Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm fertirelin txhaj nyob rau hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo fertirelin txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Fertirelin Txhajyog ib qho hluavtaws polypeptide gonadotropin- tso cov tshuaj hormone (GnRH) analog nrog fertirelin ua nws cov ntsiab lus tseem ceeb. Nws cov haujlwm lom neeg yog 2.5 mus rau 10 npaug siab dua li ntawm GnRH ntuj. Nws ua hauj lwm ob lub luag hauj lwm nyob rau hauv tib neeg thiab veterinary tshuaj, featuring meej thiab heev npaum daim ntaub ntawv.Qhov tseem ceeb ntawm qhov kev txhaj tshuaj no yog nws cov kev cai biphasic thaum ntxov: los ntawm kev khi rau pituitary GnRH receptors, nws transiently nkoos lub secretion ntawm luteinizing hormone (LH) thiab follicle {{6}) stimulation ntawm lawv cov tshuaj hormones (F{6}}) ua raws li cov tshuaj hormones. tso tawm, thaum kawg tswj endogenous testosterone thiab estrogen qib. Cov cuab yeej no ua rau nws nyiam cov tshuaj hormones kev sib deev- cov kab mob nyob ntawm cov kab mob thiab cov kev cai ntawm kev yug me nyuam.Clinically, nws tus nqi yog qhov tseem ceeb hauv cov tshuaj kho tsiaj.
Peb cov khoom Form
Fertirelin COA
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| Certificate of Analysis | ||
| Compound npe | Fertirelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 38234-21-8 | |
| Ntau | 43g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202512090051 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8 Dec 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.32% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.63% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.21% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 75 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 5 12 ppm |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -15 degree | |
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| Tshuaj Formula | C55H76N16O12 | |
| Exact Mass | 1152.58 | |
| Molecular Luj | 1153.31 | |
| m/z | 1152.58(100.0%), 1153.59(59.5%), 1154.59(17.4%), 1153.58(5.9%), 1154.58(3.5%), 1155.59(2.5%), 1154.59(2.5%), 1155.59(1.5%), 1155.59(1.0%) | |
| Elemental Analysis | C,57.62; H,6.74; N,19.20; O,16.45 | |
Mechanism of Action of Fertirelin Injection in Treatment of Ovarian Follicular Cysts hauv nyuj
Cov txheej txheem tseem ceeb ntawm Fertirelin Txhaj Tshuaj hauv kev kho cov zes qe menyuam follicular hlwv hauv nyuj yog ua kom lub cev muaj zog ntawm GnRH ntuj, khi ncaj nraim rau GnRH receptors hauv lub caj pas pituitary, qhib intracellular signaling pathways, thiab tswj cov tshuaj hormone secretion ntawm luteinizing (SH-Luteinizing). Qhov no nyob rau hauv lem intervenes nyob rau hauv follicular kev loj hlob thiab cyst regression, restores zes qe menyuam muaj nuj nqi. Nws cov txheej txheem muaj qhov tshwj xeeb thiab lub hom phiaj muaj zog, thiab tuaj yeem muab faib ua peb theem.
Theem pib: Receptor Binding thiab ua kom cov Secretory Signals
Tom qab kev tswj hwm, Fertirelin Txhaj yog sai sai absorbed rau hauv cov hlab ntsha thiab xa mus rau lub anterior pituitary caj pas, qhov twg nws tshwj xeeb khi rau GnRH receptors ntawm pituitary hlwb.Vim hais tias fertirelin muaj ib tug tshuaj qauv heev homologous rau tej yam ntuj tso GnRH, nrog rau cov kev hloov kho (6 affinity nyob rau hauv cov ntaub so ntswg ntawm lub pituitary hlwb). receptor ntau dua li ntawm natural GnRH. Raws li kev khi, nws sai sai ua rau intracellular signaling txoj hauv kev thiab pib qhov tso tawm ntawm LH thiab FSH.
Cov theem no yog luv luv, feem ntau yog 1-2 teev tom qab kev tswj hwm, nrog rau kev ua haujlwm tseem ceeb ntawm kev ua kom cov pituitary secretory kev ua si thiab tso lub hauv paus rau kev tso tawm cov tshuaj hormones tom ntej.
Qib Core: Induction ntawm LH Surge thiab Luteinization ntawm Cysts
LH secretion tsis txaus lossis ncua LH surge yog thawj qhov ua rau ntawm zes qe menyuam follicular cysts hauv nyuj: cov follicles paub tab tsis tawg thiab ovulate nyob rau hauv LH surge, ua rau kom nruam cov kua follicular thiab cyst tsim.Tom qab khi rau cov receptors, Fertirelin injection ib tug loj npaum li cas. lub sij hawm (2-6 teev tom qab kev tswj hwm), tsim kom muaj LH surge uas yog 2-3 npaug zog tshaj qhov siab ntawm lub cev. Qhov surge no ua ncaj qha rau ntawm granulosa hlwb ntawm cystic follicles.
