Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam txhab kev paub ntau tshaj plaws thiab cov chaw muag khoom ntawm cov tshuaj ntsiav tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo kisspeptin capsules rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Kisspeptin ntsiav tshuajyog ib qho kev npaj tshwj xeeb ua nrog Kisspeptin-10 ua cov khoom tseem ceeb. Nws yog peptide nrog cov haujlwm tseem ceeb hauv lub cev hauv tib neeg lub cev, encoded los ntawm KISS1 noob thiab muaj li ntawm 10 amino acids. Nws ua lub luag haujlwm tseem ceeb hauv kev tswj cov hypothalamic pituitary gonadal axis (HPG axis) los ntawm kev khi tshwj xeeb rau G protein txuas nrog receptor GPR54. Tam sim no, feem ntau ntawm lawv nyob rau theem tshawb fawb thiab tseem tsis tau siv dav hauv kev kho mob. Nws ib nrab-lub neej yog luv luv, nws yog yooj yim metabolized sai sai nyob rau hauv lub cev, thiab nws yog dav faib, uas tej zaum yuav muaj kev cuam tshuam tsis zoo rau cov ntaub so ntswg. Yog li ntawd, yuav ua li cas kom ua tiav kev xa khoom zoo, tswj kev noj ntau npaum li cas, thiab ncua nws lub sijhawm ua haujlwm yog qhov kev sib tw tseem ceeb uas yuav tsum tau kov yeej hauv kev tshawb fawb thiab kev tsim kho yav tom ntej.
Peb cov khoom los ntawm
Kisspeptin-10 (tib neeg) COA
Kev siv hauv kev kho mob plawv
Kisspeptin ntsiav tshuajNws yog ib qho zoo vasoconstrictor thiab angiogenesis inhibitor. Hauv kev tshawb fawb ntawm cov hlab plawv, nws cov txheej txheem ntawm kev ua haujlwm feem ntau yog nyob ntawm kev tswj hwm ntawm vascular endothelial hlwb thiab vascular du leeg hlwb. Los ntawm kev khi rau GPR54 receptor, cov kev taw qhia qis qis tuaj yeem qhib tau, cuam tshuam rau systolic thiab diastolic xeev ntawm cov hlab ntsha. Cov kev sim hauv vitro tau pom tias muaj kev nce ntxiv hauv kev sib txuas ntawm THP-1 hlwb rau HUVEC (tib neeg umbilical leeg endothelial hlwb), uas yog nyob ntawm qhov ua kom ntawm GPR54 receptors. Thaum cov hlwb raug pretreated nrog GPR54 antagonist P234, cell adhesion induced los ntawm Kisspeptin-10 tau inhibited loj, qhia tias GPR54 yog lub hom phiaj tseem ceeb rau Kisspeptin-10 kom ua rau vasoconstriction thiab angiogenesis inhibition.
Kev tshawb fawb ntxiv tau pom tias nws tuaj yeem txhim kho qhov kev nthuav qhia ntawm ntau yam kab mob inflammatory thiab cell adhesion molecules hauv HUVECs, suav nrog TNF -, IL-6, MCP-1, ICAM-1, VCAM-1, thiab E-selective protein. Cov molecules no ua lub luag haujlwm tseem ceeb hauv kev tshwm sim thiab kev loj hlob ntawm vascular o thiab atherosclerosis. Qhov nce ntawm cov protein qhia ntawm ICAM-1 thiab VCAM-1 yog sib npaug rau qhov nce hauv mRNA qib, qhia tias Kisspeptin-10 tuaj yeem tswj hwm qhov kev qhia ntawm cov molecules ntawm qib transcriptional, yog li cuam tshuam rau kev ua haujlwm ntawm cov hlwb endothelial thiab vascular permeability.
Hauv kev kawm txog tsiaj cov qauv ntawm atherosclerosis, nws kuj qhia tau hais tias lub luag haujlwm tseem ceeb ntawm kev tswj hwm. ApoE -/- nas (cov nas uas nquag siv atherosclerosis qauv nas) tau siv los ua cov khoom tshawb fawb los soj ntsuam cov teebmeem ntawm Kisspentin-10 lossis P234, GPR54 antagonist, ntawm kev txhim kho atherosclerosis. Cov txiaj ntsig tau pom tias kev txhaj tshuaj Kisspeptin-10 tuaj yeem ua rau qeeb ntawm cov hlab ntsha ntawm daim tawv nqaij cov ntshav hauv ApoE --/- nas muaj hnub nyoog 13 txog 17 lub lis piam, uas tej zaum yuav cuam tshuam rau vasoconstriction. Nyob rau tib lub sij hawm, thaum lub sij hawm kev loj hlob ntawm atherosclerotic lesions, qhov luaj li cas ntawm cov kab mob, infiltration ntawm monocytes / macrophages, thiab cov ntsiab lus ntawm vascular du leeg hlwb (VSMC) muaj ib co kev cuam tshuam.
Thaum ua ke nrog GPR54 antagonist P234, P234 tuaj yeem cuam tshuam qhov tsim ntawm atherosclerosis induced los ntawm Kisspeptin -10, uas ntxiv kev lees paub lub luag haujlwm tseem ceeb ntawm GPR54 receptor hauv kev tswj hwm ntawm atherosclerosis los ntawm Kisspeptin-10. Tsis tas li ntawd, cov kev tshawb fawb metabolomics raws li GC / TOF-MS hauv cov nas pom kev hloov pauv hauv plawv metabolites hauv nas kho nrog Kisspeptin-10. Kev soj ntsuam kev sib kis ntawm electron microscopy (TEM) tau pom cov kev hloov pauv hauv cov qauv mitochondrial, uas yuav pab tau kom nkag siab txog cov txheej txheem uas Kisspeptin-10 kev kho mob hloov kho lub plawv thiab muab cov lus qhia tshiab rau kev tshawb nrhiav pathogenesis thiab kho cov tswv yim kho mob ntawm cov kab mob plawv.
Cov kev siv tshuaj kho mob muaj peev xwm nyob rau hauv cov hlab plawv feem ntau yog tsom rau kev kho thiab tiv thaiv cov kab mob vascular. Vim nws cov vasoconstriction thiab angiogenesis inhibition zog, Kisspentin-10 yuav dhau los ua lub hom phiaj tshiab rau kev kho mob atherosclerosis, hemangioma thiab lwm yam kab mob. Txawm li cas los xij, kev tshawb fawb tam sim no tseem ntsib qee qhov teeb meem. Ntawm qhov one hand, lub mechanism ntawm kev txiav txim tsis tau elucidated tag nrho, tshwj xeeb tshaj yog nyob rau hauv lub complex physiological ib puag ncig ntawm lub cev.
Nws cuam tshuam nrog lwm txoj hauv kev qhia thiab nws qhov cuam tshuam rau ntau hom cell xav tau ntxiv hauv -kev tshawb fawb tob. Ntawm qhov tod tes, yuav ua li cas kom ua tiav lub hom phiaj xa khoom thiab txo nws cov kev mob tshwm sim hauv cov ntaub so ntswg uas tsis yog lub hom phiaj yog qhov teeb meem tseem ceeb hauv kev txhais nws mus rau hauv kev kho mob. Tsis tas li ntawd, kev nyab xeeb thiab kev ua tau zoo ntawm kev siv sij hawm ntev - kuj yuav tsum tau kuaj xyuas los ntawm kev sim tsiaj thiab kev sim tshuaj.
Cov ntawv thov hauv thaj tsam ntawm neuroscience
Cov ntshav -brain barrier (BBB) yog ib qho tseem ceeb qauv uas tswj lub homeostasis ntawm lub hauv paus paj hlwb, thiab nws txoj kev ncaj ncees yog ib qho tseem ceeb rau kev tiv thaiv neurons los ntawm cov teeb meem tshuaj. Kev cuam tshuam ntawm cov ntshav- lub paj hlwb teeb meem yog ib qho kab mob tshwm sim hauv ntau yam kab mob paj hlwb, uas tuaj yeem ua rau muaj kev cuam tshuam tsis zoo xws li neuroinflammation thiab oxidative kev nyuaj siab, ua rau cov hlab ntsha puas tsuaj ntxiv. Nws tau pom lub luag haujlwm tseem ceeb hauv kev tiv thaiv kev ncaj ncees ntawm cov ntshav- lub hlwb thaiv.
Hais txog HIV ntsig txog neurocognitive disorders (HAND), kev tshawb fawb tau pom tias HIV-1 Tat protein tuaj yeem cuam tshuam kev ncaj ncees ntawm cov hlab ntsha-hlwb barrier, ua rau neuroinflammation thiab oxidative stress.
Pab neeg tshawb fawb los ntawm First Affiliated Tsev Kho Mob ntawm Xi'an Jiaotong University tau lees paub los ntawm hauv vitro thiab hauv vivo kev sim uaskisspeptin capsulesmuaj peev xwm upregulate cov kev qhia ntawm nruj junction protein Claudin-5 los ntawm inhibiting RhoA/ROCK txoj kev, txo tus kab mob HIV-1 Tat induced oxidative kev nyuaj siab (tso MDA qib, nce CAT kev ua si) thiab tso tawm ntawm inflammatory yam tseem ceeb (IL-6, TNF -), lub zog los tiv thaiv cov ntshav. Hauv kev tsom xam ib leeg, tsom mus rau cov ntaub ntawv tseem ceeb ntawm cov noob caj noob ces tau txhim kho cov qauv los ntawm kev sib luag ntawm qhov tob thiab txo cov nqi, ntxiv nthuav tawm cov txheej txheem molecular ntawm Kisspeptin-10 hauv kev tiv thaiv cov ntshav-hlwb barrier.
Tsis tas li ntawd, kev tshawb fawb txog mob stroke ischemic stroke (AIS) kuj tau qhia txog kev tiv thaiv ntawm cov ntshav - hlwb barrier.
Ib txoj kev tshawb fawb tau siv C57BL/6 nas los tsim ib qho qauv ntawm nruab nrab cerebral artery occlusion (MCAO), tom qab ntawd kho nrog Kisspeptin-10. Cov txiaj ntsig tau pom tias nws tuaj yeem txhim kho lub paj hlwb tsis txaus hauv cov nas, txo qhov ntim ntawm lub paj hlwb thiab cov ntshav- lub paj hlwb barrier permeability, thiab txhawb kev qhia ntawm Claudin-10. Hauv vitro thwmsim tau ua los ntawm tib neeg lub hlwb microvascular endothelial hlwb (HBMVECs) los simulate ischemic mob, thiab nws tau pom tias Kisspeptin-10 inhibits endothelial cell oxidative kev nyuaj siab thiab teeb meem cuam tshuam los ntawm activating Nrf2 signaling txoj kev. Qhov kev sim Nrf2 ntsiag to tau lees paub lub luag haujlwm tseem ceeb ntawm txoj hauv kev no. Qhov no qhia tau hais tias txoj kev Nrf2/Claudin-10 tuaj yeem txo cov ntshav-hlwb thaiv kev puas tsuaj thiab neuroinflammation hauv ischemic stroke, muab lub hauv paus theoretical rau kev txhim kho cov kev kho mob.
Neuroinflammatory kev cai
Neuroinflammation yog ib hom kab mob ntawm ntau yam kab mob hauv lub paj hlwb, nrog rau Alzheimer's disease, Parkinson's disease, ntau yam sclerosis, thiab lwm yam. Hauv txoj kev tshawb HAND, inhibition ntawm RhoA / ROCK txoj hauv kev tau siv los txo qhov kev tso tawm ntawm cov kab mob xws li IL-6 thiab TNF - , yog li txo cov lus teb neuroinflammatory. Cov kab mob inflammatory no ua lub luag haujlwm tseem ceeb hauv cov txheej txheem ntawm neuroinflamation, ua kom microglia thiab astrocytes, ntxiv tso tawm ntau tus neeg kho mob, tsim lub voj voog vicious, thiab ua rau cov hlab ntsha puas tsuaj. Cov tshuaj tiv thaiv kab mob tuaj yeem ua tiav los ntawm kev thaiv cov kab mob inflammatory no, rhuav tshem lub voj voog, thiab tiv thaiv cov neurons los ntawm kev puas tsuaj.
Hauv txoj kev tshawb fawb ntawm ischemic stroke, nws kuj tau pom tias muaj kev cuam tshuam rau cov kab mob neuroinflamation. Los ntawm kev ua kom Nrf2 txoj kev taw qhia, nws muaj peev xwm txo qis mitochondrial reactive oxygen hom (ROS) qib, nce superoxide dismutase (SOD) kev ua, txo oxidative kev nyuaj siab rau paj hlwb, thiab inhibit qhov tso tawm ntawm inflammatory yam, li no alleviating neuroinflammatory teb. Qhov no qhia tias Kisspeptin-10 tuaj yeem ua rau muaj kev tiv thaiv neuroprotective los ntawm kev tswj cov kev sib cuam tshuam ntawm oxidative kev nyuaj siab thiab inflammatory teb.
Kev txawj ntse muaj nuj nqi cuam tshuam
Txawm hais tias tam sim no muaj kev tshawb fawb me me ntawm qhov cuam tshuam ncaj qha ntawm Kisspeptin-10 ntawm kev paub txog kev ua haujlwm, raws li qhov muaj ntawm Kisspeptin receptors nyob rau hauv lub hlwb thaj tsam sab nraum lub hypothalamus (xws li hippocampus thiab amygdala), nws tau kwv yees tias tej zaum yuav muaj kev sib txuas ntawm Kisspeptin-10 thiab kev txawj ntse. Lub hippocampus plays lub luag haujlwm tseem ceeb hauv kev tsim cov kev nco tshiab thiab spatial navigation, thaum lub amygdala yog ze rau kev tswj hwm kev xav thiab kev nco ua ke. Qhov cuam tshuam rau cov cheeb tsam ntawm lub hlwb no yuav cuam tshuam nrog txoj hauv kev uas tswj kev ntxhov siab thiab kev coj tus cwj pwm, yog li cuam tshuam rau neural plasticity thiab kev xav ntawm kev xav, cuam tshuam ncaj qha rau txoj kev kawm.
Hauv txoj kev xav, nws kuj tseem tuaj yeem ua lub luag haujlwm hauv kev txo qis kev paub txog kev cuam tshuam nrog cellular aging lossis neurodegenerative kab mob. Raws li hnub nyoog nce, neurons maj mam muaj hnub nyoog, neural plasticity txo, thiab kev txawj ntse muaj nuj nqi kuj poob. Los ntawm kev tswj cov txheej txheem xws li neuroinflammation thiab oxidative kev nyuaj siab, nws muaj peev xwm txhim kho qhov chaw nyob ntawm cov neurons, txhawb cov neural plasticity, thiab yog li ncua cov txheej txheem ntawm kev txawj ntse poob. Txawm li cas los xij, kev tshawb fawb ntxiv yog xav tau kom paub tseeb tias cov kev xav no los ntawm kev tshawb nrhiav cov teebmeem tshwj xeeb thiab cov txheej txheem ntawmkisspeptin capsulesntawm kev paub txog kev ua haujlwm los ntawm kev sim tsiaj thiab kev sim tshuaj.
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