhov siab, tsis muaj kev ua siab loj, tsis zoo rau kev sib raug zoo, thiab txawm tias muaj teeb meem loj ntawm kev puas siab puas ntsws (xws li kev nyuaj siab, kev puas siab puas ntsws, ADHD, thiab lwm yam), uas tuaj yeem ua rau neeg laus. Yog li ntawd, nrhiav kev kho kom zoo yog qhov tseem ceeb rau kev txhim kho lub neej thiab kev noj qab haus huv ntawm cov neeg mob me.
(2) Cov txheej txheem thov tshwj xeeb
Kho koob tshuaj: Thaum kho nocturnal enuresis, thawj koob tshuajKev txhaj tshuaj desmopressin acetateyog 0.2 milligrams noj ua ntej yuav mus pw; Yog tias cov nyhuv kho tsis tseem ceeb, nws tuaj yeem nce mus rau 0.4 milligrams. Tom qab siv tas li rau 3 lub hlis, cov tshuaj yuav tsum raug tso tseg tsawg kawg ib lub lim tiam los ntsuam xyuas seb puas tsim nyog kho ntxiv. Thaum lub sij hawm kev kho mob, nws yog ib qho tsim nyog yuav tau kho cov tshuaj raws li qhov xwm txheej ntawm tus me nyuam kom ua tiav cov txiaj ntsig zoo tshaj plaws.
Kev sib xyaw ua ke: 4th International Urinary Incontinence Advisory Committee (ICI) Qib A pom zoo nws siv los ua cov tshuaj kho mob hmo ntuj. Thaum pw tsaug zog tsis zoo lossis tsis tuaj yeem kho nrog kev kho kom tsaug zog, nws yog ib qho kev nyab xeeb thiab muaj txiaj ntsig zoo rau kev kho mob enuresis hauv cov menyuam yaus. Nws yog thawj - kab tshuaj rau kev kho mob thawj zaug enuresis, tshwj xeeb tshaj yog tsim rau cov menyuam yaus uas muaj nocturia thiab lub zais zis siab. Lub caij no, cov txheej txheem kuaj mob thiab kev kho mob tso tawm los ntawm ICCS hauv 2010 tau pom zoo tias kev kho tus cwj pwm yuav tsum tau siv los ua lub hauv paus rau txhua yam kev kho mob rau cov menyuam yaus uas muaj enuresis.
Yog li ntawd, thaum kho nocturnal enuresis, nws feem ntau ua ke nrog kev coj cwj pwm, xws li kev coj noj coj ua, kev tawm tswv yim txog kev puas siab puas ntsws, kev qhia zais zis, thiab sau cov zis ntau zaus. Piv txwv li, cov niam txiv yuav tsum tau pab lawv cov menyuam tsim cov kev tso zis tsis tu ncua thiab zam kev ntxhov siab ntau dhau uas tuaj yeem ua rau muaj kev ntxhov siab ntawm lub hlwb;
Kho koj lub sijhawm pw tsaug zog kom tsis txhob muaj kev ntxhov siab ntau dhau ua ntej yuav mus pw; Ua kom lub zais zis ua haujlwm xws li tso zis raws sijhawm thiab cov leeg hauv plab hauv plab.
Cov ntaub ntawv
Cov lus piav qhia ntawm tus yam ntxwv ntawm tus kab mob (cov tsos mob xws li nqhis dej thiab tso zis ntau zaus, polyuria, khaus khaus, thiab haus dej ntau dhau) los ntawm cov phau ntawv kho mob, xws li cov tsos mob ntawm central polyuric syndrome tau piav qhia hauv "Internal Medicine".
Raws li kev tshawb nrhiav thiab kev txheeb xyuas ntawm cov neeg mob nyob hauv ntau qhov kev tshawb fawb soj ntsuam, suav nrog kev cuam tshuam ntawm kev ua neej zoo thiab kev kho mob, cov kev tshawb fawb muaj feem ntau pom muaj nyob hauv phau ntawv kho mob xws li Suav Phau Ntawv Xov Xwm ntawm Endocrinology thiab Metabolism.
Kev hloov koob tshuaj: Cov ntaub ntawv ntawm thawj koob tshuaj thiab koob tshuaj hloov pauv rau cov neeg laus thiab menyuam yaus yog muab los ntawm cov ntaub ntawv tshawb fawb soj ntsuam. Cov kev tshawb fawb no tau txiav txim siab ntau npaum li cas los ntawm kev soj ntsuam cov ntaub ntawv thiab kev tshuaj xyuas, feem ntau pom nyob rau hauv cov ntawv xov xwm xws li Clinical Pediatrics.
Cov teebmeem ntawm desmopresin acetate thiab pituitrin ntawm kev loj hlob, kev cog lus, thiab tso tawm ntawm cov kab mob siab hepatic stellate (https://pmc.ncbi.nlm.nih.gov/articles/PMC12770225/)
FAQ
Dab tsi uaKev txhaj tshuaj desmopresin acetateua?
Nws yog siv los kho mob plawv cranial ntshav qab zib insipidus. Qhov no yog ib qho mob uas ua rau lub cev poob dej ntau dhau thiab ua rau lub cev qhuav dej. Nws kuj tseem siv los tswj kev pw tsaug zog (nocturnal enuresis), thiab tso zis ntau zaus thiab nqhis dej ntau dhau los ntawm qee hom kev raug mob ntawm lub hlwb lossis kev phais hlwb.
Vim li cas desmopresin raug txwv?
DDAVP tsis raug txwv thoob ntiaj teb tab sis raug txwv hauv kev ua kis las los ntawm World Anti-Doping Agency (WADA) vim tias nws yog cov tshuaj diuretic thiab npog ntsej muag, pab cov neeg ncaws pob hloov pauv cov ntshav ib ntus (hemodilution) los nkaum kev ua tau zoo- txhim kho tshuaj lossis poob phaus rau kev ua kis las. Nws siv nyob rau hauv qee cov ntaub ntawv qhov ntswg rau bedwetting (enuresis) tau txwv nyob rau hauv qee lub teb chaws vim muaj kev pheej hmoo loj xws li hyponatremia (cov ntshav tsis tshua muaj sodium) thiab qaug dab peg, ua rau rov qab thiab hloov mus rau hauv qhov ncauj.
Dab tsi yuav tsum zam thaum noj desmopresin?
Yog tias koj noj desmopressin los kho lub txaj- ntub dej, koj tus kws kho mob yuav hais kom koj tsis txhob haus dej haus tsawg kawg ib teev ua ntej koj noj desmopressin thiab tsawg kawg 8 teev tom qab koj noj desmopressin. Ua tib zoo ua raws li koj tus kws kho mob cov lus qhia kom tsis txhob muaj kev phiv loj heev.
Yuav ua li cas yog tias koj haus tom qab noj desmopresin?
Yog tias koj tus menyuam noj cov kua dej ntau hauv ib teev ua ntej yuav mus pw thiab tom qab ntawd siv desmopressin raws li tau qhia, cov kua dej ntau dhau yuav tsis tuaj yeem tawm hauv lub cev los ntawm cov zis tso zis. Hloov chaw, cov kua dej ntau hauv lub cev yuav maj mam sib sau hauv cov ntaub so ntswg thiab cov hlab ntsha, ua rau pom cov kua dej khaws cia. Qhov txawv txav ntawm cov dej no tuaj yeem ua rau muaj kev kho mob hu ua hyponatremia, uas yog hais txog qhov tsis txaus ntseeg ntawm sodium hauv cov ntshav. Cov cim ceeb toom ntawm hyponatremia feem ntau muaj xws li mob taub hau tsis tu ncua, malaise, xeev siab thiab ntuav rov tshwm sim.
Cim npe nrov: Desmopressin acetate txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom