Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm fertirelin txhaj nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo fertirelin txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Fertirelin txhaj tshuajyog ib qho hluavtaws polypeptide gonadotropin- tso cov tshuaj hormone (GnRH) analog nrog fertirelin ua nws cov ntsiab lus tseem ceeb. Nws cov haujlwm lom neeg yog 2.5 mus rau 10 npaug siab dua li ntawm GnRH ntuj. Nws ua hauj lwm ob lub luag hauj lwm nyob rau hauv tib neeg thiab veterinary tshuaj, featuring meej thiab heev npaum daim ntaub ntawv.Qhov tseem ceeb ntawm qhov kev txhaj tshuaj no yog nws cov kev cai biphasic thaum ntxov: los ntawm kev khi rau pituitary GnRH receptors, nws transiently nkoos lub secretion ntawm luteinizing hormone (LH) thiab follicle {{6}) stimulation ntawm lawv cov tshuaj hormones (F{6}}) ua raws li cov tshuaj hormones. tso tawm, thaum kawg tswj endogenous testosterone thiab estrogen qib. Cov cuab yeej no ua rau nws nyiam cov tshuaj hormones kev sib deev- cov kab mob nyob ntawm cov kab mob thiab cov kev cai ntawm kev yug me nyuam.Clinically, nws tus nqi yog qhov tseem ceeb hauv cov tshuaj kho tsiaj.
Peb cov khoom Forms
Fertirelin COA
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| Certificate of Analysis | ||
| Compound npe | Fertirelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 38234-21-8 | |
| Ntau | 43g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202612090051 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8 Dec 2029 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.32% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.63% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.21% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 75 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 12 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -15 degree | |
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| Tshuaj Formula | C55H76N16O12 | |
| Exact Mass | 1152.58 | |
| Molecular Luj | 1153.31 | |
| m/z | 1152.58(100.0%), 1153.59(59.5%), 1154.59(17.4%), 1153.58(5.9%), 1154.58(3.5%), 1155.59(2.5%), 1154.59(2.5%), 1155.59(1.5%), 1155.59(1.0%) | |
| Elemental Analysis | C,57.62; H,6.74; N,19.20; O,16.45 | |
Mechanism of Action of Fertirelin nyob rau hauv kev kho mob ntawm Ovarian Follicular Cysts nyob rau hauv nyuj
Lub ntsiab mechanism ntawmkev txhaj tshuaj fertirelinNyob rau hauv kev kho ntawm zes qe menyuam follicular cysts nyob rau hauv nyuj yog ua raws li lub physiological muaj nuj nqi ntawm tej yam ntuj tso GnRH, khi precisely rau GnRH receptors nyob rau hauv lub anterior pituitary caj pas, qhib intracellular signaling txoj kev, thiab tswj lub secretion ntawm luteinizing hormone (LH) thiab follicle SH-stimulating. Qhov no nyob rau hauv lem intervenes nyob rau hauv follicular kev loj hlob thiab cyst regression, restores zes qe menyuam muaj nuj nqi. Nws cov txheej txheem muaj qhov tshwj xeeb thiab lub hom phiaj muaj zog, thiab tuaj yeem muab faib ua peb theem.
Theem pib: Receptor Binding thiab ua kom cov Secretory Signals
Tom qab kev tswj hwm, fertirelin tau nrawm nrawm rau hauv cov hlab ntsha thiab xa mus rau lub caj pas pituitary, uas nws tshwj xeeb khi rau GnRH receptors ntawm pituitary hlwb.Vim tias fertirelin muaj cov qauv tshuaj lom neeg zoo heev rau ntuj GnRH, nrog kev hloov kho cov qauv (6 qhov kev hloov pauv ntawm cov khoom siv rau hauv cov khoom seem), yog ntau dua li ntawm natural GnRH. Thaum khi, nws sai sai ua rau intracellular signaling txoj hauv kev thiab pib qhov tso tawm ntawm LH thiab FSH.
Qib Core: Induction ntawm LH Surge thiab Luteinization ntawm Cysts
LH secretion tsis txaus lossis ncua LH surge yog thawj qhov ua rau ntawm zes qe menyuam follicular cysts hauv nyuj: cov follicles paub tab tsis tawg thiab ovulate nyob rau hauv LH surge, ua rau kom tsis tu ncua ntawm cov kua follicular thiab cyst tsim.Tom qab khi rau receptors, tsim cov fertirelin nyob rau hauv lub sij hawm luv luv. (2-6 teev tom qab kev tswj hwm), tsim kom muaj LH surge uas yog 2-3 npaug zog tshaj qhov siab tshaj plaws ntawm lub cev. Qhov surge no ua ncaj qha rau ntawm granulosa hlwb ntawm cystic follicles.
Theem Rov Qab: Txoj Cai ntawm FSH Secretion thiab Txhawb Kev Noj Qab Haus Huv Follicular Development
Thaum inducing LH surge thiab txhawb cyst regression, fertirelin kuj tseem tswj hwm FSH secretion. FSH ua rau cov hauv paus hauv paus thiab cov hauv paus hauv lub zes qe menyuam, txhawb lawv txoj kev loj hlob mus rau hauv cov follicles noj qab haus huv.Raws li cov hlwv maj mam rov qab, lub cev ntawm lub zes qe menyuam tau rov qab los, thiab kev tso tawm ntawm FSH thiab LH ua kom sib npaug, nteg cov hauv paus rau cov kab mob estrus thiab ovulation tom qab, thiab tsis txhob rov qab ua dua. Kev kho mob. Ntxiv rau, cov qauv polypeptide ntawm fertirelin nta cov metabolism sai thiab tsis muaj qhov seem.
Cov Lus Qhia Tshwj Xeeb rau Fertirelin hauv Kev Kho Ovarian Follicular Cysts hauv nyuj
Therapeutic nyhuv ntawmkev txhaj tshuaj fertirelinnyob tsis tau tsuas yog nyob rau hauv nws cov pharmacological kev ua tab sis kuj nyob rau hauv standardized soj ntsuam kev xyaum.
Kev kuaj pom tseeb thiab kev lees paub ntawm cov lus qhia
Ua ntej kev kho mob, kev kuaj mob dav dav ntawm zes qe menyuam follicular cysts yuav tsum tau ua nrog kev soj ntsuam kev soj ntsuam + qhov quav palpation + tshuaj ntsuam xyuas cov tshuaj hormones, kom tsis txhob muaj misdiagnosis nrog luteal cysts, qog ntawm zes qe menyuam, lossis lwm yam mob (xws li kev kho mob sib txawv, xws li luteal cysts yog kho nrog prostaglandins).
Cov txheej txheem kuaj mob
Kev soj ntsuam Estrus
Persisent estrus (nymphomania) los yog ntev anestrus, tshwj xeeb tshaj yog nyob rau hauv high-yielding nyuj 1-3 lub hlis tom qab yug me nyuam.
Qhov quav palpation
Cov qauv cystic> 2.5 cm nyob rau hauv lub cheeb, mos, tsis mob, me ntsis txav, nrog rau qhov loj ntawm zes qe menyuam thiab tsis paub tab corpus luteum.
Kev ntsuam xyuas Hormone
plasma lossis mis nyuj progesterone qib <1 ng/mL paub meej tias zes qe menyuam follicular cysts.
Noj
Standardized Administration: Dosage thiab Route
Kev noj tshuaj thiab txoj kev yuav tsum ua raws li cov qauv kev kho mob, kho raws li lub cev qhov hnyav, cyst loj, thiab lub sijhawm muaj kab mob.
Tus qauv tshuaj kho mob yog 86 ug fertirelin rau ib tug nyuj raws li ib qho kev txhaj tshuaj, sib haum rau 2 mL rau ib qho kev txhaj tshuaj (43 ug / mL fertirelin acetate).
Rau cov mob hnyav (cyst> 5 cm lossis ntev> 30 hnub): rov ua tib koob tshuaj 10-14 hnub tom qab thawj zaug txhaj tshuaj.
Rau cov nyuj sib zog (< 300 kg) or heifers: reduce to 60–70 μg to avoid superovulation.
Txoj kev tswj hwm
Kev txhaj tshuaj (xws li): pib sai dua, LH nce hauv 2-6 teev.
Kev txhaj tshuaj intramuscular: yooj yim dua rau kev ua liaj ua teb loj, LH nce hauv 4-8 teev.
Ob txoj kev ua tiav cov txiaj ntsig kho mob ntau dua 85%.
Lub sijhawm
Nws tuaj yeem siv tau thaum ua liaj ua teb txhua hnub. Nws raug nquahu kom tsis txhob pub mis nyuj thiab mis nyuj peaks kom txo tau kev ntxhov siab. Rau nyuj nyob rau hauv khaus estrus, tswj thaum tus cwj pwm zoo siab yog me ntsis. Kev saib xyuas los txhawb Ovarian rov qab: Kev tswj xyuas tom qab yog qhov tseem ceeb rau cyst regression thiab zes qe menyuam muaj nuj nqi.Nutritional regulation: balanced diet, tsis txhob ntau lub zog / siab-fat pub. Ntxiv cov protein, vitamins, thiab minerals los txhawb kev kho zes qe menyuam. Txhim kho qhov tsis zoo ntawm lub zog sib npaug hauv cov nyuj tom qab yug me nyuam. Kev tswj kev ntxhov siab: ib puag ncig ruaj khov, tsis txhob tuav ntau zaus, hloov pauv tam sim ntawd, kub heev, muaj neeg coob coob, lossis sib ntaus sib tua. Kev ntxhov siab cuam tshuam pituitary hormone secretion thiab kev siv tshuaj.
* Kev saib xyuas estrus: cov nyuj feem ntau pom muaj estrus 20-22 hnub tom qab kho. Ua cov tshuaj tua kab mob 12-24 teev tom qab estrus. Yog tias tsis muaj estrus nyob rau hauv 14 hnub, prostaglandin yuav siv tau los pab induction.
Qhov zoo ntawm Fertirelin rau Ovarian Follicular Cysts hauv nyuj
Piv nrog rau cov tshuaj ib txwm siv (piv txwv li, hCG, LHRH-A3), fertirelin muaj plaub qhov zoo: txhim khu kev qha, kev nyab xeeb siab, kev ua haujlwm yooj yim, thiab kev siv nyiaj ntau.
Txhim khu kev qha, nrawm nrawm nrog qis rov tshwm sim
Kev ua yeeb yam lom neeg yog 2.5-10 npaug ntawm GnRH ntuj, ua rau muaj kev ruaj khov thiab ntev LH surge.Cysts poob qis hauv 3-7 hnub thiab daws tag nrho hauv 10-14 hnub. Tus nqi ua tau zoo: 85%-95% (vs. 60%-70% rau cov tshuaj ib txwm muaj: 5%). (vs. 15%–20% rau cov tshuaj ib txwm siv), vim yog synchronized FSH cov cai thiab kev kho kom zoo ntawm folliculogenesis.
Kev nyab xeeb siab, tsis muaj qhov cuam tshuam tsis zoo los yog qhov seem seem
Fertirelin yog ib qho hluavtaws polypeptide structurally ze rau endogenous GnRH. Nws tau sai sai metabolized rau hauv cov amino acids tsis muaj cov ntaub so ntswg thiab yuav tsis ua rau cov nqaij los yog mis nyuj zoo, uas muaj 0-hnub tshem tawm rau nyuj thiab 0-teev tshem tawm cov mis nyuj. Nws tsis tshua ua rau mob hauv zos, ua xua lossis tsis qab los noj mov thiab tsis muaj kev cuam tshuam rau cov kua mis. Tsuas yog qhov kev zoo siab tsis ntev los no tuaj yeem tshwm sim hauv qee tus tsiaj me, uas ua rau tsis muaj kev kho mob.
Siv tau yooj yim, haum rau kev ua liaj ua teb loj
Kev tswj hwm yooj yim (IV lossis IM). Kev txhaj tshuaj IM tuaj yeem ua tau los ntawm cov neeg ua liaj ua teb nyob rau hauv kev saib xyuas kws kho tsiaj.Feem ntau yuav tsum tau txhaj tshuaj ib zaug xwb, nrog rau koob thib ob nkaus xwb rau cov mob hnyav. Haum rau kev kho mob batch hauv cov mis nyuj loj thiab nqaij nyuj.
Tus Nqi-Kev Ua Tau Zoo
Kev ceev faj txog kev kho mob
Txhawm rau kom muaj txiaj ntsig thiab zam kev pheej hmoo, cov hauv qab no yuav tsum tau ua raws:
Rau zes qe menyuam follicular cysts nkaus xwb. Tsis txhob siv rau hauv nyuj cev xeeb tub (tej zaum yuav ua rau rho menyuam). Paub meej tias tsis cev xeeb tub ua ntej siv.
Tsis txhob sib xyaw nrog cov tshuaj alkaline (piv txwv li, sodium bicarbonate), uas degrade fertirelin thiab txo cov nyhuv.
Khaws kaw, tiv thaiv lub teeb, ntawm 2-8 degree. Tsis txhob siv yog turbid, precipitated, los yog discolored.
Kev tswj kev noj tshuaj nruj me ntsis: overdose yuav ua rau superovulation; underdose tsis muaj txiaj ntsig. Txo kev noj tshuaj rau heifers thiab nyuj me.
Veterinary tshuaj. Tsuas yog siv raws li kev taw qhia ntawm tus kws kho tsiaj muaj ntawv tso cai. Khaws cov ntaub ntawv tswj xyuas kom tiav rau kev saib xyuas thiab kev taug qab.
Cov yam ntxwv ruaj khov
Cov tshuaj stability ntawmkev txhaj tshuaj fertirelinmuaj kev cuam tshuam los ntawm qhov kub thiab txias, lub teeb, thiab lwm yam.Thaum khaws cia hauv qhov ntim, lub teeb- tiv thaiv tej yam kev mob ntawm 2–8℃(tub yees), lub txee lub neej yog mus txog 24 lub hlis.Nws nyob ruaj khov rau luv luv -lub sij hawm cia (tsis pub ntau tshaj 7 hnub) ntawm chav tsev kub (qis dua 25 degrees). Txawm li cas los xij, ntev -lub sij hawm raug kub siab (siab tshaj 30 degree) los yog lub teeb muaj zog yuav ua rau degradation ntawm polypeptide saw, ib tug txo nyob rau hauv active ingredient cov ntsiab lus, thiab txo cov nyhuv. alkaline ib puag ncig (pH> 7.0) ua kom nws cov degradation.
Ntsiab Physicochemical Properties
Cov khoom xyaw nquag hauv kev txhaj tshuaj, fertirelin (acetate), yog dawb los yog tawm -cov hmoov dawb, tsis muaj ntxhiab, dawb soluble hauv dej, me ntsis soluble hauv methanol, thiab insoluble nyob rau hauv uas tsis yog -polar solvents xws li diethyl ether thiab chloroform, ua tau raws li cov dej {{2} kev txhaj tshuaj nrog cov kua qaub acidic. pH ntau ntawm 4.5–6.5, uas yog ze rau lub cev pH ntawm cov tsiaj thiab tuaj yeem txo qhov kev khaus hauv zos tom qab txhaj tshuaj. Tsis tas li ntawd, fertirelin yog optically active, nrog rau ib qho kev sib hloov ntawm +40℃rau +50℃(hauv dej ntawm ib tug concentration ntawm 10 mg / ml), ib tug raug tshuaj yam ntxwv ntawm nws polypeptide qauv.
Compatibility yam ntxwv
Qhov kev txhaj tshuaj no tuaj yeem siv ua ke nrog cov kws kho tsiaj feem ntau siv prostaglandins (xws li cloprostenol sodium) thiab tshuaj tua kab mob, tsis muaj kev cuam tshuam tshuaj lom neeg lossis cov tshuaj lom lossis tsim kev puas tsuaj. Nws tuaj yeem siv ua ke rau kev tsim cov tsiaj txhu kev cai.Txawm li cas los xij, kev sib xyaw nrog cov tshuaj alkaline (xws li sodium bicarbonate txhaj) yog txwv tsis pub kom tsis txhob degradation ntawm cov khoom xyaw nquag tshwm sim los ntawm kev nce pH.Meanwhile, nws tsis pom zoo kom sib tov dig muag nrog lwm cov tshuaj hormonal, thiaj li tiv thaiv kev cuam tshuam nrog nws cov tshuaj metabolism thiab hauv vivo.
FAQ
Yuav ua li cas yog lub tseem ceeb pharmacological mechanism ntawm Fertirelin?
Fertirelin yog ib qho hluavtaws GnRH analogue uas khi tshwj xeeb rau gonadotropin - tso tawm cov tshuaj hormones ntawm anterior pituitary gonadotrophs. Nws txhawb nqa qhov kev tso tawm ntawm cov tshuaj luteinizing hormone thiab follicle-cov tshuaj stimulating, kho endogenous gonadal cov tshuaj hormones tswj follicular kev loj hlob ntawm cov poj niam thiab testosterone synthesis nyob rau hauv txiv neej. Nws cov qauv peptide hloov kho txhim kho metabolic stability piv rau haiv neeg GnRH thiab ua kom ntev hauv -vivo lub sijhawm ua haujlwm zoo.
Dab tsi yog daim ntawv thov kev kho mob tseem ceeb ntawm Fertirelin?
Nws yog dav siv rau ovulation induction nyob rau hauv pab reproductive kev kho mob los kho anovulatory infertility los ntawm hypothalamic -pituitary dysfunction. Dhau li ntawm tib neeg kev kho me nyuam, cov peptide kuj yog feem ntau siv nyob rau hauv cov tsiaj yug tsiaj los synchronize estrus cycles ntawm cov tsiaj nyeg thiab txhawb cov concentrated ovulation, optimizing yug me nyuam efficiency rau npua, nyuj thiab yaj. Nws kuj tseem tuaj yeem pab kho qhov sib txawv ntawm pituitary -gonadal axis mob los ntawm kev kuaj endocrine stimulation.
Dab tsi tshwm sim tsis zoo thiab kev ceev faj txog tshuaj noj rau kev tswj hwm Fertirelin?
Cov kev mob tshwm sim me me thiab ib ntus feem ntau tshwm sim tom qab kev tswj hwm subcutaneous, feem ntau muaj me me erythema ntawm qhov chaw txhaj tshuaj, mob taub hau thiab plab plab me ntsis; Cov tsos mob me me no feem ntau tshwm sim hauv 1 mus rau 2 hnub yam tsis muaj kev kho mob ntxiv. Qhov kev npaj no yog nruj me ntsis txwv tsis pub rau cov neeg mob uas raug kev txom nyem los ntawm cov tshuaj hormones - rhiab malignant qog thiab cov kab mob siab heev ntawm zes qe menyuam. Cov kws kho mob yuav tsum tau kho cov kev tswj hwm ntau npaum li cas raws li cov neeg mob cov tshuaj ntsuam xyuas kev sib deev hauv cov tshuaj hormones, txhawm rau tiv thaiv overstimulation ntawm gonadal plab hnyuv siab raum thiab txo qhov kev pheej hmoo ntawm zes qe menyuam hyperstimulation syndrome.
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