Nyob rau hauv high-concentration LH, granulosa hlwb sai heev undergo luteinization, synthesize thiab secrete progesterone. Meanwhile, lub cyst phab ntsa shrinks thiab thickens, follicular kua yog maj absorbed, thiab cyst ntim txo sai heev.Cov txheej txheem no yog tus yuam sij rau cyst regression thiab lub ntsiab yog vim li cas rau cov txhim khu kev qha kev ntawm Fertirelin Txhaj. Piv nrog rau cov tshuaj ib txwm siv, nws ua rau muaj kev ruaj khov thiab ruaj khov LH surge, ua kom tag nrho cov luteinization ntawm cystic follicles thiab tiv thaiv rov tshwm sim.
Theem Rov Qab: Txoj Cai ntawm FSH Secretion thiab Txhawb Kev Noj Qab Haus Huv Follicular Development
Thaum inducing LH surge thiab txhawb cyst regression, Fertirelin Txhaj kuj tseem tswj hwm FSH secretion. FSH ua rau cov hauv paus hauv paus thiab cov hauv paus hauv lub zes qe menyuam, txhawb lawv txoj kev loj hlob mus rau kev noj qab haus huv ntawm cov follicles.Raws li cov hlwv maj mam regress, lub zes qe menyuam ib txwm rov qab los, thiab kev tso tawm ntawm FSH thiab LH ua kom sib npaug, tso cov hauv paus rau kev noj qab haus huv tom qab estrus thiab ovulation.
Tsis tas li ntawd, cov qauv polypeptide ntawm Fertirelin Txhaj Tshuaj muaj cov metabolism sai thiab tsis muaj qhov seem. Thaum tswj hwm cov tshuaj hormone secretion, nws tsis cuam tshuam qhov sib npaug ntawm lwm cov tshuaj hormones hauv nyuj lossis ua rau muaj kev puas tsuaj ntxiv rau zes qe menyuam, ua kom tiav kev ua haujlwm ntawm zes qe menyuam.
Tswv yim Specifications rau Fertirelin Txhaj Tshuaj nyob rau hauv kev kho Ovarian Follicular Cysts nyob rau hauv nyuj
Cov nyhuv kho ntawm Fertirelin Txhaj Tshuaj yog nyob ntawm tsis tsuas yog ntawm nws cov tshuaj ua haujlwm tab sis kuj tseem nyob ntawm kev coj ua raws cai. Txhawm rau kom muaj txiaj ntsig zoo thiab txo qis kev cuam tshuam tsis zoo, peb-kauj ruam ntawm kev kuaj mob kom raug - kev tswj hwm tus qauv - kev saib xyuas kev tshawb fawb yuav tsum tau ua raws li cov lus qhia hauv qab no.
Kev kuaj pom tseeb thiab kev pom zoo ntawm cov lus qhia
Ua ntej kev kho mob, kev kuaj mob dav dav ntawm zes qe menyuam follicular cysts yuav tsum tau ua nrog kev soj ntsuam kev soj ntsuam + qhov quav palpation + tshuaj ntsuam xyuas cov tshuaj hormones, kom tsis txhob muaj misdiagnosis nrog luteal cysts, qog ntawm zes qe menyuam, lossis lwm yam mob (xws li kev kho mob sib txawv, xws li luteal cysts yog kho nrog prostaglandins).
Diagnostic cov txheej txheem:
Kev soj ntsuam Estrus
Persisent estrus (nymphomania) los yog ntev anestrus, tshwj xeeb tshaj yog nyob rau hauv high-yielding nyuj 1-3 lub hlis tom qab yug me nyuam.
Qhov quav palpation
Cov qauv cystic> 2.5 cm inch, mos, tsis mob, txav me ntsis, nrog rau cov zes qe menyuam loj thiab tsis paub tab corpus luteum.
Kev ntsuam xyuas Hormone
plasma lossis mis nyuj progesterone qib <1 ng/mL paub meej tias zes qe menyuam follicular cysts.
Standardized Administration: Dosage and Route
Kev noj tshuaj thiab txoj kev yuav tsum ua raws li cov qauv kev kho mob, kho raws li lub cev qhov hnyav, cyst loj, thiab lub sijhawm muaj kab mob.
Kev noj tshuaj
Tus qauv tshuaj kho mob yog 86 ug fertirelin rau ib tug nyuj raws li ib qho kev txhaj tshuaj, sib haum rau 2 mL ib txhaj tshuaj (43 ug / mL fertirelin acetate).
Rau cov mob hnyav (cyst> 5 cm lossis ntev> 30 hnub): rov ua tib koob tshuaj 10-14 hnub tom qab thawj zaug txhaj tshuaj.
Rau cov nyuj sib zog (< 300 kg) or heifers: reduce to 60–70 μg to avoid superovulation.
Txoj kev tswj hwm
Kev txhaj tshuaj (xws li): pib sai dua, LH nce hauv 2-6 teev.
Kev txhaj tshuaj intramuscular: yooj yim dua rau kev ua liaj ua teb loj, LH nce hauv 4-8 teev.
Ob txoj kev ua tiav cov txiaj ntsig kho mob ntau dua 85%.
Lub sijhawm
Nws tuaj yeem siv tau thaum ua liaj ua teb txhua hnub. Nws raug nquahu kom tsis txhob pub mis nyuj thiab mis nyuj peaks kom txo tau kev ntxhov siab. Rau nyuj nyob rau hauv khaus estrus, tswj thaum coj cwj pwm zoo siab heev.
Kev Saib Xyuas Kev Tshawb Fawb los txhawb Ovarian rov qab
Kev tswj xyuas tom qab kev tswj hwm yog qhov tseem ceeb rau cyst regression thiab kev ua haujlwm ntawm zes qe menyuam.
Kev tswj hwm kev noj zaub mov zoo: kev noj zaub mov kom zoo, tsis txhob noj ntau lub zog / rog ntau. Ntxiv cov protein, vitamins, thiab minerals (tshwj xeeb yog Se, Zn, vitamin E) los txhawb kev kho zes qe menyuam. Txhim kho qhov tsis zoo ntawm lub zog sib npaug hauv cov nyuj uas muaj txiaj ntsig zoo tom qab yug menyuam.
Kev tswj kev ntxhov siab: ib puag ncig ruaj khov, zam kev tuav ntau zaus, hloov pauv tam sim ntawd, qhov kub thiab txias heev, overcrowding, lossis sib ntaus sib tua. Kev ntxhov siab cuam tshuam pituitary hormone secretion thiab kev siv tshuaj.
Kev saib xyuas estrus: cov nyuj feem ntau pom muaj estrus 20-22 hnub tom qab kho. Ua cov tshuaj tua kab mob 12-24 teev tom qab estrus. Yog tias tsis muaj estrus nyob rau hauv 14 hnub, prostaglandin yuav siv tau los pab induction.
Qhov zoo ntawm Fertirelin Txhaj Tshuaj rau Ovarian Follicular Cysts hauv nyuj
Piv nrog rau cov tshuaj ib txwm siv (piv txwv li, hCG, LHRH-A3), Fertirelin Txhaj Tshuaj muaj plaub qhov zoo: txhim khu kev qha, kev nyab xeeb siab, kev ua haujlwm yooj yim, thiab tus nqi siab.
Txhim khu kev qha, nrawm nrawm nrog qis rov tshwm sim
Kev ua haujlwm lom neeg yog 2.5-10 npaug ntawm GnRH ntuj, ua rau muaj kev ruaj khov thiab ntev LH surge.
Cysts ntsws me ntsis hauv 3-7 hnub thiab daws tag nrho hauv 10-14 hnub.
Tus nqi ua tau zoo: 85%–95% (vs. 60%–70% rau cov tshuaj tsoos).
Tus nqi rov tshwm sim: tsuas yog 3%–5% (vs. 15%–20% rau cov tshuaj ib txwm siv), vim yog synchronized FSH kev tswj hwm thiab kev kho kom zoo ntawm folliculogenesis.
Kev nyab xeeb siab, tsis muaj kev cuam tshuam tsis zoo lossis kev pheej hmoo ntawm residue
Raws li polypeptide compound zoo ib yam li endogenous GnRH, fertirelin yog metabolized sai heev rau cov amino acids uas tsis muaj cov ntaub so ntswg thiab tsis muaj kev cuam tshuam rau cov nqaij los yog mis nyuj zoo.
Lub sij hawm rho tawm: 0 hnub rau nyuj, 0 teev rau mis nyuj.
Tsis muaj teeb meem hauv zos, ua xua, lossis txo qis qab los noj mov. Tsis muaj qhov tsis zoo rau cov kua mis tawm. Tsuas yog qhov tsis tshua muaj kev ntxhov siab nyob rau hauv cov xwm txheej hnyav, uas daws tau tus kheej.
Siv tau yooj yim, haum rau kev ua liaj ua teb loj
Kev tswj hwm yooj yim (IV lossis IM). Kev txhaj tshuaj IM tuaj yeem ua tau los ntawm cov neeg ua liaj ua teb nyob rau hauv kev saib xyuas kws kho tsiaj.Feem ntau yuav tsum tau txhaj tshuaj ib zaug xwb, nrog rau koob thib ob nkaus xwb rau cov mob hnyav. Haum rau kev kho mob batch hauv cov mis nyuj loj thiab nqaij nyuj.
Tus Nqi-Kev Ua Tau Zoo
Kev kho ib zaug xwb tsis tas yuav siv tshuaj ntxiv. Kev ua tau zoo thiab tsis tshua muaj tshwm sim ua rau lub sijhawm qhib, rov tsim cov mis nyuj, thiab txo qis kev lag luam los ntawm kev xeeb tub. Tsawg zog thiab cov nqi tshuaj ua rau nws xaiv kev lag luam rau cov neeg ua liaj ua teb.
Kev ceev faj txog kev kho mob
Txhawm rau kom muaj txiaj ntsig thiab zam kev pheej hmoo, cov hauv qab no yuav tsum tau ua raws:
Rau zes qe menyuam follicular cysts nkaus xwb. Tsis txhob siv rau hauv nyuj cev xeeb tub (tej zaum yuav ua rau rho menyuam). Paub meej tias tsis cev xeeb tub ua ntej siv.
Tsis txhob sib xyaw nrog cov tshuaj alkaline (piv txwv li, sodium bicarbonate), uas degrade fertirelin thiab txo cov nyhuv.
Khaws kaw, tiv thaiv lub teeb, ntawm 2-8 degree. Tsis txhob siv yog turbid, precipitated, los yog discolored.
Kev tswj kev noj tshuaj nruj me ntsis: overdose yuav ua rau superovulation; underdose tsis muaj txiaj ntsig. Txo kev noj tshuaj rau heifers thiab nyuj me.
Veterinary tshuaj. Tsuas yog siv raws li kev taw qhia ntawm tus kws kho tsiaj muaj ntawv tso cai. Khaws cov ntaub ntawv tswj xyuas kom tiav rau kev saib xyuas thiab kev taug qab.
Ntsiab Physicochemical Properties
Cov khoom xyaw nquag hauv kev txhaj tshuaj, fertirelin (acetate), yog dawb los yog tawm -cov hmoov dawb, tsis muaj ntxhiab, dawb soluble hauv dej, me ntsis soluble hauv methanol, thiab insoluble nyob rau hauv uas tsis yog -polar solvents xws li diethyl ether thiab chloroform, ua tau raws li cov dej {{2} kev txhaj tshuaj nrog cov kua qaub acidic. pH ntau ntawm 4.5–6.5, uas yog ze rau lub cev pH ntawm cov tsiaj thiab tuaj yeem txo qhov kev khaus hauv zos tom qab txhaj tshuaj. Tsis tas li ntawd, fertirelin yog optically active, nrog rau ib qho kev sib hloov ntawm +40℃rau +50℃(hauv dej ntawm ib tug concentration ntawm 10 mg / ml), ib tug raug tshuaj yam ntxwv ntawm nws polypeptide qauv.
Cov yam ntxwv ruaj khov
Cov tshuaj ruaj khov ntawm Fertirelin Txhaj yog cuam tshuam los ntawm qhov kub thiab txias, lub teeb, thiab lwm yam.Thaum khaws cia hauv qab kaw, lub teeb - tiv thaiv tej yam kev mob ntawm 2–8℃(tub yees), lub txee lub neej yog mus txog 24 lub hlis.Nws nyob ruaj khov rau luv luv - lub sij hawm cia (tsis pub ntau tshaj 7 hnub) ntawm chav tsev kub (qis dua 25 degrees). Txawm li cas los xij, ntev -lub sij hawm raug kub siab (siab tshaj 30 degree) los yog lub teeb muaj zog yuav ua rau degradation ntawm polypeptide saw, ib tug txo nyob rau hauv active ingredient cov ntsiab lus, thiab txo cov nyhuv. alkaline ib puag ncig (pH> 7.0) ua kom nws cov degradation.
Compatibility yam ntxwv
Qhov kev txhaj tshuaj no tuaj yeem siv ua ke nrog cov kws kho tsiaj feem ntau siv prostaglandins (xws li cloprostenol sodium) thiab tshuaj tua kab mob, tsis muaj kev cuam tshuam tshuaj lom neeg lossis cov tshuaj lom lossis tsim kev puas tsuaj. Nws tuaj yeem sib koom ua ke siv rau kev tswj hwm tsiaj txhu.
Txawm li cas los xij, kev sib xyaw ua ke nrog cov tshuaj alkaline (xws li tshuaj sodium bicarbonate) raug txwv kom tsis txhob degradation ntawm cov khoom xyaw nquag tshwm sim los ntawm kev nce pH. Meanwhile, nws tsis pom zoo kom sib tov dig muag nrog lwm cov tshuaj hormonal, txhawm rau tiv thaiv kev cuam tshuam nrog nws cov tshuaj lom neeg thiab hauv vivo metabolism.
Cim npe nrov: fertirelin txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom