Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm nonapeptide-1 serum hauv Suav teb. Zoo siab txais tos rau cov lag luam wholesale bulk zoo nonapeptide-1 serum muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Nonapeptide-1 ntshavyog bioactive polypeptide daim tawv nqaij brightening essence nrog Nonapeptide-1 raws li nws cov khoom tseem ceeb ua haujlwm. Nws xaiv nyob rau hauv lub epidermal txheej ntawm daim tawv nqaij yam tsis tau nkag mus rau lub dermis kom ua rau lub cellular kev nyuaj siab ntau dhau. Meanwhile, nws zoo antagonizes kev khi ntawm alpha-MSH (melanocyte-stimulating hormone) rau MC1R receptor ntawm melanocytes, thaiv melanin ntau lawm cov cim ntawm lub hauv paus thiab inhibiting melanosome thauj mus rau stratum corneum kom xa dual-fadingway thiab melanin brightness.
Nws muab cov kev ua tau zoo ruaj khov hauv kev ua kom tawv nqaij pigmentation thiab tsis pom kev zoo nkauj, ua kom tag nrho - nruab hnub thov. Sib npaug cov txiaj ntsig whitening nrog ntev - lub sij hawm ntawm daim tawv nqaij txias, nws hais txog kev mob kev lag luam tsis tu ncua ntawm cov pa ua kom dawb huv -xws li khaus khaus, yuav tsum zam lub teeb thiab tom qab- kho cov xim rov qab.
Peb Cov Khoom Muag Khoom
Nonapeptide-1COA
Leveraging peb lub zog tseem ceeb: melanin inhibition, superior biocompatibility thiab dav formulation compatibility,nonapeptide-1 ntshavtau nthuav dav tshaj li tus qauv ntawm lub ntsej muag brightening skincare rau hauv peb qhov sib txawv niche lem: tsom qhov muag, daim tawv nqaij -nourishing pleev thiab tshwj xeeb cov plaub hau tu, sau cov kev sib txawv ntawm cov khoom siv tshuaj pleev ib ce rau pigmentation, post- pleev xim rau daim tawv nqaij thiab cov plaub hau pigmentation txawv txav.
Targeted Eye Care
Cov khoom muag yog qhov zoo tshaj plaws polypeptide whitening raw khoom tsim rau ilv periorbital daim tawv nqaij, featuring ob irreplaceable sib txawv qhov zoo. Ua ntej, nws qhov mob me me thiab tsis yog -kev cuam tshuam cov txheej txheem cuam tshuam melanin synthesis nkaus xwb los ntawm cov teeb liab thaiv tsis yog kev puas tsuaj rau melanocytes, tshem tawm cov khaus khaus rau cov tawv nqaij periorbital. Thib ob, nws qhov hnyav molecular hnyav tiv thaiv kev nkag mus ntau dhau uas ua rau milia buildup, thaum ua kom nrawm nrawm los ntawm sebum- tsis txaus periorbital barrier kom ncav cuag cov xim deposits hauv daim tawv nqaij.
Piv nrog rau cov khoom siv qhov muag pom kev ci ntsa iab, nws muab cov txiaj ntsig triple synergistic: thaiv periorbital alpha-MSH cov cim qhia los txwv kev tsim cov melanin tshiab, metabolizing hnub nyoog nto xim deposits, thiab kho me me periorbital o los tiv thaiv cov pigmentation rov tshwm sim.
Thib peb-cov ntaub ntawv soj ntsuam tib neeg cov ntaub ntawv qhia tau hais tias 28 hmo sib law liag ntawm daim ntawv thov ntawm Nonapeptide-1 tshwj xeeb qhov muag ntshav tau txo qis qhov nruab nrab ntawm 4.92% ntawm cov xim sib txawv ntawm cov xim pigmented tsaus nti ntawm cov kev sim, nrog xoom qhia tsis zoo tshwm sim nrog rau periorbital allergy, stinging lossis milia breakout.
Daim tawv nqaij -Nourishing Makeup
Concealed Brightening & Skin Conditioning Mechanism
Nws boasts exceptional formulation stability nrog tsis kam mus rau kub, acid thiab alkali. Nws seamlessly integrates nrog aqueous, oily thiab hmoov cosmetic bases yam tsis muaj kev cuam tshuam cov thawj kev pab them nqi, hnav tsis kam thiab tawv nqaij xav ntawm lub hauv paus, tsim nyog nws raws li ib tug raug concealed skincare additive.
Nws ob lub-kev ua pleev xim- kev sib xyaw ntawm daim tawv nqaij muaj qhov ua kom zoo nkauj tam sim ntawd thiab ntev- lub sij hawm sib sib zog nqus txias: Ntawm qhov chaw, nws lub teeb yuag, translucent kev ntxhib los mos optimizes hmoov adhesion kom txo tau daim npog qhov ncauj - zoo li tiav thiab xa cov luminous brightening.
Hauv qab txheej pleev, nws txhawb nqa melanin- inhibiting kev ua si dhau 8-10 teev ntawm kev hnav, alleviating oxidative dullness induced los ntawm hmoov txhuam thiab sab nraud UV raug, thiab txo qis salllowness thiab inflammatory pigmentation stemming los ntawm ntev - siv pleev xim.
Tsis zoo li moisturizing los yog anti-aging additives uas muaj nyob rau hauv nourishing pleev, Nonapeptide-1 ncaj qha lub hom phiaj ntawm cov kev txhawj xeeb saum toj kawg nkaus ntawm cov neeg pleev kob nquag- dullness thiab daj complexions-ua tiav instant brightening raws li daim ntawv thov pleev thiab sustained whitening tom qab pleev tshem tawm.
Mainstream Cosmetic Application Scenarios & Product Advantages
Nonapeptide-1 ntshavyog dav siv nyob rau hauv peb lub ntsiab cosmetic pawg: primer essences, tawv nqaij -nourishing foundations thiab brightening concealers. Qhov ntau npaum li cas ntawm 0.2% -1% muab cov txiaj ntsig ci ntsa iab ntev yam tsis hloov lub hauv paus viscosity lossis hnav lub neej ntev.
Kev sim tshuaj kho mob rau cov neeg hnav khaub ncaws ntev ntev qhia tau tias 30 hnub ntawm kev siv cov Nonapeptide zoo ib yam-1-infused nourishing foundation txo cov tawv nqaij salllowness Performance index los ntawm 3.7% thiab ua rau muaj txiaj ntsig zoo tom qab ntxuav ntawm daim tawv nqaij translucency, txhim kho cov tshuaj pleev ib ce los ntawm cov tshuaj pleev ib ce rau kev kho mob. Tsis tas li ntawd, cov khoom xyaw yog non-photosensitive, possibilities tsis muaj kev nyab xeeb rau nruab hnub nrig cov qauv thiab sib xws nrog cov qauv tshuaj pleev ib ce rau txhua lub caij.
Daim ntawv thov Niche hauv Kev Kho Plaub Hau
Unaddressed Pigmentation Challenges nyob rau hauv kev lag luam tu plaub hau
Kev xaav pej xeem feem ntau koom nrog melanin nkaus xwb nrog cov tawv nqaij, tab sis melanocyte kev ua hauv cov hauv paus plaub hau ncaj qha dictates plaub hau xim. Cov tawv taub hau thiab cov plaub hau pigment teeb meem tau loj hlob zuj zus, encompassing post- inflammatory tawv taub hau pigmentation, tsaus hyperpigmentation cim tom qab rov tshwm sim cov plaub hau poob thiab redness raws cov plaub hau, pigment dysregulation nyob rau hauv cov hauv paus hniav nyob ib ncig ntawm cov plaub hau grey tshiab, thiab cov xim tsis sib xws ntawm cov tshuaj zas plaub hau.
Cov khoom siv tu plaub hau feem ntau tsom rau kev ua kom zoo, tswj roj thiab tshem tawm dandruff, tsis muaj lub hom phiaj ua haujlwm los hloov cov kev ua ntawm follicular melanocyte. Tsis muaj cov kev daws teeb meem yav dhau los rau cov tawv taub hau pigmentation thiab cov plaub hau tsaus nti. Lub zog los ntawm lub hom phiaj melanin- tshem tawm cov khoom, cov khoom lag luam tau nkag mus rau hauv cov dej hiav txwv xiav uas tsis muaj kev tu plaub hau.
Mechanism of Action on Scalp & Hair
Nonapeptide-1 ua rau melanocytes nyob ib puag ncig ntawm cov tawv taub hau saum tawv taub hau, thaiv cov alpha ntau dhau -MSH tso tawm los ntawm tawv taub hau o txhawm rau tiv thaiv tawv taub hau melanin txuam nrog thiab ploj tom qab- pob txuv tawv taub hau discoloration thiab kev sib txhuam plaub hau.
Nws kuj maj mam tswj follicular melanocyte kev ua si kom alleviate follicular pigment dysregulation, stabilizing ntuj plaub hau melanin thiab mitigating oxidative dryness thiab xim fading ntawm cov plaub hau strands.
Tsis zoo li daim ntawv thov kev tu tawv nqaij uas thov kom muaj zog melanin fading kev ua tau zoo, cov qauv kev tu plaub hau tsuas yog xav tau qis qis (0.1% -0.5%) ntawm Nonapeptide-1 kom xa cov kev xav tau txias. Nws tsis ua rau khaus khaus khaus tawv taub hau thiab tsis muaj kev phiv xws li tawv taub hau khaus lossis khaus ntau ntxiv.
Tsim los ntawm polypeptide lub tsev qiv ntawv tshuaj ntsuam xyuas thev naus laus zis thiab kev tshawb fawb molecular lom ntawm melanocytes, Nonapeptide-1 tau ua tiav peb theem: kev tshawb fawb txog kev tshawb fawb, lub hom phiaj siv tau thiab cov khoom lag luam zoo nkauj. Nws tag nrho R & D ncua sij hawm ncua lub sijhawm xyoo 1990 mus txog rau thaum ntxov 2000s, kos lub cim kev ua tiav hauv cov khoom siv whitening polypeptide raw khoom.
Kev Tshawb Fawb Lub Hom Phiaj Tseem Ceeb & Kev Ntsuam Xyuas Ua Ntej Polypeptide (1990-1994)
Nyob rau hauv thaum ntxov 1990s, lub ntiaj teb no cosmetic skincare kev lag luam ntsib ib tug bottleneck nyob rau hauv whitening active kev loj hlob. Cov khoom siv hluavtaws ua kom zoo nkauj ua rau muaj qhov tsis zoo xws li cytotoxicity thiab photosensitivity, tsav kev kawm tshawb fawb mus rau cov tshuaj dawb dawb uas tau txais los ntawm cov tib neeg endogenous signaling molecules.
Pab neeg tshawb fawb coj los ntawm Channa K. Jayawickreme ntawm Yale University Tsev Kawm Ntawv Tshuaj Kho Mob tau pib nthuav dav - spectrum polypeptide lub tsev qiv ntawv tshuaj ntsuam xyuas qhov kev pab cuam, ua hauv vitro cellular soj ntsuam ntawm tag nrho ntawm 31,360 tus qauv sib txawv polypeptide compounds. Lub hom phiaj tseem ceeb ntawm kev tshuaj ntsuam xyuas yog antagonist polypeptides muaj peev xwm thaiv alpha-MSH- mediated melanin activation signals.
Thaum pib tsim los tsim cov tshuaj tua kab mob polypeptides, qhov project tau mus txog qhov kev hloov pauv tseem ceeb thaum cov kev ntsuam xyuas tom ntej tau npaj tsis tau pom tias muaj zog melanin - hloov pauv kev ua haujlwm hauv qee yam tsis muaj npe hu ua nonapeptide, tso lub hauv paus rau kev txhim kho Nonapeptide-1.
Molecular Structure Finalization & Mechanism Validation (1994–1998)
Hauv xyoo 1994, pab pawg tau tsim cov khoom siv dag zog ntawm Nonapeptide-1 siv 5–13 amino acid sib lawv liag ntawm endogenous human alpha-MSH ua tus qauv, txhais nws cov qauv peptide tshwj xeeb: Met-Pro-D-Ph-Arg-D-Trp-Phe-Lys-Pro-Val-NH₂. 5th residue D-Trp thiab 6th residue Phe raug txheeb xyuas raws li qhov chaw tseem ceeb hauv kev sib khi.
Hauv vitro cellular kuaj tau sau tseg MC1R receptor antagonism IC50 tus nqi qis li 11.7 nM, qhia txog ultra- muaj zog lub hom phiaj khi affinity. Xyoo 1998, cov kev tshawb fawb txog kev tshawb fawb tau raug luam tawm hauv Phau Tsom Faj Txog Tshuaj lom neeg, lees paub tias nws tsis yog -cytotoxic profile thiab tsis yog- cuam tshuam rau kev ua haujlwm melanocyte physiological, qhov txawv ntawm cov tshuaj ntxuav hniav dawb.
Cosmetic Commercialization & Formulation Iteration (1999–2005)
Xyoo 1999, European thiab Asmeskas cov tuam txhab biotechnology tau txais daim ntawv tso cai patent los pib ua lag luam loj ntawm Nonapeptide-1 raw khoom, pib siv feem ntau hauv cov txheej txheem ntawm lub ntsej muag whitening essence.
Los ntawm 2005, kev nce qib hauv kev xa khoom siv thev naus laus zis tau ua rau Nonapeptide-1 kev sib raug zoo nrog ntau yam matrices rau kev tu lub qhov muag, pleev thiab tu plaub hau, ua tiav nws qhov kev hloov pauv los ntawm ib qho -cov khoom siv tu tawv nqaij ua haujlwm rau cov khoom siv tshuaj pleev ib ce uas muaj ntau yam thiab ua rau lub sijhawm tshwj xeeb ntawm daim ntawv thov.
Kev txwv & kev ua haujlwm tsis zoo
Nws tsuas yog inhibits tshiab melanin synthesis thiab tsis tuaj yeem sai metabolize hnub nyoog melanin twb tso rau ntawm daim tawv nqaij; ua ke nrog vitamin C los yog txiv hmab txiv ntoo acid derivatives yog yuav tsum tau kom ceev qhov chaw fading.
Nws kuj loj molecular hnyav ua rau tsis muaj zog transdermal permeability nyob rau hauv yooj yim aqueous daws; liposomes los yog polyol penetration enhancers yog yuav tsum tau kom tag nrho xa cov nquag mus rau melanocytes nyob rau hauv lub basal txheej.
Thaum siv ib leeg, nws qhov chaw -fading ceev lags qab siab -potency tyrosinase inhibitors; compound formulation doubles nws whitening efficiency.
HPLC Chromatographic Profile
Kev khaws cia tshwj xeeb ntawm kev thim rov qab -theem C18 chromatographic kab; nrhiav wavelength teem ntawm 280 nm. Rau tshuaj pleev ib ce-qib raw khoom, lub ntsiab ncov purity yog ntau dua los yog sib npaug rau 98.0%, thiab tus neeg peptide impurity Tsawg dua los yog sib npaug rau 2.0%. Daim ntawv ntsev acetate ntawm Nonapeptide-1 nthuav tawm lub sijhawm ua ntej me ntsis elution thiab dej solubility zoo dua.
Pawg Spectrometric yam ntxwv
Qhov tseem ceeb ntawm ESI huab hwm coj spectrum ncov yog [M+H]⁺=1207.65, uas yog tus cim rau cov ntaub ntawv raw cov ntaub ntawv pov thawj. Oxidative impurities tsim cov theem nrab peaks nrog loj hloov ntawm +16 thiab +32, sib xws rau mono-oxidized thiab di-oxidized methionine (Met) derivatives feem.
Kev Tswj Xyuas Zoo Specifications rau Microbes thiab Heavy Metals
Rau lyophilized hmoov: endotoxin Tsawg dua lossis sib npaug li 50 EU / mg; tag nrho aerobic microbial suav ＜10 CFU/mg. Tsis muaj Salmonella thiab Staphylococcus aureus. Cov ntsiab lus ntawm cov hlau hnyav xws li txhuas, arsenic, mercury thiab cadmium nyob deb tshaj qhov txwv tau teev tseg los ntawm lub teb chaws cov qauv tshuaj pleev ib ce, thiab peptide qhia tias tsis muaj kev nyiam ua cov hlau hnyav.
Cov ntaub ntawv
- Cenexa Labs. Nonapeptide-1 Peptide Kev Tshawb Fawb - Ua tiav Phau Ntawv Qhia [EB/OL]. 2026.
- Jayawickreme C. K. Melanocortin Receptor Antagonist Peptide Kev Tshawb Fawb[J].Phau ntawv Journal of Biological Chemistry, 1998.
- Kopeptide Biotechnology. Ib Txoj Kev Kho Mob Dawb Tshiab rau Cov tawv nqaij rhiab heev: Kopeptide Nonapeptide-1 Muab Tsawg-Irritation Long-Term Spot Fading with 1000 Da Macromolecules[EB/OL]. 2025.
- MedChemExpress. Nonapeptide-1 (Melanostatine-5) Product Technical Manual [EB/OL]. 2026.
- Sennopeptide. SNPep® NP-1 Nonapeptide-1 Raw Material Efficacy & Human Clinical Test Report[EB/OL]. 2026.
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