Qhov zoo tshaj plaws itraconazole creamyog ib qho dav -spectrum tshuaj tiv thaiv kab mob, nrog nws cov ntsiab lus tseem ceeb yog itraconazole, cov khoom siv hluavtaws ntawm triazole. Nws tua tau zoo lossis inhibits kev loj hlob thiab kev loj hlob ntawm ntau yam fungi los ntawm inhibiting lub synthesis ntawm ergosterol nyob rau hauv fungal cell membranes, cuam tshuam lub cell membrane qauv. Thaum siv cov tshuaj pleev itraconzole, nws yog ib qho tsim nyog los ntxuav thiab qhuav qhov chaw cuam tshuam, tom qab ntawd siv cov tshuaj pleev kom tsim nyog sib npaug rau thaj chaw muaj kab mob thiab me me ntawm daim tawv nqaij ib puag ncig nws, 1-2 zaug hauv ib hnub. Kev kho mob feem ntau yog 2-4 lub lis piam, thiab lub sijhawm tshwj xeeb yuav tsum tau hloov kho raws li hom kab mob. Piv txwv li, tinea pedis thiab tinea corporis feem ntau yuav tsum tau siv tas li 2-4 lub lis piam, thaum tinea pedis thiab tinea versicolor tuaj yeem muaj kev kho mob me ntsis. Thaum kho, thaj chaw cuam tshuam yuav tsum tau ceev kom huv si thiab qhuav, tsis txhob hnav khaub ncaws nruj lossis siv cov khoom tu tawv nqaij khaus khaus los txhawb kev nqus tshuaj thiab kho cov teebmeem.
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb cov khoom tsim
Itraconazole +. COA
Formulation thiab tsos qhia
Itraconzole ointment belongs rau sab nraud ib nrab- daim ntawv ntau npaum li cas, uas feem ntau muab faib ua ob hom: qab zib thiab tshuaj pleev raws li qhov sib txawv ntawm matrix muaj pes tsawg leeg thiab txheej txheem. Nws lub ntsiab active ingredient yog itraconzole, uas yog ib tug thib peb - tiam triazole broad - spectrum antifungal tshuaj uas exerts bactericidal los yog bacteriostatic los ntawm tshwj xeeb inhibiting lub synthesis ntawm ergosterol nyob rau hauv fungal cell daim nyias nyias, cuam tshuam kev ntseeg ntawm daim nyias nyias. Tus tsim ntawm daim foos no yog ua raws li cov kev xav tau hauv qab no:
Localized targeting: Cov tshuaj ua ncaj qha rau ntawm qhov chaw ntawm daim tawv nqaij kab mob, sai sai nkag mus rau hauv lub stratum corneum, ua rau siab concentration tsub zuj zuj nyob rau hauv qhov chaw ntawm qhov txhab, thiab txhim kho cov nyhuv antibacterial.
Kev tso tawm tsis tu ncua thiab tswj kev tso tawm: Semi khoom matrix tuaj yeem ncua sijhawm nyob ntawm cov tshuaj ntawm daim tawv nqaij, txo qhov zaus ntawm kev tswj hwm (feem ntau 1-2 zaug hauv ib hnub), thiab txhim kho kev ua raws li tus neeg mob.
Kev txhim kho kev nyab xeeb: Los ntawm kev txwv qhov kev nqus ntawm cov tshuaj, kev pheej hmoo ntawm kev mob plab hnyuv, lub siab ua haujlwm tsis zoo, thiab lwm yam kev mob tshwm sim tuaj yeem tshwm sim los ntawm qhov ncauj.zoo tshaj plaws itraconazole creamtxo qis, tshwj xeeb tshaj yog rau cov kab mob me me mus rau nruab nrab ntawm cov kab mob fungal.
Kev siv ntau yam scenario: Cov nplaum nplaum muaj cov dej noo, nrog rau cov tawv nqaij zoo nkauj, haum rau cov tawv nqaij los yog exudative (xws li ncaws pob hom pob khaus); Cov tshuaj pleev ib ce muaj cov roj ntau thiab muaj zog moisturizing, ua rau nws zoo dua rau cov tawv nqaij qhuav thiab tawg (xws li mob tinea corporis).
(1) Xim thiab kev ntxhib los mos
Cream: Lub hauv paus yog dawb los yog tawm dawb, nrog rau qhov muag heev thiab zoo nkauj zoo nkauj, zoo extensibility, thiab nqus sai tom qab thov. Tsis muaj qhov pom tseeb greasy zoo rau ntawm daim tawv nqaij. Qee cov khoom yuav tshwm sim me ntsis daj lossis lub teeb liab vim qhov sib ntxiv ntawm cov khoom xyaw moisturizing xws li vitamin E lossis urea.
Ointment: Lub hauv paus yog ib lub pob tshab semi pob tshab los yog milky dawb muab tshuaj txhuam nrog cov roj cov ntsiab lus siab thiab kev ntxhib los mos. Tom qab daim ntawv thov, nws tsim cov roj tiv thaiv zaj duab xis thiab tsim nyog rau kev siv hmo ntuj lossis qhov chaw qhuav.
Kev txheeb xyuas tshwj xeeb: Yog tias muaj cov tshuaj hormones (xws li kev npaj sib xyaw), lo lus "hormone" lossis xim ceeb toom (xws li lub teeb liab) yuav raug cim, thiab yuav tsum ua raws li cov lus qhia kho mob.
(2) Ntim daim ntawv
Cov khoom ntim khoom: Aluminium tubes (lub teeb muaj zog tiv thaiv, tiv thaiv kev ruaj ntseg tshuaj) los yog yas hoses (lub teeb yuag thiab yooj yim nqa) feem ntau siv. Qee cov khoom siv siab- kawg siv lub taub hau tsis muaj menyuam tsim kom tsis txhob muaj kuab paug thib ob.
Specification thiab Peev Xwm: Cov lus qhia tshwj xeeb yog 10g / vial (portable) lossis 15g / vial (tsev), thiab qee lub npe muaj 30g ntim ntim loj kom tau raws li qhov ntev -cov kev xav tau kho.
Yeeb Nkab qhov ncauj tsim: Lub taw qhia lossis angled txiav tsim ua kom muaj kev tswj xyuas meej ntawm ib qho extrusion ntim (feem ntau yog 0.5-1cm paste ntev), txo cov khib nyiab; Kev tsim lub hau npog kev nyab xeeb rau menyuam yaus tuaj yeem tiv thaiv kev sib cuag tsis zoo.
Cov ntawv sau ntxiv: Lub npe tshuaj, qhov concentration (xws li 1%), ntau lawm batch naj npawb, hnub tas sij hawm, thiab "siv sab nraud" daim ntawv ceeb toom qhia meej meej ntawm lub ntim. Qee cov khoom tau nruab nrog cov neeg siv phau ntawv lossis cov lus qhia qhia.
Daim ntawv ntau npaum thiab cov yam ntxwv ntawm itracoazole ointment ncaj qha cuam tshuam rau nws cov txiaj ntsig thiab kev nyab xeeb. Piv txwv li, qhov kev ntxhib los mos ntawm qab zib yog qhov tsim nyog rau cov neeg mob lub caij ntuj sov lossis oily ntawm daim tawv nqaij, thaum lub zog moisturizing ntawm cov tshuaj pleev tuaj yeem txo cov tawv nqaij qhuav thaum lub caij ntuj no; Lub teeb thaiv kev tiv thaiv ntawm aluminium tube ntim pab tswj cov tshuaj ruaj khov thiab ua kom lub neej ntev. Cov neeg mob yuav tsum ua tib zoo tshuaj xyuas qhov tshwm sim ua ntej siv. Yog tias pom muaj xim tsis zoo, txheej txheej, lossis ntxhiab tsw hauv qab zib, nws yuav tsum tau nres tam sim ntawd thiab tus kws kho mob yuav tsum sab laj. Tsis tas li ntawd, kev khaws cia kom zoo (tsis txhob siv lub teeb, kaw, thiab khaws cia hauv chav sov) tuaj yeem ua kom cov tshuaj zoo thiab tsis txhob cuam tshuam rau kev ua tau zoo vim matrix deterioration.
Qhov zoo tshaj plaws itraconazole creamNws yog ib qho tshuaj tiv thaiv kab mob, nrog rau nws cov khoom tseem ceeb yog itraconzole, uas belongs rau triazole derivative class. Cov tshuaj no siv cov tshuaj tiv thaiv kab mob los ntawm inhibiting lub synthesis ntawm ergosterol, ib feem tseem ceeb ntawm fungal cell membranes, cuam tshuam kev ncaj ncees thiab permeability ntawm lub cell membrane, ua rau to ntawm fungal cell txheem thiab tuag.
1. Kab mob fungal superficial
Tinea manus (tus neeg ncaws pob ko taw, tinea manus): tshwm sim ntawm daim tawv nqaij erythema, hlwv, scaling, thiab khaus. Itraconzole tshuaj pleev tuaj yeem tua cov kab mob zoo thiab txo cov tsos mob.
Tinea corporis thiab tinea crus: feem ntau pom nyob rau hauv lub pob tw thiab puab tais, nthuav tawm raws li ncig erythema nrog nplai. Cov tshuaj pleev tuaj yeem siv ncaj qha rau thaj tsam cuam tshuam.
Pityriasis versicolor (hws me ntsis): tshwm sim los ntawm Malassezia, tus cwj pwm los ntawm depigmentation lossis deposition me ntsis. Itraconzole tuaj yeem cuam tshuam cov kab mob fungal thiab kho cov xim ntawm daim tawv nqaij.
Candidal papules: feem ntau pom nyob rau hauv quav xws li armpits thiab puab tais, yam ntxwv los ntawm moist erythema thiab satellite papules. Ointment tuaj yeem txo cov kab mob fungal.
2. Mucosal fungal kab mob
Qhov ncauj candidiasis: feem ntau pom nyob rau hauv cov me nyuam mos, cov me nyuam yaus, thiab cov neeg mob immunocompromised, tus cwj pwm los ntawm dawb thaj ua rau thaj thiab mob ntawm lub qhov ncauj mucosa. Itraconzole tshuaj pleev tuaj yeem siv rau hauv zos kom txo qis kev nqus dej.
Cov kab mob fungal ntawm qhov chaw mos: Txawm hais tias qhov chaw mos suppositories yog cov kev kho mob tseem ceeb, cov tshuaj pleev tuaj yeem siv tau los ua kev kho mob rau qhov chaw mos candidal dermatitis los txo qhov khaus thiab liab.
3. Cov kab mob tshwj xeeb
Botrytis cinerea thiab histiocytosis: Itraconzole ointment tuaj yeem siv los ua lwm txoj hauv kev thaum tsis siv tshuaj rau qhov ncauj lossis kev kho mob hauv zos.
Cov lus qhia rau kev tswj kev sib tham thiab kev siv tshuaj sib xyaw
Kev tswj hwm tshuaj sib cuam tshuam
Raws li ib qho tshuaj tiv thaiv kab mob triazole, itraconzole exerts nws cov nyhuv los ntawm inhibiting ergosterol synthesis ntawm fungal cell membranes. Txawm li cas los xij, nws cov metabolism yog nyob ntawm daim siab cytochrome P450 enzyme system (CYP3A4), yog li muaj kev pheej hmoo ntawm kev cuam tshuam nrog ntau yam tshuaj, uas yuav tsum tau tswj nruj:
CYP3A4 inhibitors, xws li antidepressants (fluoxetine), calcium channel blockers (nifedipine), immunosuppressants (cyclosporine), thiab lwm yam, tuaj yeem cuam tshuam cov metabolism ntawm itraconzole thaum siv ua ke, ua rau muaj kev nce hauv cov ntshav cov tshuaj concentration, nce kev pheej hmoo ntawm plawv toxicity (xws li QT ncua ntev), daim siab puas, thiab lwm yam.
Cov lus qhia txog kev tswj hwm: Tsis txhob ua ke nrog cov muaj zog CYP3A4 inhibitors; Yog tias tsim nyog, saib xyuas electrocardiogram, lub siab ua haujlwm, thiab cov tshuaj concentration, thiab kho qhov ntau npaum li cas.
CYP3A4 inducers, xws li tshuaj antiepileptic (phenytoin sodium, carbamazepine), tshuaj tiv thaiv tuberculosis (rifampicin), thiab lwm yam, tuaj yeem ua kom cov metabolism ntawm itraconzole thiab txo nws cov txiaj ntsig.
Cov lus qhia txog kev tswj hwm: Thaum siv ua ke, nws yog ib qho tsim nyog los saib xyuas kev tswj hwm ntawm cov kab mob fungal thiab nce koob tshuaj itraconzole lossis hloov kho cov phiaj xwm yog tias tsim nyog.
Warfarin: Itraconzole tuaj yeem cuam tshuam nws cov metabolism, txhim kho nws cov nyhuv anticoagulant, thiab ua rau muaj kev pheej hmoo los ntshav.
Digoxin: Itraconzole inhibits lub raum tubular secretion, ua rau kom nce qib ntawm digoxin ntshav, uas yuav ua rau arrhythmia.
Statins, xws li lovastatin thiab simvastatin, tuaj yeem ua rau muaj kev pheej hmoo ntawm rhabdomyolysis thaum siv ua ke.
Cov lus qhia txog kev tswj hwm: Thaum siv cov tshuaj saum toj no ua ke, nws yog ib qho tsim nyog yuav tsum tau saib xyuas cov ntsuas coagulation, digoxin concentration, thiab creatine kinase, kho cov koob tshuaj lossis hloov nrog cov tshuaj uas cuam tshuam rau cov metabolism (xws li fluvastatin).
Cov lus pom zoo thiab kev ceev faj rau kev sib xyaw ua ke
Raws li hom kab mob thiab tus neeg mob tus mob,zoo tshaj plaws itraconazole creamtuaj yeem siv ua ke nrog cov tshuaj hauv qab no, tab sis nruj me ntsis ua raws li cov lus qhia thiab contraindications yuav tsum tau:
Cov tshuaj tiv thaiv kab mob sab nraud, xws li ketoconazole cream thiab terbinafine cream, tuaj yeem siv ua ke nrog itraconzole cream los kho cov kab mob fungal ntawm daim tawv nqaij (xws li tinea pedis thiab tinea corporis).
Mechanism: Kev sib xyaw ua ke hauv zos tuaj yeem txhim kho cov tshuaj tiv thaiv kab mob thiab txo cov kev pheej hmoo ntawm cov tshuaj tiv thaiv.
Ceeb Toom: Tsis txhob siv cov tshuaj uas muaj zog ua kom khaus (xws li salicylic acid) ua ke los tiv thaiv kev puas tsuaj rau daim tawv nqaij.
Corticosteroids, xws li hydrocortisone cream, tuaj yeem siv ua ke nrog itraconzole cream rau luv luv -lub sij hawm kho cov kab mob fungal nrog mob hnyav (xws li pob khaus).
Mechanism: Hormones alleviate o, itraconzole clears fungi, thiab synergistically shortens kev kho mob.
Kev Ceeb Toom: Kev siv sijhawm ntev ua ke tuaj yeem ua rau muaj kev phiv tshuaj hormone (xws li tawv nqaij atrophy), thiab lub sijhawm siv yuav tsum nruj me ntsis (tsawg dua lossis sib npaug li 2 lub lis piam).
请替换当前内内 Architectural tsim & npaj cepteur sint occaecat cupidatat proident, coj kuv tus ntsuj plig tag nrho, zoo li cov qab zib thaum sawv ntxov lub caij nplooj ntoos hlav uas kuv txaus siab nrog kuv tag nrho...Khoos phis tawj tsim & kev npaj cepteur cov sint occaecat cupidatat tag nrho kuv lub caij nplooj ntoos hlav zoo li lub caij nplooj ntoo hlav, uas kuv nyiam heev. txaus siab nrog kuv tag nrho Lorem ipsum dolor zaum ament, consectetur adipisicing elit, sed ua eiusmod tempor incididunt labore thiab dolore magna aliqua. nws enim ad minim veniam.
Qhov ncauj itraconzole: haum rau cov kab mob loj lossis kis kab mob (xws li tinea capitis thiab onychomycosis), cov tshuaj pleev xim tuaj yeem pab tswj cov tsos mob hauv zos.
Ceeb Toom: Cov tshuaj yuav tsum saib xyuas lub siab ua haujlwm thiab tsis txhob ua ke nrog cov tshuaj hepatotoxic (xws li acetaminophen).
teeb meem xav tau kev saib xyuas:
Cov teebmeem ntawm lub siab
Hauv cov neeg ua haujlwm noj qab haus huv siv itraconzole, ib ntus, asymptomatic txo qis ntawm sab laug ventricular ejection feem, uas ploj ntawm nws tus kheej ua ntej txhaj tshuaj ntxiv. Itraconzole tau pom qhov tsis zoo inotropic cuam tshuam thiab muaj qee yam cuam tshuam nrog cov lus ceeb toom ntawm lub plawv tsis ua haujlwm. Qhov tshwm sim ntawm qhov tshwm sim ntawm lub plawv tsis ua hauj lwm yog siab dua nyob rau hauv cov neeg mob nrog ib koob tshuaj txhua hnub ntawm 400mg piv rau cov tshuaj uas qis dua, qhia tau hais tias qhov kev pheej hmoo ntawm lub plawv tsis ua hauj lwm yuav nce ntxiv nrog cov koob tshuaj txhua hnub ntawm cov khoom no.
Itraconzole yuav tsum tsis txhob siv rau cov neeg mob uas muaj lub plawv tsis ua haujlwm lossis keeb kwm ntawm lub plawv tsis ua haujlwm, tshwj tsis yog tias cov txiaj ntsig zoo tshaj qhov tsis zoo. Cov yam tseem ceeb uas yuav tsum tau xav txog hauv kev ntsuam xyuas ntawm tus kheej cov txiaj ntsig thiab qhov tsis zoo suav nrog qhov hnyav ntawm tus kab mob, hom kev tswj hwm (xws li koob tshuaj txhua hnub), thiab tus neeg muaj feem cuam tshuam rau lub plawv tsis ua haujlwm. Cov kev pheej hmoo no suav nrog kab mob plawv, xws li ischemic lossis valvular heart disease; Cov kab mob ntsws hnyav, xws li mob ntsws obstructive pulmonary; Lub raum tsis ua haujlwm thiab lwm yam kab mob edematous. Cov kws kho mob yuav tsum qhia rau cov neeg mob no txog cov tsos mob thiab cov tsos mob ntawm congestive lub plawv tsis ua hauj lwm, siv tshuaj ceev faj, thiab saib xyuas lawv cov tsos mob thiab cov tsos mob ntawm congestive lub plawv tsis ua hauj lwm thaum kho. Yog tias cov tsos mob thiab cov tsos mob tshwm sim thaum kho, kev kho mob nrog itraconzole yuav tsum tau nres.
Calcium channel blockers muaj qhov tsis zoo inotropic, uas txhim kho cov nyhuv ntawm itraconzole. Tsis tas li ntawd, itraconzole tuaj yeem cuam tshuam cov metabolism ntawm calcium channel blockers, thiab kev pheej hmoo ntawm lub plawv tsis ua haujlwm nce ntxiv thaum ua ke nrog itraconzole thiab calcium channel blockers, uas yuav tsum tau saib xyuas.
Cim npe nrov: zoo tshaj plaws itraconazole qab zib, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom