Shaanxi Bloom Tech Co., Ltd. yog ib qho ntawm cov neeg tsim khoom lag luam thiab cov chaw muag khoom ntawm imidacloprid moxidotin kua tshuaj pleev hauv Suav teb. Txais tos rau kev lag luam wholesale loj zoo zoo imidacloprid moxidectin kev daws teeb meem kev muag khoom ntawm peb lub hoobkas. Cov kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Imidacloprid moxidectin kev daws teeb meemyog qhov sib txuas ua ke tau ua tiav kev tiv thaiv synchronous thiab tswj cov cab ob leeg hauv Vitro thiab hauv Vivo los ntawm kev tswj hwm kev tswj hwm. Nws cov me nyuam lub tshuab yog raws cov phiaj xwm kev puas tsuaj ntawm cov parasitic hlab ntsha los ntawm ob lub zog nquag. Nws yog cov yeeb tshuaj uas suav nrog uas ua tiav kev tiv thaiv synchronous thiab kev tswj hwm parasites ob sab hauv thiab sab nraum lub cev los ntawm kev tswj hwm lub cev. Nws yog dav siv rau kev tiv thaiv thiab kev kho mob mub, zuam, heavworms, thiab cov pa taws nematodes hauv cov dev thiab miv. Nws cov ntsiab lus zoo nyob hauv cov nyhuv synergistic ntawm dual nquag cov khoom xyaw, sib txuas ua ke nyob rau hauv vivo cleaticicidal cov khoom ntawm moxifloxacin.
Peb Cov Khoom
Qhia Qhia thiab Tshuaj Lom Zem
Qhia tau rau miv:
Sab nraud parasites: ceev kev ceev faj thiab kho mob mub (miv mub) thiab pob ntseg mite mob (pob ntseg khaus khaus).
Parasites nyob rau hauv lub cev: kev kho mob plab zom mov ntawm cov kab mob (cov laus, tsis paub tab, thiab L4 theem larvae ntawm miv taub hau ascarids thiab tubular hook lub ncauj nematodes).
Kev Kho Mob Ntxiv: tsis haum tshuaj mob dermatitis los ntawm dev mub.
Kev tiv thaiv lub siab mob: Rau cov miv nyob hauv cov cheeb tsam uas muaj cov tshuaj uas dej caw tau ib hlis twg, pib ntawm ib hlis ua ntej lub caij pom yoov tshaj cum lossis thawm xyoo.
Qhia rau cov dev:
External parasites: treatment for flea infections (cat flea), lice infections (dog lice), ear mite infections (ear itching mites), scabies mites (scabies mites), and demodex mites (dog demodex mites).
Sab hauv Parasites: Kev kho mob ntawm vascular Ascarid thiab cov neeg laus, Canine Larvae ntawm Ruj Axwid, thiab F4 thiab Larvae ntawm Canine Filariasis), thiab kev kho mob ntawm Circulating microflasent (canine filariasis).
Kev Kho Mob Ntxiv: tsis haum tshuaj mob dermatitis los ntawm dev mub.
Txoj kev noj tshuaj thiab noj
Cov txheej txheem kev ua haujlwm ntawm cov txheej txheem:
Cov Thawj Coj Lub Vev Xaib: Daim tawv nqaij nyob sab nraub qaum ntawm caj dab (tsis txhob yaim).
Cov kauj ruam ua haujlwm:
Lub kua muag qhib raws cov ntim ntim cov kab thiab nqa tawm cov tshuaj kho mob.
Tev tawm sab nraub qaum, tshem lub hau thiab ntxiglmidacloprid moxidectin kev daws teeb meemupside cia rau hauv lub raj qhib.
Tig lub hau thiab unscrew lub xau pov thawj sib npaug ntsaws, sib cais cov plaub hau kom txog thaum cov tawv nqaij raug.
Tso sab xub ntiag ntawm qhov poob qis ntawm daim tawv nqaij, nyem tawm tag nrho cov tshuaj, thiab nias tus kheej 2-3 lub sij hawm los xyuas kom meej extrusion.
Npog thaj chaw me nyuam nrog plaub hau.
Dosage txheem: Siv 0.1ml rau 1mg lub cev hnyav (muaj 10mg imidacloprid thiab 1mg moxifloxacin) ib hlis ib zaug.
Cov kev ua haujlwm dev:
Cov Thawj Coj Lub Vev Xaib: Thov 3-4 tee rau ntawm daim tawv nqaij ntawm ob scapulas nyob sab nraub qaum thiab pob tw.
Dosage txheem: Siv 0.1ml rau 1mg lub cev hnyav (muaj 10mg iMidacloprid thiab 2.5mg moxifloxacin) ib hlis ib zaug.
Molecular txheej txheem ntawm kev nqis tes ua: dual nres hom phiaj parasitic hlab ntsha
Imidacloprofrid belongs rau lub thib ob -}}}} хotinic acetylcholine recetor (Nachr) hauv Postsynaptic ntawm cov kab ntawm cov kab hauv qab. Qhov no receptor yog ib qho tseem ceeb channel rau kev coj ua ntsuas kev lag luam, lub luag haujlwm tau txais acetylcholine (ACH) tso tawm los ntawm presynaptic memcra thiab ua rau cov hlab ntsha tsis sib haum.
Cov txheej txheem ntawm kev nqis tes ua:
Kev sib tw khi: iMidacloprid muaj cov qauv molecular zoo sib xws rau acetylcholine thiab tuaj yeem sib tw khi rau cov Nachr.
Nruam tom ntej qhib ntawm channel: tom qab khi rau cov receptors, imidacloprid ua rau tsis muaj kev xaiv ntawm ion (Nae) thiab ua rau muaj kev cuam tshuam deterolarization ntawm neurons.
Daim paib hloov chaw cuam tshuam: Nruam cov depolarization nurends neurons los ntawm kev ua tau zoo, thaum kawg ua rau cab tuag tes tuag taw thiab kev tuag.
Cov txiaj ntsig tshwj xeeb:
There are structural differences between insect nAChR and mammalian receptors, and imidacloprid has extremely low affinity for mammalian nAChR (supported by safety data), ensuring drug safety.
Siv tau rau cov neeg laus dev, cov menyuam kab Larvae, thiab qe, nws tuaj yeem tua tau ntau dua 98% ntawm cov qe mub ib puag ncig hauv 48 teev.
Imidacloprid moxidectin kev daws teeb meemYog mactrocyclic lactone Antiparasitic cov tshuaj uas ua tiav cov teebmeem ntawm kev txhim kho cov rhiab ntawm gamma aminobutyric acid (GABA) cov receptors. Nws lub hom phiaj muaj xws li inisibeffons hauv nematodes thiab neuromuscular junctions hauv arthropods.
Cov txheej txheem ntawm kev nqis tes ua:
Gaba Receptor Ua Haujlwm: Tom qab khi rau Gaba Receptors, moxifloxacin txhim kho qhov chaw qhib zaus ntawm chloride ion (clen ion) classing ntau tshaj.
Neuromuscular tuag tes tuag taw: qhov cuam tshuam ntawm cl ⁻ Ua rau lub cev muaj peev xwm, thiab ua kom lub cev muaj zog ntawm Nematropod leeg hlwb, qhov kawg ua rau kev so thiab tuag tes tuag taw ntawm cov kab lub cev.
Cov kab laum Glutamate: Moxibustin tuaj yeem xaiv khi rau Glutamate Mediated Chloride Ion raws cov kev sib kis, txuas ntxiv mus nrog kev kos npe rau kev nkag mus.
Broad spectrum manifestation:
Kev tua tus nqi ntawm cov neeg mob plawv (L3 / L4 theem larvae ntawm canine Filarial cab) thiab cov pa taws nematodes (ascarids, hookworms) yog tshaj 99%.
Cov txiaj ntsig ed ntawm ectoparasites xws li pob ntseg mites thiab scabies mites yog tsawg li 0.03mg / kg, thiab ib qho kev tswj hwm tuaj yeem tswj lub sijhawm tiv thaiv ntawm 84 hnub.
Synergistic effect: Compound deworming strategy of 1+1>2
Imidacloprid tau faib tawm sai sai ntawm lub cev saum npoo av los ntawm sebaceous gland zais cia, sib sau ib mub tua glea tua thaj tsam li ntawm 48 teev; Moxibustin penetrates daim tawv nqaij thiab nkag mus rau hauv cov hlab ntshav, ua haujlwm tsis tu ncua ntawm nematodes thiab cov microfilaments hauv lub cev. Sib txuas ntawm ob kom ua tiav:
Kev ceev faj sab nraud: iMidacloPrid block tom qhov kis tau tom qab kis sab nraud xws li dev mub thiab ntshauv.
Kev Kho Mob Hauv Tsev: Moxibusion tshem tawm cov cab hauv lub cev thiab ua kom cov hmoov av ua rau muaj cov kab mob ib yam li filariasis.
Cov ntaub ntawv kho mob txhawb:
Hauv cov rooj sib txig sib kis, tus kho tus nqi ntawm kev npaj ua ke yog 30% siab tshaj qhov ntawm ib qho tshuaj.
Qhov tsim kom loj hlob ntawm Flea Pupae nyob rau ib puag ncig kav rau ntau tshaj 6 lub lis piam, txo qhov kev pheej hmoo ntawm kev rov ua haujlwm.
Lub sij hawm synergy: ceev nrawm + ntev -} kav tiv thaiv
Cov khoom ntiag tug ntawm imidacloprid (100% tua tuag hauv 24 teev) ua tiav cov cuab yeej ntawm Moxifoxacin (cov ntshav nce kom tswj tau rau 1 lub hlis):
Kev tswj hwm theem: Imidacloprid sai li sai tau uncergiciates ua xua los ntawm Flea tom hauv cov tsiaj.
Kev tiv thaiv ntev: Moxifloxacin tsis tu ncua|Nematode kev loj hlob thiab thaiv cov kev tsiv teb tsaws ntawm cov kab mob ntawm lub siab.
PharcermeMinetic siv tau:
Tom qab thawj thawj coj, imidacloprofrid tseem nyob ntawm lub cev saum ntuj kom txog thaum kev pab tswj hwm tom ntej.
Moxifloxacin nce mus txog nws cov ntshav ncov siab 4-9 hnub tom qab kev tswj hwm thiab yog maj mam metabolized thiab excreted nyob rau hauv ib hlis.
Chaw Tsim Tshuaj Pharmaciininetic: Tsim qauv rau kev xa tshuaj transdermal
Imidaclofrid: nto faib thiab metabolism
Distributionchism:
Tom qab hloov chaw rau kev hloov pauv, nws kis tau raws tus qog sebaceous thiab kev tso cov hauv paus plaub hau thiab pob Corume.
Ib zaj yeeb yaj kiab tiv thaiv tau tsim los ntawm cov khoob ntawm cov plaub mos, uas muaj kev sib chwv tua cov nyhuv ntawm dev mub thiab kab menyuam.
Cov kev ntsuas metabolic:
Nws feem ntau evaporates qeeb los ntawm stratum ntawm daim tawv nqaij, nrog me me metabolized los ntawm cov hlab ntshav.
Ib nrab - Lub neej yog kwv yees li 72 teev, ua kom muaj kev txhawb nqa zoo thaum lub sijhawm noj mov.
Moxibustin: hauv vivo permeration thiab tsub zuj zuj
Penetration mechanism:
Cov duab lipophilic txhawb nqa nws cov kev nkag mus rau hauv cov txheej dermis thiab mus rau hauv lub capillary network.
Kev ua tiav hauv cov ntaub so ntswg adipose, nrog kev xav tau zoo rau ntau dua 21 hnub.
Cov kev ntsuas metabolic:
Metabolized los ntawm daim siab Cytochrome P450 enzyic system, cov khoom lag luam tsis muaj zog.
Kev ua yeeb yam raug nplua yog feem ntau yog qhov ua tau, nrog cov zis ua rau tsawg dua 5%.
Kho mob tseem ceeb:
Compound npaj tuaj yeem muab ib zaug ib hlis ib zaug los tswj cov kev txhawj xeeb thiab txo qhov kev pheej hmoo ntawm kev siv tsis raug.
Nws yog ib qho tsim nyog yuav tsum nruj nruj licking thiab fortpress neurotoxicity hauv MDR1 Gene Mute Mutant cov tsiaj xws li kev sib tsoo.
Kev tiv thaiv kev ruaj ntseg: Ntau kev tiv thaiv los txo qis kev pheej hmoo
Imidacloprid muaj ib qho kev sib txuam rau cov tsiaj muaj tsiaj txhu rau 1000 npaug ntawm 1000 npaug qis dua li ntawm kab, zam nruab nrab ntawm cov hlab ntsha toxicity.
Lub hom phiaj Gabifoxacin tsuas muaj nyob rau hauv invertebrates thiab muaj cov nyhuv tsis muaj zog ntawm cov tsiaj mammalian junctions.
MIV SIV: 0.1ML rau 1MG lub cev hnyav (muaj 10mg ntawm imidacloprid thiab 1mg ntawm moxifloxacin).
DOG DO: 0.1ml ib 1kg lub cev hnyav (muaj 10mg ntawm imidacloprid thiab 2.5mg ntawm moxifloxacin).
Nrom tsis pub siv cov tsiaj uas muaj ntau dua 1kg kom tsis txhob muaj ntau yam ntxiv.
Kev Kho Mob Licking: Tam sim ntawd yaug lub qhov ncauj nrog dej huv thiab ua kom cov pa roj carbon monoxide kom nqus cov tshuaj.
Kev tswj hwm cov tsos mob neurologian sedation thaum tremors thiab drooling tshwm sim los tswj kev ua pa thiab kev ruaj khov kev ruaj khov.
Kev tswj hwm ib puag ncig: cais cov tsiaj ua ntej kev kho mob dries mus forfend cross licking.
Mechanism optimization hauv cov ntawv thov kho mob
Tshuaj Yeeb Tshuaj: Kev ntsuas tshuaj pub rau lub tswv yim
Kev siv sijhawm ntev ntawm ib qho khoom siv yuav induce parasite tsis kam, thaum sib txuas ua qauv ncua kev txhim kho ntawm ob lub phiaj phiaj kev tawm tsam.
Nws raug nquahu kom hloov mus rau lwm cov tshuab kev nqis tes ua (xws li Celestin) txhua 2-3 xyoos.
Ib puag ncig Synergy: Mub txoj kev cuam tshuam
Imidacloprofrid tua ob tus neeg laus thiab kab menyuam, thaumlmidacloprid moxidectin kev daws teeb meeminhibits qe daug, sib sau ua tiav cov saw ntawm kev tswj hwm.
Nws yog ib qho tsim nyog los tshem cov qe uas tseem tshuav nyob hauv ib puag ncig hauv kev sib txuas nrog kev kho mob ib puag ncig (xws li imidaclid tshuaj tsuag).
Tshwj xeeb kev yoog raws: Ntau Tsiaj Tswj Xyuas Tsev Neeg
Cais cov tsiaj rau 1-2 teev tom qab kev tswj hwm kom yuam lawv los ntawm kev sib khi ib leeg.
Kev sib tsoo yuav tsum tau hnav Elizabeth Rings kom tsis txhob yaim rov qab mob.
Kev sib cuam tshuam yeeb tshuaj thiab lwm cov kev daws teeb meem
Kev sib cuam tshuam yeeb tshuaj
Taboo combnation:
Ua ke siv nrog macrolides xws li Ivermectin thiab Doramectin yuav nce txoj kev pheej hmoo ntawm Neurotoxicity.
Ua ke siv nrog carbamate cov tshuaj tua kab yuav txhim kho acetylcholine receptor inhibition inheption inhibition increptor inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inhibition inible.
Ceev faj kev sib txuas:
Ua ke siv nrog sedatives yuav ua rau cov tsos mob neuralological.
Thaum siv hauv kev sib txuas nrog anticoagulants, qhov kev pheej hmoo ntawm kev los ntshav yuav tsum tau saib xyuas.
Cim npe nrov: Imidacloprid moxidectrin cov tshuaj pleev, cov chaw muag khoom, chaw tsim khoom, chaw tsim khoom, lag luam wholesale, yuav, nqe, loj, loj, rau muag