Shaanxi BLOOM Tech Co., Ltd. yog ib tug ntawm cov uas paub txog manufacturers thiab lwm tus neeg ntawm nystatin tshuaj pleev 15g nyob rau hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo nystatin ointment 15g rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Nystatin ointment 15 gyog ib qho classic polyene antifungal tshuaj pleev xim tsuas yog siv los kho cov tawv nqaij thiab cov kab mob mucosal los ntawm cov kab mob rhiab heev xws li Candida albicans. Nws cov ntsiab lus tseem ceeb, mycostatin, khi rau ergosterol hauv cov kab mob fungal, cuam tshuam cov membrane permeability thiab ua rau cov khoom tseem ceeb xws li cov poov tshuaj ions thiab nucleotides tawm hauv lub cell, thaum kawg ua rau fungal tuag. Nws muaj dual antibacterial thiab bactericidal teebmeem.
Pharmacological yam ntxwv thiab formulation tsim:
Cov khoom lag luam uas muaj emulsifiable paste feem ntau muaj 100000 units / gram ntawm cov khoom xyaw nquag, thiab cov matrix yog cov sib xyaw ntawm cov roj ntxhia roj thiab Vaseline dawb, kom ntseeg tau tias cov tshuaj tsim cov yeeb yaj kiab tiv thaiv ntawm daim tawv nqaij thiab ua kom lub sijhawm ua haujlwm hauv zos. Qhov no tsis yog dej soluble matrix tuaj yeem ncua sijhawm khaws cov tshuaj ntawm daim tawv nqaij, txhim kho cov permeability hauv zos, thiab zam kev tiv thaiv kab mob uas yuav tshwm sim los ntawm dej-raws li matrices. Nws yuav tsum tau muab sau tseg tias lanolin, raws li ib tug excipient nyob rau hauv tej yam emulsifiable pastes, yuav ua rau muaj kev tsis haum tshuaj. Cov ntaub ntawv kho mob tau pom tias cov neeg mob uas muaj kab mob scrotal eczema muaj qhov khaus khaus tom qab siv tshuaj, thiab cov kev ntsuam xyuas thaj ua rau pom tias muaj kev nkag siab zoo rau lanolin. Hloov mus rau cream yam tsis muaj cov khoom xyaw no tuaj yeem txo cov tsos mob. Cov tshuaj muaj zog ruaj khov, tuaj yeem khaws cia rau 36 lub hlis hauv qhov chaw txias ntawm 20-25 degree. Nws raug nquahu kom siv nws li ntawm 3 lub hlis tom qab qhib kom tsis txhob muaj kab mob microbial.
Tshuaj specifications:
Cov txheej txheem ntawm kev kho mob yog smear thaj tsam cuam tshuam ob zaug ib hnub rau 10-14 hnub; Cov kab mob mucosal yuav tsum tau ncua ntev li 14-21 hnub. Kev siv cov tshuaj tua kab mob emulsifiable muab tshuaj txhuam los yog tshuaj tua kab mob yog pom zoo rau cov kab mob sib xyaw lossis tawv tawv, xws li candidal balanitis hauv cov neeg mob ntshav qab zib uas yuav tsum tau kho nrog ketoconazole.
Cov ntaub ntawv ntxiv ntawm chemical compound:
Peb cov khoom tsim
Nystatin +. COA
Raws li cov tshuaj classic polyene antifungal,nystatin tshuaj pleev 15 gtau dhau los ua cov tshuaj pob zeb rau kev kho cov kab mob fungal permeates txij li thaum nws tshwm sim nyob rau hauv nruab nrab xyoo pua 20th, ua tsaug rau nws cov txheej txheem tshwj xeeb ntawm kev ua thiab kev siv dav hauv kev kho mob.
Tinea corporis thiab cruris thiab perianal permeate: Nws muaj feem xyuam rau refractory cutaneous candidiasis nyob rau hauv cov neeg mob immunosuppressed (xws li AIDS, ntev -cov neeg siv glucocorticoid). Cov ntaub ntawv kho mob qhia tau hais tias tom qab 2 lub lis piam ntawm kev kho mob nrog cov tshuaj tua kab mob emulsifiable yooj yim, 85% ntawm cov neeg mob ua tiav cov kab mob fungal, tab sis sib xyaw permeates (xws li kev sib xyaw ntawm cov kab mob thiab cov kab mob fungi) xav tau kev siv tshuaj tua kab mob emulsifiable paste ua ke.
Cov pob khaus ua ke nrog cov kab mob Candida: Cov ntaub qhwv thaj tsam ntawm cov menyuam yug tshiab yog qhov ua rau Candida permeate theem nrab vim qhov chaw ntub dej, tshwm sim zoo li - txhais erythema nrog satellite lesions. It is recommended to smear emulsifiable paste after daily cleaning for 7-10 days, and to increase the frequency of diaper changes to reduce recurrence.
Qhov ncauj candidiasis (thrush): Txawm hais tias cov tshuaj tua kab mob tsis yog cov tshuaj uas nyiam tshaj plaws, nws feem ntau yog tov nrog glycerol thiab siv rau qhov ncauj mucosal daim ntawv thov hauv kev kho mob, tshwj xeeb tshaj yog rau cov me nyuam mos thiab cov me nyuam yaus uas tiv taus qhov ncauj tshem tawm. Ceev faj tsis txhob nqos thiab yoo mov li ntawm 30 feeb tom qab noj cov tshuaj.
2. Daim ntawv thov nyob rau hauv lub teb ntawm gynecology:
Vulvar Vaginal Candidiasis (VVC): Cov kev npaj sib xyaw xws li Nifedorax Mycostatin Vaginal mycostatinor (muaj 0.5g Nifedorax thiab 200000 units ntawm Mycostatin) txhim kho kev ua tau zoo los ntawm kev sib koom ua ke. Ib koob tshuaj ib zaug yog sib npaug rau 7-hnub kev kho mob raws li kev ua tau zoo, tab sis kev ua raws li tus neeg mob siab dua. Nws yuav tsum tau hais qhia tias kev ua poj niam cev xeeb tub yog qhov tsim nyog, thiab cov neeg koom nrog kev sib deev tsis xav tau kev kho mob niaj hnub.
Kev Tiv Thaiv VVC rov tshwm sim: Rau cov neeg mob uas muaj ntau dua lossis sib npaug li 4 ntu hauv ib xyoos, nws raug nquahu kom muab tshuaj rau qhov chaw mos ib lub lim tiam rau 6 lub hlis. Txawm li cas los xij, kev siv sijhawm ntev - yuav tsum tau ceev faj tiv thaiv cov tshuaj tiv thaiv. Muaj ib kis tau tshaj tawm nyob rau hauv kev kho mob qhov twg cov kab mob resistant tshwm sim tom qab siv tshuaj dua.
Compound mycostatinor (muaj triamcinolone acetonide, neomyci sulfate, thiab permethrin) yog dav siv rau kev kho mob otitis externa hauv dev thiab miv. Nws kev sib xyaw ua ke ntawm cov tshuaj tua kab mob, tshuaj tua kab mob, tshuaj tiv thaiv - mob, thiab tshuaj tua kab tuaj yeem txo cov kev kho mob. Piv txwv li, hauv cov neeg mob Malassezia otitis externa kho nrog kev kho ua ke, tus nqi kho tau nce los ntawm 62% siv Mycostatin ib leeg mus rau 89%.
Kev siv, ntau npaum li cas thiab kev kho mob
Adult Standard Programne
Kab mob ntawm daim tawv nqaij: Smartwice ib hnub rau thaj tsam cuam tshuam rau lub sijhawm kho ntawm 14-21 hnub. Rau erosive tinea pedis ntawm cov ntiv tes,nystatin tshuaj pleev 15 gNws raug nquahu kom siv kev sib xyaw ntawm 10% salicylic acid cream kom soften lub stratum corneum thiab txhim khu kev nkag mus.
Kab mob hauv qhov chaw mos: Siv ib koob tshuaj ntawm 200000 units ntawm emulsifiable paste intravaginal lossis ib zaug ib hnub rau 7 hnub sib law liag. Cov cuab yeej siv tshuaj tshwj xeeb yuav tsum tau ua kom ntseeg tau tias cov tshuaj nkag mus rau hauv lub ncauj tsev menyuam ncaj qha.
Kev kis kab mob hauv qhov ncauj: Smear 500000 units (sib xyaw nrog glycerin) mus rau thaj tsam cuam tshuam 4 zaug hauv ib hnub tom qab noj mov kom txo qis plab hnyuv.
Kev siv cov txheej txheem tuaj yeem ua tiav raws li hauv qab no:
1. Kev npaj ua ntej noj tshuaj
Ntxuav thaj chaw muaj kev cuam tshuam: Ua tib zoo ntxuav thaj chaw muaj kab mob nrog dej me me los yog cov kua ntsev kom tshem tawm cov av thiab cov kua qaub.
Paub meej cov lus qhia: Xyuas kom meej tias cov permeate yog tshwm sim los ntawm cov kab mob rhiab heev xws li Candida, thiab tsis txhob siv cov kab mob los yog kab mob permeates.
Kev tshuaj xyuas kev ua xua: Tshawb xyuas cov tshuaj muaj pes tsawg leeg (xws li lanolin matrix), thiab txwv tsis pub siv rau cov tshuaj tsis haum rau mycostatinor excipients.
2. Kev siv tshuaj thiab zaus
Kev kis kab mob ntawm daim tawv nqaij: Siv cov tshuaj emulsifiable uas tsim nyog (kwv yees li 100000 units / gram) ob zaug hauv ib hnub thiab smear nws sib npaug rau thaj tsam cuam tshuam thiab 1-2 centimeters ntawm daim tawv nqaij noj qab haus huv nyob ib puag ncig nws. Maj mam zaws kom txog thaum absorbed.
Mucosal kab mob (xws li qhov ncauj candidiasis): Nws yuav tsum tau tov nrog glycerol thiab siv plaub zaug ib hnub twg. Kev yoo mov yuav tsum tau ua tsis pub dhau 30 feeb tom qab noj tshuaj; Qhov chaw mos permeate yuav tsum tau siv cov tshuaj tshwj xeeb dispenser, ib hnub ib zaug, ntxig tob rau hauv qhov chaw mos ua ntej yuav mus pw.
Cov chaw tshwj xeeb: xws li perianal permeates, thaj chaw cuam tshuam yuav tsum tau ntxuav tom qab tso quav ua ntej siv tshuaj; Ko taw permeates tuaj yeem nrog los ntawm hnav khau thiab thom khwm.
3. Kev kho mob
Cov txheej txheem kho mob: Cov tawv nqaij permeates feem ntau kav li 10-14 hnub, mucosal permeates siv 14-21 hnub, thiab txawm tias cov tsos mob ploj mus, tag nrho cov txheej txheem kho yuav tsum tau ua kom tiav txhawm rau tiv thaiv kev rov tshwm sim.
Kev ntsuas kev ua tau zoo: Kab lis kev cai ntawm cov kab mob fungal yuav tsum tau kuaj xyuas txhua 2 lub lis piam. Yog tias tsis muaj kev txhim kho tom qab 4 lub lis piam, qhov kev kuaj mob lossis kev kho mob yuav tsum tau rov ntsuam xyuas lossis hloov kho.
Kev tiv thaiv rov qab: Rau cov neeg mob uas muaj cov permeates rov qab (xws li Ntau dua lossis sib npaug li 4 zaug hauv ib xyoos), nws raug pom zoo kom tswj xyuas kev kho mob ib zaug ib lim piam rau 6 lub hlis.
4. Xa tshuaj kho mob
Khaws thaj chaw cuam tshuam kom qhuav: Tsis txhob siv lub sijhawm ntev sealing thiab bandaging, vim tias qhov chaw ntub dej tuaj yeem ua rau cov permeate tuaj yeem ua rau tsis zoo.
Tsis txhob khaus khaus: Ncua kev siv cov khoom siv dej cawv lossis tshuaj ntxuav tes thaum siv tshuaj.
Kev soj ntsuam cov tshuaj tiv thaiv: Yog tias muaj qhov kub hnyiab, erythema lossis lwm yam khaus hauv zos, cov tshuaj concentration tuaj yeem diluted lossis siv cov tshuaj emulsifiable los hloov; Kev ua xua hnyav yuav tsum tsis txhob siv tshuaj thiab kho mob tam sim ntawd.
Nystatin ointment 15 g, raws li cov tshuaj tiv thaiv kab mob hauv zos, txawm hais tias nws cov tshuaj sib cuam tshuam tsis yog qhov tseem ceeb ntawm kev siv tshuaj, cov ntsiab lus tseem ceeb hauv qab no tseem yuav tsum tau txiav txim siab los xyuas kom meej cov tshuaj muaj kev nyab xeeb thiab ua tau zoo:
Kev sib tham nrog cov tshuaj hauv zos
1. Kev tsis haum tshuaj ntawm lanolin muaj cov matrix
Lub matrix ntawm cream muaj lanolin, uas yuav ua rau muaj kev tsis haum tshuaj tiv thaiv. Yog tias cov neeg mob nkag siab rau lanolin (xws li tus neeg mob scrotal eczema uas muaj qhov khaus khaus tom qab noj tshuaj thiab tau lees paub tias muaj kev tsis haum los ntawm kev kuaj thaj), lawv yuav tsum tau hloov mus rau cov tshuaj nplaum los yog cov tshuaj nplaum uas tsis muaj cov khoom xyaw no kom tsis txhob ua rau cov permeate ntau dhau los ntawm kev tsis haum tshuaj.
2. Kev pheej hmoo cuam tshuam nrog kev siv cov glucocorticoids ua ke
Kev npaj ua ke, xws li kev sib xyaw ntawm mycostatinor thiab Triamcinolone Acetylide, tuaj yeem npog cov tsos mob permeate lossis ua rau cov kab mob fungal kis tau. Piv txwv li, kev siv lub sij hawm ntev - siv cov tshuaj nplaum uas muaj corticosteroids tuaj yeem cuam tshuam cov tshuaj tiv thaiv kab mob hauv zos, ua rau muaj kab mob tsis tu ncua. Yog li ntawd, txwv rau luv luv -lub sij hawm, me me- teev siv, thiab nruj soj ntsuam ntawm permeate zuj zus.
3. Synergistic/antagonistic nyhuv nrog tshuaj tua kab mob mycostatinor
Synergistic effect: Rau kev sib xyaw permeates (xws li kab mob fungal copermeate), tshuaj tua kab mob (xws li mupirocin) tuaj yeem siv ua ke. Tab sis nws yuav tsum tau siv rau hauv cov khaubncaws sab nraud povtseg, thawj smear tshuaj tua kab mob mycostatinor, thiab tom qab ntawd smear cream tom qab 30 feeb ib ntus kom tsis txhob muaj kev cuam tshuam tshuaj cuam tshuam rau kev nqus.
Kev pheej hmoo tiv thaiv: Tsis txhob siv cov tshuaj mycostatinors uas muaj cov tshuaj tua kab mob aminoglycoside xws li amikacin sulfate thiab gentamicin, vim tias Mycostatin's matrix tuaj yeem txo qhov permeability ntawm cov tshuaj tua kab mob hauv zos thiab ua rau lawv cov tshuaj tua kab mob tsis muaj zog.
Kev sib cuam tshuam nrog qhov ncauj / txhaj tshuaj
1. Cov nyhuv synergistic ntawm qhov ncauj tshuaj tiv thaiv kab mob
Cov lus qhia rau kev siv ua ke: mycostatinor tuaj yeem ua ke nrog ketoconazole hauv qhov ncauj lossis fluconazole rau kev cuam tshuam los yog kab mob candidal permeate (xws li refractory candidal balanitis hauv cov neeg mob ntshav qab zib). Piv txwv li, nyob rau hauv cov neeg mob uas mycostatinor ib leeg tsis kho tau 4 lub lis piam, cov tsos mob tau tswj tau sai thaum ua ke nrog ketoconazole detergent.
Ceeb Toom: Daim siab ua haujlwm yuav tsum tau saib xyuas vim tias imidazole tshuaj tiv thaiv kab mob tuaj yeem ua rau lub siab puas tsuaj, thaum mycostatinor tsis nqus qhov ncauj thiab tsis ua rau muaj kev pheej hmoo. Txawm li cas los xij, yuav tsum muaj kev ntsuam xyuas dav dav rau kev kho ua ke.
2. Kev sib tham nrog cov tshuaj tiv thaiv kab mob
Kev siv cov tshuaj tiv thaiv kab mob ntev ntev (xws li glucocorticoids thiab cyclosporine) ua rau muaj kev pheej hmoo ntawm Candida permeate hauv cov neeg mob. Cov tshuaj emulsifiable tuaj yeem siv tau los tiv thaiv hauv qhov ncauj kab noj hniav los yog daim tawv nqaij mucosa, tab sis yuav tsum tau ceev faj tias kev tiv thaiv kab mob yuav npog cov tsos mob permeate thiab ua rau cov tshuaj qeeb.
3. Cov nyhuv nqus ntawm plab acid txo cov tshuaj
Kev nqus ntawm mycostatinor qhov ncauj npaj yog nyob ntawm qhov chaw ntawm gastric acid. Yog tias cov neeg mob siv proton twj tso kua mis inhibitors (xws li omeprazole) lossis H ₂ receptor antagonists (xws li ranitidine) ib txhij, nws tuaj yeem txo qhov nqus ntawm qhov ncauj ntawm mycostatinor, tab sis kev siv hauv zos (xws li mycostatinor) tsis cuam tshuam.
Tshuaj noj zaub mov sib cuam tshuam
Nystatin ointment 15 gyog ib hom tshuaj pleev uas feem ntau tsis tas yuav tsum tau hloov kho kev noj haus. Tab sis yog tias tus neeg mob noj cov tshuaj mycostatinorpreparations ntawm qhov ncauj tib lub sijhawm, yuav tsum tau saib xyuas:
Kev noj zaub mov muaj roj ntau: tuaj yeem ncua kev nqus tshuaj, tab sis nws qhov tseem ceeb hauv kev kho mob tsuas yog txwv vim tias mycostatinor yuav luag tsis nqus thaum noj qhov ncauj.
Calcium/magnesium uas muaj cov khoom noj: Yog tias noj ua ke nrog qhov ncauj mycostatinor, nws tuaj yeem txo kev nqus vim chelation, tab sis kev siv hauv zos tsis muaj qhov kev txhawj xeeb no.
Xyoo 1940 yog 'lub hnub nyoog kub' ntawm cov tshuaj tua kab mob. Xyoo 1928, Fleming tau tshawb pom cov tshuaj penicillin thiab ua tiav qhov loj - cov khoom tsim tawm thaum xyoo 1940, ua rau muaj kev tshoov siab rau cov zej zog kev tshawb fawb zoo siab rau kev tshawb nrhiav "cov mos txwv zoo nkauj" los ntawm cov kab mob. Txawm li cas los xij, penicillin feem ntau tsom cov kab mob thiab tsis muaj zog tiv thaiv kab mob fungal. Thaum lub sij hawm ntawd, thrush, vaginitis, thiab kab mob ntawm daim tawv nqaij fungal tshwm sim los ntawm Candida tau tshwm sim heev, thiab tsis muaj txoj kev kho mob zoo, ua rau mob tsis taus rau cov neeg mob. Cov zej zog kho mob tau mob siab rau tos ntsoov rau cov tshuaj tua kab mob uas tuaj yeem tiv thaiv kab mob.
Xyoo 1944, ob tus kws kho mob microbiologists los ntawm Northern Regional Research Laboratory (NRRL) ntawm Tebchaws Meskas Lub Tsev Haujlwm Saib Xyuas Kev Ua Liaj Ua Teb (USDA), Rachel Fuller Brown thiab Elizabeth Lee Hazy, tau sau cov qauv av los ntawm cov cuab yeej ntiag tug hauv Orleans County, New Jersey, Tebchaws Asmeskas.
Rachel Brown yog tus kws paub txog tshuaj lom neeg uas tau txais Ph.D. hauv Chemistry los ntawm University of Illinois ntawm Urbana Champaign, tshwj xeeb hauv fungal chemistry. Elizabeth Hazy yog tus kws kho mob microbiologist zoo heev. Lawv kev sib xyaw ua ke - kev sib xyaw ua ke zoo tshaj plaws ntawm chemistry thiab microbiology - tau tsim lub hauv paus rau kev tshawb pom zoo ntawm nystatin.
Tom qab cov qauv av raug coj rov qab mus rau qhov chaw kuaj mob, Dr. Hazy cais tawm thiab coj cov kab mob hauv nws. Nws sai sai pom ib qho actinomycete los ntawm cov qauv, uas nws kab lis kev cai supernatant pom muaj zog antifungal kev ua si, tshwj xeeb tshaj yog nyob rau hauv inhibiting kev loj hlob ntawm Candida albicans. Qhov no actinomycete tom qab raug txheeb xyuas tias yog Streptomyces norvegicus.
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