Bethanechol Creamyog ib qho tshuaj cholinergic los ntawm nws cov tshuaj muaj pes tsawg leeg thiab tuaj yeem txhawb nqa muscarinic acetylcholine receptors (mAChR). Thaum tsim los ua ib lub qab zib, nws tuaj yeem txhawb nqa cholinergic receptors hauv cov ntaub so ntswg hauv zos los ntawm kev siv tshuaj pleev. Nws yog siv nyob rau hauv kev kho mob rau cov mob ntawm lub zos du nqaij dysfunction. Piv txwv li, nyob rau hauv qee cov neeg mob uas tsis muaj zog zais zis detrusor nqaij contraction vim lub zos neurogenic dysfunction, tshuaj pleev ib ce ntawm cov tshuaj pleev ib ce tuaj yeem txhawb nqa mAChR ntawm lub zais zis detrusor leeg, yog li txhim kho detrusor contraction thiab pab txhim kho voiding muaj nuj nqi. Hais txog lub plab zom mov, thaum siv rau cov cheeb tsam uas qeeb hauv zos plab hnyuv motility, nws muaj peev xwm txhawb txoj hnyuv motility, pab txhawb rau cov kev pab ntawm cov tsos mob hauv zos xws li plab hnyuv thiab plab hnyuv.
Daim ntawv ntau npaum yog qab zib, tab sis tam sim no tsis muaj kev lees paub dav dav kev sib koom ua ke. Cov lus qhia tshwj xeeb ntawm cov tshuaj nplaum feem ntau yog teem los ntawm cov khoom xws li cov tshuaj concentration thiab lub peev xwm ntim. Piv txwv li, tej zaum yuav muaj ntau qhov sib txawv ntawm cov nplaum nplaum, xws li 1%, 2%, thiab lwm yam., thiab lub peev xwm ntim kuj tuaj yeem muaj ntau yam xws li 10g, 20g, 30g, thiab lwm yam, kom tau raws li qhov xav tau ntawm cov neeg mob sib txawv. Txawm li cas los xij, cov kev qhia tshwj xeeb no tsuas yog ua raws li kev xav ntawm cov qauv tshuaj pleev ib ce, thiab qhov tshwj xeebBethanechol Creamspecifications yuav tsum tau txiav txim raws li qhov tseeb ntau lawm thiab kev kho mob daim ntawv thov.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb Cov Khoom
Bethanechol +. COA
Pharmacological teebmeem thiab cov yam ntxwv
(1) Kev sib cuam tshuam nrog cov tshuaj anticholinesterase
Mechanism ntawm kev ua: Anticholinesterase tshuaj xws li Neostigmine tuaj yeem cuam tshuam cholinesterase kev ua haujlwm, txo cov hydrolysis ntawm acetylcholine, thiab yog li ua kom cov concentration ntawm acetylcholine hauv synaptic cleft.
Kev cuam tshuam kev kho mob: Tej zaum yuav ua rau muaj kev sib kis ntau dhau ntawm cov nqaij ntshiv plab, ua rau muaj kev phiv xws li mob plab, raws plab, xeev siab, ntuav, thiab lwm yam; Nyob rau hauv cov ntsiab lus ntawm cov zis, nws yuav ua rau lub zais zis ntau dhau detrusor cov leeg, ua rau kom nquag tso zis, ceev, mob thaum tso zis, thiab txawm tias urinary incontinence; Nws kuj tseem tuaj yeem ua rau cov leeg nqaij bronchial du, ua rau mob hawb pob lossis ua rau mob hawb pob, thiab ua rau cov hlab plawv tsis zoo xws li lub plawv dhia qeeb thiab txo cov ntshav siab. Kev ntsuas teb: Kev sib xyaw ua ke ntawm ob yuav tsum zam. Yog tias tsim nyog siv lawv ua ke, tus neeg mob cov tsos mob thiab cov tsos mob yuav tsum tau saib xyuas kom zoo, thiab cov tshuaj noj yuav tsum tau hloov kho lossis txiav tawm raws li qhov hnyav ntawm qhov tshwm sim tsis zoo.
(2) Kev sib cuam tshuam nrog M receptor antagonists
Mechanism of action: M receptor antagonists xws li atropine thiab scopolamine tuaj yeem thaiv mAChR thiab inhibit qhov cuam tshuam ntawm cholinergic neurons. Thaum siv ua ke nrog Bethanecol, nws tiv thaiv cov teebmeem ntawm Bethanecol thiab txo nws txoj kev kho mob.
Kev cuam tshuam kev kho mob: Yog tias M receptor antagonists siv ib txhij hauv kev kho mob plab hnyuv atony, tso zis tso quav thiab lwm yam kab mob, Bethanecol yuav tsis zoo ua lub luag haujlwm ntawm kev txhawb nqa plab hnyuv thiab lub zais zis detrusor contraction, ua rau kev kho mob tsis zoo.
Kev ntsuas teb: Tsis txhob siv ob qho tshuaj ib txhij. Yog tias tus neeg mob tam sim no siv M receptor antagonist, nws yuav tsum txiav tawm ib ntus, nyob ntawm ib nrab ntawm - lub neej ntawm cov tshuaj thiab tus neeg mob tus mob.
(1) Kev sib cuam tshuam nrog cov leeg nqaij du
Cov txheej txheem ntawm kev ua: Cov leeg nqaij du xws li nifedipine, verapamil, thiab lwm yam calcium channel blockers tuaj yeem cuam tshuam cov calcium ions nkag mus rau hauv cov leeg nqaij, ua rau cov leeg nqaij du. Bethanecol induces smooth nqaij contraction los ntawm stimulating mAChR, thaum ob qho tib si cuam tshuam.
Kev cuam tshuam kev kho mob: thaum siv ua ke, nws tuaj yeem cuam tshuam qhov kev ua tau zoo ntawm ib leeg, cuam tshuam rau kev kho mob ntawm plab hnyuv so, tso zis tso quav thiab lwm yam kab mob. Piv txwv li, hauv kev kho mob plab hnyuv laxity, kev txhawb nqa ntawm Bethanecol ntawm lub plab zom mov tuaj yeem ua rau tsis muaj zog los ntawm cov leeg nqaij so, ua rau qeeb rov qab ntawm plab hnyuv motility.
Kev ntsuas teb: Sim tsis txhob siv ob qho tshuaj ua ke. Yog tias lawv yuav tsum tau siv ua ke, ua tib zoo saib tus neeg mob qhov kev hloov pauv thiab kho cov tshuaj ntau npaum li cas raws li kev kho mob.
(2) Kev sib cuam tshuam nrog cov tshuaj uas cuam tshuam rau cov leeg nqaij uterine
Mechanism of action: Qee cov tshuaj xws li oxytocin tuaj yeem ua rau cov leeg nqaij du, thaum Bethanecol kuj muaj qee yam excitatory nyhuv ntawm uterine du nqaij. Kev sib xyaw ua ke ntawm ob tuaj yeem txhim kho qhov stimulation ntawm uterine du nqaij, ua rau ntau dhau uterine contractions.
Kev cuam tshuam hauv kev kho mob: Hauv kev ua menyuam yaus, nws tuaj yeem ua rau muaj teeb meem loj xws li kev nyuaj siab ntawm fetal thiab uterine rupture. Tshwj xeeb tshaj yog nyob rau hauv cov poj niam cev xeeb tub los yog tom qab yug me nyuam, yuav tsum tau ceev faj thaum siv nws.
Kev ntsuas teb: Rau cov poj niam cev xeeb tub thiab tom qab yug me nyuam, kev sib xyaw ntawm Bethanecol thiab oxytocin yuav tsum raug zam. Yog tias tsim nyog siv nws vim qhov xwm txheej, nws yuav tsum tau ua raws li kev saib xyuas zoo thiab kev npaj pab thawj zaug yuav tsum tau ua.
(2) Kev sib cuam tshuam nrog cov tshuaj digitalis
Mechanism of action: Cov tshuaj Digitalis xws li digoxin tuaj yeem txhim kho myocardial contractility thiab ua rau lub plawv dhia qeeb. Lub bradycardia tshwm sim los ntawm Bethanecol tuaj yeem ua ke nrog cov teebmeem ntawm cov tshuaj digitalis, ua rau muaj kev pheej hmoo ntawm plawv nres.
Kev cuam tshuam ntawm kev kho mob: Tej zaum yuav ua rau arrhythmia, xws li bradycardia, atrioventricular block, thiab lwm yam, uas tuaj yeem ua rau lub neej - hem hauv qhov mob hnyav.
Kev ntsuas teb: Bethaechol yuav tsum zam rau cov neeg mob siv cov tshuaj digitalis. Yog tias tsim nyog siv vim yog qhov mob, ua tib zoo saib xyuas cov kev hloov hauv electrocardiogram thiab kho cov tshuaj noj kom raws sijhawm.
(1) Kev sib cuam tshuam nrog cov tshuaj tiv thaiv kab mob
Mechanism of action: Qee cov tshuaj tiv thaiv kev puas siab puas ntsws xws li chlorpromazine muaj cov nyhuv anticholinergic thiab tuaj yeem thaiv mAChR. Thaum siv ua ke nrog Bethanecol, nws antagonizes cov teebmeem ntawm Bethanecol.
Kev cuam tshuam kev kho mob: txo cov kev ua tau zoo ntawm Bethanecol hauv kev kho mob ntawm plab hnyuv atony, tso zis tso quav thiab lwm yam kab mob.
Kev ntsuas teb: Tsis txhob siv ob qho tib si tib lub sijhawm. Yog tias tus neeg mob siv cov tshuaj tiv thaiv kev puas siab puas ntsws, txoj kev kho mob yuav tsum tau hloov kho raws li tus kws kho mob cov lus qhia.
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(2) Kev sib cuam tshuam nrog cov tshuaj tiv thaiv
Mechanism ntawm kev ua: Thawj tiam antihistamines xws li diphenhydramine muaj anticholinergic teebmeem thiab tuaj yeem thaiv mAChR. Kev sib xyaw nrog Bethanecol tuaj yeem tsim cov teebmeem antagonistic.
Kev cuam tshuam kev kho mob: cuam tshuam rau kev ua tau zoo ntawm Bethanecol thiab txo cov nyhuv kho.
Kev ntsuas teb: Sim tsis txhob siv ob qho tshuaj ua ke. Yog tias lawv yuav tsum tau siv ua ke, ua tib zoo saib tus neeg mob qhov kev hloov pauv thiab kho cov tshuaj ntau npaum li cas raws li kev kho mob.
kev siv thiab ntau npaum li cas
Cov tshuaj no tsuas yog siv rau sab nraud xwb. Thov nruj me ntsis rau thaj chaw cuam tshuam raws li tau hais hauv cov lus qhia. Ua ntej siv, ntxuav qhov chaw raug mob kom huv si, qhuav nws, thiab xyuas kom meej tias nws nyob twj ywm thiab tsis puas. Siv cov tshuaj nplaum tsim nyog sib npaug rau thaj tsam cuam tshuam, tom qab ntawd maj mam zaws rau lub sijhawm luv kom tso cai nqus. Tsis txhob sib cuag nrog cov mucous daim nyias nyias xws li qhov muag, qhov ncauj, thiab qhov ntswg kom tiv thaiv kev khaus.
Tam sim no tsis muaj kev sib koom ua ke ntawm kev siv tshuaj, thiab qhov ntau npaum li cas yuav txawv nyob ntawm seb tus neeg mob tus mob, hnub nyoog, qhov hnyav, qhov chaw thiab qhov chaw ntawm qhov txhab. Feem ntau hais lus, cov kws kho mob yuav tsim cov phiaj xwm tshuaj kho tus kheej raws li cov xwm txheej tshwj xeeb ntawm cov neeg mob. Piv txwv li, rau cov neeg mob uas muaj qhov txhab me me, cov tshuaj nplaum me me tuaj yeem siv txhua zaus; Rau cov neeg mob uas muaj qhov txhab loj dua lossis mob hnyav dua, nws yuav tsum tau nce qhov koob tshuaj kom tsim nyog. Feem ntau, kev siv txhua hnub yuav yog 2-4 zaug, tab sis qhov tshwj xeeb zaus yuav tsum ua raws li tus kws kho mob cov lus qhia.
Qhov zaus thiab lub sijhawm ntawm cov tshuaj yuav tsum raug kho raws li tus neeg mob qhov kev hloov pauv thiab cov lus teb rau kev kho mob. Nyob rau theem pib ntawm kev kho mob, cov tshuaj nquag yuav tsum tau tswj cov tsos mob sai li sai tau. Raws li tus mob zoo tuaj, qhov zaus ntawm cov tshuaj tuaj yeem txo qis. Qhov ntev ntawm kev kho mob kuj txawv nyob ntawm tus kab mob, thiab qee cov kab mob hnyav yuav tsum tsis txhob noj tshuaj tom qab cov tsos mob tau txo qis hauv lub sijhawm luv luv; Rau qee cov kab mob ntev, kev kho mob ntev - yuav tsim nyog. Cov kws kho mob yuav tshuaj xyuas tus neeg mob tsis tu ncua thiab txiav txim siab seb puas yuav siv tshuaj ntxiv lossis kho cov phiaj xwm kho mob.
Cov lus nug nquag
Yuav ua li cas kom tsis txhob tsaug zog?
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Txhawm rau kom tsis txhob tsaug zog los ntawm kev tso zis (nocturia), txwv cov kua dej, caffeine, thiab cawv rau ob peb teev ua ntej pw, tso zis ua ntej pw, thiab tsa koj ob txhais ceg thaum yav tsaus ntuj kom txo cov kua dej; yog tias kev hloov pauv txoj kev ua neej tsis pab, mus ntsib kws kho mob kom txiav txim siab txog cov teeb meem xws li pw tsaug zog apnea lossis zais zis ntau dhau.
Dab tsi yog cov tshuaj zoo tshaj plaws rau kev tso zis?
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Tsis muaj ib qho tshuaj "zoo tshaj" rau kev tso zis (UI); Nws nyob ntawm hom (kev xav, kev ntxhov siab, sib xyaw) thiab ua rau, tab sis cov kev xaiv muaj xws li cov tshuaj anticholinergics (oxybutynin, tolterodine, solifenacin) thiab beta -3 agonists (mirabegron) rau lub zais zis ntau dhau, so lub zais zis cov leeg, thaum SNRIs (duloxetine) pab kev ntxhov siab hauv pem teb los ntawm kev ntxiv dag zog rau cov hlab ntsha (mirabegron) thiab ntxiv dag zog rau cov hlab ntshav. pab cov txiv neej nrog cov teeb meem prostate. Cov tshuaj estrogen tuaj yeem pab cov poj niam, thiab kev txhaj tshuaj Botox yog siv rau cov mob hnyav.
Puas yog tso zis txhua 2 teev ib txwm?
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Kev tso zis txhua 2 teev (lossis 10-12 zaug hauv ib hnub) tuaj yeem yog qhov qub yog tias koj haus dej ntau, cev xeeb tub, lossis noj cov tshuaj diuretics, tab sis nws nquag tshaj li 6-8 zaug hauv ib hnub thiab tej zaum yuav ua rau lub zais zis ntau dhau (OAB) lossis lwm qhov teeb meem yog tias nws cuam tshuam lub neej lossis los nrog lwm cov tsos mob xws li mob ceev lossis mob, mus ntsib kws kho mob.
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