Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm kev txhaj tshuaj sincalide hauv Suav teb. Txais tos rau kev lag luam wholesale bulk zoo siab sincalide txhaj rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Sincalide Txhajyog ib qho khoom siv cholecystokinin octapeptide diagnostic tus neeg saib xyuas uas yog ua raws li cov teebmeem ntawm lub cev ntawm CCK, ua haujlwm tseem ceeb rau kev ntsuam xyuas ntawm pancreatobiliary muaj nuj nqi. Kev tswj hwm hauv cov hlab ntsha, nws ua haujlwm sai thiab muaj peev xwm ua rau lub zais zis muaj zog, ua kom pom tseeb kev soj ntsuam ntawm lub gallbladder muaj nuj nqi ua ke nrog ultrasound thiab radiography, thiab tseem txhawb nqa cov qauv ntawm cov kua tsib rau kev tshuaj ntsuam xyuas.
Peb Cov Khoom Muag Khoom
Sincalide COA
 |
||
| Certificate of Analysis | ||
| Compound npe | Sincalide | |
| Qib | Pharmaceutical qib | |
| CAS Nr. | 25126-32-3 | |
| Ntau | 39g | |
| Ntim txheem | PE hnab + Al foil hnab | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
| Ntau No. | 202601090056 | |
| MFG | Peb 9, 2026 | |
| EXP | Peb 8, 2029 | |
| Qauv |
|
|
| Yam khoom | Enterprise txheem | Kev txheeb xyuas qhov tshwm sim |
| Qhov tshwm sim | Dawb los yog yuav luag dawb hmoov | Ua raws |
| Cov ntsiab lus dej | Tsawg dua lossis sib npaug li 5.0% | 0.54% |
| Poob rau ziab | Tsawg dua lossis sib npaug li 1.0% | 0.42% |
| Hnyav Hlau | Pb Tsawg dua lossis sib npaug li 0.5ppm | N.D. |
| Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Hg Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Cd Tsawg dua lossis sib npaug li 0.5ppm | N.D. | |
| Purity (HPLC) | Ntau dua lossis sib npaug li 99.0% | 99.98% |
| Ib qho impurity | <0.8% | 0.52% |
| Tag nrho microbial suav | Tsawg dua lossis sib npaug li 750cfu / g | 95 |
| E. Coli | Tsawg dua lossis sib npaug li 2MPN / g | N.D. |
| Salmonella | N.D. | N.D. |
| Ethanol (los ntawm GC) | Tsawg dua lossis sib npaug li 5000ppm | 500ppm ua |
| Cia | Khaws rau hauv qhov chaw kaw, tsaus, thiab qhuav hauv qab -20 degree | |
|
|
||
|
|
||
| Tshuaj Formula | C49H62N10O16S3 | |
| Exact Mass | 1142.35 | |
| Molecular Luj | 1143.27 | |
| m/z | 1142.35(100.0%), 1143.35(53.0%), 1144.36(13.8%), 1144.35(13.6%), 1145.35(7.2%), 1143.35(3.7%), 1144.35(3.3%), 1143.35(2.4%), 1145.36(2.3%), 1144.35(2.0%), 1146.35(1.9%), 1145.36(1.7%), 1144.35(1.3%) | |
| Elemental Analysis | C,51.48; H,5.47; N,12.25; O,22.39; S,8.41 | |
Gallbladder-Cov ntaub ntawv ntsig txog
(1) Daim ntawv thov hauv Kev Ntsuas Cov Kab Mob Ntshav Qab Zib
Ib qho ntawm cov kev siv tseem ceeb ntawmSincalide Txhajyog qhov dynamic ntsuam xyuas ntawm lub gallbladder contractile muaj nuj nqi. Nws yog dav siv nrog ntau yam kev kuaj pom xws li ultrasound, cholecystography, thiab radionuclide imaging, sawv cev rau cov cuab yeej kho mob tseem ceeb rau kev txheeb xyuas qhov txawv txav ntawm lub gallbladder. Nws cov kev siv tseem ceeb suav nrog kev kuaj mob thiab kev soj ntsuam ntawm ntau yam kab mob hauv lub gallbladder, xws li kev tshuaj ntsuam xyuas thiab kev pom zoo ntawm tus mob cholecystitis, gallbladder contractile dysfunction, thiab adenomyomatosis. Ua raws li kev tswj hwm hauv cov hlab ntsha, nws ua rau lub cev muaj zog ntawm lub gallbladder contraction, tso cai rau kev soj ntsuam ntawm kev cog lus amplitude, atherosclerosis, thiab lub sij hawm kom ncov cov lus teb los txiav txim siab ua haujlwm zoo.
Rau cov neeg mob uas muaj lub gallbladder polyps los yog cholelithiasis, cov khoom no yog siv rau preoperative gallbladder muaj nuj nqi kev ntsuam xyuas kom meej contractile cia, muab pov thawj tseem ceeb rau cov neeg mob xaiv nyob rau hauv lub gallbladder- khaws cia kev phais thiab tsis txhob muaj teeb meem tom qab lub gallbladder muaj nuj nqi. Tsis tas li ntawd, nws hloov cov kev sim noj rog ib txwm muaj nyob rau hauv cov xwm txheej uas xav tau qhov tseeb, cov txiaj ntsig tau rov ua dua tshiab los ntawm kev hloov pauv hauv plab zom mov ntawm tus kheej thiab kev noj zaub mov tsis zoo, tshwj xeeb tshaj yog rau cov neeg mob uas tsis muaj sijhawm yoo mov, tsis muaj zog digestive, lossis tsis muaj peev xwm zam tau cov rog rog.
Piv nrog rau cov pluas noj rog, qhov kev cog lus siab tshaj plaws yog ua tiav hauv 5-15 feeb tom qab txhaj tshuaj, nrog cov lus teb sai thiab ruaj khov, txhim kho kev kuaj mob kom zoo thiab raug thaum txo cov teeb meem tshwm sim los ntawm kev sib txawv ntawm cov rog rog thiab kev nqus. Rau cov neeg mob yoo mov rau ntau tshaj 24 teev, nws tuaj yeem ua rau lub zais zis khoob ua ntej kev kuaj pom, txhim kho kev pom thiab pab tshawb pom qhov mob me.
Cov ntaub ntawv qhov chaw: Tuam Tshoj Cov Ntaub Ntawv Kho Mob Query Platform, Sincalide Pob Ntxig; Medscape Reference, Clinical Practice Guidelines for Sincalide; Nrov Science Tuam Tshoj, Kev Tshawb Fawb Kev Tshawb Fawb Kev Tshawb Fawb -Cov Tshuaj Kho Mob
Los ntawm lub zog ua kom lub gallbladder contraction, cov khoom no txhawb kev tso tawm cov kua tsib hauv lub zais zis rau hauv duodenum, tso cai rau sau cov segmented bile kuaj los ntawm duodenal kua rau siab -zoo kua tsib compositional tsom xam. Daim ntawv thov no yog siv dav hauv kev kuaj mob thiab kev tswj xyuas ntau yam kab mob biliary.
Tshwj xeeb, nws txhawb nqa kev kuaj mob thiab kev soj ntsuam etiological ntawm kev xav tias cov roj cholesterol gallstones, kab mob cholestatic daim siab, kab mob biliary, thiab qog nqaij hlav hauv plab. Cov qauv suav nrog cov kab mob hauv cov kua tsib (Fraction A), gallbladder bile (Fraction B), thiab hepatic bile (Fraction C) - tshwj xeeb tshaj yog cov concentrated thiab tus sawv cev Fraction B - raug tshuaj xyuas rau ntau qib ntawm cov roj cholesterol, bile ntsev, thiab phospholipids, nrog rau cov kab mob qog noj ntshav, thiab cov tshuaj tua kab mob.
Rau cov neeg mob uas muaj cov pob zeb roj cholesterol, cov kua tsib cov tshuaj ntsuam xyuas txheeb xyuas cov txheej txheem lithogenic thiab txiav txim siab seb cov kua tsib puas yog supersaturated nrog cov cholesterol. Hauv kab mob siab cholestatic, nws pab kom paub qhov txawv ntawm hepatocellular los ntawm obstructive cholestasis. Rau cov kab mob biliary, kab lis kev cai ntawm cov kua tsib txheeb xyuas cov kab mob pathogenic. Hauv cov qog nqaij hlav hauv lub cev, kev kuaj cytological ntawm cov kua tsib ua rau kev tshawb pom ntxov ntawm cov qog hlwb atypical, kov yeej qhov kev txwv ntawm cov qauv ntsuas uas tsis tuaj yeem txheeb xyuas cov kua tsib ncaj qha thiab txhawb kev txiav txim siab kho mob- ua. Daim ntawv thov no tseem saib xyuas cov txiaj ntsig ntawm kev kho mob litholytic los ntawm kev sib piv cov kua tsib ua ntej thiab tom qab kho.
Cov ntaub ntawv qhov chaw: Sincalide.com, Kev Tshuaj Xyuas Cov Ntaub Ntawv rau Sincalide rau Kev Txhaj Tshuaj; Kete Bio, Daim Ntawv Thov Sincalide hauv Pancreatobiliary Function Diagnosis; DailyMed, SINCALIDE Label
Pancreas -Cov ntawv thov ntsig txog
(1) Daim ntawv thov nyob rau hauv kev sib xyaw ua ke ntawm Exocrine Pancreatic Function
Sincalide Txhajyog nquag siv ua ke nrog secretin, tsim cov kub - qauv raws tu qauv rau kev soj ntsuam exocrine pancreatic muaj nuj nqi. Nws tau siv dav hauv kev kuaj mob thiab kev ntsuas kev ua haujlwm ntawm ntau yam kab mob pancreatic thiab sawv cev rau kev kho mob tseem ceeb rau kev ntsuas kev ua haujlwm ntawm pancreatic parenchymal. Cov kev qhia muaj xws li kev kuaj mob thiab kev mob ntawm tus mob pancreatitis, mob qog noj ntshav pancreatic, cystic fibrosis, thiab postoperative pancreatic insufficiency, tshwj xeeb tshaj yog rau kev tshuaj xyuas thaum ntxov subclinical pancreatic dysfunction.
Nws hais txog qhov txwv ntawm CT, MRI, thiab lwm yam kev kuaj pom, uas tsuas yog qhia txog kev hloov pauv ntawm morphological yam tsis muaj kev cuam tshuam txog kev ua haujlwm zais cia.Secretin feem ntau ua rau pancreatic ductal hlwb los txhawb dej thiab bicarbonate secretion, thaum sincalide lub hom phiaj pancreatic acinar hlwb kom induce tso digestive enzymes nrog rau amylase, prostease lipase.
Ua ke, lawv tau soj ntsuam tag nrho cov secretory ntim, bicarbonate concentration, thiab digestive enzyme kev ua, tag nrho xav txog exocrine pancreatic muaj nuj nqi. Cov txheej txheem no txhawb nqa etiological kev faib tawm ntawm cov kab mob pancreatic, xaiv cov tswv yim kho mob (xws li, kev coj noj coj ua ntawm kev hloov kho pancreatic enzyme hloov kho rau exocrine insufficiency), thiab kev soj ntsuam prognostic los ntawm kev saib xyuas kev ua haujlwm zais cia los ntsuas cov kab mob thiab kev kho mob. Nws kuj tseem siv los ntsuas kev ua haujlwm graft tom qab hloov pauv pancreas.
Cov ntaub ntawv qhov chaw: DailyMed, SINCALIDE Label; Medscape Reference, Standard Practice for Sincalide in Pancreatic Function Testing; Fresenius Kabi, Phau Ntawv Thov Kev Kho Mob rau SINCALIDE rau Kev Txhaj Tshuaj
Thaum ua ke nrog secretin rau exocrine pancreatic function test, cov khoom no pab kom tau txais siab -zoo duodenal aspirates rau cytological thiab enzymatic tsom xam, feem ntau yog siv rau thaum ntxov soj ntsuam thiab sib txawv ntawm pancreatic kab mob thiab periampullary kab mob. Cov lus qhia muaj xws li kev tshuaj ntsuam xyuas ntxov rau pancreatic cancer thiab periampullary carcinoma, theem ntawm tus mob pancreatitis ntev, thiab kev sib txawv ntawm cov kab mob benign thiab malignant pancreatic.
Hauv kev mob pancreatitis ntev, duodenal aspirates qhia ntau cov kab mob inflammatory thiab fibrin fragments, nrog rau kev tsom xam enzymatic qhia txo qis amylase thiab lipase kev ua haujlwm, pab txhawb kev ntsuas qhov hnyav nrog rau cov tsos mob kho mob. Hauv cov kab mob pancreatic lossis periampullary carcinoma, cytological smears thiab kuaj kab mob kuaj pom cov qog nqaij hlav atypical, thiab ua ke nrog cov cim qog xws li CA19-9, ua rau muaj txiaj ntsig zoo rau kev kuaj pom ntxov thiab kev cuam tshuam. Nws kuj tseem cuam tshuam txog kev ua haujlwm tsis zoo ntawm tus txiav ua haujlwm los ntawm tus mob pancreatitis ntev tiv thaiv kab mob qog noj ntshav, txo qis kev kuaj mob tsis zoo thiab kuaj tsis tau. Daim ntawv thov no kov yeej cov kev txwv ntawm cov duab pom zoo hauv kev kuaj mob qog noj ntshav thaum ntxov, txhawb kev kuaj mob thiab kho cov kab mob pancreatic.
Cov ntaub ntawv qhov chaw: Fresenius Kabi, Clinical Application Manual for SINCALIDE for Injection; Kev soj ntsuam ntawm Pancreatic Test Indicators rau Cov Kws Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Tshaj Lij Kev Tshawb Fawb Kev Tshawb Fawb Kev Tshawb Fawb Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Txog Kev Tshawb Fawb Kev Tshawb Fawb Mayo Clinic, Clinical Practice Guidelines for Sincalide
Expanded Application Scenarios
Raws li qhov tshwj xeeb CCK receptor agonist,Sincalide Txhajyog dav siv nyob rau hauv physiological thiab pathological kev tshawb fawb ntawm txoj hnyuv motility, muab cov cuab yeej tseem ceeb rau kev kawm txog cov kab mob ntawm cov kab mob plab hnyuv. Nws cov ntawv thov tseem ceeb suav nrog kev ntsuam xyuas ntawm antroduodenal kev sib koom tes thiab kev ua haujlwm pyloric sphincter, nrog rau kev tshawb fawb txog kev ua haujlwm ntawm kev ua haujlwm dyspepsia, gastroparesis, thiab lwm yam kab mob.
Hauv kev tshawb fawb tshawb fawb, cov khoom no tuaj yeem ua rau CCK receptor- cov lus teb physiological mediated los soj ntsuam lub contractile atherosclerosis thiab kev siv ntawm plab hnyuv du nqaij, soj ntsuam kev sib koom ua ke ntawm antroduodenal, tshawb xyuas cov kev so thiab kev cog lus ntawm pyloric sphincter, thiab tshawb xyuas cov txheej txheem hauv plab hnyuv. Hauv cov neeg mob uas muaj kev ua haujlwm dyspepsia lossis gastroparesis, nws tuaj yeem ua rau lub plab zom mov kom sib piv cov lus teb sib txawv ntawm tus kheej thiab tshuaj xyuas kev sib koom ua ke ntawm cov tshuaj hormones plab hnyuv siab raum (xws li, CCK) thiab kev tsis sib haum xeeb, ua pov thawj kev sim rau cov kab mob.
Tsis tas li ntawd, nws yog siv los kawm txog cov txheej txheem ntawm kev ua haujlwm ntawm plab hnyuv motility-modulating agents los ntawm kev soj ntsuam lawv cov teebmeem ntawm sincalide-stimulated gastrointestinal teb thiab txheeb xyuas lawv lub hom phiaj molecular, txhawb kev txhim kho cov tshuaj prokinetic. Cov ntawv thov no txuas ntxiv dhau ntawm tib neeg kev tshawb fawb mus rau tsiaj cov qauv, hla kev tshawb fawb thiab kev txhais lus hauv plab hnyuv.
Cov ntaub ntawv qhov chaw: Fresenius Kabi, SINCALIDE Cov Lus Qhia rau Kev Siv Hauv Cov Neeg Tshwj Xeeb; Kete Bio, Kev Tshawb Fawb Kev Tshawb Fawb hauv Kev nthuav dav ntawm Sincalide; benchchem.com, Daim Ntawv Thov ntawm Sincalide hauv Preclinical Models
Indications thiab contraindications
Sincalide yog ib qho khoom siv hluav taws xob ntawm cholecystokinin (CCK), tshwj xeeb CCK-8, feem ntau yog siv rau hauv kev kuaj mob plab hnyuv, nrog rau kev soj ntsuam ntawm pancreatic thiab gallbladder muaj nuj nqi, nrog rau kev kuaj plab hnyuv ntawm X-ray (fluoroscopy).
Contraindications: Siv yog nruj me ntsis txwv tsis pub rau cov neeg uas muaj hypersensitivity rau sincalide. Kev nyab xeeb thiab kev ua tau zoo ntawm cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo tsis tau tsim; yog li ntawd, siv nyob rau hauv cov pej xeem no tsis pom zoo.
Cov ntaub ntawv qhov chaw: Cov khoom los ntawm Kete Biotechnology Co., Ltd.; Cov khoom qhia los ntawm ChemicalBook
FAQ
Dab tsi yog qhov mechanism ntawm kev txiav txim ntawm sincalide?
+
-
Intravenous (bolus) kev tswj hwm ntawm sincalideua rau kom sai ntawm lub gallbladder uas ua rau siab tshaj plaws hauv 5 mus rau 15 feeb, piv nrog rau qhov kev txhawb nqa ntawm cov pluas noj rog uas ua rau muaj kev sib kis loj heev uas ua rau ntau tshaj tom qab kwv yees li 40 feeb.
Dab tsi yog sincalide siv rau?
+
-
Kev txhaj tshuaj Sincalide yog ib qho kev pabcuam kuaj mob sivlos pab kuaj xyuas qee yam teeb meem ntawm lub gallbladder thiab pancreas. Nws kuj tseem siv los ua kom lub plab zom mov kom sai kom txo tau cov hluav taws xob raug thaum lub sij hawm kuaj plab hnyuv (xws li, fluoroscopy, x- kev kuaj hluav taws xob).
Dab tsi yog cov khoom xyaw hauv sincalide?
+
-
Txhua lub koob txhaj tshuaj ntawm sincalide muab cov hmoov dawb dawb uas tsis yog pyrogenic lyophilized muaj 5 mcg sincalide nrog 30 mg arginine hydrochloride, 15 mg lysine hydrochloride, 170 mg mannitol, 4 mg methionine, 2 mg pentetic acid, potassium mc2, 0.000. phosphate dibasic, thiab 0.04 mg sodium ...
Cim npe nrov: Sincalide txhaj tshuaj, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom