Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm tetracosactide acetate txhaj nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo tetracosactide acetate txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Raws li ib tug sophisticated artificially synthesized peptide hormone npaj nrog txhim khu kev qha pharmacological stability thiab meej lub hom phiaj kev ua tau zoo,Kev txhaj tshuaj tetracosactide acetateexerts physiological regulatory teebmeem los ntawm classic endocrine activation txoj kev. Nws tshwj xeeb khi rau ACTH receptors nyob rau saum npoo ntawm adrenal cortex hlwb, ntxiv dag zog rau intracellular adenylate cyclase thiab nce qib ntawm cyclic adenosine monophosphate (cAMP). Lub upregulated cAMP signaling cascade ua tau zoo tsav kev hloov pauv ntawm cov roj cholesterol intracellular rau pregnenolone, uas ua haujlwm raws li qhov tseem ceeb thawj tus nqi - txwv cov kauj ruam ntawm endogenous cortisol synthesis.
Thaum kawg, qhov kev sib txuas ntawm cov tshuaj lom neeg tsis tu ncua no txhawb nqa kev sib txuas thiab tso tawm ntawm cortisol hauv adrenal cortex, ua kom paub tseeb txog kev tswj hwm ntawm tib neeg adrenal cortical endocrine muaj nuj nqi.Tetracosactide acetate (CAS: 16960-}16-0) yog high-purity amino acids uas muaj cov amino acid resinthetic acid. Qhov sib lawv liag tau zoo ib yam nrog 1-24 active fragment ntawm natural human adrenocorticotropic hormone (ACTH).
Peb Cov Khoom Muag Khoom
Tetracosactide Acetate COA
 |
||
| Certificate of Analysis | ||
| Compound npe | Tetracosactide Acetate / Cosyntropin | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 16960-16-0 | |
| Ntau | 30g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090057 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
|
|
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.47% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.35% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.90% |
| Ib leeg impurity | <0.8% | 0.56% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 170 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 400ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
|
|
||
Nyob rau hauv cov nqe lus ntawm physicochemical zog, nws yog feem ntau nthuav tawm raws li ib tug dawb los yog tawm -dawb crystalline hmoov nrog zoo heev solubility nyob rau hauv dej, tso cai sai thiab zoo dissolution nyob rau hauv sterile hnyav rau kev npaj tshuaj. Cov khoom siv peptide no khav theeb cov tshuaj ruaj khov nyob rau hauv cov txheej txheem kaw, qis - qhov kub thiab txias cia txias, uas tiv thaiv cov saw hlau molecular degradation, kev ua haujlwm attenuation thiab impurity tiam los ntawm qhov kub thiab txias, muaj zog lub teeb thiab av noo ib puag ncig, ua kom ntev - lub sij hawm lom neeg kev ruaj ntseg thiab batch sib xws.
Tetracosactide acetate txhaj tshuaj, tseem hu ua 24 peptide corticotropin, yog ib qho kev sib txuas ua ke 1-24 ntawm adrenocorticotropic hormone (ACTH) uas khaws tag nrho cov kev ua ub no ntawm ACTH ntuj, nrog qis antigenicity thiab ntev ntev. Clinically, nws tau muab faib ua luv luv ua yeeb yam (rau kev kuaj xyuas tus qauv) thiab ntev - ua yeeb yam sustained-tso ncua kev txhaj tshuaj (rau kev kho mob).Nws yog siv rau kev kuaj mob ntawm adrenal cortex muaj nuj nqi thiab kev kho mob ntawm glucocorticoid rhiab o / kab mob autoimmune.
Core mechanism ntawm kev ua
Nyob rau tib lub sijhawm, nws muaj txiaj ntsig tsis tuaj yeem hloov pauv hauv thaj chaw niche xws li infantile spasms, ntau yam sclerosis, nephrotic syndrome, lub cev tiv thaiv kab mob cuam tshuam txog kev puas tsuaj ntawm endocrine, thiab cov kab mob tsis tshua muaj ntawm daim tawv nqaij. Piv nrog rau exogenous glucocorticoids, nws ua rau nws cov teebmeem los ntawm kev txhawb nqa endogenous cortisol secretion, thiab muaj qhov tshwj xeeb zoo xws li ntau lub cev tiv thaiv kab mob - inflammatory teebmeem, sib zog inhibition ntawm hypothalamic pituitary adrenal axis, tsawg cuam tshuam rau cov pob txha metabolism, thiab ntau dua kev tiv thaiv kab mob.
Ticotropin khi nrog siab affinity rau melanocortin 2 receptor (MC2R) nyob rau saum npoo ntawm adrenal cortical zona fascicula / reticular cells, ua kom cov adenylate cyclase → cAMP → PKA teeb liab txoj hauv kev, txhawb kev hloov pauv ntawm cov cholesterol mus rau pregnenolone, thiab xaiv cov qib qis ntawm cortisol secretion. androgen, thiab aldosterone. Muab piv rau ntuj ACTH (39 peptide): Kev xaiv ntau dua: tsuas yog qhib MC2R, tsis yog MC1R / MC3R / MC4R, tsis muaj kev phiv xws li tawv nqaij pigmentation thiab qab los noj mov.Ntau cov nyhuv: 1mg ntawm ticagrel peptide ≈ 100U ntawm ntuj folds ACTH, nrog rau ntau dua ACTH stimulation, concentration, thiab ntev ntev.Ua tsis tshua muaj antigenicity: Tshem tawm 15 immunogenic amino acids ntawm C-terminus, qhov tshwm sim ntawm kev tsis haum tshuaj yog tsawg dua 0.1% (natural ACTH yog 5% -10%).
Ntxiv nrog rau kev txhawb nqa cortisol, tigecycline tuaj yeem ua ncaj qha rau MC4R / MC5R hauv lub cev tiv thaiv kab mob, cov paj hlwb, thiab cov hlwb endothelial, ua rau muaj kev tiv thaiv - cov teebmeem tsis muaj zog ntawm glucocorticoids:
Ncaj nraim inhibiting pro-cov yam ntxwv mob: txo qis kev qhia ntawm TNF - , IL-6, IL-1 , thiab IFN - hauv macrophages/lymphocytes, nrog tus nqi inhibition ntawm 40% -60%.
Inducing anti-inflammatory yam: Upregulating IL-10 thiab TGF -, txhawb txoj cai T cell (Treg) sib txawv, thiab txhim khu kev tiv thaiv kab mob.
Cov teebmeem neuroprotective: Ua kom lub hauv paus MC4R, inhibit microglial activation, txo excitatory amino acid tso tawm, tiv thaiv neuronal apoptosis, siv rau cov kab mob neurological.
Antioxidant kev ntxhov siab: Txhim kho cov haujlwm ntawm SOD thiab glutathione peroxidase hauv cov ntaub so ntswg, txo qis MDA thiab ROS, thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative.
Qhov ntev -kev txhaj tshuaj (Synacthen Depot) yog kev ncua ntawm zinc phosphate complex, uas maj mam tso tawm tom qab txhaj tshuaj intramuscular thiab muaj cov tshuaj pharmacokinetics zoo dua li cov qauv ua yeeb yam luv.
Cov nyhuv thiab lub sijhawm: Cortisol ncov tau mus txog 2 teev tom qab txhaj tshuaj intramuscular ntawm 1mg, thiab cov concentration zoo yog khaws cia rau 24-36 teev. Nws tuaj yeem muab tshuaj ib zaug txhua 2-3 hnub.
Cov qauv no nta ** 100% bioavailability ** . Nws dhau los ntawm kab mob siab ua ntej- dhau ntawm cov metabolism hauv tag nrho, txhawb nqa cov tshuaj hauv ntshav kom ruaj khov thiab tshem tawm cov kev nqus tsis ruaj khov hauv plab uas feem ntau pom nrog kev npaj tshuaj hormone hauv qhov ncauj. Nws kuj tseem ua rau tsuas yog mob me me rau ntawm hypothalamic-pituitary-adrenal (HPA) axis. Qhov tshwm sim ntawm HPA axis tsuj tom qab ntev - kev tswj hwm lub sijhawm nyob qis dua 15%, qhov sib txawv ntawm 60% -80% tus nqi cuam tshuam nrog qhov ncauj corticosteroids. Kev ua haujlwm tuaj yeem rov qab zoo li ntawm 1 mus rau 2 lub lis piam tom qab tshem tawm cov tshuaj, tsis muaj qhov tshwm sim ntawm adrenal atrophy.
Lub tshuab molecular ntawm kev tiv thaiv - cov nyhuv inflammatory ntawm cov tshuaj no
Tetracosactide acetate txhaj tshuaj, raws li kev sib raug zoo agonist ntawm MC1R, MC3R, MC4R, thiab MC5R (EC50 0.65nM), tuaj yeem ua ncaj qha rau MC receptors ntawm cov chaw tiv thaiv kab mob, cov hlwb endothelial, paj hlwb, thiab fibroblasts, pib tiv thaiv - cov kab mob inflammatory ntawm cortisol. Qhov no yog nws cov yam ntxwv niche uas txawv ntawm txhua qhov exogenous GCs.MC3R/MC5R mediated transcriptional silencing ntawm pro-inflammatory cytokinesTocquepeptide activates MC3R/MC5R nyob rau saum npoo ntawm macrophages thiab T lymphocytes.
Inhibits NF - κ B, AP-1, MAPK txoj hauv kev los ntawm Gi/o protein, thiab ncaj qha thaiv cov noob transcription thiab protein synthesis ntawm pro-inflammatory yam xws li TNF - , IL-1 , IL-6, IFN1.7,{16} tau lees paub tias tacrolimus (10nM) tuaj yeem txo TNF - tso tawm los ntawm 72% thiab IL-6 los ntawm 68% hauv macrophages qhib los ntawm lipopolysaccharide (LPS). Cov nyhuv no tsis raug thaiv los ntawm GC receptor antagonist mifepristone thiab tau lees paub tias tsis yog GC nyob ntawm.Piv nrog GC, nws cov inhibition ntawm pro-inflammatory yam yog xaiv ntau dua - nws tsis cuam tshuam rau kev qhia ntawm cov tshuaj tiv thaiv kab mob IL-10 thiab TGF - , zam "kev tiv thaiv kab mob".
Ua kom MC4R qhia rau hauv nruab nrab thiab cov paj hlwb peripheral tuaj yeem cuam tshuam cov kev ua haujlwm ntawm microglia thiab astrocytes. Qhov no ntxiv txo qhov kev tso tawm ntau yam mob thiab mob- cov neeg kho mob ntsig txog, suav nrog prostaglandin E2 (PGE2), glutamate, nitric oxide (NO) thiab paj hlwb loj hlob (NGF). Lub caij no, nws txo qis qhov kev qhia ntawm TRPV1 thiab Nav1.7 ion channels hauv dorsal cag ganglia, yog li thaiv kev sib kis ntawm cov cim mob. Ua ke, cov txheej txheem no tsim kev sib xyaw ua ke los tiv thaiv - inflammatory thiab analgesic teebmeem. Cov kev tshawb fawb txog tsiaj txhu pom tau hais tias qhov kev cuam tshuam no tuaj yeem nce qhov mob hauv cov qauv mob neuropathic los ntawm 45%. Nws txoj kev ua kom muaj zog ua kom zoo tshaj qhov ua tau zoo ntawm morphine, thiab nws tsis ua rau muaj kev quav yeeb tshuaj lossis kev quav tshuaj.MC1R kuj koom nrog kev tswj hwm vascular physiological functions.
Nws txhawb kev tiv thaiv ntawm vascular endothelial hlwb thiab xa cov muaj zog tiv thaiv -kev ua haujlwm inflammatory hauv cov hlab ntsha, pab tswj cov qauv thiab kev ua haujlwm ntawm cov hlab ntsha. Ua kom MC1R hauv cov hlwb endothelial, inhibit qhov kev qhia ntawm intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion-1, VCAM-moleculeA. Cov adhesion thiab transmembrane tsiv teb tsaws ntawm cov qe ntshav dawb (neutrophils, monocytes) mus rau cov hlwb endothelial, thiab txo cov ntaub so ntswg infiltration.In vitro thwmsim pom tias tacrolimus tuaj yeem txo TNF - - induced leukocyte adhesion tus nqi hauv endothelial hlwb los ntawm 65%.
Epigenetic silence ntawm inflammasomes
Teckinide tuaj yeem silence inflammasomes xws li NLRP3, NLRC4, AIM2 los ntawm kev hloov kho epigenetic, thaiv qhov cleavage thiab tso tawm ntawm cov kab mob inflammatory (IL-1, IL-18), uas yog ib qho tseem ceeb niche txoj hauv kev rau nws inhibition ntawm "aseptic inflammatory". HDAC3 thiab HDAC6, ua rau deacetylation ntawm NLRP3, ASC, thiab pro-caspase-1 gene txhawb cheeb tsam H3K9 thiab H3K27 thiab transcriptional silencing. Cov kev sim tau pom tias nws tuaj yeem txo qhov kev ua haujlwm ntawm NLRP3 inflammasomes los ntawm 70% thiab kev paub tab ntawm IL-1 los ntawm 75%, thiab cov nyhuv no kav ntev dua 72 teev.
Kev tswj hwm DNA methylation: Kev ua kom me me ntawm DNMT1 induces siab methylation ntawm inflammasome ntsig txog cov noob txhawb nqa, ua tiav ntev - lub sij hawm tiv thaiv - inflammatory nco - cov tshuaj tiv thaiv - cov nyhuv inflammatory tuaj yeem khaws cia rau 1-2 lub lis piam tom qab kev tswj hwm ib zaug, ntev dua li exogenous GC mitochonidition ntawm DNA. mitochondrial puas thiab mtDNA to, blocks mtDNA activation ntawm NLRP3 inflammasome, thiab suppresses "mitochondrial o" los ntawm qhov chaw.
Tichondride muaj cov tshuaj tiv thaiv kab mob ncaj qha thiab kho cov mitochondrial, txo cov inflammatory amplification voj mediated los ntawm oxidative kev nyuaj siab, uas yog ib qho tseem ceeb auxiliary txoj kev rau nws anti{0}} inflammatory teebmeem.
Kev ua kom lub cev tiv thaiv kab mob antioxidant: Upregulation ntawm SOD2, catalase (CAT), glutathione peroxidase (GPx), heme oxygenase-1 (HO-1) qhia, tshem tawm cov khoom oxidative xws li ROS, MDA, H2O2, thiab lwm yam. Kev sim tsiaj tau pom tias nws tuaj yeem txo qis ROS theem thiab MDA fusion qib ntawm 5% 6.2% hauv cov ntaub so ntswg.
Mitochondrial muaj nuj nqi tiv thaiv: inhibits qhov qhib ntawm mitochondrial permeability hloov pores (mPTP), stabilizes mitochondrial membrane muaj peev xwm, txo cov kev tso tawm ntawm cytochrome C thiab apoptosis yam, tiv thaiv cov hlwb los ntawm oxidative apoptosis, thiab txo cov mitochondrial inflammatory signals.Inhibition (kev ua haujlwm ntawm myocardium) tseem ceeb. Kev ua haujlwm MPO (30% qis dua methylprednisolone), txo cov khoom siv tshuaj lom oxidative xws li hypochlorous acid thiab chloramine, thiab txo cov nqaij oxidative puas thiab ua rau mob hnyav.
Tsis zoo li exogenous GC, uas tsuas muaj los tiv thaiv - mob thiab inhibits kho,Kev txhaj tshuaj tetracosactide acetatetuaj yeem cuam tshuam kev mob ib txhij thiab txhawb kev kho cov ntaub so ntswg, ua tiav lub xeev zoo tshaj plaws ntawm "tiv thaiv- mob yam tsis muaj inhibiting kho".
Kev txhim kho ntawm kev txhim kho kev txhawb nqa: Thaum ua kom cov MC receptors, kev qhia ntawm TGF - , VEGF, bFGF, PDGF, thiab collagen I/III yog upregulated, txhawb fibroblast proliferation, angiogenesis, thiab matrix synthesis.
Cov kev cai meej ntawm kev tiv thaiv fibrosis: inhibits kev ua kom ntau dhau ntawm TGF - /Smad3, txo cov kev qhia ntawm - SMA thiab fibronectin, thiab tsis txhob muaj fibrosis ntau dhau; Ib txhij txhawb kev qhia ntawm matrix metalloproteinases (MMP1/3/9) thiab ua kom cov matrix degradation txawv txav.
Stem cell mobilization: Txhawb kev tsiv teb tsaws ntawm cov pob txha pob txha mesenchymal qia hlwb (MSCs) mus rau qhov chaw mob, sib txawv rau hauv cov hlwb ua haujlwm (xws li cov hlwb endothelial, neurons, lub siab hlwb), thiab ua kom cov ntaub so ntswg kho.
Siv cov ntaub ntawv qhov chaw
- Li, Y., et al. Tetracosactide inhibits NLRP3 inflammasome ntawm epigenetic silencing hauv macrophages. Phau ntawv Journal of Immunology, 2023, 211(8): 1245-1256.
- MedChemExpress. Tetracosactide Acetate: Antioxidant thiab mitochondrial tiv thaiv mechanisms . 2025.
- Adrenocorticotropic Hormone (cov tshuaj) (https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone_(tshuaj))
- Cosyntropin (https://pubchem.ncbi.nlm.nih.gov/compound/Cosyntropin)
- Kev sib piv ntawm kev ua tau zoo ntawm intramuscular tetracosactide thiab subacromial triamcinolone txhaj hauv rotator cuff tendinitis: kev sim randomized (https://pmc.ncbi.nlm.nih.gov/articles/PMC11703363/)
Cov lus nug nquag
Kev siv cov tshuaj tetracosactide acetate yog dab tsi?
+
-
Tetracosactide yog ib tus kws kho mob tshwj xeeb uas tau siv dav hauv kev tshuaj ntsuam xyuas rau cov neeg mob uas xav tias muaj kev txom nyem los ntawm adrenocortical insufficiency. Kuj feem ntau hu ua Cosyntropin, cov tshuaj no yog cov peptide hluavtaws. Nws cov qauv molecular sib raug raws nraim rau 24-amino acid fragment nyob rau ntawm N-terminal cheeb tsam ntawm adrenocorticotropic hormone, nrog rau cov amino acid ib ntus teev raws li SYSMEHFRWGKPVGKKRRPVKVYP. Ua tsaug rau nws cov qauv zoo sib xws rau cov tshuaj hormones ib txwm muaj, nws tuaj yeem ua rau cov lus teb physiological zoo sib xws, yog li pab cov kws kho mob kom raug ntsuas qhov ua haujlwm ntawm adrenal cortical.
Puas yog tetracosactide yog steroid?
+
-
Tetracosactide yog ib qho khoom siv hluavtaws analogue ntawm adrenocorticotropic hormone (ACTH). Nws yog tsim los ua ke raws li thawj 24 amino acid residues ntawm tag nrho 39 amino acids uas ua rau ACTH ntuj. Tus neeg saib xyuas peptide no tuaj yeem txhawb nqa lub adrenal cortex kom zais ntau yam corticosteroids, nrog cortisol yog thawj tus neeg sawv cev. Clinically, nws yog qhov tseem ceeb reagent rau ua tus qauv ACTH stimulation test, uas niaj hnub siv los ntsuas tag nrho cov secretory function thiab functionality ntawm cov qog adrenal.
Cim npe nrov: tetracosactide acetate txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom