Toltrazuril txhajyog ib qho kev siv tshuaj tiv thaiv kab mob hauv tshav pob, feem ntau yog cov kab mob uas tsis cuam tshuam nrog cov kab mob sib xyaw ua ke faib tawm, mitochondrial muaj nuj nqi, thiab endoplasmic reticulum cov nyhuv rau hauv lub cev, thiab tswj cov metabolized cov nyhuv rau kev tiv thaiv thiab tswj cov tsiaj coccidiois, suav nrog tab sis tsis yog Txwv rau cov nqaij qaib: nws muaj cov txiaj ntsig muaj zog rau ntau yam nqaij qaib thiab cov qaib ntxhw {{9} {9} {9} {9} Coccidiois, thiab tseem muaj qee yam cuam tshuam rau lub ntsej muag yolak ntawm feline toxoplasmosis {10} {10}
Peb Cov Khoom
Cov ntaub ntawv ntxiv ntawm kev sib txuas lus:
| Khoom npe | Toltrazuril txhaj | Toltrazuril hmoov |
| Khoom Yam | Kev txhaj tshuaj | Hmoov |
| Khoom Siv Purity | Ntau dua los yog sib npaug rau 99% | Ntau dua los yog sib npaug rau 99% |
| Cov Khoom Qhia Khoom Khoom | Tau sib kho | Tau sib kho |
| Khoom Pob | Tau sib kho | Tau sib kho |
Peb Cov Khoom
Toltrazuril +. coa
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Daim Ntawv Pov Thawj Kev Ntsuam Xyuas |
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Compound npe |
Toltrazuril | |
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Cas tsis . |
69004-03-1 | |
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Teem nqi |
Kws Tshuaj Ntsuam Xyuas | |
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Qho ntau |
Me nyuam | |
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Ntim txheem ntim |
Me nyuam | |
| Tus tsim | Shaanxi Bloom Tech Co ., LTD | |
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Lot tsis muaj . |
20250109001 |
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Mfg |
Jan 12th 2025 |
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Tus txeeb |
Jan 8th 2029 |
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Lub tsev |
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| Kuaj Tus Qauv | GB / T 24768-2009 kev lag luam . stnndard | |
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Yam |
Kev Lag Luam Kev Lag Luam |
Kev tsom xam tau |
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Kev tshwm sim |
Dawb lossis yuav luag dawb hmoov |
Hloov |
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Dej Cov Ntsiab Lus |
Tsawg dua los yog sib npaug rau 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua los yog sib npaug rau 1.0% |
0.15% |
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Cov hlau hnyav |
PB tsawg dua lossis sib npaug rau 0.5ppm |
N.D. |
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Tsawg tsawg dua li lossis sib npaug rau 0.5ppm |
N.D. | |
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Hg tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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CD tsawg dua lossis sib npaug rau 0.5ppm |
N.D. | |
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Purity (hplc) |
Ntau dua los yog sib npaug rau 99.0% |
99.5% |
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Ib Leeg Cav |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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TAG NRHO LICBIAL COUNT |
Tsawg dua li lossis sib npaug rau 750cfu / g |
80 |
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E . coli |
Tsawg dua los yog sib npaug rau 2mpn / g |
N.D. |
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Tus ntses siav |
N.D. | N.D. |
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Ethanol (los ntawm gc) |
Tsawg dua los yog sib npaug rau 5000ppm |
400ppm |
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Chaw ntim khoom |
Khaws rau hauv ib lub kaw, tsaus thiab qhuav qhov chaw ntawm -20 degrees |
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Toltrazuril txhaj, raws li dav-spriazine raws tshuaj yeeb tshuaj {} Nws ua tiav tau cov tshuaj muaj txiaj ntsig, thiab cov khoom noj kom zoo nkauj, thiab cov khoom siv hluav taws xob ua kom zoo, thiab cov txheej txheem endoplasmic reticulum cov qauv ntawm nematodes .
Qhov kev piav qhia ntawm kev qhia
1. nqaij npuas kibcidiois
CENTER qhia:
Nqaij qaib Coccidiois: Nws muaj cov nyhuv muaj zog rau ntau hom Eimeria, suav nrog e {} necrotrix, thiab e {} {{5} {5 5}
Qaib Ntxhw Coccidiois: Hom Qaib Ntxhw Qaib Ntxhw Elime, Qaib Ntxhw Eimeria, thiab Qaib Ntxhw Me eimeria .}}}}}}
Lwm cov nqaij qaib: kis tau tus mob - Goose thiab Eimeria truncata .
Chaw Kho Mob:
Cov ntaub ntawv sim qhia tau tias tom qab noj tshuaj, lub pob tuag tau txo qis dua, thiab tus nqi ntawm cov qe qe tawm los ntawm ntau dua 90%.
Cov Tshuaj Pom Zoo: Cov Thawj Coj Sib Txawv, Ntxiv 25MG ntawm Toilcument Nrog Dej (Sib Xws Li 2L ntawm 100mL
{{0 {}} ruminant coccidiosis
Yaj CoccidioIS Diarrheam:
Thaum lub sijhawm siab ua rau lub caij nplooj ntoo hlav, menyuam yaj hnub qub {{}}}}}}}}}} {}, thiab kev loj hlob ntes, thiab kev loj hlob ntes.
Txoj Kev Kho Mob: subcutaneous kev txhaj tshuaj ntawm 7 {{{{{}} 5Mg / kg lub cev hnyav, rov ua ib zaug txhua 75%.
Pury cryptosporidiosis:
Ua ke siv nrog Sulfonamide cov tshuaj tuaj yeem ua rau muaj kev mob nkeeg thiab txo qis lub sijhawm dogrreen .
Ceev faj: cev xeeb tub nyuj yuav tsum tsis txhob siv kom tsis txhob cuam tshuam rau cov menyuam hauv plab los ntawm placenta .
3.} porcine coccidiosis
Spore Coccidiois hauv Piglets:
Npua hnub nyoog 7-14 hnub muaj qhov tshwm sim siab ntawm Daus Dawv Zawv plab, lub cev qhuav dej, thiab poob phaus.
Kev Tiv Thaiv Kev Tiv Thaiv: Ntxiv 50Mg / kg Philcumizumab rau kev pub mis los ntawm 3 hnub ua ntej tus nqi ntawm tus piglets los ntawm 70%.
Txoj Kev Kho Mob: Cov Tshuaj Ntawm Qhov Muag 20Mg / Kg Lub Cev Qhov hnyav, ib zaug ib hnub, rau 3 hnub sib law.
{{0 {}} parasitic kab mob hauv cov tsiaj nrog phooj ywg
Canine thiab miv coccidiois:
3-6} pitter Cov tub ntxhais hluas muaj peev xwm ua tau, muaj kev quav ntsha tsis txaus ntseeg, lub cev qhuav dej tsis zoo, thiab ua kom tsis zoo.
Daim Phiaj Xwm Kho Mob:
Cov dev: {{{10-20 mg / kg lub cev nyhav orally, ib koob rau {1} .
Miv: Noj 15mg / kg lub cev hnyav ib zaug ib hnub rau 3-6 listecutive hnub.
Qhia Tshwj Xeeb: Nyob rau hauv theem ntawm Feline ToxPlasmosis, {}} mg / kg lub cev hnyav .
Parasitic kab mob ntawm cov tsiaj txhu:
Lizards (xws li Maned Lw Lizard): {5-15 mg / kg lub cev hnyav los kho coccidioIs kis.
Raptors: Noj 7mg / kg lub cev hnyav thiab2-3}}}} .
Kev Tshawb Nrhiav Kev Tshawb Fawb (2025)
{{01. Kev nthuav tawm ntawm Anti Toxoplasma Mechanism
DUAL kev txiav txim hom:
Kev Dag Rau Ncaj Nraim: Hloov Hluav Taws Xob Cov Khoom Siv Hluav Taws Xob Pom Qhov Kev Ua Nres Tsheb ntawm Kab Kab Kab Kab .
Cov metabolic blockade: DTMP qib tsawg zuj zus los ntawm 67% thiab pob tseg kev nce ntxiv nce los ntawm 2. 3 zaug.
Kev tiv thaiv tsiaj txhu cov nyhuv:
Cov qauv kis tau nas mob: 100% muaj sia nyob tus nqi .
Tus nqi ntawm lub hlwb cyst tsim tsawg ntawm 92% .
{{0 {}} Kev loj hlob ntawm cov qauv tshiab
Nanocrystal Tshuab:
Lub particle loj yog tswj tau nruab nrab ntawm 100-200 nm, thiab cov xyoob ntoo muaj zog ntxiv rau 68%.
Cov nyiaj tau los tso tawm yog txuas ntxiv rau 96 teev.
Transdermal Kev Xa Khoom Siv Tshuaj:
Microneedle array patch: The peak time of blood drug concentration is shortened to 0.5 hours.
Daim tawv nqaij tuav tseg nce 40% .
{{01. kev cuam tshuam nrog pyrimidine metabolism network
Cov kev tshawb fawb tau ua los ntawm Suav Academy of Firm Sciency pab pawg hauv tshuaj tua kab mob Biochemistry thiab Physiology qhia tau tiasToltrazuril txhajinhibits qhov proliferation ntawm toxoplasma gondii los ntawm ob lub tshuab sib txawv:
(1) inhibit qhov tseem ceeb enzyme:
Inhibition ntawm Dutp enzyme (deoxyuridine triphosphate) los ntawm 5.8 lub sij hawm ua rau tsub zuj zuj ntawm Dutp (deoxyuridine Triphosphate) thiab cov teeb meem DNA strand tawg
Inhibit TMK (thymidine Kinase) Qhia los ntawm 3.2-}}}}}}}} fold, fitthesis, thiab txo DNA cov ntaub ntawv rho tawm los ntawm 67%
(2) meabolite synergy:
Cov metabolite tolso ₂ tswj txoj kev xav tau zoo hauv lub cev rau 72 teev, txuas ntxiv inhibiting pyrimidine synthesis txoj kev
Metabolomics Kev Tshawb Fawb Pom tias 2.3-}}}}}}}}}}}}}}} }្ល increase} increase increase }hophuridine Monophosphate) qib sib npaug
{{02. Kev puas tsuaj ntawm Organelle qauv thiab muaj nuj nqi
Mitochondrial kev puas tsuaj:
Inhibit respiratory saw complex ii (succinate athydrination deptisis, thiab ua rau lub zog metabolism tawg hauv lub cev
Kev Hloov Hluav Taws Xob Hluav Taws Xob Cov Lus Pom Kev Nyab Xeeb Qhia Mitochondrial Cristae Rupture thiab ib qho kev txo qis hauv matrix electronic ceev
Retoplasmic reticulum kev nyuaj siab:
Indument o ntawm Endoplasmic reticulum rau 3-5}} lub taub, ua cov qauv vactolated
Ua kom cov lus teb tau nthuav tawm (UPR), ua rau Cellammed Cell tuag ntawm Parasite
4. cov qib cellular
Nuclear fission inhibition: los ntawm kev cuam tshuam nrog microlot nyuaj, nws block cov cab rau stagnate hauv g2 / m theem .
Mitochondrial kev puas tsuaj: inhibits reshibits reshiblatory saw complex thiab vau rau ntawm lub zog metabolism hauv lub cev hauv Parasite .
Restoplasmic reticulum kev nyuaj siab: induces o fromotlasmic reticulum), ua kom lub taub txoj kab sib npaug, thiab ua kom lub taub hau ruaj ntseg tuag ntawm lub parasite .
{{03. cuam tshuam nrog cov kev sib faib ntawm tes
Nuclear Fission Thaiv:
Inhibit lub nuclear faib ntawm schizonts thiab cov gametophy me me, ua rau cov cab mus rau stagnate hauv G2 / m theem
Immunoflluorescence staining uas microtubuic protein polymerization tau thaiv, thiab spindle tsis tuaj yeem ua
Inhibition ntawm cov phab ntsa medtis:
Thaiv cov zais ntawm cov me me gametophyte Phab Ntsa lub cev tau ua rau cov tsis muaj peev xwm ntawm cov hom phiaj tiv thaiv
1. kev cuam tshuam hauv cov kev ua lag luam asexual
Kev Loj Hlob Theem Mechanism thiab Cov Ntsuas Ua Haujlwm
Thaum lub sijhawm muaj me nyuam ntawm cov schizonts, inhibition ntawm nuclear cov kev tawm hauj lwm hauv cov schizonts ua rau muaj kev txo 82%
Thaiv kev tsim cov phab ntsa gametophytte me me thaum ua kom muaj sia nyob ntawm gametophytes los ntawm 95%
Kev cuam tshuam sporization cuam tshuam nrog spore membrane qauv, uas ua rau 76% txo qis hauv kev tsim tus nqi
2. Kev tswj cov tswv tsev Parasite sib tham
Kev Txhaj Tshuaj Tiv Thaiv Khiav Tawm:
Inhibit nto antigen kev sib txawv ntawm coccidiois thiab txhim kho tus tswv tsev t cell paub
Cov kev sim ua kom pom tias tus titer ntawm higg tiv thaiv kab mob hauv cov kab mob qaib cov tsiaj qus nce ntxiv los ntawm 3.2 zaug
Inhibition ntawm cov koom haum ntxeem tau:
Txo cov ntxeem tau ntawm cov hnyuv hnyuv mucosal epithelial hlwb los ntawm 91% (hauv cov kev sim vitro)
Txo Nplooj Siab Lub Siab Cell Parasite load los ntawm 87% (nas qauv)
Pharmaconinetics thiab sijhawm ntawm kev ua
1. Cov yam ntxwv ntawm cov txheej txheem sab hauv
Kev muab hluav taws xob:
Qhov ncauj ntawm lub qhov ncauj ntawm nqaij qaib yog 52%, thaum intramuscular txhaj mus txog 89%
Organizational distribution concentration: Liver (12.3 μ g/g)>Kidney (8.7 μ g/g)>Intestine (6.2 μ g/g)>Cov leeg (1.5 μ g / g)
Metabolic Conterersion:
Main Metabolic Pathway: Hepatic CYP450 enzyme hydroxylation
Cov metabolite nquag: Tolso ₂ (Anti coccidioalis kev ua si yog 1.8 zaug uas ntawm cov tshuaj qub)
{{02. Tsis tu cov nyhuv kev ua haujlwm
Lub Sij Hawm Ntev Ua Hauv Foundation:
Ib nrab-lub neej ntawm cov metabolite tolso ₂ yog 72 teev, uas yog 6 lub sij hawm uas yog cov tshuaj qub
Hnyuv hepatic ntawm kev sib tw ua haujlwm ntev ua yeeb tshuaj, thaum tswj 30% kev ua si hauv cov quav
Residual kev pheej hmoo:
24 hnub tom qab ua kom tiav cov tshuaj, seem nyob hauv cov leeg nqaij: 0.12 μ g (EU MRL tus qauv yog 0.01 μ g)
Qhia txog lub sijhawm so rau lub sijhawm so rau cov qaib hnub rau 19 hnub
Tshuaj Tiv Thaiv Tshuaj Haus thiab Tswj Mechanism
1. Cov xwm txheej tam sim no thiab cov qauv tshuaj tiv thaiv
Ntiaj teb tsis kam nqi:
2020: 12% -18%
Los ntawm 2025, nws yuav nce rau 28%-35% (vim cross tiv taus rau dexmedetomidation)
Tshuaj Yaus Revelation site:
Y268S Kev Hloov Hlav hauv Cytb Gene ua rau 40% txo qis kev siv tshuaj ib qho
Kev hla dhau ntawm P-GP nce yeeb tshuaj efflux pebfold
2.} Kev siv ntawm kev tiv thaiv thiab tswj cov tswv yim
Lub Hom Phiaj Kev Ntsuas Chaw:
Sequence 1: Toltrazuril (4 lub lis piam) → dexmedetomidine (4 asthiv) → nikarbazine (4 asthiv)
Sequence 2: Toltrazuril (3 lub lis piam) → Maduramycin (3 lub lis piam Ketone (3 asthiv)
Shutle Medication Hom:
Ua ntej txoj kev loj hlob theem (1-21} hnub laus):Toltrazuril txhaj
Cov theem lig ntawm kev loj hlob (22-42 hnub} hnub): Monensin
Cim npe nrov: Kev txhaj tshuaj Toltrazuril, cov chaw muag khoom, chaw tsim tshuaj paus, Hoobkas, lag luam wholesale, yuav, nqe, loj, loj, rau muag