Doxycycline (doxt) poob, thib ob - tiam tetracycline tshuaj tua kab mob, tau ua lub hauv paus hauv kev kho cov kab mob sib kis txij li nws tau qhia hauv xyoo 1960. Nws qhov dav -spectrum antibacterial kev ua haujlwm, ntev ib nrab- lub neej, thiab tshwj xeeb los tiv thaiv- cov khoom inflammatory tau tsim nws lub luag haujlwm tseem ceeb. Nrog kev nce qib hauv kev tsim cov thev naus laus zis, doxt tee (cov kua hauv qhov ncauj npaj) tau txais txiaj ntsig tseem ceeb hauv kev kho mob vim lawv qhov kev tswj hwm cov tshuaj, tsim nyog rau kev siv menyuam yaus, thiab yooj yim rau cov neeg tshwj xeeb (xws li cov neeg uas muaj teeb meem nqos). Kab lus no tshawb xyuas qhov muaj txiaj ntsig thiab cov teeb meem ntawm doxt poob los ntawm kev xav nrog rau cov tshuaj siv tshuaj, kev siv tshuaj kho mob, kev tswj kev nyab xeeb, thiab kev tshawb fawb tsis ntev los no.
Cov kab mob ua pa
Pathogen Coverage thiab Efficiency: Doxt nthuav tawm cov tshuaj tiv thaiv muaj zog tiv thaiv kab mob atypical xws li Mycoplasma pneumoniae, Chlamydia, thiab Legionella pneumophila, ua rau nws cov tshuaj xaiv rau mycoplasma mob ntsws rau ob tus menyuam yaus thiab cov neeg laus. Cov ntaub ntawv kho mob qhia txog kev kho tus nqi ntau dua 90%, nrog rau kev cuam tshuam ntawm cov hniav me me thaum lub sij hawm luv luv - siv sijhawm (tsawg dua lossis sib npaug li 21 hnub), kov yeej cov contraindications cuam tshuam nrog tshuaj tua kab mob tetracycline.
Synergistic kho rau cov kab mob sib xyaw:Hauv kev ua liaj ua teb tsiaj txhu thiab nqaij qaib, sib txuas doxt nrog florfenicol ntawm qhov sib piv 2: 1 ib txhij inhibits 50S thiab 30S subunits ntawm cov kab mob ribosomes, ua tiav cov protein synthesis blockade. Piv txwv li, hauv kev kho mob swine kis kab mob pleuropneumonia, qhov kev kho no txo qis kev tuag los ntawm 40% thiab txo cov sijhawm kho mob los ntawm 3 hnub.
Cov tswv yim rau Kev Tiv Thaiv Tshuaj -Resistant Strains:Rau mycoplasma-cov kab mob resistant, kev sib txuas ntawm ampicillin sulfate nrog polymyxin sulfate tsim ib qho kev siv tshuaj tua kab mob triple (kev puas tsuaj ntawm cov cell membranes, inhibition ntawm thawj 30S subunit binding, thiab thaiv ntawm 50S subunit peptide saw elongation), rov qab rhiab heev rau doxt. Cov kev tshawb fawb hauv chav kuaj pom tias cov txheej txheem no ua rau muaj kev cuam tshuam ntau dua rau cov tshuaj ntau yam - tiv thaiv E. coli los ntawm 35% mus rau 89%.
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kev noj qab haus huv ntawm qhov ncauj
Hauv kev noj qab haus huv ntawm qhov ncauj, kev paub txog kev noj qab haus huv feem ntau tau tsom mus rau kev saib xyuas txhua hnub xws li txhuam hniav thiab siv cov tshuaj ntxuav qhov ncauj. Txawm li cas los xij, kev tshawb fawb tsis ntev los no tau qhia tias cov tshuaj tua kab mob hu ua doxycycline (DOXT) tau ntsiag to tawm los ua "kev tiv thaiv tsis pom" ntawm qhov ncauj qhov ncauj. Nws tsis tsuas yog ua kom pom qhov ua tau zoo tshaj plaws hauv kev kho cov kab mob ntawm qhov ncauj tab sis kuj muaj peev xwm tshwj xeeb hauv kev tiv thaiv cov hniav caries thiab inhibiting periodontal o.
Ob tus neeg saib xyuas ntawm cov kab mob tua kab mob thiab tiv thaiv- cov khoom ua kom mob
Doxycycline belongs rau tetracycline chav kawm ntawm cov tshuaj tua kab mob thiab muaj ib tug tshwj xeeb thiab zoo heev antibacterial mechanism. Nws inhibits kev khi ntawm aminoacyl-tRNA los ntawm kev khi tshwj xeeb rau A txoj haujlwm ntawm 30S subunit ntawm cov kab mob ribosomes, yog li thaiv cov kab mob protein synthesis. Cov txheej txheem no ua rau doxycycline tuaj yeem pom muaj zog inhibitory cuam tshuam rau ntau yam kab mob hauv qhov ncauj, xws li Streptococcus mutans thiab Porphyromonas gingivalis.
Dab tsi yog qhov tshwj xeeb tshaj yog tias doxycycline kuj muaj cov tshuaj tiv thaiv tseem ceeb - mob. Hauv kev kho mob ntawm qhov ncauj inflammatory kab mob xws li periodontitis thiab qhov ncauj ulcers, doxycycline tuaj yeem inhibit qhov kev tso tawm ntawm cov kab mob inflammatory, txo cov ntaub so ntswg edema thiab mob, thiab txhawb kev kho mucosal. Qhov no ob hom tshuaj tua kab mob thiab tiv thaiv- cov nyhuv inflammatory ua rau doxycycline tee ntau yam cuab yeej hauv kev kho mob ntawm qhov ncauj mucosal.
Ib Lub Tswv Yim Tshiab rau Kev Tiv Thaiv Kab Mob
Kev kho hniav caries yog ib qho ntawm cov kab mob ntau tshaj plaws nyob rau hauv lub qhov ncauj kab noj hniav, thiab nws qhov tshwm sim yog ze ze rau kev tsim ntawm biofilms los ntawm cov kab mob cariogenic xws li Streptococcus mutans. Cov kab mob no tsim biofilms rau ntawm cov hniav uas nyuaj rau tshem tawm, tsim cov tshuaj acidic uas ua rau enamel thiab thaum kawg ua rau tsim cov kab noj hniav. Cov txheej txheem kev tiv thaiv kab mob kab mob ib txwm vam khom feem ntau ntawm cov tshuaj fluoride, thaum doxycycline tee muab cov tswv yim tiv thaiv tshiab.
Kev tshawb fawb tau pom tias doxycycline tuaj yeem chelate nrog calcium ions, neutralize acidic tshuaj nyob rau hauv lub qhov ncauj kab noj hniav, thiab txo cov erosion ntawm enamel. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam cov biofilm tsim ntawm mutans streptococci thiab txo cov colonization muaj peev xwm ntawm cov kab mob cariogenic. Txawm hais tias tam sim no tsis muaj qhov tshwj xeeb doxycycline qhov ncauj poob rau hauv kev ua lag luam, cov kev tshawb fawb uas twb muaj lawm qhia tias doxycycline formulated rau hauv qis -concentration, qeeb- tso qhov ncauj poob yuav dhau los ua cov khoom sib tw rau kev tiv thaiv kab mob tshiab, tshwj xeeb tshaj yog rau cov neeg mob uas muaj kab mob caries thaum kho orthodontic.
"Targeted Therapy" rau Periodontal Inflamation
Periodontitis yog ib qho ntawm cov kab mob feem ntau tshwm sim hauv qhov ncauj kab noj hniav, thiab nws qhov tshwm sim muaj feem cuam tshuam nrog kev tsim cov kab mob biofilm hauv cov hnab ris periodontal thiab tso tawm ntawm cov kab mob inflammatory. Kev kho mob ib txwm muaj nyob rau ntawm cov khoom siv khib nyiab ntau (xws li scaling thiab curettage) thiab kev siv cov tshuaj tua kab mob hauv zos (xws li chlorhexidine), tab sis cov txheej txheem no feem ntau ua tsis tiav tag nrho cov kab mob biofilm nyob rau hauv cov hnab tshos periodontal thiab ua rau muaj kev loj hlob ntawm cov kab mob.
Qhov tshwm sim ntawm doxycycline tee muab ib txoj hauv kev tshiab rau kev kho mob ntawm lub cev. Los ntawm kev thov hauv zos ntawm doxycycline tee, cov tshuaj tuaj yeem ua ncaj qha rau ntawm cov kab mob biofilm nyob rau hauv lub hnab ntim khoom, ua kom muaj zog tiv thaiv kab mob thiab tiv thaiv - cov teebmeem inflammatory. Nyob rau tib lub sijhawm, vim yog kev tsim cov biofilm tiv thaiv los ntawm doxycycline thaum lub sijhawm siv hauv zos hauv lub qhov ncauj kab noj hniav, nws txo qis kev yaig ntawm cov kua qaub ntawm cov ntaub so ntswg, yog li txhawb kev kho thiab rov tsim cov ntaub so ntswg.
Daim tawv nqaij thiab cov ntaub so ntswg mos
Dual Anti-inflammatory thiab Antibacterial Action
Doxycycline suppresses Propionibacterium acnes thiab neutrophil chemokines kom txo tau cov kab mob inflammatory mediator tso tawm, ua ib qho kev kho mob rau nruab nrab - rau - pob txuv loj. Kev saib xyuas koob tshuaj ntawm 40mg / hnub ua ke nrog metronidazole gel ua kom lub sijhawm daws teeb meem erythema luv dua 50% thaum ua rau muaj kev pheej hmoo qis dua li cov tshuaj noj tshuaj ntau dua -.
Kev nkag mus ntawm Follicular Barrier
Nws cov qauv lipophilic txhawb kev nkag mus rau hauv cov qog sebaceous, tsim kom muaj cov tshuaj tiv thaiv kab mob hauv cov hauv paus plaub hau. Cov kev tshawb fawb tsiaj pom tau hais tias nanocrystalline tee ua tiav cov ntshav ntshav siab tshaj 2.3 npaug ntau dua li cov qauv tsim, ntxiv dag zog rau kev kho mob.
Kev kho mob tshwj xeeb
Rau furuncles, boils, thiab cellulitis tshwm sim los ntawm Staphylococcus aureus thiab Streptococcus, doxt tee ceev o daws teeb meem thiab kho qhov txhab. Thaum ua ke nrog mupirocin tshuaj pleev, nws txo cov pustule daws lub sij hawm los ntawm 40%.
Kev Kho Mob Kab Mob Tib Neeg
Scrub Typhus Treatment
Hauv kev kho mob 100 tus neeg mob typhus, doxt tau muab tshuaj rau qhov ncauj ntawm 0.2g ib koob tshuaj ib zaug ib hnub, ua ke nrog vitamin B6 20mg, rau 4-5 hnub sib law liag. Hauv 6 teev ntawm kev kho mob, cov neeg mob lub cev kub pib txo qis, rov qab mus rau qhov qub tsis pub dhau 24 teev. Ua raws li- kev tshuaj xyuas 15 hnub tom qab pom tias txhua tus neeg mob tau zoo zoo yam tsis muaj rov tshwm sim dua. Cov tsos mob xws li eschar, ulceration, lymphadenopathy, thiab pob liab liab tau daws. Kev kuaj fluorescent antibody qhia tau tias seroconversion hauv 80% ntawm cov neeg mob. Cov ntaub ntawv no tau lees paub tias doxt lub zog inhibitory cuam tshuam tawm tsam typhus rickettsia thiab nws cov ntaub ntawv muaj kev nyab xeeb siab nrog kev siv sijhawm luv.
Kev Kho Mob Chlamydia Trachomatis Kab Mob Hauv Cov Poj Niam
Xya caug- cuaj tus poj niam uas muaj tus kab mob Chlamydia trachomatis qhov chaw mos tau txais kev kho doxt thiab microwave ua ke. Doxt tau noj ntawm qhov ncauj ntawm 0.1 g ob zaug ib hnub rau ntau tshaj peb lub lis piam sib law liag, ua ke nrog kev kho mob microwave (20-30 W, 30 feeb ib zaug, txhua hnub rau 14 hnub). Cov txiaj ntsig tau pom tias kev sib xyaw ua ke tau txhim kho cov txiaj ntsig kho tau zoo, tshwj xeeb tshaj yog tawm tsam cov tshuaj tiv thaiv kab mob - tiv taus. Microwave therapy txhim kho cov tshuaj nkag mus los ntawm kev txhim kho cov ntshav ncig hauv zos.
Kev kho mob encephalitis tshwm sim los ntawm tus kab mob anaplasma felis
Ib tug txiv neej muaj hnub nyoog 24- xyoo tau txais tus mob ua npaws, qaug dab peg, thiab tsis nco qab. Anaplasma felis tau kuaj pom hauv cov kua cerebrospinal los ntawm kev sib luag ntawm metagenomic. Tom qab kuaj mob, tus neeg mob tau txais kev kho doxt (0.1 g ib koob, txhua 12 teev). Tom qab 4 hnub, kev nco qab rov qab los, lub cev kub li qub, thiab qaug dab peg. Cov ntaub ntawv no qhia tau hais tias doxt yog cov tshuaj tua kab mob ntawm kev xaiv rau feline rickettsial kab mob, nthuav tawm cov txiaj ntsig tshwj xeeb hauv cov kab mob hauv nruab nrab paj hlwb.
Kev kho mob rau tsiaj txhu thiab nqaij qaib kab mob
Kev kho kab mob ua pa thiab E. coli Co- kis kab mob hauv qaib
Hauv kev ua liaj ua teb broiler, doxt feem ntau yog siv los kho cov kab mob ua pa thiab co- kis kab mob los ntawm Mycoplasma, E. coli, thiab lwm yam kab mob. Piv txwv li, hauv ib rooj plaub, kev sib xyaw ua ke ntawm doxt (200 mg / kg pub) + levofloxacin (100 mg / kg pub) tau muab los ntawm pub rau 5-7 hnub sib law liag. Qhov no tau ntxiv nrog amoxicillin (50 mg / L dej) + electrolyte-enriched multivitamin hauv dej haus, tswj tus kab mob zoo. Thaum ua ke nrog florfenicol, doxt txhim kho synergistic tua cov teebmeem tawm tsam E. coli thiab mycoplasma, txhim kho cov nqi kho tau zoo.
Kev kho mob Swine Respiratory Diseases thiab Hemoparasites
doxt pom ntau daim ntawv thov hauv kev tswj kab mob swine. Piv txwv li, kev kho mob hnoos qhuav, hnoos ntub, thiab ua tsis taus pa muaj kev sib xyaw ua ke ntawm doxt + polymyxin + florfenicol + Ma Xing Shi Gan. Los ntawm kev sib koom ua ke thiab kev hloov kho koob tshuaj, cov txheej txheem no ib txhij tswj kev ua pa ua pa thiab kis kab mob thib ob. Rau cov ntshav parasites zoo li Toxoplasma gondii thiab Haemobartonella nyob rau hauv npua, combining doxt nrog compound sulfonamide cov tshuaj nkag mus rau hauv cov kab mob parasite thiab blocks protein synthesis, ua kom tiav eradication.
Kev tiv thaiv kab mob ua pa ntev thiab E. coli Co- kis kab mob hauv qaib
Thaum tiv thaiv kab mob ua pa ntev thiab kab mob E. coli hauv broilers, doxt txo tus kab mob los ntawm kev tswj lub plab microbiota thiab txhim kho kev tiv thaiv. Piv txwv li, ntxiv doxt (100-200mg / kg) los noj kom txo tau Mycoplasma thiab E. coli carriage tus nqi hauv pab tsiaj. Nws siv ua ntej thiab tom qab ib puag ncig kev ntxhov siab (xws li kev hloov pauv tsiaj, tshuaj tiv thaiv) zoo tiv thaiv kab mob.
Kev Kho Mob Adjuvant
Doxycycline-Induced CHD5 Gene Expression Inhibits Leukemia Cell Loj hlob:
Hauv kev tshawb fawb siv cov kab mob leukemia (piv txwv li, HL-60, Jurkat, KG-1a), cov kws tshawb fawb tau siv cov kab mob lentiviral thiab tetracycline-inducible qhia rau induce exogenous CHD5 noob qhia ntawm doxt (DOX). Cov txiaj ntsig kev sim pom tau tias piv rau pawg tswj hwm, cov hlwb sib koom ua ke nrog TREAutoR3 thiab TREAutoR3-CHD5 tau nthuav tawm ntau CHD5 qhia qib, nce los yog ntau dua cov uas pom hauv cov hlwb mononuclear. Qhov kev tshawb pom no qhia tau hais tias doxt tuaj yeem cuam tshuam rau kev coj tus cwj pwm lom neeg ntawm leukemia los ntawm kev tswj cov kev qhia ntawm cov noob tshwj xeeb (xws li CHD5), muab lub hom phiaj tshiab molecular rau kev kho mob leukemia.
Doxt ua tus neeg sawv cev pabcuam hauv kev tshawb fawb txog kev kho mob leukemia:
Hauv kev tshawb fawb txog kev kho mob myeloid leukemia (AML), doxt qee zaum ua haujlwm ua tus neeg sawv cev ua ke nrog lwm cov tshuaj khomob lossis cov tshuaj tsom. Piv txwv li, hauv qee qhov kev sim tshuaj, cov neeg mob tau txais kev kho mob sib xyaw ua ke uas muaj doxt los ntsuas nws qhov cuam tshuam rau kev kho mob thiab kev ciaj sia. Txawm hais tias doxt tsis yog tus kws kho mob tseem ceeb hauv cov txheej txheem no, nws tuaj yeem txhim kho kev kho mob tag nrho los ntawm kev tiv thaiv - mob, tshuaj tua kab mob, lossis kev tiv thaiv kab mob - hloov cov teebmeem. Txawm li cas los xij, vim qhov nyuaj ntawm cov txheej txheem kev kho mob leukemia, qhov tshwj xeeb kev pab ntawm doxt yuav tsum muaj kev ntsuam xyuas dav dav nrog rau lwm cov tshuaj thiab cov kev kho mob.
Muaj peev xwm Mechanisms ntawm doxt hauv Kev Kho Mob Leukemia:
Gene Regulation: Raws li tshuaj tua kab mob tetracycline, doxt tuaj yeem cuam tshuam rau leukemia cell proliferation, sib txawv, thiab apoptosis los ntawm inducing cov kev qhia ntawm cov noob tshwj xeeb xws li CHD5.
Anti-Inflammatory thiab Immunomodulatory Effects: Cov neeg mob Leukemia feem ntau pom cov lus teb inflammatory thiab kev tiv thaiv kab mob. Doxt's anti-inflammatory thiab immunomodulatory zog tuaj yeem pab txo qhov mob thiab txhim kho kev tiv thaiv kab mob, yog li ua kom cov neeg mob ua siab ntev thiab ua raws li kev kho mob.
Antimicrobial Effects: Cov neeg mob leukemia feem ntau ua rau kis kab mob vim muaj kev tiv thaiv kab mob. Doxt cov tshuaj tiv thaiv kab mob tuaj yeem tiv thaiv thiab kho tus kab mob -txog cov teeb meem, txo cov kev pheej hmoo kho mob.
Cov ntawv thov tshiab
Tshaj tawm -Kev Tiv Thaiv Kev Tiv Thaiv Kab Mob (PEP) rau Malaria
Hauv malaria- thaj chaw muaj kab mob, doxt qhov ncauj tshuaj tuaj yeem ua haujlwm tom qab- kis tau tus kab mob. Pib kev kho mob 1-2 hnub ua ntej nkag mus rau hauv cheeb tsam endemic thiab txuas ntxiv rau 4 lub lis piam tom qab tawm mus txo qis kev pheej hmoo kis mob los ntawm 80%. Nws cov txiaj ntsig suav nrog kev tswj hwm qhov ncauj yooj yim thiab tswj tau cov kev mob tshwm sim, ua rau nws tsim nyog rau cov neeg caij luv luv -.
Biodefense System
Raws li qhov nyiam prophylactic rau kev kis tus kab mob anthrax, doxt qhov ncauj daws tau yooj yim rau kev faib tawm sai. Nws cov kua formulation txo qis kev pheej hmoo kis kab mob cuam tshuam nrog kev tswj hwm cov hlab ntsha. Teb Chaws Asmeskas CDC xaiv nws raws li Qeb Ib cov tshuaj khaws cia rau bioterrorism teb.
Veterinary Applications
Hauv kev ua liaj ua teb tsiaj txhu, doxt tee (los yog cov hmoov soluble) tau dav siv los kho swine dyspnea, duck bacillosis, thiab avian bacillosis kab mob. Piv txwv li, hauv kev kho mob swine respiratory kab mob, kev sib xyaw ua ke ntawm doxt + florfenicol + antipyretic tshuaj qhia tau hais tias muaj txiaj ntsig zoo thiab ua haujlwm zoo dua hauv kev tswj hwm kev sib xyaw ntawm Mycoplasma thiab kab mob.
Daim ntawv thov kev kho mob ntawm doxt qhov muag tee yog hloov los ntawm "kev kho mob" mus rau "kev tiv thaiv kev tiv thaiv" thiab "cov tshuaj muaj tseeb." Nyob rau hauv lub neej yav tom ntej, nrog rau txoj kev loj hlob ntawm tshiab formulations xws li nanocrystalline qhov muag tee thiab thermosensitive hydrogels, lawv bioavailability thiab lub hom phiaj muaj peev xwm yuav txhim kho ntxiv. Piv txwv li, nanocrystalline tee txo txoj hnyuv plab, txhim kho kev ua raws li tus neeg mob; thermosensitive hydrogel drops form sustained - tso tawm cov yeeb yaj kiab ntawm qhov chaw ntawm lub qhov muag lossis hauv qhov chaw mos, ncua kev siv tshuaj mus ntev dua 12 teev. Tsis tas li ntawd, kev koom ua ke genomic sequencing nrog tshuab kev kawm algorithms los tsim cov ntaub ntawv ntawm doxt- cov kab mob resistant ua rau tus kheej cov kev taw qhia tshuaj, muab cov kev daws teeb meem ntau dua rau kev tiv thaiv thoob ntiaj teb - kev kho kab mob.
Cov lus nug nquag
Doxycycline qhov muag tee siv rau dab tsi?
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Thaum siv raws li ophthalmic tee, doxycycline yog siv nyob rau hauvkho ntau yam ntawm qhov muag los ntawm kev tsom mus rau cov kab mob kis ncaj qha rau ntawm qhov chaw- thaj chaw cuam tshuam ntawm qhov muag. Cov txheej txheem tom qab doxycycline qhov ua tau zoo yog nyob rau hauv nws lub peev xwm los inhibit protein synthesis hauv cov kab mob.
Puas yog doxy yog tshuaj tua kab mob muaj zog?
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Doxycycline zoo heev vim nws yog dav -spectrum bacteriostatic tshuaj tua kab mob. Nws kho ntau tus kab mob thiab kab mob parasitic zoo li malaria. Nws kuj yog siv los kho anthrax, ib qho ntawm cov kab mob tsawg thiab hnyav kis los ntawm cov tsiaj qus.
Doxy doxycycline siv rau dab tsi?
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Doxycycline hyclate yog dej -soluble, broad-spectrum tetracycline tshuaj tua kab mob siv los kho ntau yam kab mob, suav nrog pob txuv, kab mob sib kis (STIs), xws li chlamydia, syphilis, thiab gonorrhea, kab mob Lyme, malaria prophylaxis, thiab kab mob (Mycoplaxis).
Cim npe nrov: doxycycline tee, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom