Octreotide Acetate Txhajyog ib qho khoom siv hluavtaws octapeptide somatostatin analog uas simulates cov haujlwm ntawm ntuj somatostatin thiab ua rau muaj ntau yam teebmeem ntawm lub cev los ntawm kev khi rau cov receptors tshwj xeeb. Cov txheej txheem tseem ceeb yog txhawm rau inhibit adenylate cyclase kev ua haujlwm, txo qis hauv cov cellular adenosine monophosphate qib, yog li thaiv cov tshuaj hormone synthesis thiab tso tawm.
Nyob rau hauv cov nqe lus ntawm cov tshuaj hormone secretion, cov tshuaj no yuav inhibit lub pathological secretion ntawm kev loj hlob hormone (GH), thyroid stimulating hormones, gastrointestinal thiab pancreatic endocrine hormones. Rau cov neeg mob uas muaj acromegaly, nws tuaj yeem txo cov ntshav qab zib insulin-zoo li kev loj hlob qib-1 thiab txo cov tsos mob xws li mob taub hau thiab mob pob qij txha; Rau cov qog nqaij hlav hauv plab thiab pancreatic endocrine, nws tuaj yeem cuam tshuam qhov tso tawm ntawm gastrin, glucagon, thiab txo cov tsos mob xws li raws plab thiab mob plab.
Raws li kev tswj hwm kev ua haujlwm ntawm cov hlab ntsha, kev txhaj tshuaj octreotide acetate tuaj yeem xaiv txo cov ntshav ntws thiab siab ntawm cov hlab ntsha ntawm lub portal thiab nws cov kev cuam tshuam ntawm cov hlab ntsha, txo qhov siab ntawm txoj hlab pas thiab gastric varices, thiab txo qhov kev pheej hmoo ntawm esophageal thiab gastric variceal los ntshav los ntawm 20% -30% hauv kev kho mob cirrh hypertension.
Nyob rau hauv cov nqe lus ntawm kev loj hlob ntawm tes inhibition, cov tshuaj no tuaj yeem cuam tshuam ncaj qha rau kev loj hlob ntawm plab hnyuv, pancreatic, neuroendocrine qog hlwb, ua rau lub voj voog ntawm tes raug ntes, thiab inhibit qog angiogenesis, ncua kev loj hlob dawb ntawm cov neeg mob.
| Khoom npe | Octreotide Acetate hmoov | Octreotide Acetate Solution | Octreotide Acetate Txhaj |
| Yam khoom | Hmoov | Kev daws | Txhaj tshuaj |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable |
| Daim ntawv khoom | Organic synthesis | Organic synthesis | Organic synthesis |
Octreotide Acetate COA
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| Certificate of Analysis | ||
| Compound npe | Octreotide Acetate | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 83150-76-9 | |
| Ntau | 3 37,3kg | |
| Ntim txheem | 25kg / nruas | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202501090049 | |
| MFG | Peb 9, 2025 | |
| EXP | Peb 8, 2028 | |
| Qauv |
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| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.49% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.32% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib qho impurity | <0.8% | 0.47% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 80 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab 2-8 degree | |
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Cov ntaub ntawv tseem ceeb ntawm cov tshuaj
Cov khoom xyaw tseem ceeb yog octreotide acetate, thiab cov khoom muaj xws li lactic acid, mannitol, thiab sodium bicarbonate. Nws cov khoom yog tsis muaj xim thiab cov kua ntshiab.
Cov tshuaj no yuav tsum tau muab khaws cia rau hauv qhov chaw tsaus ntawm 2-8℃rau lub tub yees kom nws ruaj khov thiab ua haujlwm tau zoo, thiab nws lub neej txee feem ntau yog 36 lub hlis.
Common specifications rauKev txhaj tshuaj octreotide acetateyog nyob rau hauv daim ntawv ntawm 1ml tov sib xws rau txawv octreotide txheem. Cov ntsiab lus tseem ceeb suav nrog 0.05mg / 1ml, 0.1mg / 1ml, 0.2mg / 1ml, 0.3mg / 1ml, thiab qee cov khoom yuav muab cov lus qhia ntawm 0.5mg / 1ml.
Common specifications muaj xws li:
Qhov kev qhia tshwj xeeb ntawm kev txhaj tshuaj no yog tsim rau cov neeg mob uas xav tau koob tshuaj me me, xws li kev kho thawj zaug ntawm qee yam kab mob hauv plab hnyuv thiab pancreatic endocrine qog.
Qhov no yog ib qho kev qhia dav dav siv rau ntau yam kev qhia, xws li esophageal gastric variceal los ntshav, tiv thaiv pancreatic postoperative teeb meem, gastrointestinal pancreatic endocrine hlav, thiab acromegaly.
Rau cov neeg mob uas xav tau koob tshuaj ntau dua, xws li kev kho mob theem kawg ntawm qee yam kab mob hauv plab thiab pancreatic endocrine qog lossis ntev -kev kho mob acromegaly, qhov kev qhia tshwj xeeb ntawm kev txhaj tshuaj no yuav raug xaiv.
Qhov kev qhia tshwj xeeb ntawm kev txhaj tshuaj no yog siv rau qee lub sijhawm tshwj xeeb, xws li thaum cov neeg mob muaj cov lus teb tsis zoo rau cov tshuaj txo qis lossis thaum yuav tsum tau tswj hwm tus mob sai.
Tsis tas li ntawd, qee cov khoom lag luam tuaj yeem muab qhov tshwj xeeb ntawm 0.5mg / 1ml, tab sis nws tsis tshua muaj.
Acetate octreotide txhaj tshuaj yog tsim nyog rau kev kho mob ntawm ntau yam kab mob, feem ntau suav nrog cov hauv qab no:
Cirrhosis cuam tshuam los ntshav:
Siv rau kev kho mob thaum muaj xwm txheej ceev ntawm esophageal gastric variceal los ntshav los ntawm cirrhosis, feem ntau ua ke nrog kev kho tshwj xeeb xws li endoscopic sclerotherapy. Vim lub siab ua haujlwm tsis zoo thiab nce siab nyob rau hauv lub portal vein system, cov neeg mob uas muaj cirrhosis yog feem ntau ua rau esophageal gastric variceal rupture thiab los ntshav. Kev txhaj tshuaj acetate octreotide ua lub luag haujlwm thaum muaj xwm txheej ceev kom tsis txhob los ntshav thiab tiv thaiv kom rov los ntshav los ntawm kev txo cov hlab ntshav siab thiab txo qis kev pheej hmoo los ntshav.
Tiv thaiv cov teeb meem postoperative ntawm pancreatic phais:
Cov teeb meem xws li pancreatic fistula thiab plab hnyuv fistula tuaj yeem tshwm sim tom qab phais mob pancreatic. Kev txhaj tshuaj acetate octreotide tuaj yeem txo cov kua dej hauv plab, txhawb kev kho fistula, thiab txo qhov kev pheej hmoo ntawm cov teeb meem. Feem ntau, 0.1mg subcutaneous txhaj yog siv, peb zaug ib hnub, rau kev kho mob tas li ntawm 7 hnub. Thawj qhov kev txhaj tshuaj yuav tsum tau muab tsawg kawg 1 teev ua ntej kev phais.
Kev kho mob ntawm pancreatitis:
Rau mob pancreatitis, tshwj xeeb tshaj yog nyob rau theem pib,Kev txhaj tshuaj octreotide acetatetuaj yeem tswj tus mob sai sai thiab txo cov tsos mob ntawm kev kho mob. Nws tuaj yeem cuam tshuam lub basal secretion thiab stimulated secretion ntawm pancreas, inhibit qhov kev ua ntawm pancreatic enzymes thiab phospholipase A2, txo lub siab nyob rau hauv lub pancreatic duct, tshem tawm co toxins uas ua rau necrosis, txhawb lub reticuloendothelial system, txhim khu kev ua hauj lwm ntawm lub mononuclear phagocytic cell system, tswj cov cascadeby cov tshuaj tiv thaiv nyob rau hauv lub cev. tiv thaiv kab mob pancreatic thiab tiv thaiv kev loj hlob ntawm cov kab mob pancreatic hauv mob pancreatitis.
Mob plab thiab pancreatic endocrine qog:
Nws tuaj yeem txo cov tsos mob thiab cov cim qhia txog kev mob plab hnyuv thiab pancreatic endocrine qog. Muaj pov thawj txaus los qhia tias cov khoom no muaj txiaj ntsig zoo tiv thaiv ntau hom qog.
Cov qog nqaij hlav nrog carcinoid syndrome:
Cov neeg mob qog nqaij hlav carcinoid feem ntau muaj cov tsos mob carcinoid, tshwm sim raws li lub ntsej muag tawm, raws plab, mob hawb pob, thiab lwm yam tsos mob. Kev txhaj tshuaj acetate octreotide tuaj yeem txo cov tsos mob no los ntawm kev tswj kev tso tawm ntawm cov tshuaj hormones cuam tshuam.
VIP qog:
VIP cov neeg mob qog nqaij hlav secrete ntau ntawm vasoactive plab hnyuv peptide, ua rau mob raws plab, hypokalemia, thiab lwm yam. Cov tshuaj no tuaj yeem tiv thaiv kev zais ntawm vasoactive plab hnyuv peptide thiab txhim kho cov tsos mob ntawm tus neeg mob.
Glucagon qog:
Glucagon tso tawm ntau dhau rau cov neeg mob qog glucagon, ua rau cov tsos mob xws li ntshav qab zib thiab necrotic erythema migrans. Kev txhaj tshuaj acetate octreotide tuaj yeem txo qis glucagon thiab txo tus kab mob.
Gastrinoma/Zollinger Ellison Syndrome:
Feem ntau ua ke nrog kev xaiv H2 receptor antagonists, thiab antacids yuav raug ntxiv raws li qhov tsim nyog. Cov neeg mob uas muaj gastrinoma muaj ntau qhov tso tawm ntawm gastrin, uas ua rau lub plab acid secretion thiab ua rau plab hnyuv thiab lwm yam kab mob. Kev txhaj tshuaj acetate octreotide tuaj yeem cuam tshuam gastrin secretion, txo cov kua qaub hauv plab, thiab txhawb kev kho mob ntawm lub plab.
Insulin qog:
Siv rau kev tiv thaiv ua ntej ntawm hypoglycemia thiab kev saib xyuas cov ntshav qab zib ib txwm nyob hauv cov qog nqaij hlav pancreatic. Cov neeg mob uas muaj insulinoma feem ntau muaj cov tshuaj insulin ntau dhau thiab cov tsos mob ntawm hypoglycemia. Cov tshuaj no tuaj yeem cuam tshuam cov tshuaj insulin secretion thiab tiv thaiv qhov tshwm sim ntawm hypoglycemia.
Kev loj hlob hormone tso tawm cov qog nqaij hlav:
Muaj peev xwm inhibit qhov tso tawm ntawm kev loj hlob hormone tso tawm yam, txo cov qib kev loj hlob hormone, thiab txo cov tsos mob.
Acromegaly:
Rau cov neeg mob acromegaly uas tau ua tsis tiav kev phais, kev kho hluav taws xob, lossis dopamine receptor agonist therapy, cov tsos mob tuaj yeem tswj tau los ntawm kev txo cov concentration ntawm kev loj hlob hormone (GH) thiab kev loj hlob hormone mediator C. Nws kuj tseem siv tau rau cov neeg mob acromegaly uas tsis tuaj yeem lossis tsis kam mus phais, nrog rau cov neeg mob nyob rau lub sijhawm luv luv uas siv hluav taws xob kho tsis tau. Los ntawm inhibiting qhov tso tawm ntawm kev loj hlob hormone, cov neeg mob tuaj yeem txhim kho cov tsos mob xws li cov pob txha txawv txav thiab cov nqaij mos hyperplasia tshwm sim los ntawm kev loj hlob ntau dhau lawm.
Cov tshuaj sib cuam tshuam
Octreotide Acetate Txhaj, raws li ib tug somatostatin analogue, koom nrog ntau yam tshuaj sib cuam tshuam uas yuav cuam tshuam rau kev nqus, metabolism, lossis kev ua tau zoo ntawm lwm cov tshuaj. Nyob rau tib lub sijhawm, nws tus kheej kev ua tau zoo kuj tuaj yeem cuam tshuam nrog lwm yam tshuaj. Cov hauv qab no yog cov ncauj lus kom ntxaws txog nws cov tshuaj sib cuam tshuam:
Cyclosporine:
Octreotide acetate tuaj yeem txo cov hnyuv nqus ntawm cyclosporine, yog li cuam tshuam rau nws cov tshuaj tiv thaiv kab mob. Yog tias tsim nyog, kev saib xyuas cov ntshav siab ntawm cyclosporine yuav tsum tau txiav txim siab, thiab kev hloov kho kom tsim nyog yuav tsum tau ua raws li kev soj ntsuam teb.
Cimetidine:
Octreotide acetate tuaj yeem ncua kev nqus ntawm Cimetidine, cuam tshuam rau nws lub peev xwm los inhibit gastric acid secretion. Yog li ntawd, thaum siv ua ke, yuav tsum tau them nyiaj mloog rau kev soj ntsuam kev hloov pauv ntawm tus neeg mob cov tsos mob thiab kho cov phiaj xwm tshuaj yog tias tsim nyog.
Bromocriptin: Thaum ua ke nrog octreotide acetate, nws yuav ua rau kom muaj bioavailability ntawm Bromocriptin, yog li txhim kho nws cov dopamine receptor agonistic nyhuv. Qhov no tuaj yeem ua rau muaj kev pheej hmoo ntawm kev phiv xws li orthostatic hypotension thiab arrhythmia. Yog li ntawd, thaum siv ua ke, nws yog ib qho tsim nyog yuav tsum tau saib xyuas tus neeg mob cov ntshav siab thiab lub plawv dhia, thiab yog tias tsim nyog, txo cov koob tshuaj bromocriptine.
Beta blockers thiab calcium channel blockers: Cov tshuaj no feem ntau yog siv los kho mob ntshav siab thiab kab mob plawv. Octreotide acetate tuaj yeem txhim kho cov nyhuv inhibitory ntawm cov tshuaj no ntawm myocardial kev ua haujlwm, ua rau bradycardia lossis hypotension. Cov neeg mob yuav tsum tau ua tib zoo saib xyuas lawv cov mob plawv thiab kho lawv cov phiaj xwm tshuaj raws sijhawm thaum siv ua ke.
CYP3A4 cov tshuaj metabolic: Octreotide acetate tuaj yeem cuam tshuam kev loj hlob hormone secretion, yog li cuam tshuam rau kev tshem tawm cov tshuaj metabolized los ntawm cytochrome P450 (CYP) 3A4 enzyme. Tshwj xeeb tshaj yog rau cov tshuaj nrog nqaim kho ntau yam, xws li quinidine thiab terfenadine, yuav tsum tau ceev faj thaum ua ke nrog octreotide acetate. Cov tshuaj ntshav siab ntawm cov tshuaj no tuaj yeem nce ntxiv vim muaj kev cuam tshuam ntawm octreotide acetate, ua rau muaj kev pheej hmoo ntawm kev phiv tshuaj.
Cov tshuaj insulin thiab qhov ncauj hypoglycemic:
Octreotide acetate tuaj yeem cuam tshuam rau cov ntshav qabzib, yog li thaum siv nrog cov tshuaj insulin lossis cov tshuaj hypoglycemic ntawm qhov ncauj, qhov ntau npaum li cas ntawm cov tshuaj hypoglycemic no yuav tsum tau kho. Qhov no yog vim octreotide acetate tuaj yeem cuam tshuam qhov tso tawm ntawm insulin thiab glucagon, yog li hloov pauv cov ntshav qabzib.
Rifampicin:
Raws li cov tshuaj tiv thaiv tuberculosis, rifampicin tuaj yeem ua kom cov metabolism ntawm octreotide acetate thiab txo nws cov ntshav plasma concentration. Qhov no tuaj yeem ua rau txo qis qhov ua tau zoo ntawm octreotide acetate, yog li kev noj tshuaj octreotide acetate yuav tsum tau hloov kho raws li kev soj ntsuam teb.
Lipid tswj cov tshuaj, xws li statins, yuav tsum tau saib xyuas kom muaj kev pheej hmoo ntawm cov leeg nqaij toxicity thaum siv nrog octreotide acetate. Qhov no yog vim octreotide acetate tuaj yeem cuam tshuam cov txheej txheem metabolic ntawm cov leeg nqaij, thiab thaum siv nrog statins, nws tuaj yeem ua rau muaj kev pheej hmoo ntawm cov leeg nqaij. Yog li ntawd, kev saib xyuas cov neeg mob tsis tu ncua yog tsim nyog thaum siv los ua ke kom sai thiab tswj cov leeg nqaij toxicity.
Kev sib cuam tshuam nrog cyclosporine thiab cimetidine:
Octreotide acetate tuaj yeem txo cov hnyuv nqus ntawm cyclosporine thiab ncua lub plab zom mov ntawm cimetidine, yog li kev hloov kho ntau npaum li cas yuav tsim nyog thaum siv cov tshuaj no.
Dosage adjustment nrog rau lwm yam tshuaj:
Thaum ua ke nrog beta adrenergic receptor blockers, calcium channel blockers, cov tshuaj uas tswj cov kua dej thiab electrolyte tshuav, insulin, thiab cov tshuaj tiv thaiv hauv qhov ncauj, kev kho koob tshuaj yuav tsum tau ua kom muaj kev nyab xeeb thiab ua tau zoo ntawm kev kho mob.
Qhov cuam tshuam rau CYP3A4 cov tshuaj metabolism hauv:
Somatostatin analogs tuaj yeem txo qis tus nqi ntawm cov tshuaj uas paub tias metabolized los ntawm cytochrome P450 (CYP) 3A4, uas tej zaum yuav yog vim lawv inhibition ntawm kev loj hlob hormone secretion.
Yog li ntawd, yuav tsum tau ceev faj thaum sivKev txhaj tshuaj octreotide acetateua ke nrog cov tshuaj uas yog metabolized los ntawm CYP3A4 thiab muaj qhov nqaim kho qhov ntsuas, xws li quinidine thiab terfenadine. Tus neeg mob cov lus teb yuav tsum tau saib xyuas kom zoo, thiab cov tshuaj yuav tsum tau hloov yog tias tsim nyog.
Cim npe nrov: octreotide acetate txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom