SS-31 Txhaj

Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm ss-31 txhaj tshuaj hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo ss-31 txhaj tshuaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.

SS-31 Txhaj, ib tug hluavtaws tetrapeptide nrog meej mitochondrial lub hom phiaj muaj peev xwm, tawg los ntawm cov kev txwv ntawm kev kho ib txwm siv los ntawm leveraging nws cov qauv molecular thiab mechanism ntawm kev ua. Nws zoo nkag mus rau cov ntshav- lub hlwb thaiv thiab tshwj xeeb khi rau cardiolipin nyob rau hauv lub puab mitochondrial membrane ntawm neuronal hlwb. Qhov no tso cai rau nws los tswj oxidative kev nyuaj siab tshuav ntawm nws qhov chaw, stabilize mitochondrial membrane qauv, thiab restore zog metabolism efficiency. Nws muab cov phiaj xwm tshiab rau kev kho mob rau kev cuam tshuam ntawm cov kab mob neurodegenerative, thiab nws qhov pom tau tias muaj peev xwm tiv thaiv kab mob thoob plaws ntau hom kab mob tau nce zuj zus los ua qhov tseem ceeb ntawm kev tshawb fawb hauv daim teb no.

 

Peb cov khoom Form

 

sS-31 hmoov

sS-31 txhaj

sS-31 tsi

TSI-31 COA

Certificate of Analysis
Compound npe	Elamipretide
Qib	Pharmaceutical qib
CAS Nr.	736992-21-5
Ntau	35g
Ntim txheem	PE hnab + Al foil hnab
Chaw tsim tshuaj paus	Shaanxi BLOOM TECH Co., Ltd
Ntau No.	202501090036
MFG	Peb 9, 2025
EXP	Peb 8, 2028
Qauv
Yam khoom	Enterprise txheem	Kev txheeb xyuas qhov tshwm sim
Qhov tshwm sim	Dawb los yog yuav luag dawb hmoov	Ua raws
Cov ntsiab lus dej	Tsawg dua lossis sib npaug li 5.0%	0.38%
Poob rau ziab	Tsawg dua lossis sib npaug li 1.0%	0.28%
Hnyav Hlau	Pb Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Hg Tsawg dua lossis sib npaug li 0.5ppm	N.D.
	Cd Tsawg dua lossis sib npaug li 0.5ppm	N.D.
Purity (HPLC)	Ntau dua lossis sib npaug li 99.0%	99.98%
Ib leeg impurity	<0.8%	0.45%
Tag nrho microbial suav	Tsawg dua lossis sib npaug li 750cfu / g	90
E. Coli	Tsawg dua lossis sib npaug li 2MPN / g	N.D.
Salmonella	N.D.	N.D.
Ethanol (los ntawm GC)	Tsawg dua lossis sib npaug li 5000ppm	400ppm ua
Cia	Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree

Cov kab mob neurodegenerative (xws li Alzheimer's disease thiab post-stroke neurological dysfunction) tau tshwm sim los ua cov teeb meem kev noj qab haus huv thoob ntiaj teb hauv cov ntsiab lus ntawm cov neeg laus. Lawv cov txheej txheem pathological yog qhov nyuaj thiab sib cuam tshuam, nrog rau qhov teeb meem tseem ceeb nyob rau hauv kev ua haujlwm tsis zoo ntawm mitochondrial muaj nuj nqi hauv cov hlwb neuronal - qhov twg overloaded oxidative kev nyuaj siab, depleted zog metabolism, thiab uncontrolled apoptosis ua ib tug vicious voj voog. Qhov no thaum kawg ua rau poob neuronal, synaptic puas, thiab kev txawj ntse thiab lub cev muaj zog poob. Cov kev kho mob tam sim no feem ntau tsom mus rau ib qho kab mob pathological, ua rau muaj kev tiv thaiv kev tiv thaiv kab mob thiab kev ua haujlwm kho tsis yooj yim kom ua tiav.

I. Molecular Advantages of Blood-Brain Barrier Penetration thiab Targeted Localization

SS-31, leveraging nws cov yam ntxwv molecular yam ntxwv (cationic aromatic motif sib npaug nrog nruab nrab hydrophilicity thiab hydrophobicity), muaj peev xwm kov yeej lub physiological barrier txwv ntawm cov ntshav - hlwb barrier. Tsis zoo li cov tshuaj zoo tib yam, uas tawm tsam kom nkag mus rau hauv lub hlwb cov ntaub so ntswg, qhov zoo ntawm nws cov molecular nto tuaj yeem tsim cov electrostatic sib cuam tshuam nrog cov anionic Cheebtsam ntawm cov endothelial cell membranes ntawm cov ntshav - hlwb barrier. Ua ke nrog daim nyias nyias muaj peev xwm nkag tau ntawm hydrophobic aromatic rings, qhov no ua rau muaj txiaj ntsig zoo ntawm kev thauj mus los, thaum kawg ua rau muaj kev cuam tshuam zoo tshaj plaws hauv cov mitochondrial membrane ntawm paj hlwb. Cov yam ntxwv ntawm lub hom phiaj no tso cai rau nws ua ncaj qha rau ntawm lub cev puas tsuaj hauv cov kab mob neurodegenerative, tso lub hauv paus rau cov teebmeem neuroprotective tom ntej.

II. Multidimensional Regulatory Mechanisms of Oxidative Stress in Nerve Cells

Hauv cov kab mob neurodegenerative, qhov tsis sib xws ntawm oxidative kev nyuaj siab hauv paj hlwb (ntau dhau ntawm cov pa oxygen reactive) yog qhov tseem ceeb ua rau kev puas tsuaj ntawm tes.SS-31 txhaj tshuajtswj oxidative kev ntxhov siab los ntawm ntau txoj hauv kev:

III. Thaiv Pathological qhib ntawm mPTP thiab ua kom muaj sia nyob Neuronal

 

Qhov txawv txav ntawm qhov mitochondrial permeability transition pore (mPTP) yog ib qho tseem ceeb ua rau neuronal apoptosis hauv cov kab mob neurodegenerative:

Nyob rau hauv cov kab mob pathological, stimuli xws li ischemia thiab oxidative kev nyuaj siab tuaj yeem ua rau qhib ntau dhau ntawm mPTP, ua rau lub cev qhuav dej ntawm mitochondrial membrane muaj peev xwm thiab o lossis tawg ntawm mitochondria.

Los ntawm tshwj xeeb khi rau cardiolipin nyob rau hauv lub puab mitochondrial membrane, SS-31 stabilizes lub membrane qauv thiab ncaj qha thaiv lub pathological qhib ntawm mPTP, tiv thaiv kev tso tawm ntawm mitochondrial txheem (xws li cytochrome c) mus rau hauv lub cytoplasm.

Cov txheej txheem no cuam tshuam cov tshuaj tiv thaiv cascade ntawm apoptosis, txo qhov programmed cell tuag hauv neurons, thiab tswj cov cellular kom muaj nuj nqis thiab ua haujlwm zoo ntawm cov ntaub so ntswg neural.

Cov txheej txheem tseem ceeb ntawm kev mob hlab ntsha tawg, tshwj xeeb tshaj yog tshwm sim los ntawm ischemia- raug mob reperfusion, yog tus cwj pwm los ntawm kev txo qis hauv mitochondrial zog ntau lawm tom qab kev cuam tshuam ntawm cerebral ntshav perfusion. Tom qab ntawd, kev kho cov ntshav ntws rov ua rau muaj qhov tshwm sim ntawm cov pa oxygen reactive, calcium overload, thiab cov tshuaj tiv thaiv cascade. Thaum kawg, qhov no ua rau necrosis ntawm paj hlwb hauv cheeb tsam ischemic core, apoptosis ntawm cov hlwb hauv penumbra, thiab txuas ntxiv nthuav dav ntawm thaj chaw infarct. Hauv kev teb rau cov kab mob pathological no, SS-31 ua haujlwm ntau yam thiab tsom rau cov teebmeem neuroprotective, tshwj xeeb tshaj yog tshwm sim hauv cov hauv qab no:

Mechanisms rau Halting Infarct Expansion:

Thaum lub sij hawm ischemia-reperfusion raug mob, qhov txawv txav ntawm qhov mitochondrial permeability hloov pauv qhov pore ua haujlwm tseem ceeb rau apoptosis. Los ntawm tshwj xeeb khi rau cardiolipin nyob rau hauv lub puab mitochondrial membrane, SS-31 stabilizes daim nyias nyias qauv thiab blocks lub pathological qhib ntawm no pore, yog li tiv thaiv mitochondrial o, rupture, thiab tso tawm ntawm cytochrome c. Qhov kev txiav txim no txo ​​cov programmed cell tuag nyob rau hauv cov paj hlwb ntawm thaj chaw ischemic core.

Tsis tas li ntawd, SS-31 optimizes efficiency ntawm mitochondrial electron thauj system, txo electron to ntawm Complex III, thiab txo cov tiam ntawm reactive oxygen hom xws li superoxide anions. Qhov no alleviates oxidative kev nyuaj siab puas hlwb rau cov hlwb nyob rau hauv lub ischemic penumbra, ua tau ib tug txo nyob rau hauv infarct loj los ntawm ntau tshaj 17% (raws li preclinical qauv ntaub ntawv).

 Dual Regulation of Inflammation and Edema:

Tom qab mob stroke, cov paj hlwb puas tau tso tawm pro- cov kab mob inflammatory (xws li TNF- thiab IL-6), ua rau cov lus teb hauv cheeb tsam thiab cuam tshuam cov permeability ntawm cov ntshav-hlwb barrier. Qhov no ua rau cerebral edema.SS-31 txhaj tshuajinhibits qhov ua kom cov kab mob o taw qhia txoj hauv kev kho los ntawm kev puas tsuaj mitochondrial, yog li txo qhov kev hloov pauv thiab tso tawm ntawm pro- cov yam mob inflammatory. Nyob rau tib lub sijhawm, nws txhim kho cov kev ua haujlwm mitochondrial ntawm cov hlwb endothelial hauv cov ntshav- lub hlwb thaiv, tswj cov endothelial cell kev ncaj ncees, thiab txo cov vascular permeability. Qhov no alleviates cerebral edema thiab mitigates lwm yam kev puas tsuaj rau paj hlwb los ntawm inflammatory yam.

Precise Restoration of Energy Metabolism:

Nyob rau hauv cov xwm txheej ischemic, paj hlwb cia siab rau anaerobic glycolysis rau lub zog, ua rau muaj kev cuam tshuam loj ntawm lactic acid thiab ua rau muaj kev puas tsuaj ntawm cellular ntxiv. SS-31 tuaj yeem rov ua haujlwm oxidative phosphorylation ntawm mitochondria hauv thaj chaw ischemic. Los ntawm kev ua kom lub AMPK / PGC-1 signaling txoj kev, nws txhim kho mitochondrial biogenesis thiab txhim kho ATP ntau lawm efficiency.

Tsis tas li ntawd, nws txhawb kev hloov pauv ntawm cov piam thaj los ntawm cov piam thaj oxidation mus rau fatty acid oxidation, txhim kho kev siv lub zog hauv myocardium (uas cuam tshuam rau cov ntshav cerebral), txo cov lactic acid tsub zuj zuj, thiab muab lub zog txhawb nqa rau cov paj hlwb puas. Qhov no ua rau muaj kev muaj sia nyob ntawm cov ntaub so ntswg ischemic.

 

SS-31 saib xyuas cov neeg mob Alzheimer's disease

 

Hauv Alzheimer tus kab mob qauv,SS-31 txhaj tshuajUa kom pom tseeb thiab muaj txiaj ntsig zoo los ntawm kev tiv thaiv neuroprotective los ntawm kev siv nws cov cim mitochondrial lub hom phiaj, muab cov lus cog tseg tshiab rau kev cuam tshuam hauv tus kab mob no. Lub hauv paus pathological kev loj hlob ntawm Alzheimer's kab mob revolves nyob ib ncig ntawm qhov txawv txav ntawm -amyloid rau hauv cov tshuaj lom oligomers thiab fibrillar plaques, nrog rau cov hyperphosphorylation ntawm tau protein ntau ua rau neurofibrillary tangles. Ua ke, cov txheej txheem no ua rau mitochondrial dysfunction, oxidative stress imbalance, thiab synaptic poob hauv neuronal hlwb, thaum kawg ua rau kev txawj ntse poob.

Cov tshuaj no nkag mus rau hauv cov ntshav- lub paj hlwb barrier thiab precisely accumulates nyob rau hauv lub puab mitochondrial membrane ntawm neuronal hlwb. Los ntawm tshwj xeeb khi rau cardiolipin los tsim ib qho chaw ruaj khov, nws tsis tsuas yog txhim kho kev puas tsuaj ntawm cov mitochondrial membrane, tiv thaiv kev cuam tshuam ntawm -amyloid lom oligomers, tab sis kuj optimizes efficiency ntawm electron thauj saw, txo cov tiam ntawm reactive oxygen hom ntawm qhov chaw.Concurrently, nws upregulates oxidative kev ua ub no. neuronal membranes thiab organelles, txo cov neurotoxicity ntawm -amyloid, thiab inhibits ntxiv expansion ntawm fibrillar plaques.

Hais txog qhov txawv txav ntawm phosphorylation ntawm tau protein, nws txhim kho cellular zog metabolism los ntawm kev rov ua haujlwm mitochondrial, txo qis kev ua haujlwm ntawm kinases txawv txav xws li glycogen synthase kinase 3, thiab txhawb nqa phosphatase -kho dephosphorylation ntawm tau protein. Qhov no txo ​​qis kev tsim thiab kev loj hlob ntawm neurofibrillary tangles, yog li tswj cov txheej txheem kev ncaj ncees ntawm cov hlwb neuronal. Qhov tseem ceeb, SS-31 lub hom phiaj thiab tiv thaiv mitochondrial muaj nuj nqi hauv presynaptic neurons, txhim kho ATP kev ua tau zoo, muab kev txhawb zog txaus rau kev sib txuas thiab tso tawm cov synaptic neurotransmitters, txo oxidative puas tsuaj rau postsynaptic membrane receptors, thiab txo qis synaptic poob tus nqi. Yog li ntawd, nws khaws cia ib txwm neural circuit connectivity thiab teeb liab kis tau tus mob.

SS-31, nrog mitochondrial kev ua haujlwm kho ntawm nws lub hauv paus, tau qhib txoj hauv kev tshiab muaj txiaj ntsig zoo rau kev kho cov kab mob neurodegenerative. Los ntawm ntau yam kev sib koom ua ke-xws li nkag mus rau cov ntshav- lub hlwb teeb meem rau lub hom phiaj enrichment, tswj oxidative kev nyuaj siab, thaiv qhov txawv txav ntawm lub mitochondrial permeability hloov pore, thiab tiv thaiv synaptic muaj nuj nqi - nws tsis tsuas mitigates pathological kev puas tsuaj xws li phorynaloids thiab tau ciaj sia taus thiab neural circuit integrity, zoo txhim kho kev txawj ntse thiab lub cev muaj zog dysfunction.

Piv rau cov tshuaj ib txwm siv - hom tshuaj, nws qhov kev cuam tshuam ntau yam muaj qhov zoo sib xws, thaum nws txoj kev ua siab mos thiab zoo biocompatibility ntxiv txhim kho nws lub peev xwm rau kev txhais lus kho mob. Txawm hais tias loj dua - cov kev tshawb fawb soj ntsuam tseem yuav tsum tau ua kom paub tseeb tias nws lub sijhawm ntev - kev ua tau zoo thiab tus kheej hloov pauv, thiab cov teeb meem xws li kev kho kom zoo dua qub (xws li, txuas ntxiv ib nrab- lub neej) tseem yuav tau hais txog, SS-31 tau qhia meej txog qhov muaj peev xwm ua txhaum los ntawm kev kho mob tam sim no hauv cov kab mob neurodegenerative.

Raws li kev tshawb fawb tau nce mus rau yav tom ntej, mitochondria no - cov tshuaj tiv thaiv tau cog lus tias yuav hloov pauv ntawm chav kuaj mus rau kev kho mob, muab kev cia siab tshiab rau ncua kev kis kab mob thiab txhim kho lub neej zoo rau ntau tus neeg mob. Nws kuj tseem tuaj yeem txhawb nqa kev kho mob ntawm cov kab mob neurodegenerative mus rau lub sijhawm tshiab ntawm kev ua kom raug- kho cov phiaj xwm.

• SS-31 puas tuaj yeem pab txo qhov hnyav?

SS-31 tsis yog cov tshuaj poob phaus ncaj qha tab sis txhawb kev noj qab haus huv metabolism thiab lub zog los ntawm kev tsom mus rau mitochondria, muaj peev xwm tiv thaiv cov leeg / qhov hnyav hauv xeev cov kab mob (xws li mob qog noj ntshav cachexia) thiab txhim kho cellular muaj nuj nqi, uas tuaj yeem cuam tshuam rau lub cev muaj pes tsawg leeg thiab kev ua tau zoo, tshwj xeeb tshaj yog nrog kev noj haus thiab kev tawm dag zog, es tsis yog tsuas yog suppressing qab los noj mov. Kev tshawb fawb pom tias nws tuaj yeem txhim kho kev noj qab haus huv hauv metabolic, txhim kho lub cev kev ua tau zoo ntawm cov nas hnub nyoog, thiab txhim kho lub cev muaj pes tsawg leeg hauv cov ntsiab lus tshwj xeeb, tab sis nws lub luag haujlwm hauv kev poob phaus yog ntau ntxiv txog kev ua haujlwm ntawm tes thiab kev ua haujlwm.

• Puas yog SS -31 FDA pom zoo?

SS-31: FDA pom zoo peptide rau kev noj qab haus huv mitochondrial.

Cim npe nrov: ss-31 txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom