Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm hexarelin txhaj tshuaj hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo hexarelin txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kev txhaj tshuaj Hexarelin, raws li ib tug hluavtaws loj hlob hormone tso tawm peptide (GHRP), muaj ib tug tsis loj hlob hormone (GH) - nyob rau hauv lub core neuroprotective nyhuv, uas yog feem ntau tshwm sim nyob rau hauv lub hom phiaj kev tswj ntawm inflammatory microenvironment nyob rau hauv lub hlwb, meej kho ntawm neuronal calcium homeostasis, thiab muaj zog antagonism ntawm oxidative kev nyuaj siab. Peb lub luag haujlwm tsis muaj kev ywj pheej, tab sis muaj kev cuam tshuam, tsim lub voj voog kev tswj hwm los thaiv cov txheej txheem pathological ntawm lub hauv paus paj hlwb puas. Cov hauv qab no muab cov ncauj lus kom ntxaws thiab kev piav qhia ntawm cov txiaj ntsig zoo ntawm qhov kev xav ntawm cov txheej txheem ntawm kev nqis tes ua, txoj hauv kev tswj hwm tseem ceeb, thiab cov txiaj ntsig lom neeg.
Peb Cov Khoom Muag Khoom
Hexarelin COA
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| Certificate of Analysis | ||
| Compound npe | Hexarelin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 140703-51-1 | |
| Ntau | 35g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090069 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib leeg impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
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| Tshuaj Formula | C47H58N12O6 |
| Exact Mass | 886.46 |
| Molecular Luj | 887.06 |
| m/z | 886.46 (100.0%), 887.46 (50.8%), 888.47 (12.6%), 887.46 (4.4%), 888.46 (2.3%), 889.47 (1.2%), 888.46 (1.2%) |
| Elemental Analysis | C, 63.64; H, 6.59; N, 18.95; O, 10.82 |
Targeted Brain Inflamation Control & Immune Balance
Kev txhaj tshuaj hexarelinFeem ntau ua rau kev loj hlob hormone secretagogue receptor-1a (GHSR-1a) ntawm lub hauv paus neurons thiab glial hlwb, inhibiting qhov pib thiab nthuav tawm ntawm intracerebral o los ntawm peb qhov ntev: txoj kev tsuj, cell polarization, thiab kev tiv thaiv cov ntaub so ntswg. Nws nthuav tawm cov kev cai tseem ceeb, tshwj xeeb tshaj yog nyob rau hauv mob / mob mob neuroinflammation tshwm sim los ntawm cov kab mob neurodegenerative thiab cerebral ischemia.
Raws li kev khi tshwj xeeb rau GHSR-1a, nws ncaj qha txo qis kev ua haujlwm ntawm cov khoom siv hluav taws xob nuclear-kappa B (NF-κB) txoj hauv kev los ntawm inhibiting NF-κB translocation los ntawm cytoplasm mus rau lub nucleus thiab txo nws txoj kev khi rau cov pro{6} mob. Qhov no txo qis qhov kev sau thiab tso tawm ntawm qhov tseem ceeb pro- inflammatory cytokines xws li qog necrosis factor-alpha (TNF- ), interleukin-1 (IL-1 ), thiab interleukin-6 (IL-6), yog li thaiv qhov tshwm sim ntawm cov kab mob inflammatory ntawm nws qhov chaw. Tsis tas li ntawd, Hexarelin inhibits phosphorylation ntau dhau ntawm p38, ERK, thiab JNK subtypes nyob rau hauv txoj kev mitogen-activated protein kinase (MAPK), txo qis qis qis ntawm cov kab mob inflammatory thiab tiv thaiv kev mob siab rau cov neurons los ntawm cov neeg kho mob inflammatory.
Kev cai Polarization ntawm Microglia:
Microglia, uas yog thawj lub cev tiv thaiv kab mob hauv lub hlwb, nthuav tawm pro-inflammatory M1 polarization, uas ua rau lub hauv paus ntawm cov cellular ntawm cov kab mob intracerebral. Los ntawm GHSR-1a- kev teeb tsa kev sib kho, Hexarelin txhawb kev hloov pauv ntawm M1 microglia hloov pauv mus rau cov tshuaj tiv thaiv - mob M2 phenotype. Cov txheej txheem no txo cov kev tso tawm ntawm cov kab mob sib kis xws li inducible nitric oxide synthase (iNOS) thiab cyclooxygenase-2 (COX-2) los ntawm M1 microglia thaum txhim kho qhov tso tawm ntawm cov tshuaj tiv thaiv kab mob xws li interleukin-10 (IL-10) thiab hloov pauv kev loj hlob-beta microglia (TGF). Yog li ntawd, nws pab kho lub hlwb lub cev tiv thaiv kab mob microenvironment thiab alleviates persistent neuronal puas los ntawm kev mob neuroinflammation.
Intracerebral o tuaj yeem cuam tshuam cov txheej txheem nruj ntawm cov ntshav- hlwb barrier (BBB), tso cai rau peripheral inflammatory cells thiab macromolecules nkag mus rau hauv nruab nrab paj hlwb thiab exacerbate inflammatory teb. Hexarelin tiv thaiv BBB los ntawm inhibiting inflammatory pathway-induced kev puas tsuaj rau endothelial hlwb, yog li tswj cov kev qhia thiab kev ua hauj lwm zoo ntawm nruj junction proteins (xws li, occludin thiab claudin-5). Qhov no tiv thaiv lub hauv paus infiltration ntawm peripheral inflammatory yam thiab tsim ib tug "peripheral-central" inflammatory cais barrier, averting lub amplification ntawm o nyob rau hauv lub BBB.
Precision Control ntawm Neuronal Calcium & Restoring Cellular Balance
Calcium homeostasis yog qhov tseem ceeb rau kev ua kom lub cev muaj zog, lub teeb liab hloov, thiab kev ua haujlwm organelle. Intracerebral o, ischemia, thiab oxidative kev nyuaj siab tuaj yeem ua rau muaj cov calcium ntau dhau ntawm cov neuronal -tus cwj pwm los ntawm kev txawv txav ntawm cov cellular Ca²⁺ influx thiab pathological tso tawm los ntawm cov khw muag khoom calcium hauv intracellular- thaum kawg ua rau neuronal apoptosis / necrosis. Hexarelin restores neuronal calcium homeostasis los ntawm multi- phiaj xwm kev tswj cov calcium thauj thiab metabolism, thaiv calcium overload hla plaub txheej txheem tseem ceeb: influx, tso, extrusion, thiab cia.
Kev txhaj tshuaj hexarelinncaj qha inhibits qhov qhib ntau dhau ntawm voltage-gated calcium channels (feem ntau L- hom thiab N- hom) ntawm cov cell membrane, txo cov channel permeability thiab txo cov influx ntawm extracellular Ca²⁺ raws nws cov concentration gradient. Concurrently, nws suppresses lub overactivation ntawm glutamatergic receptors (NMDA receptors), tiv thaiv tus receptors -kho nce nyob rau hauv calcium influx, yog li txo qhov txawv txav calcium uptake ntawm nws qhov chaw.
2. Inhibition of Pathological Release from Intracellular Calcium Stores
Lub endoplasmic reticulum yog thawj cov khoom siv calcium hauv cov cell hauv cov neurons. Hexarelin thaiv qhov txawv txav ntawm inositol trisphosphate receptors (IP3R) thiab ryanodine receptors (RyR) ntawm endoplasmic reticulum membrane, txo qhov tso tawm ntawm Ca²⁺ los ntawm endoplasmic reticulum mus rau hauv cytoplasm thiab tiv thaiv kom txhob muaj cov calcium ntxiv nyob rau hauv nruab nrab.
Hexarelin txhawb kev qhia thiab kev ua haujlwm ntawm plasma membrane calcium ATPase (PMCA) thiab sarco / endoplasmic reticulum calcium ATPase (SERCA) ntawm cov paj hlwb. Tus qub nquag nqus cov cytoplasmic Ca²⁺ tawm ntawm lub xovtooj tawm tsam nws cov concentration gradient, thaum tom kawg rov ua dua cytoplasmic Ca²⁺ rov qab mus rau hauv endoplasmic reticulum rau khaws cia. Txoj kev ob txoj hauv kev no txo qis cov concentration ntawm dawb intracellular Ca²⁺ thiab kho cov calcium homeostasis.
4. Kev thaiv ntawm txoj kev puas tsuaj los ntawm Calcium Overload
Txawm nyob rau hauv lub xub ntiag ntawm me ntsis txawv txav calcium tsub zuj zuj,Kev txhaj tshuaj hexarelintuaj yeem cuam tshuam cov calcium ntau dhau -nyob ntawm cov proteases (piv txwv li, calpain) thiab calcineurin. Nws txo cov calpain-kev sib haum xeeb ntawm kev degradation ntawm neuronal cytoskeletal proteins (xws li, microtubule-sociated protein tau) thiab mitochondrial membrane proteins, thaum tseem suppressing calcineurin-kev kho kom haum xeeb ntawm apoptotic signaling pathways. Qhov no thaiv cov kab mob pathological ntawm "calcium overload → protein degradation → neuronal apoptosis."
Muaj zog antagonism ntawm Neuronal Oxidative Stress thiab Kho ntawm Redox Balance
Oxidative stress yog cov txheej txheem tseem ceeb hauv kev raug mob hauv nruab nrab paj hlwb. Nws koom nrog kev tsim tawm ntau dhau ntawm cov pa oxygen reactive (ROS), xws li superoxide anions, hydroxyl radicals, thiab hydrogen peroxide, uas cuam tshuam cov neuron lub cev tiv thaiv kab mob hauv lub cev, ua rau oxidative puas tsuaj rau lipids, proteins, thiab DNA. Tsis tas li ntawd, oxidative kev nyuaj siab tuaj yeem ua rau muaj kev ua kom muaj zog thiab calcium ntau dhau. Hexarelin siv ob lub tswv yim ntawm kev tshem tawm ncaj qha thiab kev tsis ncaj ncees rau kev tawm tsam oxidative kev nyuaj siab thaum tiv thaiv mitochondria- thawj qhov chaw ntawm ROS ntau lawm- tsim lub kaw - lub voj kev tswj hwm kev tiv thaiv antioxidant.
Direct Scavenging ntawm lub hlwb ntau dhau ROS:
Hexarelin molecule nws tus kheej muaj qhov muaj peev xwm ua kom dawb radical scavenging. Nws tuaj yeem koom ncaj qha rau hauv cov tshuaj tiv thaiv redox nrog ntau dhau ROS hauv lub hlwb, ua rau cov tshuaj oxidizing zoo li superoxide anions thiab hydroxyl radicals. Qhov no txo ROS-induced lipid peroxidation puas tsuaj rau neuronal membrane phospholipids, pab tswj kev ncaj ncees thiab permeability ntawm cell membrane. Qhov no tiv thaiv kev cuam tshuam ntawm daim nyias nyias thiab cov calcium uas tom qab nkag thiab cov teeb meem ntawm txoj kev dysregulation.
Upregulation ntawm Endogenous Antioxidant System Function:
Hexarelin ua kom muaj qhov cuam tshuam ntawm cov teeb meem nuclear erythroid 2-txog yam 2 (Nrf2) txoj hauv kev. Nws txhawb kev hloov pauv ntawm Nrf2 los ntawm cytoplasm mus rau lub nucleus, qhov twg nws khi rau cov tshuaj tiv thaiv antioxidant (ARE). Qhov kev khi no pib ua cov ntawv sau thiab qhia txog ntau yam kev tiv thaiv kab mob qis qis, suav nrog superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), thiab catalase (CAT). Nyob rau tib lub sijhawm, nws txhim kho cov synthesis ntawm glutathione (GSH) hauv cov neurons, txhawb nqa cov neuron lub cev muaj peev xwm tiv thaiv antioxidant. Qhov no hloov cov kev tiv thaiv mechanism los ntawm "passive scavenging" mus rau "active tiv thaiv."
Kev tiv thaiv ntawm Mitochondrial Function thiab txo qis ntawm Mitochondrial ROS Ntau Lawm:
Mitochondria yog ob qho tib si thawj qhov chaw ntawm neuronal ROS thiab lub hom phiaj tseem ceeb ntawm oxidative kev nyuaj siab. Hexarelin pab tswj kev ruaj ntseg ntawm mitochondrial membrane muaj peev xwm thiab inhibits qhov qhib ntawm mitochondrial permeability hloov pore (mPTP). Qhov no tiv thaiv kev tso tawm ntawm apoptogenic yam xws li cytochrome c los ntawm mitochondrial matrix.
Tsis tas li ntawd, nws txhawb kev ua haujlwm ib txwm muaj ntawm cov kab mob mitochondrial, txhim kho ATP synthesis efficiency thiab txo ROS tiam los ntawm electron to ntawm cov saw. Qhov kev txiav txim no ua rau lub voj voog tsis zoo ntawm "mitochondrial kev puas tsuaj → ntau dhau ROS ntau lawm → ntau dua mitochondrial puas tsuaj," yog li txo qhov tshwm sim ntawm oxidative kev nyuaj siab ntawm nws qhov chaw.
Synergistic Regulatory Effects of the Three Mechanisms
Kev ua ntawm Hexarelin hauv mitigating intracerebral o, inhibiting calcium overload, thiab antagonizing oxidative kev nyuaj siab yog tsis cais cov xwm txheej. Hloov chaw, lawv tsim ib qho kev sib koom ua ke ntawm kev sib koom ua ke thiab kev sib koom ua ke inhibition:
Kev sib cuam tshuam ntawm Kab Mob thiab Lwm Txoj Kev
Kev ua kom kub hnyiab tuaj yeem ua rau muaj cov calcium ntau dhau ntawm neuronal thiab ntau ROS ntau lawm. Hexarelin's inhibition ntawm NF-κB thiab MAPK txoj hauv kev ncaj qha txo qhov mob -kho cov calcium channel ua kom muaj zog thiab mitochondrial ROS tso tawm.
Lub luag haujlwm ntawm Calcium Overload
Calcium overload exacerbates mitochondrial membrane muaj peev xwm tsis txaus, txhawb ROS tiam, thiab ua kom o -txoj kev proteases. Nws yog kho dua ntawm calcium homeostasis indirectly diminishes lub cascade amplification ntawm oxidative kev nyuaj siab thiab o.
Kev cuam tshuam ntawm Oxidative Stress
Kev ntxhov siab oxidative tuaj yeem cuam tshuam GHSR-1a receptor muaj nuj nqi, ua rau cov qauv ntawm calcium channels thiab calcium twj tso kua mis, thiab qhib txoj kev NF-κB. Hexarelin cov teebmeem antioxidant tiv thaiv cov qauv thiab kev ua haujlwm ntawm cov hom phiaj no, ua kom muaj kev ua tiav zoo ntawm nws cov tshuaj tiv thaiv - inflammatory thiab anti-calcium overload ua.
Qhov no ntau- lub hom phiaj, ntau- txoj kev sib koom ua ke kev tswj hwm yog tus yuam sij rau Hexarelin cov txiaj ntsig zoo neuroprotective. Nws kuj tseem ua haujlwm rau qhov no yog tus neeg sib tw tseem ceeb rau kev tshawb fawb txog kev cuam tshuam kev kho mob rau cov kab mob hauv nruab nrab paj hlwb xws li Alzheimer's kab mob, Parkinson's disease, thiab cerebral ischemia-reperfusion raug mob.
FAQ
- Puas yog Hexarelin nce HGH?
Qhov no yog ib qho muaj zog GH- tso peptide, muaj peev xwm ua rau muaj kev tso tawm GH hauv ib txwm muaj tom qab qhov ncauj, intranasal, iv, thiab sc kev tswj hwm.
- Hexarelin kav ntev npaum li cas?
Stability & Cia.Nws txawm tias ruaj khov ntawm chav tsev kub rau 3 lub lis piam, yuav tsum tau khaws cia desiccated hauv qab -18 degree. Thaum rov kho cov tshuaj no yuav tsum tau khaws cia ntawm 4℃ntawm 2-7 hnub thiab siv rau yav tom ntej hauv qab -18 degree. Rau lub sijhawm ntev cia nws raug pom zoo kom ntxiv cov khoom thauj khoom (0.1% HSA lossis BSA).
- Puas yog hexarelin tsim cov leeg?
GH plays lub luag haujlwm tseem ceeb hauv kev tsim cov protein, pab cov hlwb rov tsim kho thiab loj hlob cov leeg nqaij tom qab kev cob qhia. Cov neeg ncaws pob thiab cov kws tsim lub cev feem ntau nyiam qhov no kom rov qab tau sai dua, nce lean loj, thiab txhim kho cov txiaj ntsig kev cob qhia.
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