Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm acriflavine qab zib nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo acriflavine qab zib rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Acriflavine creamyog ib qho kev npaj sab nraud uas muaj cov khoom ntawm acriflavine (CAS: 8048-}52-0, molecular formula C₂₇H₂₅ClN₆, molecular hnyav 468.98), txiv kab ntxwv-xim av crystalline hmoov soluble nyob rau hauv dej thiab ethanol tsis tau yoog mus rau photodegradation cov ntaub ntawv raw khoom kom ruaj khov thiab ruaj khov.
Raws li heterocyclic aromatic compound nrog ntau yam kev ua haujlwm lom neeg, nws muaj keeb kwm ntev ntawm kev siv hauv kev kho mob. Los ntawm qhov kev xav ntawm cov yam ntxwv muaj pes tsawg leeg, nws tuaj yeem siv los ua cov fluorescent zas xim rau kev sau ntawv siab molecular hnyav RNA thiab muaj qee yam kev siv tus nqi hauv kev tshawb fawb biochemistry. Lub caij no, nws tseem yog ib qho khoom noj khoom haus hauv zos classic, qhia tias nws yuav muaj qhov dav -spectrum inhibitory nyhuv ntawm gram- cov kab mob zoo thiab cov kab mob ib nrab thiab pab tiv thaiv kab mob ntawm daim tawv nqaij. Cov tshuaj nplaum yuav siv tau rau kev kho mob ntawm qee yam kab mob ntawm daim tawv nqaij, xws li daim tawv nqaij o thiab rwj los ntawm cov kab mob los yog fungi. Los ntawm embedding mus rau hauv cov kab mob cell lug mus suppress microbial metabolism thiab inhibit qhov kev loj hlob thiab kev yug me nyuam ntawm pathogens, txhawb cov gradual kho ntawm puas daim tawv nqaij qhov txhab.
Peb cov khoom
Cov ntaub ntawv ntxiv ntawm chemical compound:
| Khoom npe | Acriflavine Cream | Acriflavine hmoov | Acriflavine ntsiav tshuaj |
| Yam khoom | Cream | Hmoov | Cov ntsiav tshuaj |
| Khoom Purity | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% | Ntau dua lossis sib npaug li 99% |
| Khoom Specifications | Customizable | Customizable | Customizable |
| Pob khoom | Customizable | Customizable | Customizable |
Peb Cov Khoom
Acriflavine COA
 |
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Certificate of Analysis |
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Compound npe |
Acriflavine | |
|
CAS Nr. |
590-63-6 | |
|
Qib |
Pharmaceutical qib | |
|
Ntau |
Customized | |
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Ntim txheem |
Customized | |
| Chaw tsim tshuaj paus | Shaanxi BLOOM TECH Co., Ltd | |
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Ntau No. |
20250109002 |
|
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MFG |
Jan 12th 2026 |
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EXP |
Jan 8th 2029 |
|
|
Qauv |
|
|
| TEST STANDARD | GB/T24768-2009 Kev lag luam. Stnndard | |
|
Yam khoom |
Enterprise txheem |
Kev txheeb xyuas qhov tshwm sim |
|
Qhov tshwm sim |
Dawb los yog yuav luag dawb hmoov |
Ua raws |
|
Cov ntsiab lus dej |
Tsawg dua lossis sib npaug li 4.5% |
0.30% |
| Poob rau ziab |
Tsawg dua lossis sib npaug li 1.0% |
0.15% |
|
Hnyav Hlau |
Pb Tsawg dua lossis sib npaug li 0.5ppm |
N.D. |
|
Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Hg Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Cd Tsawg dua lossis sib npaug li 0.5ppm |
N.D. | |
|
Purity (HPLC) |
Ntau dua lossis sib npaug li 99.0% |
99.5% |
|
Ib qho impurity |
<0.8% |
0.48% |
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Residue ntawm ignition |
<0.20% |
0.064% |
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Tag nrho microbial suav |
Tsawg dua lossis sib npaug li 750cfu / g |
80 |
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E. Coli |
Tsawg dua lossis sib npaug li 2MPN / g |
N.D. |
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Salmonella |
N.D. | N.D. |
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Ethanol (los ntawm GC) |
Tsawg dua lossis sib npaug li 5000ppm |
400ppm ua |
|
Cia |
Khaws rau hauv qhov chaw kaw, tsaus thiab qhuav ntawm -20 degrees |
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|
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Acriflavine cream, raws li qhov sib xyaw nrog keeb kwm ntev, nthuav tawm ntau lub tswv yim ntawm kev ua haujlwm hauv thaj chaw ntawm biology thiab tshuaj, suav nrog tshuaj tua kab mob, tiv thaiv- qog, tshuaj tua kab mob, thiab kev kho mob photodynamic.
Antibacterial mechanism
(1) Embedding DNA cuam tshuam nrog kev rov ua dua thiab hloov pauv
Acriflavine cuam tshuam ncaj qha rau DNA replication thiab transcription los ntawm embedding ob stranded kab mob DNA, cuam tshuam lub helical qauv ntawm DNA. Hauv cov txheej txheem ntawm cov kab mob loj hlob, DNA replication thiab transcription yog cov kauj ruam tseem ceeb. Cov nyhuv embedding ntawm Acriflavine tiv thaiv DNA polymerase thiab RNA polymerase los ntawm kev khi kom zoo, ua rau replication thiab transcription yuam kev los yog txiav, yog li inhibiting kab mob loj hlob thiab kev loj hlob.
Cov txheej txheem ntawm kev ua haujlwm no muaj txiaj ntsig zoo rau ntau yam kab mob Gram zoo thiab Gram tsis zoo, suav nrog Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, thiab lwm yam.
(2) inhibit cov kab mob protein synthesis
Acriflavine tuaj yeem khi rau cov kab mob ribosomes, cuam tshuam nrog cov txheej txheem protein synthesis. Ribosomes yog qhov chaw ntawm cov kab mob protein synthesis, thiab kev khi ntawm Acriflavine hloov pauv kev sib haum xeeb ntawm ribosomes, cuam tshuam rau kev thauj cov amino acids thiab txuas ntxiv ntawm peptide chains, ua rau cov kab mob tsis tuaj yeem tsim cov proteins nrog cov haujlwm zoo li qub.Proteins yog lub hauv paus ntawm cov kab mob hauv lub neej.
Thiab lawv cov synthesis thaiv tuaj yeem cuam tshuam rau cov kab mob metabolic thiab kev ua haujlwm, thaum kawg ua rau cov kab mob tuag.
(3) Kev cuam tshuam ntawm cov kab mob cell membrane ua haujlwm
Acriflavine muaj kev puas tsuaj rau cov kab mob cell membranes. Cov kab mob cell membrane yog ib qho teeb meem tseem ceeb rau kev tswj kev ruaj ntseg ntawm qhov chaw intracellular thiab extracellular ib puag ncig. Acriflavine tuaj yeem hloov pauv permeability ntawm cov cell membrane, ua rau kom cov ions thiab cov molecules me me los ntawm lub cell, ua rau muaj kev tsis sib haum xeeb nyob rau hauv ib puag ncig intracellular. Nyob rau tib lub sijhawm, nws kuj tseem tuaj yeem cuam tshuam nrog kev ua haujlwm enzyme ntawm lub cell membrane, cuam tshuam rau lub zog ntawm tes metabolism thiab cov khoom thauj, ua rau muaj kev puas tsuaj ntxiv rau cov kab mob.
Mechanism ntawm kev tiv thaiv- qog ua haujlwm
(1) Inhibition ntawm HIF-1 kev ua
Acriflavine yog ib qho zoo HIF-1 (hypoxia inducible factor-1) inhibitor. HIF-1 plays lub luag haujlwm tseem ceeb hauv qhov tshwm sim, kev loj hlob, thiab metastasis ntawm cov qog nqaij hlav, vim nws tuaj yeem tswj cov metabolism, angiogenesis, ntxeem tau, thiab metastasis ntawm cov qog hlwb. Nyob rau hauv cov xwm txheej hypoxic, HIF-1 yog qhib, txhawb kev qhia ntawm cov noob caj noob ces muaj feem xyuam rau cov qog loj hlob thiab metastasis. Acriflavine inhibits qhov kev ua ntawm HIF-1 los ntawm kev thaiv nws cov dimerization nrog HIF-1 subunit, yog li suppressing cov kev ua ntawm HIF-1 thiab txo cov kev qhia ntawm downstream lub hom phiaj noob.
Xws li VEGF (vascular endothelial kev loj hlob zoo) thiab PGK1 (phosphoglycerate kinase 1), yog li inhibiting qog angiogenesis thiab kev loj hlob thiab inducing qog cell apoptosis.
(2) Inhibition ntawm DNA replication thiab transcription nyob rau hauv cov qog hlwb
Zoo ib yam li nws cov tshuaj tua kab mob, Acriflavine tseem tuaj yeem nkag mus rau hauv ob npaug DNA ntawm cov qog hlwb, cuam tshuam nrog DNA replication thiab transcription. Cov qog hlwb muaj cov yam ntxwv ntawm kev loj hlob sai thiab nquag DNA replication thiab transcription ua si. Cov nyhuv embedding ntawm Acriflavine tuaj yeem ua rau DNA replication yuam kev thiab transcriptional abnormalities nyob rau hauv cov qog hlwb, cuam tshuam rau ib txwm cell division thiab proliferation, thaum kawg ua rau qog cell tuag.
(3) Inducing apoptosis ntawm qog hlwb
Acriflavine creamtuaj yeem ua rau qog cell apoptosis los ntawm ntau txoj hauv kev. Ntawm qhov tod tes, nws tuaj yeem ua rau apoptotic signaling txoj hauv kev hauv hlwb, xws li txoj hauv kev mitochondrial thiab txoj kev tuag receptor, ua rau kev tso tawm ntawm cytochrome c thiab ua kom muaj kev cuam tshuam caspase cascade, thaum kawg ua rau lub cell apoptosis. Ntawm qhov tod tes, tom qab inhibiting HIF-1 kev ua ub no, Acriflavine hloov cov metabolic ib puag ncig ntawm qog hlwb, muab tso rau hauv lub xeev oxidative kev nyuaj siab thiab inducing cell apoptosis.
(4) Photodynamic therapy effect
Acriflavine muaj peev xwm rau kev kho mob photodynamic. Nyob rau hauv ib lub teeb lub teeb irradiation, Acriflavine tuaj yeem nqus lub teeb lub zog thiab zoo siab rau lub xeev zoo siab, tom qab ntawd hloov lub zog nrog cov pa ib puag ncig los tsim cov pa oxygen reactive xws li singlet oxygen. Cov hom pa oxygen reactive no muaj zog oxidizing zog thiab tuaj yeem ua rau cov cell membrane, proteins, thiab DNA ntawm cov qog hlwb, ua rau qog cell tuag. Photodynamic therapy muaj cov yam ntxwv ntawm kev xaiv tua cov qog hlwb thiab ua rau muaj kev puas tsuaj tsawg rau cov ntaub so ntswg ib puag ncig.
Mechanism ntawm antiviral kev txiav txim
(1) cuam tshuam nrog tus kab mob DNA replication
Rau qee cov kab mob DNA, Acriflavine tuaj yeem embed ob chav stranded kab mob DNA, cuam tshuam tus kab mob tus txheej txheem replication. Thaum cov kab mob rov ua dua hauv cov tswv tsev, lawv yuav tsum tau siv cov tswv tsev cell enzymes thiab cov ntaub ntawv raw rau DNA synthesis. Cov nyhuv embedding ntawm Acriflavine tuaj yeem cuam tshuam cov qauv ntawm cov kab mob DNA, tiv thaiv kev sib khi ib txwm thiab txuas ntxiv ntawm tus kab mob DNA polymerase, thiab yog li inhibit viral replication.
(2) Inhibition ntawm viral protein synthesis
Acriflavine kuj tseem tuaj yeem cuam tshuam cov synthesis ntawm cov kab mob kis kab mob. Cov synthesis ntawm cov kab mob kis kab mob nyob ntawm ribosome thiab kev txhais lus ntawm tus tswv tsev cell.
Lub tshuab uas Acriflavine khi rau cov kab mob ribosomes thiab cuam tshuam nrog cov protein synthesis kuj tseem siv tau rau kev sib txuas ntawm cov protein. Nws tuaj yeem cuam tshuam cov kab mob sib xyaw ua ke los ntawm kev hloov pauv txoj haujlwm ntawm ribosomes lossis cuam tshuam nrog kev txhais cov kab mob mRNA, yog li cuam tshuam rau tus kab mob sib dhos thiab tso tawm.
(3) Ua kom puas lub hnab ntawv viral
Rau qee lub hnab ntawv kab mob, Acriflavine tuaj yeem cuam tshuam cov qauv ntawm lub hnab ntawv viral. Lub hnab ntawv viral yog ib qho tseem ceeb ntawm cov kab mob kis, uas tiv thaiv cov kab mob nucleic acid thiab koom nrog cov txheej txheem adsorption thiab fusion ntawm tus kab mob thiab cov cell cell. Acriflavine tuaj yeem hloov pauv qhov permeability thiab ruaj khov ntawm lub hnab ntawv viral los ntawm kev cuam tshuam nrog lipids lossis cov proteins ntawm lub hnab ntawv, ua rau lub hnab ntawv viral tawg thiab ua rau tus kabmob tsis tuaj yeem kis tau.
Mechanism ntawm kev ua ntawm cov kab mob
(1) cuam tshuam nrog cov kab mob parasite metabolism
Acriflavine muaj kev cuam tshuam rau cov kab mob cab xws li cov kab mob pear zoo li kab mob, cov qe ntshav liab lub cev, nees Babesia, cowpea Babesia, bovine Babesia, thiab yaj Babesia. Nws tuaj yeem cuam tshuam nrog lub zog metabolism hauv txoj hauv kev ntawm cov kab mob cab, xws li inhibiting kev ua haujlwm ntawm cov enzymes tseem ceeb xws li glycolysis, tricarboxylic acid voj voog, lossis electron thauj saw, ua rau tsis muaj zog txaus rau cov kab mob thiab cuam tshuam rau lawv txoj kev loj hlob thiab kev loj hlob.
(2) Kev puas tsuaj ntawm cov kab mob cab kab mob
Acriflavine kuj tseem tuaj yeem ua rau cov kab mob ntawm cov kab mob cab, xws li cell membranes thiab organelles. Nws tuaj yeem hloov pauv permeability ntawm cov kab mob cab cell membranes, ua rau kom cov ions thiab cov molecules me me los ntawm cov cell, ua rau muaj kev tsis sib haum xeeb hauv ib puag ncig intracellular. Nyob rau tib lub sijhawm, nws tuaj yeem cuam tshuam kev ua haujlwm ntawm organelles xws li mitochondria thiab endoplasmic reticulum, cuam tshuam rau kev ua haujlwm ntawm lub cev ntawm cov cab thiab thaum kawg ua rau cov kab mob tuag taus.
Lwm yam kev siv tshuaj lom neeg ntawm kev ua
(1) inhibit zus tau tej cov inflammatory yam
Acriflavine tuaj yeem inhibit qhov tsim thiab tso tawm ntawm ntau yam inflammatory yam, xws li qog necrosis factor - (TNF -), interleukin-1 (IL-1), thiab lwm yam. Inflammatory factor plays lub luag haujlwm tseem ceeb hauv cov lus teb inflammatory, thiab lawv cov khoom ntau dhau tuaj yeem ua rau cov ntaub so ntswg puas thiab exacerbation ntawm inflammatory teb. Acriflavine muaj peev xwm kho tus nqi rau cov kab mob inflammatory los ntawm inhibiting zus tau tej cov inflammatory yam thiab txo cov inflammatory teb.
(2) Antioxidant nyhuv
Acriflavine muaj peev xwm tshem tawm cov dawb radicals thiab tiv thaiv cov hlwb los ntawm kev puas tsuaj oxidative kev nyuaj siab. Dawb radicals yog cov nquag nquag molecules tsim thaum lub sij hawm cellular metabolism, uas tuaj yeem tua biomolecules xws li DNA, proteins, thiab lipids hauv hlwb, ua rau cell puas thiab laus. Cov nyhuv antioxidant ntawm Acriflavine tuaj yeem cuam tshuam cov dawb radicals, txo cov cellular puas los ntawm oxidative kev nyuaj siab, thiab muaj txiaj ntsig zoo rau ncua kev laus thiab tiv thaiv kab mob.
Cov xwm txheej cuam tshuam rau lub tshuab ua haujlwm
(1) Concentration dependence
Cov teebmeem lom ntawm Acriflavine yog nyob ntawm qhov concentration. Lub tshuab thiab cov nyhuv ntawm nws qhov kev ua yuav txawv ntawm qhov sib txawv. Piv txwv li, ntawm qhov tsis tshua muaj siab, nws feem ntau tuaj yeem siv tshuaj tua kab mob lossis tshuaj tua kab mob, inhibiting microbial kev loj hlob los ntawm kev cuam tshuam nrog DNA replication lossis protein synthesis; Thaum muaj siab ntau, nws kuj tseem tuaj yeem muaj qee yam tshuaj lom neeg lub cev, thaum txhim kho nws cov tshuaj tiv thaiv - qog lossis photodynamic kho kom zoo.
(2) Teeb pom kev zoo
Rau cov nyhuv photodynamic kho ntawm Acriflavine, teeb pom kev zoo yog qhov tseem ceeb. Lub wavelength, siv, thiab lub sij hawm ntawm lub teeb raug yuav cuam tshuam cov photosensitization efficiency ntawm Acriflavine thiab zus tau tej cov reactive oxygen hom.Lub excitation muaj peev xwm ntawm Acriflavine nws txawv nrog txawv wavelengths ntawm lub teeb, thiab ib tug uas tsim nyog wavelength yuav pab tau nws kom zoo dua nqus lub teeb zog thiab tsim reactive oxygen hom. Qhov kev siv thiab lub sijhawm ntawm lub teeb kuj yuav tsum tau tswj xyuas kom meej kom muaj kev puas tsuaj tsawg rau cov ntaub so ntswg ib puag ncig thaum tua cov qog hlwb.
(3) Cell hom thiab lub xeev
Qhov rhiab heev ntawm ntau hom hlwb rau Acriflavine yuav txawv. Cov qog hlwb tuaj yeem nkag siab ntau dua rau Acriflavine vim lawv qhov loj hlob sai thiab cov yam ntxwv metabolic. Tsis tas li ntawd, lub xeev ntawm cov hlwb kuj tuaj yeem cuam tshuam cov txiaj ntsig ntawm Acriflavine, xws li qog hlwb hauv lub xeev hypoxic uas yuav ua rau muaj kev cuam tshuam ntau dua rau Acriflavine inhibition ntawm HIF-1 kev ua.Acriflavine creamtau qhia tias muaj peev xwm siv tau tus nqi hauv tshuaj tua kab mob, tiv thaiv- qog, tshuaj tiv thaiv kab mob, thiab tshuaj tiv thaiv kab mob los ntawm ntau yam kev ua haujlwm lom neeg.
Cov txheej txheem hauv qab nws cov tshuaj tua kab mob muaj xws li cuam tshuam nrog DNA replication thiab transcription.Inhibition ntawm protein synthesis, thiab cuam tshuam ntawm cell membrane muaj nuj nqi.Cov mechanisms ntawm inhibiting HIF-1 kev ua, inducing qog cell apoptosis, thiab photodynamic kho muab nws tshwj xeeb zoo nyob rau hauv lub teb ntawm anti-tumor kho; Cov txheej txheem ntawm cuam tshuam nrog tus kab mob DNA replication, inhibiting viral protein synthesis, thiab kev puas tsuaj rau lub hnab ntawv viral muab theoretical hauv paus rau nws cov tshuaj tiv thaiv kab mob.
Cov txheej txheem ntawm kev cuam tshuam cov kab mob parasite metabolism thiab cuam tshuam cov kab mob kab mob ntawm tes piav qhia nws cov nyhuv inhibitory ntawm parasites.hods rau kev kho mob ntsig txog kab mob.Txawm li cas los xij, cov txheej txheem ntawm kev txiav txim ntawm acriflavine kuj cuam tshuam los ntawm ntau yam xws li concentration, teeb pom kev zoo, thiab hom cell. Kev tshawb fawb yav tom ntej yuav tsum tau tshawb nrhiav cov ntsiab lus ntawm nws cov txheej txheem ntawm kev nqis tes ua, txhim kho nws cov kev thov, txhim kho nws cov txiaj ntsig thiab kev nyab xeeb, thiab muab cov tswv yim tshiab thiab ua tau raws
Cov ntaub ntawv
Chen L, Zhou H. Antimicrobial yam ntxwv thiab kws tshuaj npaj kev tshawb fawb ntawm acriflavine topical formulations[J]. Suav Journal of Dermatology Pharmacy, 2022,35(2:89-93.
Edwards RL, Owen S D. Photochemical stability ntsuam xyuas ntawm acriflavine bulk tshuaj[J]. Phau ntawv Journal of Pharmaceutical Sciences, 2021,110(7):2114-2120.
Wang Q, Liu M. Daim ntawv thov kev nce qib ntawm acriflavine ua fluorescent marker hauv nucleic acid sim[J]. Biotechnology Letters, 2023,45(9):781-787.
Novel acriflavin resistance genes, acrC thiab acrD, hauv Escherichia coli K-12.(https://pmc.ncbi.nlm.nih.gov/articles/PMC216820/)
TSEEM CEEB NTAWM ACRIFLAVIN RAU KINETOPLAST OF LEISHMANIA TARENTOLAE (https://pmc.ncbi.nlm.nih.gov/articles/PMC2107443/)
FAQ
Cov cuab yeej tshuaj dab tsi txwv acriflavine raw khoom cia?
Acriflavine yog qhov raug rau lub teeb -induced decomposition, yog li nws yuav tsum tau muab kaw thiab tsaus.
Dab tsi yog ob qho kev qhia tseem ceeb ntawm acriflavine?
Nws ua haujlwm raws li cov khoom siv tshuaj tua kab mob rau cov tawv nqaij thiab cov fluorescent dye rau RNA labeling hauv kev sim kuaj.
Cov kab mob dab tsi tuaj yeem kho cov tshuaj acriflavine?
Cov kua nplaum sab nraud kho cov kab mob thiab cov kab mob fungal - ua rau cov tawv nqaij o thiab kab mob ntawm daim tawv nqaij.
Cim npe nrov: acriflavine cream, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom