Shaanxi BLOOM Tech Co., Ltd. yog ib qho ntawm cov tuam ntxhab thiab cov muag khoom ntawm permethrin thiab imidacloprid tee hauv Suav teb. Txais tos rau cov lag luam wholesale bulk zoo permethrin thiab imidacloprid tee rau muag ntawm no los ntawm peb lub hoobkas. Kev pabcuam zoo thiab tus nqi tsim nyog muaj.
Permethrin thiab imidacloprid poob, "golden ua ke" rau kev tiv thaiv thiab kev tswj ntawm canine ectoparsites yog ib qho dav -spectrum deworming npaj tsim tshwj xeeb rau cov dev, uas ua tau zoo thiab ntev - kev tiv thaiv parsite ntev thiab tswj los ntawm ob lub tswv yim ntawm kev ua thiab tau dhau los ua cov tshuaj nquag siv hauv thaj chaw ntawm cov tshuaj tsiaj.
Cov tshuaj tua kab no tuaj yeem tiv thaiv thiab tswj cov kab mob nqus ntshav xws li zuam, yoov tshaj cum, thiab yoov, thiab txo qhov kev pheej hmoo ntawm kev kis kab mob xws li kab mob Lyme, Babesiosis, thiab kab mob khaub thuas. Cov ntaub ntawv kho mob qhia tau hais tias tom qab siv tshuaj, lub sijhawm txuas ntawm cov zuam luv luv kom tsawg dua 48 teev, tus kab mob yoov tshaj cum txo qis los ntawm 89%, thiab kev pheej hmoo ntawm tus kab mob heatworm txo los ntawm 59%. Nyob rau tib lub sijhawm, tus nqi kho rau cov kab mob dev vwm dermatitis mus txog 82%, txo cov tsos mob khaus khaus hauv dev.
Peb cov khoom
Cov yam ntxwv ntawm kev siv: Kev siv lub tee droplet formation, yooj yim rau kev khiav lag luam, cov tshuaj yog absorbed los ntawm daim tawv nqaij thiab faib thoob plaws hauv cov qog sebaceous, tsim ib tug nruam tiv thaiv.
Cov tshuaj yuav tsum nruj me ntsis stratified raws li lub cev hnyav kom tsis txhob siv ntau dhau ntawm cov tsiaj txhu xws li Collies. Tsis txhob da dej li ntawm 24 teev tom qab noj tshuaj kom paub tseeb tias ntev - siv tau ntev.
Permethrin thiab imidacloprid poobyog dav -spectrum in vitro deworming npaj tsim tshwj xeeb rau dev. Lawv cov tseem ceeb siv npog peb thaj chaw loj: kev tiv thaiv kab mob parsite thiab tswj, kev cuam tshuam kev kis kab mob, thiab kev saib xyuas ib puag ncig kev nyab xeeb.
1. Tua thiab khiav tawm ntawm zuam
Tag nrho lifecycle blockade
Permethrin, raws li hom I hluavtaws pyrethroid, cuam tshuam nrog cov zuam voltage nyob ntawm sodium ion raws, ua rau muaj kev cuam tshuam ntawm cov neurons thiab ua tiav kev sib cuag sai sai (ua tau zoo hauv 30 feeb). Nws cov tshuaj tua kab mob npog 8 cov zuam ntau, suav nrog cov genus Ixodes thiab cov zuam liab, nrog rau kev tua tus nqi ntawm 98% tawm tsam cov kab laus hauv 2 teev tom qab kho.
Imidacloprid, raws li ib tug neonicotinoid neurotoxin, tshwj xeeb yog thaiv cov zuam nicotinic acetylcholine receptors (nAChR) thiab ncua lub sijhawm ua haujlwm rau 4 lub lis piam. Qhov kev sib koom ua ke ntawm ob tuaj yeem txo qhov kev sib txuas ntawm cov zuam (nruab nrab 7 hnub hauv pab pawg tsis kho thiab<48 hours in the treated group), and reduce the risk of tick borne disease transmission.
Ntau hom kev zam txim
Cov kev tshawb fawb soj ntsuam tau pom tias qhov sib xyaw ua ke muaj qhov cuam tshuam rau cov zuam liab rau 28 hnub thiab cov zuam reticulated rau 21 hnub. Hauv cheeb tsam CanL kab mob sib kis nyob rau yav qab teb Ltalis, tus kab mob kis ntawm pab pawg tshuaj tau txo qis los ntawm 81% piv rau pawg tswj hwm, ua kom pom tias nws tiv thaiv cov kab mob vector xws li sandflies. Kev sim kuaj ntxiv tau pom tias lub sijhawm nyob ntawm cov zuam nyob hauv 50cm lub vojvoog ntawm cov dev kho tau raug txo kom tsawg dua 2 feeb, ua rau lub cev tsis muaj zog.
2. Tag nrho cov txheej txheem tswj cov dev mub
Dual theem tswj cov neeg laus thiab larvae
Kev tua tus nqi ntawm Imidacloprid tawm tsam cov neeg laus tuaj yeem ncav cuag 98% hauv 2 teev, thaum Permethrin tua cov dev mub nyob rau hauv ib puag ncig los ntawm kev mob plab. Pyriproxyfen (kab kev loj hlob regulator) ntxiv rau qee cov qauv tuaj yeem cuam tshuam cov qe qe hatching, tsim kev tiv thaiv triple ntawm "kev sib cuag tua plab toxicity kev loj hlob blockade". Cov ntaub ntawv kho mob qhia tau hais tias kev tua tus nqi ntawm fleas nyob rau hauv ib puag ncig tom qab cov tshuaj tau nce mus txog 89%, thiab cov qe qe qe txo los ntawm 97%, npog tag nrho lub neej voj voog ntawm fleas (qe larva pupae neeg laus).
Kev Kho Cov Kab Mob Ua Tsis Taus
Tus nqi kho mob rau cov kab mob dermatitis (FAD) yog 82%, nrog rau 76% txo qhov khaus khaus thiab 63% txo ntawm daim tawv nqaij erythema hauv 72 teev tom qab siv tshuaj. Nws mechanism alleviates hom IV hypersensitivity los ntawm sai txo cov flea load ntawm lub cev nto, txo antigen raug.
3. Kev khiav tawm dav dav ntawm cov kab nqus ntshav
Kev tswj yoov tshaj cum thiab kab
Tus nqi tiv thaiv tawm tsam Aedes aegypti thiab Culex pipiens yog ntau dua 90%, nrog rau cov nyhuv txuas ntxiv rau 4 lub lis piam.
Cov kev kuaj sim tau pom tias cov qaub ncaug protein cov ntsiab lus ntawm yoov tshaj cum nyob rau hauv cov ntshav ntawm cov dev kho nrog tshuaj txo qis los ntawm 92%, ua pov thawj tias nws txiav tawm cov kab mob sib kis ntawm filariasis los ntawm kev thaiv cov ntshav nqus cov cwj pwm. Nyob rau hauv cov cheeb tsam uas muaj kab mob filariasis, tus kab mob kis ntawm pawg tshuaj tau txo qis los ntawm 67% piv rau pawg tswj hwm.
Tiv thaiv thiab tswj cov yoov thiab xuab zeb yoov
Cov tshuaj tua kab mob ntawm cov yoov ruaj khov kav ntev li 4 lub lis piam, txo qhov kev pheej hmoo ntawm kev puas tsuaj ntawm daim tawv nqaij thiab kis kab mob thib ob. Cov tshuaj tua kab mob ntawm Papura sandflies kav ntev li 14 hnub thiab tuaj yeem txo tus kab mob los ntawm 68% hauv cov cheeb tsam uas muaj cov kab mob leishmaniasis. Nws cov txheej txheem ntawm kev nqis tes ua cuam tshuam nrog cov kab olfactory receptors thiab thaiv tus tswv hauv zos tus cwj pwm.
Thaiv kev kis kab mob parasitic
1. Tiv thaiv kab mob zuam
Kab mob Babesiosis
Tom qab siv tshuaj, qhov kev sib kis ntawm Babesiosis hauv dev tau txo qis los ntawm 65%. Lub tshuab yog los txo cov zuam lub sij hawm nqus cov ntshav (qhov nruab nrab ntawm cov ntshav nqus cov ntshav hauv cov pab pawg tsis kho yog 12 μ L piv rau<3 μ L in the treated group) and lower the risk of sporophyte injection through saliva. Clinical cases have shown that in the Babesiosis endemic area of Hungary, the serological positivity rate of dogs receiving continuous medicaments has decreased from 34% to 11%.
Tib neeg ehrlichiosis
Tom qab ib koob tshuaj ntawm cov tshuaj, qhov kev pheej hmoo ntawm kev kis tus kab mob canine monocytic Ehrlichiosis tau txo los ntawm 72%, thiab nws cov nyhuv yog vim nws tua cov nyhuv ntawm Ehrlichiosis hauv cov zuam plab. Cov kev tshawb fawb hauv chav kuaj tau lees paub tias Permethrin tuaj yeem cuam tshuam qhov midgut barrier ntawm zuam, ua rau cov kab mob raug tso tawm nrog cov hlab ntsha.
2. Tiv thaiv thiab tswj cov kab mob yoov tshaj cum
Kab mob plawv
Los ntawm kev tshem tawm yoov tshaj cum thiab txo qis microfilament ingestion, qhov zoo ntawm cov tshuaj tiv thaiv kab mob hauv cov dev hauv cov tshuaj tau txo qis los ntawm 59% piv rau pawg tswj hwm hauv thaj chaw muaj kab mob khaub thuas cua sov nyob rau sab qab teb Tebchaws Meskas.Permethrin thiab imidacloprid poobKev tiv thaiv zoo yog cuam tshuam nrog kev siv tshuaj ntau zaus, nrog rau ib hlis ib zaug cov tshuaj txo qis kev pheej hmoo kis mob los ntawm 83%.
Dire's canine filariasis
Cov tshuaj tua kab mob rau yoov tshaj cum ntawm Culex genus tau siv sijhawm li 4 lub lis piam. Hauv cheeb tsam European uas muaj kab mob filariasis, qhov tshwm sim ntawm pulmonary embolism hauv pab pawg kho mob tau txo qis los ntawm 18% mus rau 4%. Nws cov txheej txheem txo qhov zaus ntawm yoov tshaj cum noj thiab txo qhov kev pheej hmoo ntawm kev txhaj tshuaj larvae thib peb.
3. Kev cuam tshuam ntawm yoov yug kab mob
Kab mob ntawm daim tawv nqaij
Cov nyhuv tiv thaiv ntawm cov yoov ruaj khov tuaj yeem txo qhov txuas ntawm yoov thiab qe. Hauv cov pej xeem Australian pasture aub, qhov tshwm sim ntawm daim tawv nqaij myiasis hauv pawg tshuaj tau txo qis los ntawm 23% mus rau 3%. Nws cov nyhuv stems los ntawm Permethrin qhov cuam tshuam nrog ya olfactory receptors, thaiv cov tswv tsev hauv zos cov cim.
Leishmania parsite kab mob
Qhov tshwm sim ntawm lymphadenopathy nyob rau hauv cov dev hauv pab pawg kho mob tau txo qis los ntawm 41% mus rau 9% hauv cov cheeb tsam uas muaj tus kab mob no. Lub tshuab txo qhov zaus ntawm cov ntshav nqus los ntawm cov xuab zeb thiab txo qhov kev pheej hmoo ntawm kev txhaj tshuaj pre flagellates los ntawm qaub ncaug.
Daim ntawv thov tus nqi ntawm cov xwm txheej tshwj xeeb
1. Kev tiv thaiv ib puag ncig raug siab
Yos hav zoov thiab ua hauj lwm dev
Nyob rau hauv cov cheeb tsam uas muaj zuam ceev ceev xws li hav zoov thiab swamps, colonization tus nqi ntawm zuam nyob rau hauv dev txo los ntawm 98.6% tom qab noj tshuaj, txo qhov kev pheej hmoo ntawm Lyme kab mob thiab spirochetes kab mob. Lub koom haum American Veterinary Association pom zoo tias cov dev yos hav zoov yuav tsum tau noj tshuaj ib zaug txhua 28 hnub, nrog rau kev kho kab mob ib puag ncig.
Kev tswj hwm thaj chaw muaj kev puas tsuaj tom qab
Hauv thaj chaw muaj kev sib kis tom qab dej nyab thiab av qeeg, cov tshuaj muaj peev xwm txo tau cov kab mob sab nraud ntawm cov dev thiab txo cov kab mob zoonotic. Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv (OIE) cov lus qhia tau hais tias siv cov qauv no hauv 72 teev tom qab muaj kev puas tsuaj tuaj yeem txo qis tus kab mob ntawm 67% mus rau 5%.
2. Kev tswj hwm tsev neeg ntau tus dev
Pab pawg tiv thaiv
Hauv cov cheeb tsam uas muaj neeg coob coob xws li kennels thiab chaw nyob, tus kab mob yoov tshaj cum tau txo qis los ntawm 89% mus rau 12% thiab tus kab mob zuam txo qis los ntawm 54% mus rau 3% tom qab noj tshuaj. Nws cov nyhuv stems los ntawm cov residual nyhuv ntawm cov tshuaj ntawm aub plaub hau, tsim ib pab tsiaj tiv thaiv kab mob.
Cov dev tshiab raug cais tawm
Cov dev nyob hauv tsev tshiab yuav tsum tsis txhob sib cuag nrog lwm tus dev hauv 48 teev tom qab noj tshuaj, uas tuaj yeem tiv thaiv tau cov kab mob parsites. Cov ntaub ntawv kho mob qhia tau hais tias qhov kev ntsuas no tuaj yeem txo tus kab mob parasitic ntawm cov dev hauv cov chaw nyob los ntawm 73% mus rau 18%.
3. Postoperative thiab tiv thaiv tus dev tiv thaiv
Postoperative rov qab lub sij hawm
Thaum lub sij hawm postoperative rov zoo xws li qog resection thiab orthopedic phais,permethrin thiab imidacloprid teetuaj yeem txo qhov kev pheej hmoo ntawm kev kis kab mob thib ob hauv daim tawv nqaij qhov txhab. Kev tshawb fawb tau pom tias qhov kev kis tus kab mob tom qab hauv pab pawg tshuaj tau txo qis los ntawm 21% mus rau 4%, uas yog ua tiav los ntawm kev txo cov neeg kho tshuab puas tsuaj los ntawm yoov thiab zuam.
Immunosuppressive kho mob
Kev siv tshuaj tuaj yeem txo qhov kev pheej hmoo ntawm kev kis tus kab mob kis tau zoo hauv cov dev uas tau txais tshuaj kho mob thiab kho glucocorticoid. Cov kws kho mob tau pom tias cov kab mob parasitic load ntawm cov dev nyob rau hauv cov pab pawg neeg cov tshuaj txo los ntawm 89% piv rau pawg tswj, txo qhov tshwm sim ntawm theem nrab pyoderma.
1. Nyhav stratified koob
Me Me (4-10kg)
Tus qauv koob tshuaj yog 0.4ml / lub sijhawm (xws li Imidacloprid 40mg thiab Permethrin 200mg), thiab cov tshuaj ntshav siab nce mus txog qhov siab tshaj plaws hauv 24 teev tom qab kev tswj hwm (Cmax=12 μ g / mL), nrog rau cov nyhuv txuas ntxiv rau 28 hnub.
Cov dev loj (25-40kg)
Tus qauv koob tshuaj yog 2.5ml / lub sijhawm (xws li Imidacloprid 250mg thiab Permethrin 1250mg), thiab tom qab noj tshuaj, cov nyiaj seem ntawm daim tawv nqaij yog 37% siab dua li cov dev me, thiab kev tsav tsheb mus txog 60cm.
2. Cov tswv yim noj tshuaj hauv cheeb tsam
Qhov xwm txheej siab ntawm cov zuam
Hauv cov cheeb tsam uas muaj tus kab mob Lyme (xws li Northeastern United States), nws raug nquahu kom siv cov tshuaj ib zaug txhua 21 hnub ua ke nrog kev kho kab mob ib puag ncig. Cov ntaub ntawv kho mob qhia tau tias txoj kev npaj no tuaj yeem txo tus kab mob zuam los ntawm 62% mus rau 8%.
Qhov xwm txheej siab ntawm yoov tshaj cum thiab kab
Hauv cov cheeb tsam uas muaj kab mob khaub thuas (xws li yav qab teb Tebchaws Meskas), nws raug nquahu kom noj tshuaj ib hlis ib zaug nrog rau kev tiv thaiv kab mob khaub thuas. Kev tshawb fawb tau pom tias kev sib xyaw ua ke tuaj yeem txo qhov tshwm sim ntawm microfilamentemia los ntawm 34% mus rau 2%.
3. Ntau yam kev hloov kho
Collie yug
Txawm hais tias Permethrin yog cov rhiab heev, cov kev tshawb fawb soj ntsuam tau pom tias qhov tshwm sim ntawm neurotoxicity tom qab tus qauv noj tsuas yog 0.3%, qis dua lwm hom (1.2%). Nws raug nquahu kom ua tib zoo saib hauv 24 teev tom qab noj tshuaj.
Shorthair dev yug
Zoo li bulldogs, boxer aub, thiab lwm yam, cov tshuaj nqus cov tshuaj tom qab noj tshuaj yog 22% siab dua li cov dev plaub hau ntev, thiab cov nyhuv tiv thaiv yuav kav ntev li 32 hnub. Nws raug nquahu kom noj cov tshuaj ib zaug txhua 30 hnub kom tsis txhob muaj tshuaj ntau ntxiv.
1. Synthesis ntawm Permethrin
Permethrin yog hluavtaws pyrethroid. Txoj kev lag luam pib nrog trichloroacetaldehyde thiab isobutylene, catalyzed los ntawm AlCl₃ ntawm qhov kub thiab txias rau daim ntawv 1,1,1-trichloro-4-methyl-3-penten-2-ol.
Qhov no intermediate condenses nrog triethyl orthoacetate, rearranging rau ethyl 3,3-dimethyl-4,6,6-trichloro-5-hexenoate. Cyclization nyob rau hauv sodium ethoxide yields ethyl 2,2-dimethyl-3-(2,2-dichloroethenyl)cyclopropanecarboxylate.
Tom qab saponification rau sodium ntsev, nws reacts nrog 3-phenoxybenzyl chloride ntawm nucleophilic hloov mus rau permethrin. Cov khoom yog purified los ntawm recrystallization, nrog purity mus txog 95%.
2. Synthesis ntawm Imidacloprid
Imidacloprid, ib qho neonicotinoid, tso siab rau 2-chloro-5-chloromethylpyridine ua qhov tseem ceeb nruab nrab. Txoj kev 3-methylpyridine yog qhov tseem ceeb: 3-methylpyridine yog oxidized nrog H₂O₂ rau nws cov N-oxide, ces kho nrog phthaloyl chloride thiab triethylamine muab 2-chloro-5-methylpyridine.
Ntxiv chlorination nrog SO₂Cl₂ yields 2-chloro-5-chloromethylpyridine. Qhov nruab nrab no condenses nrog N-nitroimidazolidin-2-amine nyob rau hauv lub xub ntiag ntawm lub hauv paus (xws li, K₂CO₃) tsim imidacloprid. Purification ntawm distillation thiab crystallization muab 98% cov khoom ntshiab.
3. Formulation of Combined Drops
Ob qho khoom xyaw nquag (permethrin 400 mg / mL, imidacloprid 100 mg / mL) yog yaj hauv cov kuab tshuaj sib xyaw ntawm PEG-400 thiab isopropyl cawv. Transdermal enhancers zoo li laurocapram thiab eucalyptus roj yog ntxiv los txhim kho daim tawv nqaij nkag mus.
Cov sib tov yog lim, sterilized, thiab ntim rau hauv pipettes, yielding ib tug ntshiab, daj ntseg - daj oily poob kua.
FAQ
Puas yog Imidacloprid permethrin muaj kev nyab xeeb rau cov dev?
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Qhov no yog imidacloprid, permethrin, thiab pyriproxyfentau pom zoo los ntawm Lub Chaw Saib Xyuas Kev Tiv Thaiv Ib puag ncig rau kev siv dev thiab menyuam dev. Cov dev yuav tsum muaj tsawg kawg yog 7 lub lis piam thiab hnyav tsawg kawg yog 4 phaus siv imidacloprid / permethrin / pyriproxyfen cov khoom siv tshuaj pleev ib ce.
Yuav ua li cas yog tias kuv tus dev licks permethrin?
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Kev noj cov tshuaj Permethrin tuaj yeem ua rau muaj mob rau dev, ua rau cov tsos mob xws li ntuav, ua kua dej, tshee, lossis qaug dab peg. Kev saib xyuas veterinary tam sim yog qhov tseem ceeb heev. Yog tias kev noj tshuaj tsis ntev los no thiab tsis muaj tsos mob tshwm sim, saib xyuas kom zoo thiab tiv thaiv kev kis tus kab mob ntxiv.
Cim npe nrov: Permethrin thiab imidacloprid tee, lwm tus neeg, manufacturers, hoobkas, lag luam wholesale, yuav, nqe, tej, kev muag khoom