Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm argipressin txhaj tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo argipressin txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Argipressinyog ib tug hluavtaws formulation uas simulates lub ntuj antidiuretic hormone nyhuv nyob rau hauv tib neeg lub cev, ua kom tiav ob lub zog ntawm vasoconstriction thiab antidiuretic. Nws cov ntsiab lus tseem ceeb, arginine vasopressin, activates V1a receptor nyob rau hauv vascular du nqaij thiab V2 receptor nyob rau hauv lub raum tubules, exerting cuam tshuam rau vasoconstriction, kub siab, reabsorption dej, thiab tso zis tso zis txo, feem.
Hauv kev siv tshuaj kho mob, nws feem ntau yog siv rau hauv ob qhov xwm txheej: ib qho yog kho mob ntshav qab zib insipidus (tsis yog lub raum), los ntawm kev txhim kho permeability ntawm lub raum tubules rau dej thiab kho cov tsos mob polyuria; Qhov thib ob yog los tswj cov hlab ntsha variceal los ntshav thiab siv nws cov txiaj ntsig vasoconstrictive kom txo tau txoj kev pheej hmoo los ntshav. Tsis tas li ntawd, cov tshuaj kuj tseem siv tau los ua ib qho kev kho mob ntxiv rau kev mob plab tom qab phais thiab ua kom cov pa hauv plab zom mov ua ntej kev kuaj mob plab X-ray.
Peb cov khoom
Argipressin COA
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| Certificate of Analysis | ||
| Compound npe | Argipressin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 113-79-1 | |
| Ntau | 50g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090069 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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Kev txhaj tshuaj Argipressin(AVP), tseem hu ua antidiuretic hormone (ADH), yog cuaj peptide hormone synthesized los ntawm hypothalamic neurons thiab tso tawm los ntawm posterior pituitary caj pas. Nws ua lub luag haujlwm tseem ceeb hauv dej thiab ntsev sib npaug, tswj ntshav siab, thiab kev ntxhov siab hauv tib neeg lub cev.
Biological synthesis txoj kev: los ntawm noob qhia mus rau molecular sib dhos ntawm cov tshuaj hormones nquag
Lub synthesis ntawm AVP pib nrog cov hlwb neuroendocrine hauv hypothalamic supraoptic nucleus thiab paraventricular nucleus, thiab cov txheej txheem tuaj yeem muab faib ua plaub theem:
Gene transcription thiab precursor protein synthesis
AVP noob nyob rau hauv ib cheeb tsam tshwj xeeb ntawm chromosome thiab encodes precursor AVP protein uas muaj 164 amino acids. Qhov precursor no muaj plaub lub luag haujlwm ua haujlwm: teeb liab peptide, AVP cuaj peptide sib lawv liag, neurophysin II, thiab copeptin. Lub teeb liab peptide coj tus precursor mus rau hauv endoplasmic reticulum thiab yog cleaved, tsim ib tug 145 amino acid pro AVP.
Intracellular processing thiab folding
Pro AVP tau txais cov tshuaj protease hydrolysis hauv Golgi apparatus los tsim AVP nonapeptide (Cys Tyr Phe Gln Asn Cys Pro Arg Gly-NH2), neurotrophin transporter protein, thiab coptin. Ntawm lawv, kev tsim cov ntawv cog lus disulfide (Cys1-Cys6) hauv AVP yog tus yuam sij rau nws txoj kev ua haujlwm zoo, uas ua rau AVP ruaj khov rau cov neeg txais khoom.
Axon thauj thiab khaws cia
Cov txheej txheem AVP khi rau cov neurotrophin transporter protein los tsim cov granules secretory, uas yog thauj raws li axon ntawm lub hypothalamic pituitary ib ntsuj av mus rau lub posterior pituitary caj pas thiab khaws cia nyob rau hauv lub Herring lub cev. Carrier proteins tsis tsuas yog tiv thaiv AVP los ntawm enzymatic hydrolysis, tab sis kuj tswj nws tso tawm efficiency.
Enzymatic activation thiab tso tawm
Thaum lub cev xav tau nws, lub caj pas pituitary tso AVP mus rau hauv cov hlab ntsha los ntawm exocytosis. AVP sai khi rau V1a thiab V2 receptors nyob rau hauv lub hom phiaj ntawm lub cev (lub raum, cov hlab ntsha, thiab lwm yam) nyob rau hauv cov hlab ntsha, exerting physiological teebmeem. Nws ib nrab -Lub neej tsuas yog 15-20 feeb thiab yuav tsum muaj kev sib txuas txuas ntxiv los tswj nws txoj haujlwm.
Cov txheej txheem tswj kev zais cia: ntau- theem tawm tswv yim network ua kom lub xeev khov kho
Kev tso tawm ntawm AVP yog tswj los ntawm triple mechanism ntawm neural, humoral, thiab tus kheej - kev tswj hwm, nrog rau lub hom phiaj tseem ceeb ntawm kev tswj cov ntshav plasma osmotic siab (280-300 mOsm / kg) thiab ntshav ntim (kwv yees li 5 L).
Kev tswj hwm osmotic siab: Ua kom pom tseeb qhov hloov pauv hauv cov kua dej ntxiv osmotic siab
Cov osmoreceptors nyob rau hauv hypothalamic supraoptic nucleus thiab paraventricular nucleus yog cov rhiab heev rau cov kev hloov hauv osmotic siab, thiab tsuas yog 1% kev hloov pauv tuaj yeem ua rau muaj kev cuam tshuam.argipressin txhaj tshuajtso tawm. Thaum plasma osmotic siab nce (xws li lub cev qhuav dej):
Depolarization ntawm osmoreceptor hlwb activates voltage-gated calcium channels, txhawb kev tso tawm ntawm AVP secretory granules.
AVP txhawb nqa qhov ntxig ntawm aquaporin 2 (AQP2) rau hauv lub raum khaws cov duct los ntawm V2 receptors, ua kom cov dej reabsorption, txo cov zis tso zis, thiab txo cov ntshav osmotic siab.
Ntawm qhov tsis sib xws, lub xeev hypotonic inhibits AVP secretion thiab ua kom cov zis tso zis kom rov qab osmotic siab tshuav.
Kev tswj ntshav ntim: reflex kev tswj ntawm lub siab receptors
Txo cov ntshav ntim (xws li los ntshav) txhawb nqa AVP secretion los ntawm cov hauv qab no:
Cardiopulmonary siab receptors: Lub nro receptors nyob rau hauv sab laug atrium thiab pulmonary veins pom ib tug txo nyob rau hauv cov ntshav ntim thiab xa cov teeb liab mus rau lub hypothalamus los ntawm lub vagus paj, txhawb kev tso tawm ntawm AVP.
Arterial siab receptors: Siab receptors nyob rau hauv carotid sinus thiab aortic arch hnov qhov txo qis hauv cov ntshav siab thiab qhib AVP secretion los ntawm sympathetic paj hlwb.
Renin angiotensin system (RAAS): Txo cov ntshav ntim activates renin secretion, thiab angiotensin II ncaj qha nkoos hypothalamic AVP synthesis.
AVP induces vascular du nqaij contraction los ntawm V1a receptors, ua rau kom ntshav siab, txo cov dej ntshiab, thiab restores ntshav ntim.
Lwm yam kev tswj hwm: kev ntxhov siab, mob, thiab tshuaj cuam tshuam
Cov lus teb kev ntxhov siab: Kev ntxhov siab xws li mob, kev raug mob, thiab kev ntxhov siab ntawm lub siab ua rau lub hypothalamic pituitary adrenal axis (HPA axis), txhawb kev sib koom ua ke ntawm AVP thiab corticotropin releasing hormone (CRH), thiab txhim kho cortisol secretion los tiv thaiv kev ntxhov siab.
Kev siv tshuaj: Ethanol inhibits AVP secretion, ua rau diuresis; Lithium ntsev, norepinephrine, thiab lwm yam tshuaj tsis ncaj qha cuam tshuam rau AVP cov nyhuv los ntawm kev cuam tshuam rau lub raum tubular muaj nuj nqi lossis receptor teeb liab hloov.
Circadian atherosclerosis: AVP secretion fluctuates ntawm nruab hnub thiab hmo ntuj, nrog ntau dua thaum hmo ntuj, uas tej zaum yuav muaj feem xyuam rau lub voj voog pw tsaug zog.
Pathological abnormalities thiab kev kho mob tseem ceeb: ob lub txim ntawm secretion disorders
AVP secretion txawv txav tuaj yeem ua rau muaj ob yam kab mob tseem ceeb: kev tso tawm ntau dhau ua rau muaj dej tuav, thiab tsis txaus tso tawm ua rau lub cev qhuav dej.
Arginine vasopressin secretion disorder syndrome (SIADH)
Vim cov qog nqaij hlav (xws li mob ntsws me me), kev puas tsuaj hauv nruab nrab ntawm lub paj hlwb (encephalitis, mob hlwb raug mob), lossis tshuaj (carbamazepine) stimulation, muaj qhov txawv txav ntawm AVP secretion, ua rau:
Kev tuav dej: hemodilution, txo cov ntshav sodium (<130 mmol/L), brain edema and convulsion in severe cases.
Cov zis sodium siab: lub raum tso tawm ntau sodium los them rau cov dej tuav, tab sis tsis tuaj yeem kho hyponatremia.
Kev kho mob yuav tsum txwv tsis pub haus dej, siv cov tshuaj diuretics (xws li tolvaptan) los thaiv V2 receptors, lossis kho qhov laj thawj.
Mob ntshav qab zib insipidus
Central diabetes insipidus: Hypothalamic or pituitary lesions (tumors, trauma) lead to impaired AVP synthesis or release, manifested as polyuria (>5 L / d), nyob tsis tswm, thiab tsis tshua muaj lub ntiajteb txawj nqus tso zis. Kev kho mob tseem ceeb yog hloov nrog desmopressin (DDAVP).
Lub raum ntshav qab zib insipidus: Tsis muaj lub raum V2 receptor lossis AQP2, insensitive rau AVP, feem ntau pom hauv cov kab mob caj ces lossis tshuaj (lithium ntsev) kev puas tsuaj. Kev kho mob yuav tsum muaj dej ntau thiab siv cov tshuaj thiazide diuretics kom txo cov zis tso zis.
AVP abnormalities nyob rau hauv cov kab mob plawv
Qib ntawm AVP nyob rau hauv cov neeg mob uas muaj lub plawv tsis ua hauj lwm nce siab, thiab lub perfusion siab tau tswj los ntawm vasoconstriction thiab dej tuav nyob rau hauv lub sij hawm thaum ntxov, tab sis lub sij hawm ntev - lub sij hawm siab AVP lub xeev aggravated lub pre thiab post load ntawm lub plawv, tsim ib tug vicious vajvoog. V1a receptor antagonists (xws li Konivatan) tuaj yeem txhim kho qhov kev mob plawv tsis ua haujlwm.
Kev tswj hwm biosynthesis thiab secretion ntawm arginine vasopressin yog ib qho qauv ntawm kev sib koom ua ke hauv cov kab mob neuroendocrine, thiab nws cov txheej txheem tseem ceeb ua tiav - lub xeev kev saib xyuas los ntawm osmotic siab thiab ntshav ntim tawm tswv yim loops. Kev tshawb fawb yav tom ntej tuaj yeem tshawb nrhiav ntxiv:
Kev nkag siab tob ntawm AVP kev tswj hwm lub network tsis yog tsuas yog muab lub hauv paus theoretical rau cov dej ntsev metabolism thiab cov kab mob plawv, tab sis kuj qhib txoj hauv kev tshiab rau kev tsim cov tswv yim kho mob rau cov kab mob neuroendocrine.
Cov lus nug nquag
Vim li cas cov txiv neej xav tau vasopressin poob rau hauv kev hlub?
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Txhim kho Vasopressin Levels
Thaum ib tug txiv neej ua ib qho kev cog lus, tsis hais nws qhov xwm txheej, testosterone qib txo, uas tom qab ntawd tso cai rau oxytocin los txuas nrog vasopressin zoo.. Qhov kev sib txuas no yog qhov tseem ceeb rau cov txiv neej kom sib koom siab nrog lawv cov neeg koom tes, txhawb kev sib raug zoo ntawm kev xav thiab kev sib txuas mus ntev -.
Dab tsi yog cov tsos mob ntawm kev tsis muaj arginine vasopressin?
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Cov tsos mob xws litso zis ntau zaus, nqhis dej heev, tso zis hmo ntuj, thiab lub cev qhuav dej. Kev kuaj mob suav nrog kev kuaj zis thiab ntshav, kuaj dej tsis txaus, thiab MRI ntawm thaj chaw pituitary. Kev kho mob suav nrog desmopressin los hloov vasopressin thiab saib xyuas cov kua dej thiab electrolyte tshuav.
Vasopressin ua dab tsi hauv kev hlub?
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Vasopressin txuas nrog tus cwj pwm ntawdua rau ntev -lub sij hawm, kev sib raug zoo monogamous. Qhov sib txawv ntawm tus cwj pwm cuam tshuam nrog kev ua ntawm ob qho tshuaj hormones tuaj yeem piav qhia tias vim li cas kev hlub kev hlub ploj mus thaum kev sib txuas zuj zus.
Dab tsi yog cov khoom noj uas muaj arginine siab heev?
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L-arginine yog ib qho amino acid uas pab lub cev tsim cov protein. Koj lub cev feem ntau ua rau tag nrho L-arginine nws xav tau. L-arginine kuj pom muaj nyob hauv cov protein ntau- cov khoom noj nplua nuj, suav nrogntses, nqaij liab, nqaij qaib, taum pauv, tag nrho cov nplej, taum thiab cov khoom siv mis nyuj. Raws li kev ntxiv, L-arginine tuaj yeem siv rau qhov ncauj thiab pleev xim.
Vim li cas cov neeg mob ntshav qab zib tso zis ntau heev thaum hmo ntuj?
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Thaum muaj cov piam thaj ntau dhau hauv koj cov ntshav, uas tshwm sim yog tias koj muaj ntshav qab zib, koj lub raum yuav tsum ua haujlwm hnyav dua kom tshem tawm nws.. Qhov no yuam kom lawv tso zis ntau dua. Cov txheej txheem tsis nres tsuas yog vim koj tsaug zog. Mob ntshav qab zib tuaj yeem ua rau koj lub raum lossis zais zis.
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